Bus and Coach from Lyon to Brussels: Compare all prices

Compare all timetables for the bus from Lyon to Brussels

Here is a selection of the cheapest bus trips from the schedule from Lyon to Brussels from various bus operators like BlaBlaCar Bus or FlixBus for the next days.

today

£26

tomorrow

£23

Friday

£22

Saturday

£29

Sunday

£24

Monday

£29

Tuesday

£38

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 45m	21:30	Lyon	Perrache Bus Stop	08:15	Brussels	Midi Bus Station	Economy	£26	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 17/12/2025 21:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 18/12/2025 08:15:00. 50 Economy ticket for £26 per person are available. Travel duration is 10h 45m
FlixBus	12h 15m	16:30	Lyon	Perrache Bus Stop	04:45	Brussels	North Station	Economy	£28	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 17/12/2025 16:30:00 to North Station, Brussels (Belgium) arriving at 18/12/2025 04:45:00. 50 Economy ticket for £28 per person are available. Travel duration is 12h 15m
FlixBus	11h 45m	19:00	Lyon	Perrache Bus Stop	06:45	Brussels	North Station	Economy	£28	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 17/12/2025 19:00:00 to North Station, Brussels (Belgium) arriving at 18/12/2025 06:45:00. 50 Economy ticket for £28 per person are available. Travel duration is 11h 45m
FlixBus	13h 45m	21:30	Lyon	Perrache Bus Stop	11:15	Brussels	North Station	Economy	£28	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 17/12/2025 21:30:00 to North Station, Brussels (Belgium) arriving at 18/12/2025 11:15:00. 50 Economy ticket for £28 per person are available. Travel duration is 13h 45m
FlixBus	11h 50m	08:40	Lyon	Perrache Bus Stop	20:30	Brussels	North Station	Economy	£35	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 17/12/2025 08:40:00 to North Station, Brussels (Belgium) arriving at 17/12/2025 20:30:00. 50 Economy ticket for £35 per person are available. Travel duration is 11h 50m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 20m	08:35	Lyon	Perrache Train Station	19:55	Brussels	North Station	Economy	£23	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 18/12/2025 08:35:00 to North Station, Brussels (Belgium) arriving at 18/12/2025 19:55:00. 50 Economy ticket for £23 per person are available. Travel duration is 11h 20m
BlaBlaCar Bus	12h 15m	08:35	Lyon	Perrache Bus Stop	20:50	Brussels	Midi Bus Station	Economy	£26	A Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 18/12/2025 08:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 18/12/2025 20:50:00. 50 Economy ticket for £26 per person are available. Travel duration is 12h 15m
BlaBlaCar Bus	10h 45m	02:45	Lyon	Perrache Train Station	13:30	Brussels	Midi Bus Station	Economy	£27	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 18/12/2025 02:45:00 to Midi Bus Station, Brussels (Belgium) arriving at 18/12/2025 13:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 10h 45m
FlixBus	13h 40m	21:30	Lyon	Perrache Bus Stop	11:10	Brussels	North Station	Economy	£31	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 18/12/2025 21:30:00 to North Station, Brussels (Belgium) arriving at 19/12/2025 11:10:00. 50 Economy ticket for £31 per person are available. Travel duration is 13h 40m
FlixBus	11h 30m	00:50	Lyon	Perrache Bus Stop	12:20	Brussels	Midi Bus Station	Economy	£32	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 18/12/2025 00:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 18/12/2025 12:20:00. 50 Economy ticket for £32 per person are available. Travel duration is 11h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 5m	00:20	Lyon	Perrache Train Station	10:25	Brussels	Midi Bus Station	Economy	£22	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/12/2025 00:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 19/12/2025 10:25:00. 50 Economy ticket for £22 per person are available. Travel duration is 10h 5m
BlaBlaCar Bus	10h 15m	05:00	Lyon	Perrache Train Station	15:15	Brussels	Midi Bus Station	Economy	£22	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/12/2025 05:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 19/12/2025 15:15:00. 50 Economy ticket for £22 per person are available. Travel duration is 10h 15m
BlaBlaCar Bus	10h 25m	01:35	Lyon	Perrache Train Station	12:00	Brussels	Midi Bus Station	Economy	£25	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/12/2025 01:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 19/12/2025 12:00:00. 50 Economy ticket for £25 per person are available. Travel duration is 10h 25m
FlixBus	10h 45m	21:30	Lyon	Perrache Bus Stop	08:15	Brussels	Midi Bus Station	Economy	£54	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 21:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 08:15:00. 50 Economy ticket for £54 per person are available. Travel duration is 10h 45m
FlixBus	11h 35m	04:00	Lyon	Perrache Bus Stop	15:35	Brussels	North Station	Economy	£58	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 04:00:00 to North Station, Brussels (Belgium) arriving at 19/12/2025 15:35:00. 50 Economy ticket for £58 per person are available. Travel duration is 11h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 5m	01:20	Lyon	Perrache Train Station	11:25	Brussels	Midi Bus Station	Economy	£29	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 20/12/2025 01:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 11:25:00. 50 Economy ticket for £29 per person are available. Travel duration is 10h 5m
BlaBlaCar Bus	10h 25m	01:35	Lyon	Perrache Train Station	12:00	Brussels	Midi Bus Station	Economy	£29	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 20/12/2025 01:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 12:00:00. 50 Economy ticket for £29 per person are available. Travel duration is 10h 25m
