Bus and Coach from St. Louis, MO to Chicago: Compare all prices

Compare all timetables for the bus from St. Louis, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

£34

tomorrow

Thursday

£27

Friday

£30

Saturday

£29

Sunday

£31

Monday

£28

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£34	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 05/05/2026 22:05:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£34	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 06/05/2026 05:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
FlixBus	5h 50m	23:30	St. Louis, MO	Gateway Station	05:20	Chicago	95th Red Line Station	Economy	£35	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/05/2026 23:30:00 to 95th Red Line Station, Chicago (USA) arriving at 06/05/2026 05:20:00. 50 Economy ticket for £35 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	10:00	St. Louis, MO	Gateway Station	16:05	Chicago	Downtown Coach Station	Economy	£35	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/05/2026 10:00:00 to Downtown Coach Station, Chicago (USA) arriving at 05/05/2026 16:05:00. 50 Economy ticket for £35 per person are available. Travel duration is 6h 5m
FlixBus	8h 35m	10:00	St. Louis, MO	Gateway Station	18:35	Chicago	95th Red Line Station	Economy	£54	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/05/2026 10:00:00 to 95th Red Line Station, Chicago (USA) arriving at 05/05/2026 18:35:00. 50 Economy ticket for £54 per person are available. Travel duration is 8h 35m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	11h 45m	02:00	St. Louis, MO	Gateway Station	13:45	Chicago	Canal & Van Buren	Economy	£27	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/05/2026 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 07/05/2026 13:45:00. 50 Economy ticket for £27 per person are available. Travel duration is 11h 45m
FlixBus	6h 5m	10:00	St. Louis, MO	Gateway Station	16:05	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/05/2026 10:00:00 to Downtown Coach Station, Chicago (USA) arriving at 07/05/2026 16:05:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 5m
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 07/05/2026 22:05:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 08/05/2026 05:45:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 15m
Greyhound US	11h 15m	02:00	St. Louis, MO	Gateway Station	13:15	Chicago	95th Red Line Station	Economy	£40	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/05/2026 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 07/05/2026 13:15:00. 50 Economy ticket for £40 per person are available. Travel duration is 11h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 50m	23:30	St. Louis, MO	Gateway Station	05:20	Chicago	95th Red Line Station	Economy	£30	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/05/2026 23:30:00 to 95th Red Line Station, Chicago (USA) arriving at 09/05/2026 05:20:00. 50 Economy ticket for £30 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£30	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 08/05/2026 22:05:00. 50 Economy ticket for £30 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£30	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 09/05/2026 05:45:00. 50 Economy ticket for £30 per person are available. Travel duration is 6h 15m
Greyhound US	11h 45m	02:00	St. Louis, MO	Gateway Station	13:45	Chicago	Canal & Van Buren	Economy	£44	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/05/2026 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 08/05/2026 13:45:00. 50 Economy ticket for £44 per person are available. Travel duration is 11h 45m
Greyhound US	11h 15m	02:00	St. Louis, MO	Gateway Station	13:15	Chicago	95th Red Line Station	Economy	£50	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/05/2026 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 08/05/2026 13:15:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 09/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 09/05/2026 22:05:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 09/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 10/05/2026 05:45:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 15m
FlixBus	5h 50m	23:30	St. Louis, MO	Gateway Station	05:20	Chicago	95th Red Line Station	Economy	£30	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 09/05/2026 23:30:00 to 95th Red Line Station, Chicago (USA) arriving at 10/05/2026 05:20:00. 50 Economy ticket for £30 per person are available. Travel duration is 5h 50m
Greyhound US	11h 15m	02:00	St. Louis, MO	Gateway Station	13:15	Chicago	95th Red Line Station	Economy	£45	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/05/2026 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 09/05/2026 13:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	02:00	St. Louis, MO	Gateway Station	13:45	Chicago	Canal & Van Buren	Economy	£50	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/05/2026 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 09/05/2026 13:45:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 45m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£31	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 10/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 11/05/2026 05:45:00. 50 Economy ticket for £31 per person are available. Travel duration is 6h 15m
FlixBus	5h 50m	23:30	St. Louis, MO	Gateway Station	05:20	Chicago	95th Red Line Station	Economy	£32	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 10/05/2026 23:30:00 to 95th Red Line Station, Chicago (USA) arriving at 11/05/2026 05:20:00. 50 Economy ticket for £32 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£32	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 10/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 10/05/2026 22:05:00. 50 Economy ticket for £32 per person are available. Travel duration is 6h 5m
Greyhound US	11h 15m	02:00	St. Louis, MO	Gateway Station	13:15	Chicago	95th Red Line Station	Economy	£41	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/05/2026 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 10/05/2026 13:15:00. 50 Economy ticket for £41 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	02:00	St. Louis, MO	Gateway Station	13:45	Chicago	Canal & Van Buren	Economy	£46	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/05/2026 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 10/05/2026 13:45:00. 50 Economy ticket for £46 per person are available. Travel duration is 11h 45m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 5m	16:00	St. Louis, MO	Gateway Station	22:05	Chicago	Downtown Coach Station	Economy	£28	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/05/2026 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 11/05/2026 22:05:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	23:30	St. Louis, MO	Gateway Station	05:45	Chicago	Downtown Coach Station	Economy	£28	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/05/2026 23:30:00 to Downtown Coach Station, Chicago (USA) arriving at 12/05/2026 05:45:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 15m
FlixBus	6h 5m	10:00	St. Louis, MO	Gateway Station	16:05	Chicago	Downtown Coach Station	Economy	£29	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/05/2026 10:00:00 to Downtown Coach Station, Chicago (USA) arriving at 11/05/2026 16:05:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 5m
Greyhound US	11h 15m	02:00	St. Louis, MO	Gateway Station	13:15	Chicago	95th Red Line Station	Economy	£36	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/05/2026 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 11/05/2026 13:15:00. 50 Economy ticket for £36 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	02:00	St. Louis, MO	Gateway Station	13:45	Chicago	Canal & Van Buren	Economy	£39	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/05/2026 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 11/05/2026 13:45:00. 50 Economy ticket for £39 per person are available. Travel duration is 11h 45m

