Which bus from Lyon to Prague is the best?
Check the bus schedule for Lyon to Prague. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus or BlaBlaCar Bus. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £58 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 09:20:00. 50 Economy ticket for £58 per person are available. Travel duration is 15h 5m
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| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £58 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 06/12/2025 08:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 14h 40m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £59 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 13:55:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 55m
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| FlixBus | 17h 5m | 21:00 | Lyon | Perrache Bus Stop | 14:05 | Prague | ÚAN Florenc | Economy | £59 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 14:05:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 5m
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| FlixBus | 16h 30m | 05:20 | Lyon | Perrache Bus Stop | 21:50 | Prague | ÚAN Florenc | Economy | £61 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £54 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 07/12/2025 08:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 14h 40m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £54 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 09:20:00. 50 Economy ticket for £54 per person are available. Travel duration is 15h 5m
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| FlixBus | 20h 30m | 09:30 | Lyon | Perrache Bus Stop | 06:00 | Prague | Wilsonova Coach Station | Economy | £55 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 07/12/2025 06:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 30m
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| FlixBus | 20h 45m | 09:30 | Lyon | Perrache Bus Stop | 06:15 | Prague | ÚAN Florenc | Economy | £55 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 06:15:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 45m
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| FlixBus | 18h 45m | 03:30 | Lyon | Perrache Bus Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £56 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £56 per person are available. Travel duration is 18h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 25m | 22:00 | Lyon | Perrache Bus Stop | 15:25 | Prague | ÚAN Florenc | Economy | £54 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 15:25:00. 50 Economy ticket for £54 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Perrache Bus Stop | 16:10 | Prague | Černý Most | Economy | £54 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 08/12/2025 16:10:00. 50 Economy ticket for £54 per person are available. Travel duration is 18h 10m
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| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £56 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 08:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 40m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £56 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 09:20:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 5m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £58 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 08/12/2025 13:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 16h 55m
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FlixBus18h 45m003:30LyonPerrache Bus Stop09:50ZurichCentral Bus Station Sihlquai0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 03:30:00 to Central Bus Station Sihlquai, Zurich (Switzerland) arriving at 09/12/2025 09:50:00. 50 Economy ticket for £18 per person are available. Travel duration is 6h 20m
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FlixBus11h 0m011:15ZurichCentral Bus Station Sihlquai22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Central Bus Station Sihlquai, Zurich (Switzerland) at 09/12/2025 11:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 22:15:00. 50 Economy ticket for £30 per person are available. Travel duration is 11h 0m
Waiting Time 1h 25m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 35m | 05:20 | Lyon | Perrache Bus Stop | 22:55 | Prague | Na Knížecí Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 22:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
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| FlixBus | 19h 5m | 05:20 | Lyon | Perrache Bus Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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| FlixBus | 20h 30m | 09:30 | Lyon | Perrache Bus Stop | 06:00 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 06:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 20h 30m
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| BlaBlaCar Bus | 21h 45m | 12:00 | Lyon | Perrache Bus Stop | 09:45 | Prague | ÚAN Florenc | Economy | £58 |
A Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 09/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 45m | 03:30 | Lyon | Perrache Bus Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 22:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 45m
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| FlixBus | 19h 5m | 05:20 | Lyon | Perrache Bus Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 13:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 55m
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| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 09:20:00. 50 Economy ticket for £45 per person are available. Travel duration is 15h 5m
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| FlixBus | 17h 5m | 21:00 | Lyon | Perrache Bus Stop | 14:05 | Prague | ÚAN Florenc | Economy | £45 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 14:05:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 30m | 02:25 | Lyon | Perrache Bus Stop | 22:55 | Prague | Na Knížecí Station | Economy | £49 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 02:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 10/12/2025 22:55:00. 50 Economy ticket for £49 per person are available. Travel duration is 20h 30m
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| FlixBus | 23h 35m | 07:20 | Lyon | Perrache Bus Stop | 06:55 | Prague | ÚAN Florenc | Economy | £53 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 06:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 23h 35m
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| FlixBus | 17h 5m | 21:00 | Lyon | Perrache Bus Stop | 14:05 | Prague | ÚAN Florenc | Economy | £53 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 14:05:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 5m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £53 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 11/12/2025 13:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 55m
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| FlixBus | 24h 20m | 07:20 | Lyon | Perrache Bus Stop | 07:40 | Prague | Na Knížecí Station | Economy | £59 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 11/12/2025 07:40:00. 50 Economy ticket for £59 per person are available. Travel duration is 24h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 15h 5m | 18:15 | Lyon | Perrache Bus Stop | 09:20 | Prague | ÚAN Florenc | Economy | £47 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 5m
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| FlixBus | 14h 40m | 18:15 | Lyon | Perrache Bus Stop | 08:55 | Prague | Na Knížecí Station | Economy | £47 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 12/12/2025 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 14h 40m
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| FlixBus | 17h 5m | 21:00 | Lyon | Perrache Bus Stop | 14:05 | Prague | ÚAN Florenc | Economy | £48 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 14:05:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
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| FlixBus | 16h 55m | 21:00 | Lyon | Perrache Bus Stop | 13:55 | Prague | Wilsonova Coach Station | Economy | £48 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 12/12/2025 13:55:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 55m
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| FlixBus | 20h 45m | 09:30 | Lyon | Perrache Bus Stop | 06:15 | Prague | ÚAN Florenc | Economy | £52 |
A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 06:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 20h 45m
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Best Price Offer: The price for the cheapest coach from Lyon to Prague is £45 on 08/12/2025. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between Lyon and Prague?
All facts for Lyon to Prague bus at a glance
Compare all coach operators like FlixBus and BlaBlaCar Bus that travel daily 10 times by bus from Lyon to Prague in one click. Book your Lyon to Prague bus ticket starting from £45!
| Cheapest Bus | £45 |
| Fastest Bus | 14h 40m |
| Earliest Coach | 03:30 |
| Latest Coach | 22:00 |
| Daily Bus Connections | 10 Ø |
| Distance | 860.7 km |
| Coach Companies | FlixBus and BlaBlaCar Bus |
What are the cheapest coach tickets from Lyon to Prague?
Every day, 10 buses from 2 coach companies leave Lyon for Prague. Check the table below to find the cheapest prices for coach tickets for this route, starting from 05/12/2025 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from Lyon to Prague
How to save money travelling from Lyon to Prague
Book the ticket from Lyon to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Lyon to Prague, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Lyon to Prague are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
Latest reviews for coach companies on the route Lyon - Prague
All bus stations and stops in Lyon and Prague
Here is a map with all coach stations in Lyon and Prague. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from Lyon to Prague
FAQs for Lyon to Prague bus
How much does a Lyon Prague coach trip cost?
How much could I save by comparing buses from Lyon to Prague?
How many connections are available for the Lyon Prague route on average every day?
How long does a bus to Prague from Lyon take?
What time is the first bus from Lyon to Prague?
What time is the last coach from Lyon to Prague?
Which bus companies serve the Lyon Prague route?
Is there a direct bus between Lyon and Prague?
What can I take with me on the bus to Prague from Lyon?
What equipment is available for the Lyon Prague bus route?
Available seat classes which are offered on the bus route Lyon to Prague
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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