Bus tickets St. Louis, MO to Chicago from £27

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Compare all timetables for the bus from St. Louis, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today
£36
tomorrow
£41
Monday
£34
Tuesday
£32
Wednesday
£27
Thursday
£27
Friday
£30

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £36
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £36
FlixBus 6h 5m 10:00 St. Louis, MO Gateway Station 16:05 Chicago Downtown Coach Station  Economy £37
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £55
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Union Station  Economy £75

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £41
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £41
FlixBus 6h 5m 10:00 St. Louis, MO Gateway Station 16:05 Chicago Downtown Coach Station  Economy £43
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £80
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Union Station  Economy £86
  • Did you know that if you travel from St. Louis, MO to Chicago via Springfield, IL, you can save more than £4? You can find the corresponding connections below.
    • FlixBus
      6h 15m
      0
      23:30
      St. Louis, MO
      Gateway Station
      01:15
      Springfield, IL
      Springfield SMTD Transfer Center Coach Stop
      0
      FlixBus
      Economy
      £11
      • Waiting Time 0h 5m
    • FlixBus
      4h 25m
      0
      01:20
      Springfield, IL
      Bus Stop
      05:45
      Chicago
      Downtown Coach Station
      0
      FlixBus
      Economy
      £26
    Travel time is 0h 10m longer, but you will save £4

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £34
FlixBus 5h 50m 23:30 St. Louis, MO Gateway Station 05:20 Chicago 95th Red Line Station  Economy £36
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £36
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Union Station  Economy £44
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £52

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 5m 10:00 St. Louis, MO Gateway Station 16:05 Chicago Downtown Coach Station  Economy £32
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £32
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £32
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £45
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Union Station  Economy £53

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 5h 50m 23:30 St. Louis, MO Gateway Station 05:20 Chicago 95th Red Line Station  Economy £27
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £27
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £27
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £41
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Canal & Van Buren  Economy £47

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £27
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £28
FlixBus 5h 50m 23:30 St. Louis, MO Gateway Station 05:20 Chicago 95th Red Line Station  Economy £29
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £46
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Canal & Van Buren  Economy £50

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 5m 10:00 St. Louis, MO Gateway Station 16:05 Chicago Downtown Coach Station  Economy £30
FlixBus 6h 5m 16:00 St. Louis, MO Gateway Station 22:05 Chicago Downtown Coach Station  Economy £30
FlixBus 6h 15m 23:30 St. Louis, MO Gateway Station 05:45 Chicago Downtown Coach Station  Economy £30
Greyhound US 11h 15m 02:00 St. Louis, MO Gateway Station 13:15 Chicago 95th Red Line Station  Economy £56
Greyhound US 11h 45m 02:00 St. Louis, MO Gateway Station 13:45 Chicago Canal & Van Buren  Economy £58

Best Price Offer: The price for the cheapest coach from St. Louis, MO to Chicago is £27 on 24/06/2026. Flexible travellers save on ticket prices.


Frequency of bus connections between St. Louis, MO and Chicago

See here how frequent the connections between St. Louis, MO and Chicago are, during different times and days of the week.
Monday is the busiest day, with more than 17 daily coaches from St. Louis, MO to Chicago. Tuesday has instead the fewest connections, with only 16 daily coaches between St. Louis, MO and Chicago.
The busiest time of the day is the Night, with 29 coaches from St. Louis, MO to Chicago, while Morning sees the fewest connections between St. Louis, MO and Chicago, with 28 offers.

Facts about coaches from St. Louis, MO to Chicago

Compare all providers like FlixBus and Greyhound US that travel 16 times every day by bus from St. Louis, MO to Chicago in one click! Book your bus ticket from St. Louis, MO to Chicago starting from £27!

Cheapest Bus £27
Fastest Bus 5h 50m
Earliest Coach 02:00
Latest Coach 23:30
Daily Bus Connections 16 Ø
Distance 422.1 km
Coach Companies FlixBus and Greyhound US

Cheapest coach connections from St. Louis, MO to Chicago

Every day, 16 buses from 2 coach companies leave St. Louis, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 20/06/2026 and for the following days.

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 15/06
Tuesday 16/06
Wednesday 17/06
Thursday 18/06
Friday 19/06
Saturday 20/06
£36
Sunday 21/06
£41
Monday 22/06
£34
Tuesday 23/06
£32
Wednesday 24/06
£30
Thursday 25/06
£30
Friday 26/06
£30
Saturday 27/06
£31
Sunday 28/06
£34
Monday 29/06
£31
Tuesday 30/06
£30
Wednesday 01/07
Thursday 02/07
£34
Friday 03/07
£38
Saturday 04/07
£33
Sunday 05/07
£31
Monday 06/07
£31
Tuesday 07/07
£31
Wednesday 08/07
£28
Thursday 09/07
£36
Friday 10/07
£33
Saturday 11/07
£29
Sunday 12/07

The cheapest time to travel from St. Louis, MO to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Chicago, for the next 30 days.
With a price starting from £27, Wednesday is the cheapest day for a coach from St. Louis, MO to Chicago. Monday instead is the most expensive day with prices starting from £31.
Evening is the cheapest day time for bus tickets from St. Louis, MO to Chicago, with £27. Morning is the most expensive time of the day with prices starting from £29.

How to save money travelling from St. Louis, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from St. Louis, MO to Chicago are also emptier.

All bus stations and stops in St. Louis, MO and Chicago

The map below shows you where to find all the bus stations in St. Louis, MO and Chicago.

Service and Comfort on the bus from St. Louis, MO to Chicago

Want to know which seat classes are available on the coaches from St. Louis, MO to Chicago? Or which bus companies serve the route St. Louis, MO to Chicago? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Chicago bus

How much does a St. Louis, MO - Chicago coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the St. Louis, MO - Chicago bus trip is available from £27 and takes 6h 15m. Compare offers and save money!

How much could I save by comparing buses from St. Louis, MO to Chicago?

The connection St. Louis, MO to Chicago is offered by 2 companies with ticket prices ranging from £27 to £86. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the St. Louis, MO - Chicago route on average every day?

Each day, the bus route from St. Louis, MO to Chicago is offered by roughly 16 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Chicago from St. Louis, MO take?

The quickest coach from St. Louis, MO to Chicago is provided by FlixBus and takes 5h 50m. Coach tickets for this connection cost £39. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from St. Louis, MO to Chicago?

The earliest bus to Chicago departs from St. Louis, MO at 02:00. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from St. Louis, MO to Chicago?

The latest bus to Chicago departs from St. Louis, MO at 23:30. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the St. Louis, MO - Chicago route?

Passengers looking to travel from St. Louis, MO to Chicago can travel with FlixBus and Greyhound US. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between St. Louis, MO and Chicago?

You can check all the direct connections between St. Louis, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the bus to Chicago from St. Louis, MO?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the St. Louis, MO Chicago bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between St. Louis, MO and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Chicago?

Prices and availability for 16 trips between St. Louis, MO and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Chicago

Here’s an overview of the most popular bus routes to St. Louis, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Monterrey, NL to St. Louis, MO coach Monterrey, NL to St. Louis, MO coach
Coach South Bend, IN to Chicago Coach South Bend, IN to Chicago
Buffalo, NY to Chicago coach Buffalo, NY to Chicago coach
Newark to Chicago bus Newark to Chicago bus
Bus Toronto, ON to Chicago Bus Toronto, ON to Chicago
CheckMyBus › Coaches in USA › Coach to St. Louis, MO › Coach to Chicago

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