What is the best way to travel from Prague to Lyon?
Looking for a trip? Check and compare all the available Buses, Carpool and Flights to Lyon from Prague. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Prague?
You can reach Lyon with just £42 by taking a Flight from EasyJet Airline, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 04/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 09:00:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 45m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 04/12/2025 23:15:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 35m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 08:15:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 09:00:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 0m
Cheapest Buses Thursday
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BlaBlaCar11h 0m010:10Prague Airport21:10Lyon0EconomyA Car from BlaBlaCar goes from , Prague Airport (Czech Republic) at 05/12/2025 10:10:00 to , Lyon (France) arriving at 05/12/2025 21:10:00. 50 Economy ticket for £47 per person are available. Travel duration is 11h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 05/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 09:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 45m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 08:15:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 5m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 09:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 0m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 05/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 08:15:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 45m
Cheapest Carpool Friday
Cheapest Buses Friday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 09:00:00. 50 Economy ticket for £51 per person are available. Travel duration is 16h 45m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 06/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 5m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 06/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 09:00:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 0m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 06/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 45m
Cheapest Buses Saturday
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 07/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 12:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 07/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 12:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 0m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 07/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 08:15:00. 50 Economy ticket for £63 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 07/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 08:15:00. 50 Economy ticket for £63 per person are available. Travel duration is 17h 45m
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Volotea28h 35m009:50Prague AirportPrague Airport - T1/214:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 09:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 08/12/2025 14:25:00. 50 Economy ticket for £77 per person are available. Travel duration is 28h 35m
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Buzz8h 10m011:25Prague AirportPrague Airport - T1/219:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 11:25:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 19:35:00. 50 Economy ticket for £84 per person are available. Travel duration is 8h 10m
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Ryanair7h 35m010:20Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 10:20:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 17:55:00. 50 Economy ticket for £113 per person are available. Travel duration is 7h 35m
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EasyJet Airline1h 45m020:05Prague AirportPrague Airport - T1/221:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 20:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 21:50:00. 50 Economy ticket for £149 per person are available. Travel duration is 1h 45m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 08/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 09:00:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 45m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 23:15:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 35m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 09:00:00. 50 Economy ticket for £47 per person are available. Travel duration is 17h 0m
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FlixBus21h 40m011:20Prague AirportPrague Airport - T1/209:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 11:20:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 09:00:00. 50 Economy ticket for £52 per person are available. Travel duration is 21h 40m
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Ryanair19h 35m013:55Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 13:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 09:30:00. 50 Economy ticket for £77 per person are available. Travel duration is 19h 35m
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LC Perú22h 20m022:35Prague AirportPrague Airport - T1/220:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LC Perú goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 22:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 20:55:00. 50 Economy ticket for £80 per person are available. Travel duration is 22h 20m
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EasyJet Airline9h 45m013:40Prague AirportPrague Airport - T1/223:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 13:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 08/12/2025 23:25:00. 50 Economy ticket for £81 per person are available. Travel duration is 9h 45m
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Jet2.com13h 50m019:40Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 09:30:00. 50 Economy ticket for £89 per person are available. Travel duration is 13h 50m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 09/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 09/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 0m
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FlixBus28h 35m000:10Prague AirportPrague Airport - T1/204:45LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 09/12/2025 00:10:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 04:45:00. 50 Economy ticket for £47 per person are available. Travel duration is 28h 35m
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FlixBus21h 50m022:45Prague AirportPrague Airport - T1/220:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 09/12/2025 22:45:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 20:35:00. 50 Economy ticket for £47 per person are available. Travel duration is 21h 50m
Cheapest Buses Tuesday
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EasyJet Airline1h 45m016:05Prague AirportPrague Airport - T1/217:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 16:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 17:50:00. 50 Economy ticket for £42 per person are available. Travel duration is 1h 45m
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Skyscanner1h 45m016:05Prague AirportPrague Airport - T1/217:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 16:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 17:50:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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Wizz Air11h 15m008:05Prague AirportPrague Airport - T1/219:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 08:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 19:20:00. 50 Economy ticket for £64 per person are available. Travel duration is 11h 15m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 11/12/2025 07:35:00. 50 Economy ticket for £95 per person are available. Travel duration is 10h 25m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 10/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 10/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 45m
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FlixBus20h 55m011:20Prague AirportPrague Airport - T1/208:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 11:20:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 08:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 20h 55m
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FlixBus17h 35m018:50Prague AirportPrague Airport - T1/212:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 18:50:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 12:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
What are the fastest trips from Prague to Lyon?