BlaBlaCar Bus	11h 5m	02:25	Lyon	Perrache Train Station	13:30	Brussels	Midi Bus Station	Economy	£29	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 20/12/2025 02:25:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 13:30:00. 50 Economy ticket for £29 per person are available. Travel duration is 11h 5m
FlixBus	10h 45m	21:30	Lyon	Perrache Bus Stop	08:15	Brussels	Midi Bus Station	Economy	£57	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 21:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 21/12/2025 08:15:00. 50 Economy ticket for £57 per person are available. Travel duration is 10h 45m
FlixBus	12h 40m	14:20	Lyon	Perrache Bus Stop	03:00	Brussels	North Station	Economy	£60	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:20:00 to North Station, Brussels (Belgium) arriving at 21/12/2025 03:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 12h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 25m	01:35	Lyon	Perrache Train Station	12:00	Brussels	Midi Bus Station	Economy	£24	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 21/12/2025 01:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 21/12/2025 12:00:00. 50 Economy ticket for £24 per person are available. Travel duration is 10h 25m
BlaBlaCar Bus	10h 5m	00:20	Lyon	Perrache Train Station	10:25	Brussels	Midi Bus Station	Economy	£25	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 21/12/2025 00:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 21/12/2025 10:25:00. 50 Economy ticket for £25 per person are available. Travel duration is 10h 5m
BlaBlaCar Bus	10h 5m	13:30	Lyon	Perrache Train Station	23:35	Brussels	Midi Bus Station	Economy	£25	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 21/12/2025 13:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 21/12/2025 23:35:00. 50 Economy ticket for £25 per person are available. Travel duration is 10h 5m
FlixBus	10h 20m	01:30	Lyon	Perrache Bus Stop	11:50	Brussels	North Station	Economy	£49	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 01:30:00 to North Station, Brussels (Belgium) arriving at 21/12/2025 11:50:00. 50 Economy ticket for £49 per person are available. Travel duration is 10h 20m
FlixBus	10h 45m	21:30	Lyon	Perrache Bus Stop	08:15	Brussels	Midi Bus Station	Economy	£53	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 21:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 08:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 10h 45m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 15m	05:00	Lyon	Perrache Train Station	15:15	Brussels	Midi Bus Station	Economy	£29	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 22/12/2025 05:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 15:15:00. 50 Economy ticket for £29 per person are available. Travel duration is 10h 15m
BlaBlaCar Bus	11h 5m	12:00	Lyon	Perrache Train Station	23:05	Brussels	Midi Bus Station	Economy	£29	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 22/12/2025 12:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 23:05:00. 50 Economy ticket for £29 per person are available. Travel duration is 11h 5m
BlaBlaCar Bus	10h 5m	01:20	Lyon	Perrache Train Station	11:25	Brussels	Midi Bus Station	Economy	£32	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 22/12/2025 01:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 11:25:00. 50 Economy ticket for £32 per person are available. Travel duration is 10h 5m
FlixBus	10h 45m	21:30	Lyon	Perrache Bus Stop	08:15	Brussels	Midi Bus Station	Economy	£53	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 21:30:00 to Midi Bus Station, Brussels (Belgium) arriving at 23/12/2025 08:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 10h 45m
FlixBus	10h 20m	01:30	Lyon	Perrache Bus Stop	11:50	Brussels	North Station	Economy	£53	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 01:30:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 11:50:00. 50 Economy ticket for £53 per person are available. Travel duration is 10h 20m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 25m	01:35	Lyon	Perrache Train Station	12:00	Brussels	Midi Bus Station	Economy	£38	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 23/12/2025 01:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 23/12/2025 12:00:00. 50 Economy ticket for £38 per person are available. Travel duration is 10h 25m
BlaBlaCar Bus	10h 45m	02:45	Lyon	Perrache Train Station	13:30	Brussels	Midi Bus Station	Economy	£39	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 23/12/2025 02:45:00 to Midi Bus Station, Brussels (Belgium) arriving at 23/12/2025 13:30:00. 50 Economy ticket for £39 per person are available. Travel duration is 10h 45m
BlaBlaCar Bus	11h 20m	08:35	Lyon	Perrache Train Station	19:55	Brussels	North Station	Economy	£39	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 23/12/2025 08:35:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 19:55:00. 50 Economy ticket for £39 per person are available. Travel duration is 11h 20m
FlixBus	11h 55m	00:50	Lyon	Perrache Bus Stop	12:45	Brussels	North Station	Economy	£55	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 00:50:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 12:45:00. 50 Economy ticket for £55 per person are available. Travel duration is 11h 55m
FlixBus	12h 40m	14:20	Lyon	Perrache Bus Stop	03:00	Brussels	North Station	Economy	£55	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 14:20:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 03:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 12h 40m

Best Price Offer: The price for the cheapest coach from Lyon to Brussels is £17 on 15/12/2025. Flexible travellers save on ticket prices.

