Which bus from Lyon to Prague is the best?
Check the bus schedule for Lyon to Prague. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus or RegioJet. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RegioJet | 15h 55m | 14:35 | Lyon | Perrache Bus Stop | 06:30 | Prague | ÚAN Florenc | Economy | £79 |
A Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 06:30:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 55m
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| RegioJet | 15h 50m | 14:35 | Lyon | Perrache Bus Stop | 06:25 | Prague | Train station Wilsonova | Economy | £79 |
A Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to Train station Wilsonova, Prague (Czech Republic) arriving at 21/12/2025 06:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 50m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £91 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:20:00. 50 Economy ticket for £91 per person are available. Travel duration is 15h 5m
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| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £91 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 21/12/2025 08:55:00. 50 Economy ticket for £91 per person are available. Travel duration is 14h 40m
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| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £94 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 15:25:00. 50 Economy ticket for £94 per person are available. Travel duration is 17h 25m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £83 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 22/12/2025 08:55:00. 50 Economy ticket for £83 per person are available. Travel duration is 14h 40m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £83 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 09:20:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 5m
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| FlixBus | 20h 30m | 09:30 | Lyon | Perrache Bus Stop | 06:00 | Prague | Wilsonova Coach Station | Economy | £95 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 06:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 30m
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| FlixBus | 20h 45m | 09:30 | Lyon | Perrache Bus Stop | 06:15 | Prague | ÚAN Florenc | Economy | £95 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 06:15:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 45m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £96 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 13:55:00. 50 Economy ticket for £96 per person are available. Travel duration is 16h 55m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 30m | 09:30 | Lyon | Perrache Bus Stop | 06:00 | Prague | Wilsonova Coach Station | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 06:00:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 30m
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| FlixBus | 20h 45m | 09:30 | Lyon | Perrache Bus Stop | 06:15 | Prague | ÚAN Florenc | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 06:15:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 45m
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| FlixBus | 19h 0m | 03:15 | Lyon | Perrache Bus Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £83 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 03:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 22:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 19h 0m
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| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £83 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 15:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Perrache Bus Stop | 16:10 | Prague | Černý Most | Economy | £83 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 23/12/2025 16:10:00. 50 Economy ticket for £83 per person are available. Travel duration is 18h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 45m | 17:05 | Lyon | Perrache Bus Stop | 10:50 | Prague | Wilsonova Coach Station | Economy | £75 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 10:50:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 45m
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| FlixBus | 18h 45m | 03:30 | Lyon | Perrache Bus Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £76 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 22:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
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| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/12/2025 08:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 14h 40m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 13:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 55m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/12/2025 09:20:00. 50 Economy ticket for £81 per person are available. Travel duration is 15h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £72 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 25/12/2025 08:55:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 40m
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| FlixBus | 17h 45m | 17:05 | Lyon | Perrache Bus Stop | 10:50 | Prague | Wilsonova Coach Station | Economy | £72 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/12/2025 10:50:00. 50 Economy ticket for £72 per person are available. Travel duration is 17h 45m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £72 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 09:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 15h 5m
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| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 15:25:00. 50 Economy ticket for £81 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Perrache Bus Stop | 16:10 | Prague | Černý Most | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 25/12/2025 16:10:00. 50 Economy ticket for £81 per person are available. Travel duration is 18h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £74 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/12/2025 08:55:00. 50 Economy ticket for £74 per person are available. Travel duration is 14h 40m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £74 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 09:20:00. 50 Economy ticket for £74 per person are available. Travel duration is 15h 5m
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| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £74 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 15:25:00. 50 Economy ticket for £74 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Perrache Bus Stop | 16:10 | Prague | Černý Most | Economy | £74 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 26/12/2025 16:10:00. 50 Economy ticket for £74 per person are available. Travel duration is 18h 10m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £81 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/12/2025 13:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 55m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 45m | 03:30 | Lyon | Perrache Bus Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £76 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 26/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/12/2025 22:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
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| FlixBus | 19h 5m | 05:20 | Lyon | Perrache Bus Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £77 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 26/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 27/12/2025 00:25:00. 50 Economy ticket for £77 per person are available. Travel duration is 19h 5m
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| FlixBus | 17h 45m | 17:05 | Lyon | Perrache Bus Stop | 10:50 | Prague | Wilsonova Coach Station | Economy | £77 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 26/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 27/12/2025 10:50:00. 50 Economy ticket for £77 per person are available. Travel duration is 17h 45m
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| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £78 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 26/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 27/12/2025 15:25:00. 50 Economy ticket for £78 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Perrache Bus Stop | 16:10 | Prague | Černý Most | Economy | £78 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 26/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 27/12/2025 16:10:00. 50 Economy ticket for £78 per person are available. Travel duration is 18h 10m
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Best Price Offer: The price for the cheapest coach from Lyon to Prague is £43 on 06/01/2026. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between Lyon and Prague?
All facts for Lyon to Prague bus at a glance
Compare all coach operators like FlixBus and RegioJet that travel daily 12 times by bus from Lyon to Prague in one click. Book your Lyon to Prague bus ticket starting from £43!
| Cheapest Bus | £43 |
| Fastest Bus | 14h 40m |
| Earliest Coach | 09:30 |
| Latest Coach | 22:00 |
| Daily Bus Connections | 12 Ø |
| Distance | 860.7 km |
| Coach Companies | FlixBus and RegioJet |
What are the cheapest coach tickets from Lyon to Prague?
Every day, 12 buses from 2 coach companies leave Lyon for Prague. Check the table below to find the cheapest prices for coach tickets for this route, starting from 20/12/2025 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from Lyon to Prague
How to save money travelling from Lyon to Prague
Book the ticket from Lyon to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Lyon to Prague, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Lyon to Prague are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
Latest reviews for coach companies on the route Lyon - Prague
All bus stations and stops in Lyon and Prague
Here is a map with all coach stations in Lyon and Prague. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from Lyon to Prague
FAQs for Lyon to Prague bus
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Available seat classes which are offered on the bus route Lyon to Prague
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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