What is the best way to travel from Prague to Lyon?
Looking for a trip? Check and compare all the available Buses, Flights and Carpool to Lyon from Prague. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Prague?
You can reach Lyon with just £45 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus14h 40m021:50PragueNa Knížecí Station12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £62 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m021:25PragueÚAN Florenc12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 22/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £62 per person are available. Travel duration is 15h 5m
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FlixBus17h 40m018:50Prague AirportPrague Airport - T1/212:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/03/2026 18:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £68 per person are available. Travel duration is 17h 40m
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FlixBus21h 0m023:50PragueWilsonova Coach Station20:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/03/2026 23:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 20:50:00. 50 Economy ticket for £70 per person are available. Travel duration is 21h 0m
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EasyJet Airline11h 35m021:10Prague AirportPrague Airport08:45Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 21:10:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:45:00. 50 Economy ticket for £104 per person are available. Travel duration is 11h 35m
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Wizz Air14h 0m018:45Prague AirportPrague Airport08:45Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 18:45:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:45:00. 50 Economy ticket for £113 per person are available. Travel duration is 14h 0m
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Volotea23h 20m009:20Prague AirportPrague Airport08:40Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Volotea goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 09:20:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:40:00. 50 Economy ticket for £124 per person are available. Travel duration is 23h 20m
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Lufthansa26h 0m006:15Prague AirportPrague Airport08:15Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Lufthansa goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 06:15:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:15:00. 50 Economy ticket for £138 per person are available. Travel duration is 26h 0m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus16h 50m016:15PragueWilsonova Coach Station09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m016:00PragueÚAN Florenc09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 17h 5m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 23:15:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 35m
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FlixBus21h 0m017:45PragueNa Knížecí Station14:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/03/2026 17:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 14:45:00. 50 Economy ticket for £50 per person are available. Travel duration is 21h 0m
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Volotea1h 45m009:35Prague AirportPrague Airport - T1/211:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 09:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/03/2026 11:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 45m
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Wizz Air18h 40m019:00Prague AirportPrague Airport13:40Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 23/03/2026 19:00:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 24/03/2026 13:40:00. 50 Economy ticket for £68 per person are available. Travel duration is 18h 40m
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EasyJet Airline1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/03/2026 15:55:00. 50 Economy ticket for £73 per person are available. Travel duration is 1h 50m
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Jet2.com13h 50m019:40Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 24/03/2026 09:30:00. 50 Economy ticket for £74 per person are available. Travel duration is 13h 50m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus22h 50m017:35PragueWilsonova Coach Station16:25LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/03/2026 17:35:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 16:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 22h 50m
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FlixBus27h 5m008:55PragueZličín12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 24/03/2026 08:55:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 12:00:00. 50 Economy ticket for £47 per person are available. Travel duration is 27h 5m
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FlixBus21h 0m017:45PragueNa Knížecí Station14:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/03/2026 17:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 14:45:00. 50 Economy ticket for £47 per person are available. Travel duration is 21h 0m
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FlixBus25h 25m013:20Prague AirportPrague Airport - T1/214:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 24/03/2026 13:20:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 14:45:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 25m
Cheapest Buses Tuesday
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FlixBus20h 30m017:30PragueWilsonova Coach Station14:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/03/2026 17:30:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 14:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 20h 30m
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FlixBus21h 0m023:50PragueWilsonova Coach Station20:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/03/2026 23:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 20:50:00. 50 Economy ticket for £45 per person are available. Travel duration is 21h 0m
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FlixBus22h 5m022:45Prague AirportPrague Airport - T1/220:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/03/2026 22:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 20:50:00. 50 Economy ticket for £45 per person are available. Travel duration is 22h 5m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/03/2026 15:10:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 5m
Cheapest Buses Wednesday
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FlixBus16h 50m016:15PragueWilsonova Coach Station09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 26/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 50m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 23:15:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 35m
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FlixBus17h 5m016:00PragueÚAN Florenc09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 17h 5m
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FlixBus19h 25m003:50PragueWilsonova Coach Station23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 26/03/2026 03:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 23:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 25m
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Skyscanner1h 45m016:10Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 16:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 17:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m016:10Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 16:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 17:55:00. 50 Economy ticket for £57 per person are available. Travel duration is 1h 45m
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Smartwings8h 55m012:00Prague AirportPrague Airport - T1/220:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 12:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £80 per person are available. Travel duration is 8h 55m
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Astra Airlines8h 40m012:15Prague AirportPrague Airport - T1/220:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Astra Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 12:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 8h 40m
Cheapest Buses Thursday
Cheapest Flights Thursday
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EasyJet Airline1h 45m016:40Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 16:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 18:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 45m
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Volotea1h 45m010:00Prague AirportPrague Airport - T1/211:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 10:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 11:45:00. 50 Economy ticket for £61 per person are available. Travel duration is 1h 45m
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Wizz Air24h 0m008:05Prague AirportPrague Airport - T1/208:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 08:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 28/03/2026 08:05:00. 50 Economy ticket for £74 per person are available. Travel duration is 24h 0m
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Buzz8h 30m007:35Prague AirportPrague Airport - T1/216:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 07:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 16:05:00. 50 Economy ticket for £80 per person are available. Travel duration is 8h 30m
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FlixBus21h 0m023:50PragueWilsonova Coach Station20:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 27/03/2026 23:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 20:50:00. 50 Economy ticket for £56 per person are available. Travel duration is 21h 0m
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FlixBus14h 40m021:50PragueNa Knížecí Station12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 27/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 12:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m021:25PragueÚAN Florenc12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 27/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 12:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 15h 5m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 27/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 23:15:00. 50 Economy ticket for £62 per person are available. Travel duration is 16h 35m
Cheapest Flights Friday
Cheapest Buses Friday
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FlixBus16h 50m016:15PragueWilsonova Coach Station10:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 28/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 10:05:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 50m
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FlixBus14h 40m021:50PragueNa Knížecí Station13:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 28/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 13:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 14h 40m
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FlixBus17h 5m016:00PragueÚAN Florenc10:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 28/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 10:05:00. 50 Economy ticket for £49 per person are available. Travel duration is 17h 5m
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FlixBus15h 5m021:25PragueÚAN Florenc13:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 28/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 13:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 15h 5m
Cheapest Buses Saturday
What are the fastest trips from Prague to Lyon?