Frequency of bus connections between Lyon and Brussels

See here how frequent the connections between Lyon and Brussels are, during different times and days of the week.

Sunday is the busiest day, with more than 47 daily coaches from Lyon to Brussels. Wednesday has instead the fewest connections, with only 6 daily coaches between Lyon and Brussels.

The busiest time of the day is the Night, with 88 coaches from Lyon to Brussels, while Evening sees the fewest connections between Lyon and Brussels, with 33 offers.

Facts about coaches from Lyon to Brussels

Compare all providers like BlaBlaCar Bus and FlixBus that travel 33 times every day by bus from Lyon to Brussels in one click! Book your bus ticket from Lyon to Brussels starting from £17!

Cheapest Bus	£17
Fastest Bus	9h 40m
Earliest Coach	08:40
Latest Coach	22:50
Daily Bus Connections	33 Ø
Distance	567.4 km
Coach Companies	BlaBlaCar Bus and FlixBus

Cheapest coach connections from Lyon to Brussels

Every day, 33 buses from 2 coach companies leave Lyon for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 17/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 15/12

Tuesday 16/12

Wednesday 17/12

£26

Thursday 18/12

£23

Friday 19/12

£22

Saturday 20/12

£29

Sunday 21/12

£24

Monday 22/12

£53

Tuesday 23/12

£38

Wednesday 24/12

£29

Thursday 25/12

£18

Friday 26/12

£70

Saturday 27/12

£53

Sunday 28/12

£53

Monday 29/12

£57

Tuesday 30/12

£74

Wednesday 31/12

£25

Thursday 01/01

£32

Friday 02/01

£44

Saturday 03/01

£48

Sunday 04/01

£40

Monday 05/01

£23

Tuesday 06/01

£20

Wednesday 07/01

£24

Thursday 08/01

£24

Friday 09/01

£19

Saturday 10/01

£17

Sunday 11/01

The cheapest time to travel from Lyon to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Lyon to Brussels, for the next 30 days.

With a price starting from £17, Saturday is the cheapest day for a coach from Lyon to Brussels. Wednesday instead is the most expensive day with prices starting from £24.

Night is the cheapest day time for bus tickets from Lyon to Brussels, with £17. Evening is the most expensive time of the day with prices starting from £26.

How to save money travelling from Lyon to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lyon to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lyon to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Lyon to Brussels are also emptier.

All bus stations and stops in Lyon and Brussels

The map below shows you where to find all the bus stations in Lyon and Brussels.

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

City Tours

Rue du Marché Aux Herbes 82

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Lyon to Brussels? Compare all modes of transports from Lyon to Brussels.

Service and Comfort on the bus from Lyon to Brussels

Want to know which seat classes are available on the coaches from Lyon to Brussels? Or which bus companies serve the route Lyon to Brussels? Below you will find answers to your questions.

FAQs about the Lyon to Brussels bus

How much does a Lyon - Brussels coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Lyon - Brussels bus trip is available from £17 and takes 10h 5m. Compare offers and save money!

How much could I save by comparing buses from Lyon to Brussels?

The connection Lyon to Brussels is offered by 2 companies with ticket prices ranging from £17 to £106. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Lyon - Brussels route on average every day?

Each day, the bus route from Lyon to Brussels is offered by roughly 33 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Brussels from Lyon take?

The quickest coach from Lyon to Brussels is provided by BlaBlaCar Bus and takes 9h 40m. Coach tickets for this connection cost £88. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Lyon to Brussels?

The earliest bus to Brussels departs from Lyon at 08:40. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Lyon to Brussels?

The latest bus to Brussels departs from Lyon at 22:50. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Lyon - Brussels route?

Passengers looking to travel from Lyon to Brussels can travel with BlaBlaCar Bus and FlixBus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Lyon and Brussels?

You can check all the direct connections between Lyon and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: BlaBlaCar Bus and FlixBus.

What can I take with me on the bus to Brussels from Lyon?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Lyon Brussels bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Lyon Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lyon to Brussels on your planned travel date.

How does CheckMyBus find the best bus deals from Lyon to Brussels?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 33 daily trips between Lyon and Brussels. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Lyon to Brussels?

Prices and availability for 33 trips between Lyon and Brussels change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Lyon to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lyon and to Brussels

Here’s an overview of the most popular bus routes to Lyon and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!