Bus and Coach from Rome to Lyon: Compare all prices

Compare all timetables for the bus from Rome to Lyon

Here is a selection of the cheapest bus trips from the schedule from Rome to Lyon from various bus operators like FlixBus or Itabus for the next days.

today

£34

tomorrow

£31

Saturday

£34

Sunday

£30

Monday

£54

Tuesday

£39

Wednesday

£34

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 04/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 04/12/2025 21:30:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 14h 30m
FlixBus	14h 55m	07:45	Rome	Tiburtina Bus Station	22:40	Lyon	Perrache Bus Stop	Economy	£40	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 04/12/2025 07:45:00 to Perrache Bus Stop, Lyon (France) arriving at 04/12/2025 22:40:00. 50 Economy ticket for £40 per person are available. Travel duration is 14h 55m
FlixBus	15h 20m	17:25	Rome	Anagnina Bus Station	08:45	Lyon	Perrache Bus Stop	Economy	£40	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 04/12/2025 17:25:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 08:45:00. 50 Economy ticket for £40 per person are available. Travel duration is 15h 20m
Itabus	15h 55m	13:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£43	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 04/12/2025 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 04:55:00. 50 Premium Economy ticket for £43 per person are available. Travel duration is 15h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£44	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 04/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 12:55:00. 50 Premium Economy ticket for £44 per person are available. Travel duration is 15h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	14h 30m	07:00	Rome	Tiburtina Coach Station	21:30	Lyon	Perrache Bus Stop	Basic	£31	A Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 05/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 21:30:00. 50 Basic ticket for £31 per person are available. Travel duration is 14h 30m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£48	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 05/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 12:55:00. 50 Premium Economy ticket for £48 per person are available. Travel duration is 15h 10m
Itabus	15h 55m	13:00	Rome	Tiburtina Coach Station	04:55	Lyon	Perrache Bus Stop	Basic	£49	A Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 05/12/2025 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 04:55:00. 50 Basic ticket for £49 per person are available. Travel duration is 15h 55m
FlixBus	14h 55m	07:45	Rome	Tiburtina Bus Station	22:40	Lyon	Perrache Bus Stop	Economy	£72	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 05/12/2025 07:45:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 22:40:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 55m
FlixBus	21h 25m	23:50	Rome	Tiburtina Bus Station	21:15	Lyon	Perrache Bus Stop	Economy	£84	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 05/12/2025 23:50:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 21:15:00. 50 Economy ticket for £84 per person are available. Travel duration is 21h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 21:30:00. 50 Economy ticket for £34 per person are available. Travel duration is 14h 30m
FlixBus	14h 55m	07:45	Rome	Tiburtina Bus Station	22:40	Lyon	Perrache Bus Stop	Economy	£40	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 07:45:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 22:40:00. 50 Economy ticket for £40 per person are available. Travel duration is 14h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£40	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 12:55:00. 50 Premium Economy ticket for £40 per person are available. Travel duration is 15h 10m
Itabus	18h 55m	10:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£56	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 10:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 04:55:00. 50 Premium Economy ticket for £56 per person are available. Travel duration is 18h 55m
FlixBus	16h 15m	21:55	Rome	Tiburtina Bus Station	14:10	Lyon	Perrache Bus Stop	Economy	£64	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 21:55:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £64 per person are available. Travel duration is 16h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£30	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 21:30:00. 50 Premium Economy ticket for £30 per person are available. Travel duration is 14h 30m
FlixBus	14h 55m	07:45	Rome	Tiburtina Bus Station	22:40	Lyon	Perrache Bus Stop	Economy	£40	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 07/12/2025 07:45:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 22:40:00. 50 Economy ticket for £40 per person are available. Travel duration is 14h 55m
FlixBus	15h 20m	17:25	Rome	Anagnina Bus Station	08:45	Lyon	Perrache Bus Stop	Economy	£40	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 07/12/2025 17:25:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 08:45:00. 50 Economy ticket for £40 per person are available. Travel duration is 15h 20m
Itabus	18h 55m	10:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£47	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/12/2025 10:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 04:55:00. 50 Premium Economy ticket for £47 per person are available. Travel duration is 18h 55m
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£48	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 07/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 12:55:00. 50 Premium Economy ticket for £48 per person are available. Travel duration is 15h 10m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£54	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 12:55:00. 50 Premium Economy ticket for £54 per person are available. Travel duration is 15h 10m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£58	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 21:30:00. 50 Premium Economy ticket for £58 per person are available. Travel duration is 14h 30m
Itabus	18h 55m	10:00	Rome	Tiburtina Bus Station	04:55	Lyon	Perrache Bus Stop	Premium Economy	£65	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 10:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 04:55:00. 50 Premium Economy ticket for £65 per person are available. Travel duration is 18h 55m
FlixBus	14h 55m	07:45	Rome	Tiburtina Bus Station	22:40	Lyon	Perrache Bus Stop	Economy	£82	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 07:45:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 22:40:00. 50 Economy ticket for £82 per person are available. Travel duration is 14h 55m
FlixBus	16h 5m	00:10	Rome	Tiburtina Bus Station	16:15	Lyon	Perrache Bus Stop	Economy	£84	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 00:10:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 16:15:00. 50 Economy ticket for £84 per person are available. Travel duration is 16h 5m