Best Price Offer: The price for the cheapest coach from St. Louis, MO to Chicago is £26 on 12/05/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between St. Louis, MO and Chicago

See here how frequent the connections between St. Louis, MO and Chicago are, during different times and days of the week.

Monday is the busiest day, with more than 16 daily coaches from St. Louis, MO to Chicago. Tuesday has instead the fewest connections, with only 12 daily coaches between St. Louis, MO and Chicago.

The busiest time of the day is the Morning, with 24 coaches from St. Louis, MO to Chicago, while Night sees the fewest connections between St. Louis, MO and Chicago, with 20 offers.

Facts about coaches from St. Louis, MO to Chicago

Compare all providers like FlixBus and Greyhound US that travel 15 times every day by bus from St. Louis, MO to Chicago in one click! Book your bus ticket from St. Louis, MO to Chicago starting from £26!

Cheapest Bus	£26
Fastest Bus	5h 50m
Earliest Coach	10:00
Latest Coach	23:30
Daily Bus Connections	15 Ø
Distance	422.1 km
Coach Companies	FlixBus and Greyhound US

Cheapest coach connections from St. Louis, MO to Chicago

Every day, 15 buses from 2 coach companies leave St. Louis, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 04/05

Tuesday 05/05

£34

Wednesday 06/05

Thursday 07/05

£30

Friday 08/05

£30

Saturday 09/05

£29

Sunday 10/05

£31

Monday 11/05

£28

Tuesday 12/05

£26

Wednesday 13/05

£26

Thursday 14/05

£26

Friday 15/05

£27

Saturday 16/05

£27

Sunday 17/05

£31

Monday 18/05

£26

Tuesday 19/05

£27

Wednesday 20/05

£26

Thursday 21/05

£34

Friday 22/05

£43

Saturday 23/05

£38

Sunday 24/05

£44

Monday 25/05

£44

Tuesday 26/05

£35

Wednesday 27/05

Thursday 28/05

£30

Friday 29/05

£29

Saturday 30/05

£29

Sunday 31/05

The cheapest time to travel from St. Louis, MO to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Chicago, for the next 30 days.

With a price starting from £26, Tuesday is the cheapest day for a coach from St. Louis, MO to Chicago. Sunday instead is the most expensive day with prices starting from £31.

Night is the cheapest day time for bus tickets from St. Louis, MO to Chicago, with £26. Morning is the most expensive time of the day with prices starting from £29.

How to save money travelling from St. Louis, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from St. Louis, MO to Chicago are also emptier.

All bus stations and stops in St. Louis, MO and Chicago

The map below shows you where to find all the bus stations in St. Louis, MO and Chicago.

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Gateway Station

S 15th St 430

95th Red Line Station

W. 95th St 14

Downtown Coach Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from St. Louis, MO to Chicago

Want to know which seat classes are available on the coaches from St. Louis, MO to Chicago? Or which bus companies serve the route St. Louis, MO to Chicago? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Chicago bus

How much does a St. Louis, MO - Chicago coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the St. Louis, MO - Chicago bus trip is available from £26 and takes 11h 45m. Compare offers and save money!

How much could I save by comparing buses from St. Louis, MO to Chicago?

The connection St. Louis, MO to Chicago is offered by 2 companies with ticket prices ranging from £26 to £58. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the St. Louis, MO - Chicago route on average every day?

Each day, the bus route from St. Louis, MO to Chicago is offered by roughly 15 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Chicago from St. Louis, MO take?

The quickest coach from St. Louis, MO to Chicago is provided by FlixBus and takes 5h 50m. Coach tickets for this connection cost £35. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from St. Louis, MO to Chicago?

The earliest bus to Chicago departs from St. Louis, MO at 10:00. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from St. Louis, MO to Chicago?

The latest bus to Chicago departs from St. Louis, MO at 23:30. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the St. Louis, MO - Chicago route?

Passengers looking to travel from St. Louis, MO to Chicago can travel with FlixBus and Greyhound US. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between St. Louis, MO and Chicago?

You can check all the direct connections between St. Louis, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the bus to Chicago from St. Louis, MO?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the St. Louis, MO Chicago bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 15 daily trips between St. Louis, MO and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Chicago?

Prices and availability for 15 trips between St. Louis, MO and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Chicago

Here’s an overview of the most popular bus routes to St. Louis, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!