You can get to Lyon from Prague in just 1h 45m with a Flight from Skyscanner. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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EasyJet Airline11h 35m021:10Prague AirportPrague Airport08:45Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 21:10:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:45:00. 50 Economy ticket for £104 per person are available. Travel duration is 11h 35m
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Wizz Air14h 0m018:45Prague AirportPrague Airport08:45Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 18:45:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:45:00. 50 Economy ticket for £113 per person are available. Travel duration is 14h 0m
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Volotea23h 20m009:20Prague AirportPrague Airport08:40Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Volotea goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 09:20:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 08:40:00. 50 Economy ticket for £124 per person are available. Travel duration is 23h 20m
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Austrian Airlines25h 0m011:05Prague AirportPrague Airport12:05Lyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Austrian Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 22/03/2026 11:05:00 to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 23/03/2026 12:05:00. 50 Economy ticket for £171 per person are available. Travel duration is 25h 0m
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FlixBus14h 40m021:50PragueNa Knížecí Station12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £62 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m021:25PragueÚAN Florenc12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 22/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £62 per person are available. Travel duration is 15h 5m
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FlixBus17h 40m018:50Prague AirportPrague Airport - T1/212:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/03/2026 18:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 12:30:00. 50 Economy ticket for £68 per person are available. Travel duration is 17h 40m
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FlixBus21h 0m023:50PragueWilsonova Coach Station20:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/03/2026 23:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 20:50:00. 50 Economy ticket for £70 per person are available. Travel duration is 21h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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Volotea1h 45m009:35Prague AirportPrague Airport - T1/211:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 09:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/03/2026 11:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/03/2026 15:55:00. 50 Economy ticket for £73 per person are available. Travel duration is 1h 50m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 24/03/2026 07:35:00. 50 Economy ticket for £83 per person are available. Travel duration is 10h 25m
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Jet2.com13h 50m019:40Prague AirportPrague Airport - T1/209:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/03/2026 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 24/03/2026 09:30:00. 50 Economy ticket for £74 per person are available. Travel duration is 13h 50m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 23/03/2026 23:15:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 35m
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FlixBus16h 50m016:15PragueWilsonova Coach Station09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m016:00PragueÚAN Florenc09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 17h 5m
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FlixBus19h 30m019:30PragueÚAN Florenc15:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/03/2026 19:30:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 24/03/2026 15:00:00. 50 Economy ticket for £50 per person are available. Travel duration is 19h 30m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus19h 15m019:30PragueÚAN Florenc14:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/03/2026 19:30:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 14:45:00. 50 Economy ticket for £53 per person are available. Travel duration is 19h 15m
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FlixBus21h 0m017:45PragueNa Knížecí Station14:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/03/2026 17:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 14:45:00. 50 Economy ticket for £47 per person are available. Travel duration is 21h 0m
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FlixBus22h 50m017:35PragueWilsonova Coach Station16:25LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/03/2026 17:35:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 16:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 22h 50m
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FlixBus25h 25m013:20Prague AirportPrague Airport - T1/214:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 24/03/2026 13:20:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 25/03/2026 14:45:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 25m
Fastest Buses Tuesday
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/03/2026 15:10:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 25/03/2026 14:30:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 08:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 45m
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FlixBus20h 30m017:30PragueWilsonova Coach Station14:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/03/2026 17:30:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 14:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 20h 30m
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FlixBus21h 0m023:50PragueWilsonova Coach Station20:50LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/03/2026 23:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 20:50:00. 50 Economy ticket for £45 per person are available. Travel duration is 21h 0m
Fastest Buses Wednesday
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Skyscanner1h 45m016:10Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 16:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 17:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m016:10Prague AirportPrague Airport - T1/217:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 16:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 17:55:00. 50 Economy ticket for £57 per person are available. Travel duration is 1h 45m
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Astra Airlines8h 40m012:15Prague AirportPrague Airport - T1/220:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Astra Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 12:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 8h 40m
