Bus tickets Prague to Lyon from £41

Compare all the coach companies and find the best price with CheckMyBus
Compare & Save Millions of buses in one click. Save up to 70%!
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus or RegioJet for the next days.

today
£59
tomorrow
£69
Friday
£74
Saturday
£79
Sunday
£81
Monday
£80
Tuesday
£77

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £59
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £59
FlixBus 17h 10m 15:05 Prague Zličín 08:15 Lyon Perrache Bus Stop  Economy £60
FlixBus 19h 10m 13:05 Prague Wilsonova Coach Station 08:15 Lyon Perrache Bus Stop  Economy £63
FlixBus 17h 0m 16:00 Prague ÚAN Florenc 09:00 Lyon Perrache Bus Stop  Economy £67

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £69
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £69
RegioJet 15h 50m 23:00 Prague ÚAN Florenc 14:50 Lyon Perrache Bus Stop  Economy £70
FlixBus 19h 25m 03:50 Prague Wilsonova Coach Station 23:15 Lyon Perrache Bus Stop  Economy £81

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 25m 03:50 Prague Wilsonova Coach Station 23:15 Lyon Perrache Bus Stop  Economy £74
FlixBus 19h 5m 04:10 Prague Na Knížecí Station 23:15 Lyon Perrache Bus Stop  Economy £74
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £80
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £80
FlixBus 16h 45m 16:15 Prague Wilsonova Coach Station 09:00 Lyon Perrache Bus Stop  Economy £85
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than £7? You can find the corresponding connections below.
    • RegioJet
      17h 25m
      0
      23:00
      Prague
      ÚAN Florenc
      08:35
      Zurich
      Central Bus Station Sihlquai
      0
      RegioJet
      Economy
      £38
      • Waiting Time 1h 15m
    • FlixBus
      6h 35m
      0
      09:50
      Zurich
      Central Bus Station Sihlquai
      16:25
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      £28
    Travel time is 2h 50m longer, but you will save £7

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 20m 11:15 Prague Wilsonova Coach Station 04:35 Lyon Perrache Bus Stop  Economy £79
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £82
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £82
FlixBus 16h 45m 16:15 Prague Wilsonova Coach Station 09:00 Lyon Perrache Bus Stop  Economy £87
FlixBus 17h 0m 16:00 Prague ÚAN Florenc 09:00 Lyon Perrache Bus Stop  Economy £87
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than £12? You can find the corresponding connections below.
    • RegioJet
      17h 25m
      0
      23:00
      Prague
      ÚAN Florenc
      08:35
      Zurich
      Central Bus Station Sihlquai
      0
      RegioJet
      Economy
      £38
      • Waiting Time 1h 15m
    • FlixBus
      6h 35m
      0
      09:50
      Zurich
      Central Bus Station Sihlquai
      16:25
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      £28
    Travel time is 2h 50m longer, but you will save £12

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 20m 12:55 Prague Zličín 08:15 Lyon Perrache Bus Stop  Economy £81
FlixBus 19h 10m 13:05 Prague Wilsonova Coach Station 08:15 Lyon Perrache Bus Stop  Economy £82
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £83
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £83
FlixBus 16h 45m 16:15 Prague Wilsonova Coach Station 09:00 Lyon Perrache Bus Stop  Economy £88
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than £14? You can find the corresponding connections below.
    • RegioJet
      17h 25m
      0
      23:00
      Prague
      ÚAN Florenc
      08:35
      Zurich
      Central Bus Station Sihlquai
      0
      RegioJet
      Economy
      £38
      • Waiting Time 1h 15m
    • FlixBus
      6h 35m
      0
      09:50
      Zurich
      Central Bus Station Sihlquai
      16:25
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      £28
    Travel time is 2h 50m longer, but you will save £14

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £80
FlixBus 15h 0m 21:25 Prague ÚAN Florenc 12:25 Lyon Perrache Bus Stop  Economy £80
FlixBus 19h 25m 03:50 Prague Wilsonova Coach Station 23:15 Lyon Perrache Bus Stop  Economy £81
FlixBus 17h 20m 11:15 Prague Wilsonova Coach Station 04:35 Lyon Perrache Bus Stop  Economy £81
FlixBus 19h 10m 13:05 Prague Wilsonova Coach Station 08:15 Lyon Perrache Bus Stop  Economy £81
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than £13? You can find the corresponding connections below.
    • RegioJet
      17h 25m
      0
      23:00
      Prague
      ÚAN Florenc
      08:35
      Zurich
      Central Bus Station Sihlquai
      0
      RegioJet
      Economy
      £38
      • Waiting Time 1h 15m
    • FlixBus
      6h 35m
      0
      09:50
      Zurich
      Central Bus Station Sihlquai
      16:25
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      £28
    Travel time is 2h 50m longer, but you will save £13

