What is the best way to travel from Prague to Lyon?
Looking for a trip? Check and compare all the available Buses, Flights and Carpool to Lyon from Prague. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Prague?
You can reach Lyon with just £30 by taking a Flight from Volotea, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Volotea1h 45m021:40Prague AirportPrague Airport - T1/223:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 20/12/2025 23:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 45m
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Air Malta24h 0m020:40Prague AirportPrague Airport - T1/220:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Malta goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 20:40:00. 50 Economy ticket for £104 per person are available. Travel duration is 24h 0m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 07:35:00. 50 Economy ticket for £132 per person are available. Travel duration is 10h 25m
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Skyscanner25h 0m011:05Prague AirportPrague Airport - T1/212:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 11:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 12:05:00. 50 Economy ticket for £166 per person are available. Travel duration is 25h 0m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 20/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £85 per person are available. Travel duration is 15h 0m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 20/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £85 per person are available. Travel duration is 14h 35m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 09:00:00. 50 Economy ticket for £93 per person are available. Travel duration is 16h 45m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 20/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 08:15:00. 50 Economy ticket for £93 per person are available. Travel duration is 17h 45m
Cheapest Flights Saturday
Cheapest Buses Saturday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 09:00:00. 50 Economy ticket for £91 per person are available. Travel duration is 16h 45m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 21/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 12:25:00. 50 Economy ticket for £91 per person are available. Travel duration is 14h 35m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 08:15:00. 50 Economy ticket for £91 per person are available. Travel duration is 17h 5m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 09:00:00. 50 Economy ticket for £91 per person are available. Travel duration is 17h 0m
Cheapest Buses Sunday
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Volotea1h 45m012:10Prague AirportPrague Airport - T1/213:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 12:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 13:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 15:55:00. 50 Economy ticket for £65 per person are available. Travel duration is 1h 50m
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Skyscanner1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 15:55:00. 50 Economy ticket for £82 per person are available. Travel duration is 1h 50m
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LOT Polish Airlines / Polskie Linie Lotnicze14h 50m019:35Prague AirportPrague Airport - T1/210:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 19:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 10:25:00. 50 Economy ticket for £123 per person are available. Travel duration is 14h 50m
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FlixBus19h 25m003:50PragueWilsonova Coach Station23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 03:50:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 23:15:00. 50 Economy ticket for £70 per person are available. Travel duration is 19h 25m
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FlixBus17h 20m011:15PragueWilsonova Coach Station04:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 11:15:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 04:35:00. 50 Economy ticket for £70 per person are available. Travel duration is 17h 20m
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FlixBus19h 5m004:10PragueNa Knížecí Station23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/12/2025 04:10:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 23:15:00. 50 Economy ticket for £70 per person are available. Travel duration is 19h 5m
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FlixBus19h 10m013:05PragueWilsonova Coach Station08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 13:05:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 08:15:00. 50 Economy ticket for £74 per person are available. Travel duration is 19h 10m
Cheapest Flights Monday
Cheapest Buses Monday
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Volotea1h 45m008:45Prague AirportPrague Airport - T1/210:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 08:45:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 10:30:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 45m
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Iberia28h 5m019:40Prague AirportPrague Airport - T1/223:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Iberia goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 24/12/2025 23:45:00. 50 Economy ticket for £122 per person are available. Travel duration is 28h 5m
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Brussels Airlines4h 20m006:50Prague AirportPrague Airport - T1/211:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 06:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 11:10:00. 50 Economy ticket for £166 per person are available. Travel duration is 4h 20m
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Lufthansa6h 15m011:50Prague AirportPrague Airport - T1/218:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Lufthansa goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 11:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £168 per person are available. Travel duration is 6h 15m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 24/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 24/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 15h 0m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 23:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 16h 35m