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Smartwings8h 55m012:00Prague AirportPrague Airport - T1/220:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/03/2026 12:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £80 per person are available. Travel duration is 8h 55m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 23:15:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 35m
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FlixBus16h 50m016:15PragueWilsonova Coach Station09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 26/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m016:00PragueÚAN Florenc09:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 09:05:00. 50 Economy ticket for £46 per person are available. Travel duration is 17h 5m
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FlixBus19h 5m004:10PragueNa Knížecí Station23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 26/03/2026 04:10:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 26/03/2026 23:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 5m
Fastest Flights Thursday
Fastest Buses Thursday
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EasyJet Airline1h 45m016:40Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 16:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 18:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 45m
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Volotea1h 45m010:00Prague AirportPrague Airport - T1/211:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 10:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 11:45:00. 50 Economy ticket for £61 per person are available. Travel duration is 1h 45m
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Brussels Airlines4h 20m006:50Prague AirportPrague Airport - T1/211:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 06:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 11:10:00. 50 Economy ticket for £122 per person are available. Travel duration is 4h 20m
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Buzz8h 30m007:35Prague AirportPrague Airport - T1/216:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 07:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 27/03/2026 16:05:00. 50 Economy ticket for £80 per person are available. Travel duration is 8h 30m
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FlixBus14h 40m021:50PragueNa Knížecí Station12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 27/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 12:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m021:25PragueÚAN Florenc12:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 27/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 12:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 15h 5m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 27/03/2026 06:40:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 27/03/2026 23:15:00. 50 Economy ticket for £62 per person are available. Travel duration is 16h 35m
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FlixBus17h 40m018:50Prague AirportPrague Airport - T1/212:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 27/03/2026 18:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 28/03/2026 12:30:00. 50 Economy ticket for £63 per person are available. Travel duration is 17h 40m
Fastest Flights Friday
Fastest Buses Friday
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FlixBus14h 40m021:50PragueNa Knížecí Station13:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 28/03/2026 21:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 13:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m021:25PragueÚAN Florenc13:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 28/03/2026 21:25:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 13:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 15h 5m
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FlixBus16h 50m016:15PragueWilsonova Coach Station10:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 28/03/2026 16:15:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 10:05:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m016:00PragueÚAN Florenc10:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 28/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 29/03/2026 10:05:00. 50 Economy ticket for £49 per person are available. Travel duration is 17h 5m
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from Prague to Lyon
What are the most popular stations in Prague and Lyon?
In Prague, you will usually depart from Wilsonova Coach Station, ÚAN Florenc or Černý Most, while in Lyon you will be arriving at Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Prague? With 7 connections between 1 Carpool, Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Lyon, you can pay as low as £45 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Lyon in just 1h 45m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Lyon are FlixBus, EasyJet Airline and Wizz Air, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Caluire-et-Cuire, and look at flights from Prague Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Lyon?
The most popular companies between Prague and Lyon, are FlixBus, EasyJet Airline and Wizz Air. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: EasyJet Airline, Wizz Air, Volotea and 9 more.
All you need to know when you travel from Prague to Lyon
Check all information on comfort and services on all modes of transports from Prague to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Lyon
How can I reach Lyon from Prague?
Every day, there are on average 7 connections between Carpool, Flight and Bus, with which you can get to Lyon from Prague.
How far is Lyon from Prague?
The distance between Prague and Lyon is 860.7 km.
What is the most ecofriendly mode of transport between Prague and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Prague to Lyon?
You can get to Lyon with just £45 by taking a Bus from FlixBus.
What is the fastest way to get from Prague to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 45m with a Flight from Skyscanner.
More routes to Prague and to Lyon
Looking for more options? Here you can see the most popular routes to Prague and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Brno to Prague
- Budapest to Prague
- Dresden to Prague
- Florence to Prague
- Frankfurt am Main to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Leipzig to Prague
- Lodz to Prague
- London to Prague
- Lyon to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Ostrava to Prague
- Salzburg to Prague
- Třebíč to Prague
- Venice to Prague
- Vienna to Prague
- Vilnius to Prague
- Zurich to Prague
- Trips to Lyon
- Aix-en-Provence to Lyon
- Aix-les-Bains to Lyon
- Annecy to Lyon
- Barcelona to Lyon
- Barcelona-El Prat Airport to Lyon
- Birmingham to Lyon
- Bordeaux to Lyon
- Bourges to Lyon
- Clermont-Ferrand to Lyon
- Dusseldorf to Lyon
- Geneva Airport to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Lille to Lyon
- Marseille to Lyon
- Milan to Lyon
- Montpellier to Lyon
- Mulhouse to Lyon
- Nantes to Lyon
- Paris to Lyon
- Rennes to Lyon
- Rouen to Lyon
- Toulouse to Lyon
- Valencia to Lyon
