Compare all timetables for the bus from St. Louis, MO to Chicago
Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Chicago from various bus operators like FlixBus or Greyhound US for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 7h 0m | 09:30 | St. Louis, MO | Gateway Station | 16:30 | Chicago | Downtown Coach Station | Economy | £26 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 05/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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| FlixBus | 5h 50m | 16:00 | St. Louis, MO | Gateway Station | 21:50 | Chicago | 95th Red Line Station | Economy | £28 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 16:00:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 5h 50m
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| FlixBus | 6h 25m | 09:30 | St. Louis, MO | Gateway Station | 15:55 | Chicago | 95th Red Line Station | Economy | £29 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Canal & Van Buren | Economy | £41 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 05/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 7h 0m | 09:30 | St. Louis, MO | Gateway Station | 16:30 | Chicago | Downtown Coach Station | Economy | £25 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 16:30:00. 50 Economy ticket for £25 per person are available. Travel duration is 7h 0m
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| FlixBus | 6h 25m | 09:30 | St. Louis, MO | Gateway Station | 15:55 | Chicago | 95th Red Line Station | Economy | £26 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 06/12/2025 15:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 25m
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| FlixBus | 6h 15m | 16:00 | St. Louis, MO | Gateway Station | 22:15 | Chicago | Downtown Coach Station | Economy | £27 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £27 per person are available. Travel duration is 6h 15m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Canal & Van Buren | Economy | £38 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 06/12/2025 14:10:00. 50 Economy ticket for £38 per person are available. Travel duration is 12h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 7h 0m | 09:30 | St. Louis, MO | Gateway Station | 16:30 | Chicago | Downtown Coach Station | Economy | £27 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 07/12/2025 16:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 7h 0m
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| FlixBus | 6h 25m | 09:30 | St. Louis, MO | Gateway Station | 15:55 | Chicago | 95th Red Line Station | Economy | £29 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 07/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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| FlixBus | 5h 50m | 16:00 | St. Louis, MO | Gateway Station | 21:50 | Chicago | 95th Red Line Station | Economy | £30 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 16:00:00 to 95th Red Line Station, Chicago (USA) arriving at 07/12/2025 21:50:00. 50 Economy ticket for £30 per person are available. Travel duration is 5h 50m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Canal & Van Buren | Economy | £41 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 7h 0m | 09:30 | St. Louis, MO | Gateway Station | 16:30 | Chicago | Downtown Coach Station | Economy | £26 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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| FlixBus | 6h 15m | 16:00 | St. Louis, MO | Gateway Station | 22:15 | Chicago | Downtown Coach Station | Economy | £28 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 15m
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| FlixBus | 6h 25m | 09:30 | St. Louis, MO | Gateway Station | 15:55 | Chicago | 95th Red Line Station | Economy | £29 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 08/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Canal & Van Buren | Economy | £39 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 08/12/2025 14:10:00. 50 Economy ticket for £39 per person are available. Travel duration is 12h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 9h 5m | 13:55 | St. Louis, MO | Gateway Station | 23:00 | Chicago | 95th Red Line Station | Economy | £36 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 23:00:00. 50 Economy ticket for £36 per person are available. Travel duration is 9h 5m
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| Greyhound US | 11h 40m | 02:00 | St. Louis, MO | Gateway Station | 13:40 | Chicago | 95th Red Line Station | Economy | £37 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 13:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 11h 40m
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| Greyhound US | 13h 40m | 08:45 | St. Louis, MO | Gateway Station | 22:25 | Chicago | 95th Red Line Station | Economy | £37 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 08:45:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 22:25:00. 50 Economy ticket for £37 per person are available. Travel duration is 13h 40m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Union Station | Economy | £42 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 10/12/2025 14:10:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 10m
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| Greyhound US | 12h 35m | 02:00 | St. Louis, MO | Gateway Station | 14:35 | Chicago | Downtown Coach Station | Economy | £42 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Downtown Coach Station, Chicago (USA) arriving at 10/12/2025 14:35:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 35m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 9h 5m | 13:55 | St. Louis, MO | Gateway Station | 23:00 | Chicago | 95th Red Line Station | Economy | £27 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 23:00:00. 50 Economy ticket for £27 per person are available. Travel duration is 9h 5m
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| FlixBus | 7h 0m | 09:30 | St. Louis, MO | Gateway Station | 16:30 | Chicago | Downtown Coach Station | Economy | £29 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 11/12/2025 16:30:00. 50 Economy ticket for £29 per person are available. Travel duration is 7h 0m
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| FlixBus | 6h 25m | 09:30 | St. Louis, MO | Gateway Station | 15:55 | Chicago | 95th Red Line Station | Economy | £31 |
A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 15:55:00. 50 Economy ticket for £31 per person are available. Travel duration is 6h 25m
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| Greyhound US | 12h 10m | 02:00 | St. Louis, MO | Gateway Station | 14:10 | Chicago | Canal & Van Buren | Economy | £33 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 11/12/2025 14:10:00. 50 Economy ticket for £33 per person are available. Travel duration is 12h 10m
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| Greyhound US | 9h 40m | 13:55 | St. Louis, MO | Gateway Station | 23:35 | Chicago | Downtown Coach Station | Economy | £33 |
A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 13:55:00 to Downtown Coach Station, Chicago (USA) arriving at 11/12/2025 23:35:00. 50 Economy ticket for £33 per person are available. Travel duration is 9h 40m
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Best Price Offer: The price for the cheapest coach from St. Louis, MO to Chicago is £25 on 06/12/2025. Flexible travellers save on ticket prices.