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FlixBus19h 25m003:50PragueWilsonova Coach Station23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/12/2025 03:50:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 23:15:00. 50 Economy ticket for £84 per person are available. Travel duration is 19h 25m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 09:00:00. 50 Economy ticket for £69 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 09:00:00. 50 Economy ticket for £69 per person are available. Travel duration is 17h 0m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 12:25:00. 50 Economy ticket for £71 per person are available. Travel duration is 14h 35m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 08:15:00. 50 Economy ticket for £71 per person are available. Travel duration is 17h 5m
Cheapest Buses Wednesday
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Volotea1h 45m021:55Prague AirportPrague Airport - T1/223:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 21:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 23:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m020:40Prague AirportPrague Airport - T1/222:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 45m
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Skyscanner1h 45m020:40Prague AirportPrague Airport - T1/222:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:25:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 45m
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LOT Polish Airlines / Polskie Linie Lotnicze4h 55m018:00Prague AirportPrague Airport - T1/222:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 18:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:55:00. 50 Economy ticket for £123 per person are available. Travel duration is 4h 55m
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RegioJet15h 50m023:00PragueÚAN Florenc14:50LyonPerrache Bus Stop0EconomyA Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 23:00:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 14:50:00. 50 Economy ticket for £70 per person are available. Travel duration is 15h 50m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 09:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 09:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 0m
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FlixBus17h 20m011:15PragueWilsonova Coach Station04:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 11:15:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 04:35:00. 50 Economy ticket for £77 per person are available. Travel duration is 17h 20m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Volotea1h 45m018:55Prague AirportPrague Airport - T1/220:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 18:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 20:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m016:40Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 16:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 18:25:00. 50 Economy ticket for £102 per person are available. Travel duration is 1h 45m
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Wizz Air11h 15m008:05Prague AirportPrague Airport - T1/219:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 08:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 19:20:00. 50 Economy ticket for £104 per person are available. Travel duration is 11h 15m
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LOT Polish Airlines / Polskie Linie Lotnicze11h 10m007:15Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 07:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 18:25:00. 50 Economy ticket for £131 per person are available. Travel duration is 11h 10m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 23:15:00. 50 Economy ticket for £77 per person are available. Travel duration is 16h 35m
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FlixBus20h 5m007:55PragueNa Knížecí Station04:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 26/12/2025 07:55:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 04:00:00. 50 Economy ticket for £80 per person are available. Travel duration is 20h 5m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 08:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 17h 5m
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FlixBus19h 20m012:55PragueZličín08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 26/12/2025 12:55:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 08:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 20m
Cheapest Flights Friday
Cheapest Buses Friday
What are the fastest trips from Prague to Lyon?
You can get to Lyon from Prague in just 1h 45m with a Flight from Volotea. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Volotea1h 45m021:40Prague AirportPrague Airport - T1/223:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 20/12/2025 23:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 45m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 07:35:00. 50 Economy ticket for £132 per person are available. Travel duration is 10h 25m
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Lufthansa CityLine18h 30m013:45Prague AirportPrague Airport - T1/208:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Lufthansa CityLine goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 13:45:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 08:15:00. 50 Economy ticket for £180 per person are available. Travel duration is 18h 30m
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Air Malta24h 0m020:40Prague AirportPrague Airport - T1/220:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Malta goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 21/12/2025 20:40:00. 50 Economy ticket for £104 per person are available. Travel duration is 24h 0m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 20/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £85 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 20/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £85 per person are available. Travel duration is 15h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 09:00:00. 50 Economy ticket for £93 per person are available. Travel duration is 16h 45m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 20/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 21/12/2025 08:15:00. 50 Economy ticket for £93 per person are available. Travel duration is 17h 5m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 21/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 12:25:00. 50 Economy ticket for £91 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 12:25:00. 50 Economy ticket for £91 per person are available. Travel duration is 15h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 09:00:00. 50 Economy ticket for £91 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 09:00:00. 50 Economy ticket for £91 per person are available. Travel duration is 17h 0m