Did you know that if you travel from Rome to Lyon via Chambery, you can save more than £18? You can find the corresponding connections below.
- Distribusion
  
  19h 0m
  
  0
  
  07:00
  
  Rome
  Tiburtina Bus Station
  
  20:00
  
  Chambery
  Coach Station
  
  0
  
  Premium Economy
  
  £30
  
  A Bus from Distribusion goes from Tiburtina Bus Station, Rome (Italy) at 07/12/2025 07:00:00 to Coach Station, Chambery (France) arriving at 07/12/2025 20:00:00. 50 Premium Economy ticket for £30 per person are available. Travel duration is 13h 0m
- FlixBus
  
  1h 30m
  
  0
  
  00:30
  
  Chambery
  Coach Station
  
  02:00
  
  Lyon
  Perrache Bus Stop
  
  0
  
  Economy
  
  £7
  
  A Bus from FlixBus goes from Coach Station, Chambery (France) at 08/12/2025 00:30:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 02:00:00. 50 Economy ticket for £7 per person are available. Travel duration is 1h 30m
Travel time is 4h 30m longer, but you will save £18

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£39	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 09/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 12:55:00. 50 Premium Economy ticket for £39 per person are available. Travel duration is 15h 10m
FlixBus	16h 0m	20:00	Rome	Tiburtina Bus Station	12:00	Lyon	Perrache Bus Stop	Economy	£60	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 09/12/2025 20:00:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 12:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 16h 0m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£62	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 09/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 21:30:00. 50 Premium Economy ticket for £62 per person are available. Travel duration is 14h 30m
FlixBus	14h 50m	13:05	Rome	Anagnina Bus Station	03:55	Lyon	Perrache Bus Stop	Economy	£65	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 09/12/2025 13:05:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 03:55:00. 50 Economy ticket for £65 per person are available. Travel duration is 14h 50m
FlixBus	14h 55m	08:50	Rome	Tiburtina Bus Station	23:45	Lyon	Perrache Bus Stop	Economy	£66	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 09/12/2025 08:50:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 23:45:00. 50 Economy ticket for £66 per person are available. Travel duration is 14h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	15h 10m	21:45	Rome	Tiburtina Bus Station	12:55	Lyon	Perrache Bus Stop	Premium Economy	£34	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/12/2025 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 12:55:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 15h 10m
Itabus	14h 30m	07:00	Rome	Tiburtina Bus Station	21:30	Lyon	Perrache Bus Stop	Premium Economy	£40	A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/12/2025 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 21:30:00. 50 Premium Economy ticket for £40 per person are available. Travel duration is 14h 30m
FlixBus	15h 20m	17:25	Rome	Anagnina Bus Station	08:45	Lyon	Perrache Bus Stop	Economy	£50	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 10/12/2025 17:25:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 08:45:00. 50 Economy ticket for £50 per person are available. Travel duration is 15h 20m
FlixBus	14h 50m	13:05	Rome	Anagnina Bus Station	03:55	Lyon	Perrache Bus Stop	Economy	£52	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 10/12/2025 13:05:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 03:55:00. 50 Economy ticket for £52 per person are available. Travel duration is 14h 50m
FlixBus	16h 0m	20:00	Rome	Tiburtina Bus Station	12:00	Lyon	Perrache Bus Stop	Economy	£53	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 10/12/2025 20:00:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 12:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 0m

Best Price Offer: The price for the cheapest coach from Rome to Lyon is £30 on 04/12/2025. Flexible travellers save on ticket prices.