You can get to Lyon from Prague in just 1h 45m with a Flight from EasyJet Airline. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 04/12/2025 23:15:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 35m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 04/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 09:00:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 09:00:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 0m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 04/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 08:15:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
Fastest Buses Thursday
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BlaBlaCar11h 0m010:10Prague Airport21:10Lyon0EconomyA Car from BlaBlaCar goes from , Prague Airport (Czech Republic) at 05/12/2025 10:10:00 to , Lyon (France) arriving at 05/12/2025 21:10:00. 50 Economy ticket for £47 per person are available. Travel duration is 11h 0m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 05/12/2025 23:15:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 35m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 05/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 09:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 09:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 0m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 06/12/2025 08:15:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 5m
Fastest Carpool Friday
Fastest Buses Friday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 09:00:00. 50 Economy ticket for £51 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 06/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 09:00:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 0m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 06/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 5m
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FlixBus17h 35m018:50Prague AirportPrague Airport - T1/212:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 06/12/2025 18:50:00 to Perrache Bus Stop, Lyon (France) arriving at 07/12/2025 12:25:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 35m
Fastest Buses Saturday
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EasyJet Airline1h 45m020:05Prague AirportPrague Airport - T1/221:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 20:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 21:50:00. 50 Economy ticket for £149 per person are available. Travel duration is 1h 45m
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Ryanair7h 35m010:20Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 10:20:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 17:55:00. 50 Economy ticket for £113 per person are available. Travel duration is 7h 35m
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Buzz8h 10m011:25Prague AirportPrague Airport - T1/219:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 11:25:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 07/12/2025 19:35:00. 50 Economy ticket for £84 per person are available. Travel duration is 8h 10m
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KLM Cityhopper25h 40m008:55Prague AirportPrague Airport - T1/210:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from KLM Cityhopper goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 07/12/2025 08:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 08/12/2025 10:35:00. 50 Economy ticket for £161 per person are available. Travel duration is 25h 40m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 07/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 12:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 07/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 12:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 0m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 07/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 08:15:00. 50 Economy ticket for £63 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 07/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 08:15:00. 50 Economy ticket for £63 per person are available. Travel duration is 17h 45m
Fastest Flights Sunday
Fastest Buses Sunday
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EasyJet Airline9h 45m013:40Prague AirportPrague Airport - T1/223:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 13:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 08/12/2025 23:25:00. 50 Economy ticket for £81 per person are available. Travel duration is 9h 45m
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Jet2.com13h 50m019:40Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 09:30:00. 50 Economy ticket for £89 per person are available. Travel duration is 13h 50m
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LOT Polish Airlines / Polskie Linie Lotnicze14h 50m019:35Prague AirportPrague Airport - T1/210:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 19:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 10:25:00. 50 Economy ticket for £128 per person are available. Travel duration is 14h 50m
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Ryanair19h 35m013:55Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 13:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 09/12/2025 09:30:00. 50 Economy ticket for £77 per person are available. Travel duration is 19h 35m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 08/12/2025 23:15:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 35m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 08/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 09:00:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 09:00:00. 50 Economy ticket for £47 per person are available. Travel duration is 17h 0m