Fastest Buses Sunday
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Volotea1h 45m012:10Prague AirportPrague Airport - T1/213:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 12:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 13:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 15:55:00. 50 Economy ticket for £65 per person are available. Travel duration is 1h 50m
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Skyscanner1h 50m014:05Prague AirportPrague Airport - T1/215:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 14:05:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 22/12/2025 15:55:00. 50 Economy ticket for £82 per person are available. Travel duration is 1h 50m
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Vueling Airlines10h 25m021:10Prague AirportPrague Airport - T1/207:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 21:10:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 07:35:00. 50 Economy ticket for £163 per person are available. Travel duration is 10h 25m
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FlixBus17h 20m011:15PragueWilsonova Coach Station04:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 11:15:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 04:35:00. 50 Economy ticket for £70 per person are available. Travel duration is 17h 20m
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FlixBus17h 35m018:50Prague AirportPrague Airport - T1/212:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 18:50:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 12:25:00. 50 Economy ticket for £77 per person are available. Travel duration is 17h 35m
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FlixBus19h 5m004:10PragueNa Knížecí Station23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/12/2025 04:10:00 to Perrache Bus Stop, Lyon (France) arriving at 22/12/2025 23:15:00. 50 Economy ticket for £70 per person are available. Travel duration is 19h 5m
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FlixBus19h 10m013:05PragueWilsonova Coach Station08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 13:05:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 08:15:00. 50 Economy ticket for £74 per person are available. Travel duration is 19h 10m
Fastest Flights Monday
Fastest Buses Monday
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Volotea1h 45m008:45Prague AirportPrague Airport - T1/210:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 08:45:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 10:30:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 45m
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Air Dolomiti3h 40m010:30Prague AirportPrague Airport - T1/214:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Dolomiti goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 10:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 14:10:00. 50 Economy ticket for £168 per person are available. Travel duration is 3h 40m
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Brussels Airlines4h 20m006:50Prague AirportPrague Airport - T1/211:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 06:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 11:10:00. 50 Economy ticket for £166 per person are available. Travel duration is 4h 20m
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Lufthansa6h 15m011:50Prague AirportPrague Airport - T1/218:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Lufthansa goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 11:50:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £168 per person are available. Travel duration is 6h 15m
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 24/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 24/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 15h 0m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 23:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 16h 35m
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FlixBus19h 5m004:10PragueNa Knížecí Station23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/12/2025 04:10:00 to Perrache Bus Stop, Lyon (France) arriving at 23/12/2025 23:15:00. 50 Economy ticket for £84 per person are available. Travel duration is 19h 5m
Fastest Flights Tuesday
Fastest Buses Tuesday
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FlixBus14h 35m021:50PragueNa Knížecí Station12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/12/2025 21:50:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 12:25:00. 50 Economy ticket for £71 per person are available. Travel duration is 14h 35m
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FlixBus15h 0m021:25PragueÚAN Florenc12:25LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 21:25:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 12:25:00. 50 Economy ticket for £71 per person are available. Travel duration is 15h 0m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 09:00:00. 50 Economy ticket for £69 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 25/12/2025 09:00:00. 50 Economy ticket for £69 per person are available. Travel duration is 17h 0m
Fastest Buses Wednesday
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Volotea1h 45m021:55Prague AirportPrague Airport - T1/223:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 21:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 23:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m020:40Prague AirportPrague Airport - T1/222:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 45m
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Skyscanner1h 45m020:40Prague AirportPrague Airport - T1/222:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:25:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 45m
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LOT Polish Airlines / Polskie Linie Lotnicze4h 55m018:00Prague AirportPrague Airport - T1/222:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 18:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 25/12/2025 22:55:00. 50 Economy ticket for £123 per person are available. Travel duration is 4h 55m