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 25m 03:50 Prague Wilsonova Coach Station 23:15 Lyon Perrache Bus Stop  Economy £77
FlixBus 19h 5m 04:10 Prague Na Knížecí Station 23:15 Lyon Perrache Bus Stop  Economy £77
FlixBus 19h 35m 09:00 Prague Wilsonova Coach Station 04:35 Lyon Perrache Bus Stop  Economy £78
FlixBus 16h 45m 16:15 Prague Wilsonova Coach Station 09:00 Lyon Perrache Bus Stop  Economy £82
FlixBus 14h 35m 21:50 Prague Na Knížecí Station 12:25 Lyon Perrache Bus Stop  Economy £82
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than £10? You can find the corresponding connections below.
    • RegioJet
      17h 25m
      0
      23:00
      Prague
      ÚAN Florenc
      08:35
      Zurich
      Central Bus Station Sihlquai
      0
      RegioJet
      Economy
      £38
      • Waiting Time 1h 15m
    • FlixBus
      6h 35m
      0
      09:50
      Zurich
      Central Bus Station Sihlquai
      16:25
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      £28
    Travel time is 2h 50m longer, but you will save £10

Best Price Offer: The price for the cheapest coach from Prague to Lyon is £41 on 07/01/2026. Flexible travellers save on ticket prices.


Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.
Friday is the busiest day, with more than 14 daily coaches from Prague to Lyon. Wednesday has instead the fewest connections, with only 10 daily coaches between Prague and Lyon.
The busiest time of the day is the Afternoon, with 42 coaches from Prague to Lyon, while Night sees the fewest connections between Prague and Lyon, with 12 offers.

Facts about coaches from Prague to Lyon

Compare all providers like FlixBus and RegioJet that travel 12 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from £41!

Cheapest Bus £41
Fastest Bus 14h 35m
Earliest Coach 06:40
Latest Coach 21:50
Daily Bus Connections 12 Ø
Distance 860.7 km
Coach Companies FlixBus and RegioJet

Cheapest coach connections from Prague to Lyon

Every day, 12 buses from 2 coach companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 17/12/2025 and for the following days.

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 15/12
Tuesday 16/12
Wednesday 17/12
£59
Thursday 18/12
£69
Friday 19/12
£74
Saturday 20/12
£79
Sunday 21/12
£81
Monday 22/12
£80
Tuesday 23/12
£77
Wednesday 24/12
£69
Thursday 25/12
£70
Friday 26/12
£77
Saturday 27/12
£80
Sunday 28/12
£77
Monday 29/12
£71
Tuesday 30/12
£71
Wednesday 31/12
£61
Thursday 01/01
£73
Friday 02/01
£72
Saturday 03/01
£69
Sunday 04/01
£65
Monday 05/01
£48
Tuesday 06/01
£46
Wednesday 07/01
£41
Thursday 08/01
£41
Friday 09/01
£43
Saturday 10/01
£42
Sunday 11/01

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.
With a price starting from £36, Monday is the cheapest day for a coach from Prague to Lyon. Tuesday instead is the most expensive day with prices starting from £46.
Night is the cheapest day time for bus tickets from Prague to Lyon, with £36. Morning is the most expensive time of the day with prices starting from £70.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Prague to Lyon are also emptier.

All bus stations and stops in Prague and Lyon

The map below shows you where to find all the bus stations in Prague and Lyon.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the coaches from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague - Lyon coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Prague - Lyon bus trip is available from £41 and takes 15h 0m. Compare offers and save money!

How much could I save by comparing buses from Prague to Lyon?

The connection Prague to Lyon is offered by 2 companies with ticket prices ranging from £41 to £116. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Prague - Lyon route on average every day?

Each day, the bus route from Prague to Lyon is offered by roughly 12 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Lyon from Prague take?

The quickest coach from Prague to Lyon is provided by FlixBus and takes 14h 35m. Coach tickets for this connection cost £59. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus to Lyon departs from Prague at 06:40. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Prague to Lyon?

The latest bus to Lyon departs from Prague at 21:50. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Prague - Lyon route?

Passengers looking to travel from Prague to Lyon can travel with FlixBus and RegioJet. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the bus to Lyon from Prague?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Prague Lyon bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 12 daily trips between Prague and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Lyon?

Prices and availability for 12 trips between Prague and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Lyon

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!
Coach to Prague from London Coach to Prague from London
Coach from Leeds to Prague Coach from Leeds to Prague
Coach Humenne to Prague Coach Humenne to Prague
Buses Katowice to Prague Buses Katowice to Prague
Coach to Lyon from Montpellier Coach to Lyon from Montpellier
Bus from Lisbon to Lyon Bus from Lisbon to Lyon
Bus Clermont-Ferrand to Lyon Bus Clermont-Ferrand to Lyon
Coach Genoa to Lyon Coach Genoa to Lyon
Popular Airport Transfers to Prague and to Lyon
CheckMyBus › Coaches in Czech Republic › Coach to Prague › Coach to Lyon

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

deals,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

for

ads

personalisation.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.