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FlixBus17h 35m018:50Prague AirportPrague Airport - T1/212:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 08/12/2025 18:50:00 to Perrache Bus Stop, Lyon (France) arriving at 09/12/2025 12:25:00. 50 Economy ticket for £52 per person are available. Travel duration is 17h 35m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 09/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 09/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 0m
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FlixBus21h 50m022:45Prague AirportPrague Airport - T1/220:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 09/12/2025 22:45:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 20:35:00. 50 Economy ticket for £47 per person are available. Travel duration is 21h 50m
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FlixBus22h 40m021:55PragueÚAN Florenc20:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 09/12/2025 21:55:00 to Perrache Bus Stop, Lyon (France) arriving at 10/12/2025 20:35:00. 50 Economy ticket for £48 per person are available. Travel duration is 22h 40m
Fastest Buses Tuesday
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EasyJet Airline1h 45m016:05Prague AirportPrague Airport - T1/217:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 16:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 17:50:00. 50 Economy ticket for £42 per person are available. Travel duration is 1h 45m
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Skyscanner1h 45m016:05Prague AirportPrague Airport - T1/217:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 16:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 17:50:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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Smartwings6h 35m012:00Prague AirportPrague Airport - T1/218:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 12:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 10/12/2025 18:35:00. 50 Economy ticket for £102 per person are available. Travel duration is 6h 35m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 11/12/2025 07:35:00. 50 Economy ticket for £95 per person are available. Travel duration is 10h 25m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 10/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 12:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 10/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 10/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 09:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 0m
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FlixBus17h 35m018:50Prague AirportPrague Airport - T1/212:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 10/12/2025 18:50:00 to Perrache Bus Stop, Lyon (France) arriving at 11/12/2025 12:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
Fastest Flights Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Prague to Lyon
What are the most popular stations in Prague and Lyon?
In Prague, you will usually depart from Wilsonova Coach Station, ÚAN Florenc or Černý Most, while in Lyon you will be arriving at Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Prague? With 7 connections between 1 Bus, Carpool and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Lyon, you can pay as low as £42 with a Flight from EasyJet Airline.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Lyon in just 1h 45m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Lyon are FlixBus, EasyJet Airline and Ryanair, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Caluire-et-Cuire, and look at flights from Prague Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Lyon?
The most popular companies between Prague and Lyon, are FlixBus, EasyJet Airline and Ryanair. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: EasyJet Airline, Ryanair, Volotea and 9 more.
All you need to know when you travel from Prague to Lyon
Check all information on comfort and services on all modes of transports from Prague to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Lyon
How can I reach Lyon from Prague?
Every day, there are on average 7 connections between Bus, Carpool and Flight, with which you can get to Lyon from Prague.
How far is Lyon from Prague?
The distance between Prague and Lyon is 860.7 km.
What is the most ecofriendly mode of transport between Prague and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Prague to Lyon?
You can get to Lyon with just £42 by taking a Flight from EasyJet Airline.
What is the fastest way to get from Prague to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 45m with a Flight from EasyJet Airline.
More routes to Prague and to Lyon
Looking for more options? Here you can see the most popular routes to Prague and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Bern to Prague
- Bratislava to Prague
- Brno to Prague
- Chemnitz to Prague
- Dresden to Prague
- Florence to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Linz to Prague
- London to Prague
- Louny to Prague
- Lyon to Prague
- Memmingen to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Paris to Prague
- Teplice to Prague
- Třebíč to Prague
- Vienna to Prague
- Zurich to Prague
- Trips to Lyon
- Bandol to Lyon
- Barcelona to Lyon
- Belfort to Lyon
- Bordeaux to Lyon
- Caen to Lyon
- Chamonix to Lyon
- Clermont-Ferrand to Lyon
- Geneva Airport to Lyon
- Girona to Lyon
- Liege to Lyon
- Madrid to Lyon
- Marseille to Lyon
- Milan to Lyon
- Montpellier to Lyon
- Mulhouse to Lyon
- Naples to Lyon
- Nuremberg to Lyon
- Paris to Lyon
- Strasbourg to Lyon
- Stuttgart to Lyon
- Toulon to Lyon
- Tours to Lyon
- Venice to Lyon
- Zurich to Lyon