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RegioJet15h 50m023:00PragueÚAN Florenc14:50LyonPerrache Bus Stop0EconomyA Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 23:00:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 14:50:00. 50 Economy ticket for £70 per person are available. Travel duration is 15h 50m
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FlixBus16h 45m016:15PragueWilsonova Coach Station09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 16:15:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 09:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m016:00PragueÚAN Florenc09:00LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 16:00:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 09:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 0m
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FlixBus17h 20m011:15PragueWilsonova Coach Station04:35LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 11:15:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 04:35:00. 50 Economy ticket for £77 per person are available. Travel duration is 17h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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Volotea1h 45m018:55Prague AirportPrague Airport - T1/220:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 18:55:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 20:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 45m
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EasyJet Airline1h 45m016:40Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 16:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 18:25:00. 50 Economy ticket for £102 per person are available. Travel duration is 1h 45m
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Air Dolomiti8h 0m010:20Prague AirportPrague Airport - T1/218:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Dolomiti goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 10:20:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 18:20:00. 50 Economy ticket for £161 per person are available. Travel duration is 8h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze11h 10m007:15Prague AirportPrague Airport - T1/218:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 26/12/2025 07:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 26/12/2025 18:25:00. 50 Economy ticket for £131 per person are available. Travel duration is 11h 10m
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FlixBus16h 35m006:40PragueÚAN Florenc23:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/12/2025 06:40:00 to Perrache Bus Stop, Lyon (France) arriving at 26/12/2025 23:15:00. 50 Economy ticket for £77 per person are available. Travel duration is 16h 35m
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FlixBus17h 5m015:10PragueÚAN Florenc08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 26/12/2025 15:10:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 08:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m014:30PragueČerný Most08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 26/12/2025 14:30:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 08:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 17h 45m
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FlixBus19h 20m012:55PragueZličín08:15LyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 26/12/2025 12:55:00 to Perrache Bus Stop, Lyon (France) arriving at 27/12/2025 08:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 20m
Fastest Flights Friday
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Prague to Lyon
What are the most popular stations in Prague and Lyon?
In Prague, you will usually depart from Wilsonova Coach Station, ÚAN Florenc or Černý Most, while in Lyon you will be arriving at Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Prague? With 8 connections between 2 Bus, Flight and Carpool operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Lyon, you can pay as low as £30 with a Flight from Volotea.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Lyon in just 1h 45m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Lyon are FlixBus, Volotea and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Caluire-et-Cuire, and look at flights from Prague Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Lyon?
The most popular companies between Prague and Lyon, are FlixBus, Volotea and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and RegioJet
Airlines: Volotea, Skyscanner, EasyJet Airline and 10 more.
All you need to know when you travel from Prague to Lyon
Check all information on comfort and services on all modes of transports from Prague to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Lyon
How can I reach Lyon from Prague?
Every day, there are on average 8 connections between Bus, Flight and Carpool, with which you can get to Lyon from Prague.
How far is Lyon from Prague?
The distance between Prague and Lyon is 860.7 km.
What is the most ecofriendly mode of transport between Prague and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Prague to Lyon?
You can get to Lyon with just £30 by taking a Flight from Volotea.
What is the fastest way to get from Prague to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 45m with a Flight from Volotea.
More routes to Prague and to Lyon
Looking for more options? Here you can see the most popular routes to Prague and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Brno to Prague
- Budapest to Prague
- Česká Lípa to Prague
- Dresden to Prague
- Florence to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Linz to Prague
- London to Prague
- Lyon to Prague
- Milan to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Paris to Prague
- Pelhřimov to Prague
- Rome to Prague
- Třebíč to Prague
- Vienna to Prague
- Vilnius to Prague
- Zurich to Prague
- Trips to Lyon
- Barcelona to Lyon
- Barcelona-El Prat Airport to Lyon
- Birmingham to Lyon
- Bologna to Lyon
- Brive-la-Gaillarde to Lyon
- Clermont-Ferrand to Lyon
- Fréjus to Lyon
- Geneva Airport to Lyon
- Genoa to Lyon
- Huez (Alpe d’Huez) to Lyon
- Madrid to Lyon
- Montpellier to Lyon
- Nancy to Lyon
- Naples to Lyon
- Nice to Lyon
- Paris Charles de Gaulle Airport to Lyon
- Paris to Lyon
- Perpignan to Lyon
- Saint-Étienne to Lyon
- Strasbourg to Lyon
- Thionville to Lyon
- Toulon to Lyon
- Turin to Lyon
- Zurich to Lyon
