Bus and Coach from Prague to Lyon: Compare all prices

Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus or RegioJet for the next days.

today

£46

tomorrow

Thursday

£43

Friday

Saturday

Sunday

Monday

£44

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	21h 10m	07:35	Prague	ÚAN Florenc	04:45	Lyon	Perrache Bus Stop		Economy	£46	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 03/02/2026 07:35:00 to Perrache Bus Stop, Lyon (France) arriving at 04/02/2026 04:45:00. 50 Economy ticket for £46 per person are available. Travel duration is 21h 10m
	FlixBus	20h 50m	07:55	Prague	Na Knížecí Station	04:45	Lyon	Perrache Bus Stop		Economy	£46	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 03/02/2026 07:55:00 to Perrache Bus Stop, Lyon (France) arriving at 04/02/2026 04:45:00. 50 Economy ticket for £46 per person are available. Travel duration is 20h 50m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	RegioJet	15h 50m	23:00	Prague	ÚAN Florenc	14:50	Lyon	Perrache Bus Stop		Economy	£43	A Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 05/02/2026 23:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/02/2026 14:50:00. 50 Economy ticket for £43 per person are available. Travel duration is 15h 50m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 55m	08:50	Prague	ÚAN Florenc	04:45	Lyon	Perrache Bus Stop		Economy	£44	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 09/02/2026 08:50:00 to Perrache Bus Stop, Lyon (France) arriving at 10/02/2026 04:45:00. 50 Economy ticket for £44 per person are available. Travel duration is 19h 55m
	FlixBus	19h 35m	09:10	Prague	Na Knížecí Station	04:45	Lyon	Perrache Bus Stop		Economy	£44	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 09/02/2026 09:10:00 to Perrache Bus Stop, Lyon (France) arriving at 10/02/2026 04:45:00. 50 Economy ticket for £44 per person are available. Travel duration is 19h 35m

Best Price Offer: The price for the cheapest coach from Prague to Lyon is £38 on 25/02/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.

Monday is the busiest day, with more than 2 daily coaches from Prague to Lyon. Thursday has instead the fewest connections, with only 1 daily coaches between Prague and Lyon.

The busiest time of the day is the Morning, with 4 coaches from Prague to Lyon, while Evening sees the fewest connections between Prague and Lyon, with 1 offers.

Facts about coaches from Prague to Lyon

Compare all providers like FlixBus and RegioJet that travel 1 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from £38!

Cheapest Bus	£38
Fastest Bus	15h 50m
Earliest Coach	07:35
Latest Coach	09:10
Daily Bus Connections	1 Ø
Distance	860.7 km
Coach Companies	FlixBus and RegioJet

Cheapest coach connections from Prague to Lyon

Every day, 1 buses from 2 coach companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/02/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 02/02

Tuesday 03/02

£53

Wednesday 04/02

£47

Thursday 05/02

£44

Friday 06/02

£50

Saturday 07/02

£52

Sunday 08/02

£50

Monday 09/02

£45

Tuesday 10/02

£43

Wednesday 11/02

£42

Thursday 12/02

£43

Friday 13/02

£47

Saturday 14/02

£46

Sunday 15/02

£47

Monday 16/02

£43

Tuesday 17/02

£42

Wednesday 18/02

£42

Thursday 19/02

£41

Friday 20/02

£46

Saturday 21/02

£48

Sunday 22/02

£46

Monday 23/02

£39

Tuesday 24/02

£40

Wednesday 25/02

£38

Thursday 26/02

£39

Friday 27/02

£42

Saturday 28/02

£44

Sunday 01/03

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.

With a price starting from £39, Monday is the cheapest day for a coach from Prague to Lyon. Tuesday instead is the most expensive day with prices starting from £40.

Evening is the cheapest day time for bus tickets from Prague to Lyon, with £43. Morning is the most expensive time of the day with prices starting from £44.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Prague to Lyon are also emptier.

All bus stations and stops in Prague and Lyon

The map below shows you where to find all the bus stations in Prague and Lyon.

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Coach Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Černý Most

Bryksova

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the coaches from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague - Lyon coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Prague - Lyon bus trip is available from £38 and takes 15h 50m. Compare offers and save money!

How much could I save by comparing buses from Prague to Lyon?

The connection Prague to Lyon is offered by 2 companies with ticket prices ranging from £38 to £46. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Prague - Lyon route on average every day?

Each day, the bus route from Prague to Lyon is offered by roughly 1 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Lyon from Prague take?

The quickest coach from Prague to Lyon is provided by RegioJet and takes 15h 50m. Coach tickets for this connection cost £43. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus to Lyon departs from Prague at 07:35. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Prague to Lyon?

The latest bus to Lyon departs from Prague at 09:10. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Prague - Lyon route?

Passengers looking to travel from Prague to Lyon can travel with FlixBus and RegioJet. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the bus to Lyon from Prague?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Prague Lyon bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Prague and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Lyon?

Prices and availability for 1 trips between Prague and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Lyon

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!