Bus and Coach from Rome to Lyon: Compare all prices

Compare all timetables for the bus from Rome to Lyon

Here is a selection of the cheapest bus trips from the schedule from Rome to Lyon from various bus operators like Itabus for the next days.

today

£29

tomorrow

£29

Thursday

£24

Friday

£24

Saturday

£24

Sunday

£24

Monday

£24

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop		Premium Economy	£29	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 03/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 04/02/2026 12:55:00. 50 Premium Economy ticket for £29 per person are available. Travel duration is 15h 10m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop		Premium Economy	£29	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 04/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 05/02/2026 12:55:00. 50 Premium Economy ticket for £29 per person are available. Travel duration is 15h 10m
	Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop		Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 04/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 04/02/2026 21:30:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 14h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	16h 25m	08:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/02/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 16h 25m
Itabus	15h 25m	09:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/02/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 25m
Itabus	15h 55m	13:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/02/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 04:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 12:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 10m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 05/02/2026 21:30:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 14h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	16h 25m	08:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/02/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 16h 25m
Itabus	15h 25m	09:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/02/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 25m
Itabus	15h 55m	13:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/02/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/02/2026 04:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 07/02/2026 12:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 10m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Economy	£32	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 21:30:00. 50 Economy ticket for £32 per person are available. Travel duration is 14h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	15h 25m	09:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/02/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 25m
Itabus	15h 55m	13:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/02/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/02/2026 04:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 08/02/2026 12:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 10m
Itabus	16h 25m	08:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£27	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/02/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/02/2026 00:25:00. 50 Premium Economy ticket for £27 per person are available. Travel duration is 16h 25m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/02/2026 21:30:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 14h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	15h 25m	09:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/02/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/02/2026 00:25:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 25m
Itabus	16h 25m	08:00	Rome	Tiburtina Bus Station	00:25	Lyon	Perrache Bus Stop	Premium Economy	£27	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/02/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/02/2026 00:25:00. 50 Premium Economy ticket for £27 per person are available. Travel duration is 16h 25m
Itabus	15h 55m	13:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£29	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/02/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/02/2026 04:55:00. 50 Premium Economy ticket for £29 per person are available. Travel duration is 15h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 09/02/2026 12:55:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 15h 10m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£43	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/02/2026 21:30:00. 50 Premium Economy ticket for £43 per person are available. Travel duration is 14h 30m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop		Premium Economy	£24	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 09/02/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 10/02/2026 12:55:00. 50 Premium Economy ticket for £24 per person are available. Travel duration is 15h 10m
	Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop		Premium Economy	£29	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 09/02/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/02/2026 21:30:00. 50 Premium Economy ticket for £29 per person are available. Travel duration is 14h 30m

Best Price Offer: The price for the cheapest coach from Rome to Lyon is £22 on 28/02/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between Rome and Lyon

See here how frequent the connections between Rome and Lyon are, during different times and days of the week.

Friday is the busiest day, with more than 17 daily coaches from Rome to Lyon. Tuesday has instead the fewest connections, with only 2 daily coaches between Rome and Lyon.

The busiest time of the day is the Morning, with 43 coaches from Rome to Lyon, while Afternoon sees the fewest connections between Rome and Lyon, with 12 offers.

Facts about coaches from Rome to Lyon

Compare all providers like Itabus that travel 11 times every day by bus from Rome to Lyon in one click! Book your bus ticket from Rome to Lyon starting from £22!

Cheapest Bus	£22
Fastest Bus	14h 30m
Earliest Coach	21:45
Latest Coach	21:45
Daily Bus Connections	11 Ø
Distance	749.0 km
Coach Companies	Itabus

Cheapest coach connections from Rome to Lyon

Every day, 11 buses from 1 coach companies leave Rome for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/02/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 02/02

Tuesday 03/02

£24

Wednesday 04/02

£24

Thursday 05/02

£24

Friday 06/02

£24

Saturday 07/02

£24

Sunday 08/02

£53

Monday 09/02

£24

Tuesday 10/02

£34

Wednesday 11/02

£24

Thursday 12/02

£24

Friday 13/02

£24

Saturday 14/02

£24

Sunday 15/02

£24

Monday 16/02

£24

Tuesday 17/02

£24

Wednesday 18/02

£34

Thursday 19/02

£35

Friday 20/02

£49

Saturday 21/02

£24

Sunday 22/02

£25

Monday 23/02

£24

Tuesday 24/02

£39

Wednesday 25/02

£24

Thursday 26/02

£24

Friday 27/02

£24

Saturday 28/02

£22

Sunday 01/03

The cheapest time to travel from Rome to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Lyon, for the next 30 days.

With a price starting from £22, Saturday is the cheapest day for a coach from Rome to Lyon. Tuesday instead is the most expensive day with prices starting from £24.

Morning is the cheapest day time for bus tickets from Rome to Lyon, with £24. Evening is the most expensive time of the day with prices starting from £24.

How to save money travelling from Rome to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Rome to Lyon are also emptier.

All bus stations and stops in Rome and Lyon

The map below shows you where to find all the bus stations in Rome and Lyon.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Largo Guido Mazzoni 4

Tiburtina Coach Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Lyon? Compare all modes of transports from Rome to Lyon.

Service and Comfort on the bus from Rome to Lyon

Want to know which seat classes are available on the coaches from Rome to Lyon? Or which bus companies serve the route Rome to Lyon? Below you will find answers to your questions.

FAQs about the Rome to Lyon bus

How much does a Rome - Lyon coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Rome - Lyon bus trip is available from £22 and takes 16h 25m. Compare offers and save money!

How much could I save by comparing buses from Rome to Lyon?

The connection Rome to Lyon is offered by 1 companies with ticket prices ranging from £22 to £59. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Rome - Lyon route on average every day?

Each day, the bus route from Rome to Lyon is offered by roughly 11 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Lyon from Rome take?

The quickest coach from Rome to Lyon is provided by Itabus and takes 14h 30m. Coach tickets for this connection cost £34. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Rome to Lyon?

The earliest bus to Lyon departs from Rome at 21:45. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Rome to Lyon?

The latest bus to Lyon departs from Rome at 21:45. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Rome - Lyon route?

Passengers looking to travel from Rome to Lyon can travel with Itabus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Rome and Lyon?

You can check all the direct connections between Rome and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Itabus.

What can I take with me on the bus to Lyon from Rome?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Rome Lyon bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Rome to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between Rome and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Rome to Lyon?

Prices and availability for 11 trips between Rome and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Rome to Lyon

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Rome and to Lyon

Here’s an overview of the most popular bus routes to Rome and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!