Frequency of bus connections between St. Louis, MO and Chicago
Monday
is the busiest day, with more than 14 daily coaches from St. Louis, MO to Chicago. Wednesday has instead the fewest connections, with only 7 daily coaches between St. Louis, MO and Chicago.
The busiest time of the day is the Morning, with 22 coaches from St. Louis, MO to Chicago, while Night sees the fewest connections between St. Louis, MO and Chicago, with 13 offers.
Facts about coaches from St. Louis, MO to Chicago
Compare all providers like FlixBus and Greyhound US that travel 12 times every day by bus from St. Louis, MO to Chicago in one click! Book your bus ticket from St. Louis, MO to Chicago starting from £25!
| Cheapest Bus | £25 |
| Fastest Bus | 5h 50m |
| Earliest Coach | 02:00 |
| Latest Coach | 23:30 |
| Daily Bus Connections | 12 Ø |
| Distance | 422.1 km |
| Coach Companies | FlixBus and Greyhound US |
Cheapest coach connections from St. Louis, MO to Chicago
Every day, 12 buses from 2 coach companies leave St. Louis, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/12/2025 and for the following days.
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday
01/12
Tuesday
02/12
Wednesday
03/12
Thursday
04/12
Friday
05/12
£29
Saturday
06/12
£29
Sunday
07/12
£27
Monday
08/12
£31
Tuesday
09/12
Wednesday
10/12
£36
Thursday
11/12
£31
Friday
12/12
Saturday
13/12
£28
Sunday
14/12
Monday
15/12
Tuesday
16/12
£29
Wednesday
17/12
Thursday
18/12
Friday
19/12
£34
Saturday
20/12
Sunday
21/12
Monday
22/12
Tuesday
23/12
Wednesday
24/12
£34
Thursday
25/12
£33
Friday
26/12
£32
Saturday
27/12
£30
Sunday
28/12
The cheapest time to travel from St. Louis, MO to Chicago
With a price starting from £25, Saturday is the cheapest day for a coach from St. Louis, MO to Chicago. Wednesday instead is the most expensive day with prices starting from £31.
Morning
is the cheapest day time for bus tickets from St. Louis, MO to Chicago, with £25. Evening is the most expensive time of the day with prices starting from £28.
How to save money travelling from St. Louis, MO to Chicago
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from St. Louis, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from St. Louis, MO to Chicago are also emptier.Beloved bus companies from St. Louis, MO to Chicago
These are the most booked bus companies between St. Louis, MO to Chicago from our users.
FlixBus from St. Louis, MO to Chicago
Here you will find the key facts about the FlixBus bus route St. Louis, MO to Chicago:
| Cheapest Price | £25 |
| Fastest Coach | 5h 50m |
| Earliest Coach | 09:30 |
| Last Coach | 23:30 |
| Daily Connections | 11 Ø |
| Found on | 02/12/2025 |
All bus stations and stops in St. Louis, MO and Chicago
The map below shows you where to find all the bus stations in St. Louis, MO and Chicago.
Compare the bus with other modes of transport
The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from St. Louis, MO to Chicago? Compare all modes of transports from
St. Louis, MO to Chicago.
Service and Comfort on the bus from St. Louis, MO to Chicago
Want to know which seat classes are available on the coaches from St. Louis, MO to Chicago? Or which bus companies serve the route St. Louis, MO to Chicago? Below you will find answers to your questions.
FAQs about the St. Louis, MO to Chicago bus
How much does a St. Louis, MO - Chicago coach trip cost?
This depends on, among other things, the day and travel time. The cheapest ticket for the St. Louis, MO - Chicago bus trip is available from £25 and takes 7h 0m. Compare offers and save money!
How much could I save by comparing buses from St. Louis, MO to Chicago?
The connection St. Louis, MO to Chicago is offered by 2 companies with ticket prices ranging from £25 to £45. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.
How many connections are available for the St. Louis, MO - Chicago route on average every day?
Each day, the bus route from St. Louis, MO to Chicago is offered by roughly 12 busses. By using our search, you can compare bus schedules and find your ideal trip.
How long does a bus to Chicago from St. Louis, MO take?
The quickest coach from St. Louis, MO to Chicago is provided by FlixBus and takes 5h 50m. Coach tickets for this connection cost £28. However, keep in mind that the connection can take longer due to traffic.
What time is the first bus from St. Louis, MO to Chicago?
The earliest bus to Chicago departs from St. Louis, MO at 02:00. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.
What time is the last coach from St. Louis, MO to Chicago?
The latest bus to Chicago departs from St. Louis, MO at 23:30. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.
Which bus companies serve the St. Louis, MO - Chicago route?
Passengers looking to travel from St. Louis, MO to Chicago can travel with FlixBus and Greyhound US. Compare all available bus tickets with our search to book the trip that works best for you.
Is there a direct bus between St. Louis, MO and Chicago?
You can check all the direct connections between St. Louis, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.
What can I take with me on the bus to Chicago from St. Louis, MO?
Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the St. Louis, MO Chicago bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.
What equipment is available for the St. Louis, MO Chicago bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Chicago on your planned travel date.
Available seat classes which are offered on the bus route St. Louis, MO to Chicago
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to St. Louis, MO and to Chicago
Here’s an overview of the most popular bus routes to St. Louis, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Transfers to St. Louis, MO and to Chicago