Frequency of bus connections between Rome and Lyon

See here how frequent the connections between Rome and Lyon are, during different times and days of the week.

Friday is the busiest day, with more than 27 daily coaches from Rome to Lyon. Tuesday has instead the fewest connections, with only 14 daily coaches between Rome and Lyon.

The busiest time of the day is the Evening, with 58 coaches from Rome to Lyon, while Night sees the fewest connections between Rome and Lyon, with 12 offers.

Facts about coaches from Rome to Lyon

Compare all providers like FlixBus and Itabus that travel 22 times every day by bus from Rome to Lyon in one click! Book your bus ticket from Rome to Lyon starting from £30!

Cheapest Bus	£30
Fastest Bus	14h 30m
Earliest Coach	00:10
Latest Coach	23:50
Daily Bus Connections	22 Ø
Distance	749.0 km
Coach Companies	FlixBus and Itabus

Cheapest coach connections from Rome to Lyon

Every day, 22 buses from 2 coach companies leave Rome for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 01/12

Tuesday 02/12

Wednesday 03/12

Thursday 04/12

£30

Friday 05/12

£55

Saturday 06/12

£34

Sunday 07/12

£30

Monday 08/12

£54

Tuesday 09/12

£34

Wednesday 10/12

£34

Thursday 11/12

£35

Friday 12/12

£30

Saturday 13/12

£34

Sunday 14/12

£40

Monday 15/12

£41

Tuesday 16/12

£30

Wednesday 17/12

£51

Thursday 18/12

£40

Friday 19/12

£62

Saturday 20/12

£40

Sunday 21/12

£40

Monday 22/12

£40

Tuesday 23/12

£79

Wednesday 24/12

£70

Thursday 25/12

£44

Friday 26/12

£44

Saturday 27/12

£70

Sunday 28/12

The cheapest time to travel from Rome to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Lyon, for the next 30 days.

With a price starting from £30, Sunday is the cheapest day for a coach from Rome to Lyon. Monday instead is the most expensive day with prices starting from £40.

Morning is the cheapest day time for bus tickets from Rome to Lyon, with £30. Afternoon is the most expensive time of the day with prices starting from £40.

How to save money travelling from Rome to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Rome to Lyon are also emptier.

All bus stations and stops in Rome and Lyon

The map below shows you where to find all the bus stations in Rome and Lyon.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Largo Guido Mazzoni 4

Tiburtina Coach Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Jean-Macé Train Station

Maison Carrée Bus Stop

Les Charrières 69570

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Lyon? Compare all modes of transports from Rome to Lyon.

Service and Comfort on the bus from Rome to Lyon

Want to know which seat classes are available on the coaches from Rome to Lyon? Or which bus companies serve the route Rome to Lyon? Below you will find answers to your questions.

FAQs about the Rome to Lyon bus

How much does a Rome - Lyon coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Rome - Lyon bus trip is available from £30 and takes 14h 30m. Compare offers and save money!

How much could I save by comparing buses from Rome to Lyon?

The connection Rome to Lyon is offered by 2 companies with ticket prices ranging from £30 to £156. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Rome - Lyon route on average every day?

Each day, the bus route from Rome to Lyon is offered by roughly 22 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Lyon from Rome take?

The quickest coach from Rome to Lyon is provided by Itabus and takes 14h 30m. Coach tickets for this connection cost £39. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Rome to Lyon?

The earliest bus to Lyon departs from Rome at 00:10. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Rome to Lyon?

The latest bus to Lyon departs from Rome at 23:50. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Rome - Lyon route?

Passengers looking to travel from Rome to Lyon can travel with FlixBus and Itabus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Rome and Lyon?

You can check all the direct connections between Rome and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Itabus.

What can I take with me on the bus to Lyon from Rome?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Rome Lyon bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Lyon on your planned travel date.

Available seat classes which are offered on the bus route Rome to Lyon

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Rome and to Lyon

Here’s an overview of the most popular bus routes to Rome and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!