Which bus from Lyon to Prague is the best?
Check the bus schedule for Lyon to Prague. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus or BlaBlaCar Bus. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 25m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 15:25 | Prague | ÚAN Florenc | Economy | £49 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 18/06/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 19/06/2026 15:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 16:10 | Prague | Černý Most | Economy | £49 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 18/06/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 19/06/2026 16:10:00. 50 Economy ticket for £49 per person are available. Travel duration is 18h 10m
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| FlixBus | 17h 15m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 11:20 | Prague | Wilsonova Coach Station | Economy | £50 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 18/06/2026 18:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/06/2026 11:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 17h 15m
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| FlixBus | 17h 5m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:35 | Prague | Wilsonova Coach Station | Economy | £51 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 18/06/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/06/2026 14:35:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 5m
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| FlixBus | 14h 50m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 08:55 | Prague | Na Knížecí Station | Economy | £51 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 18/06/2026 18:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 19/06/2026 08:55:00. 50 Economy ticket for £51 per person are available. Travel duration is 14h 50m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 25m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 15:25 | Prague | ÚAN Florenc | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 19/06/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/06/2026 15:25:00. 50 Economy ticket for £57 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 16:10 | Prague | Černý Most | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 19/06/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 20/06/2026 16:10:00. 50 Economy ticket for £57 per person are available. Travel duration is 18h 10m
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| FlixBus | 14h 50m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 08:55 | Prague | Na Knížecí Station | Economy | £59 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 19/06/2026 18:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 20/06/2026 08:55:00. 50 Economy ticket for £59 per person are available. Travel duration is 14h 50m
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| BlaBlaCar Bus | 21h 45m | 12:00 | Lyon | Perrache Train Station | 09:45 | Prague | ÚAN Florenc | Economy | £82 |
A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/06/2026 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/06/2026 09:45:00. 50 Economy ticket for £82 per person are available. Travel duration is 21h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 45m | 03:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/06/2026 22:15:00. 50 Economy ticket for £57 per person are available. Travel duration is 18h 45m
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| FlixBus | 19h 5m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 21/06/2026 00:25:00. 50 Economy ticket for £57 per person are available. Travel duration is 19h 5m
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| FlixBus | 17h 5m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:35 | Prague | Wilsonova Coach Station | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 21/06/2026 14:35:00. 50 Economy ticket for £57 per person are available. Travel duration is 17h 5m
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| FlixBus | 17h 35m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 22:55 | Prague | Na Knížecí Station | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 20/06/2026 22:55:00. 50 Economy ticket for £57 per person are available. Travel duration is 17h 35m
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| FlixBus | 17h 15m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:45 | Prague | ÚAN Florenc | Economy | £57 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 21:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/06/2026 14:45:00. 50 Economy ticket for £57 per person are available. Travel duration is 17h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 25m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 15:25 | Prague | ÚAN Florenc | Economy | £59 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 21/06/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/06/2026 15:25:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 25m
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| FlixBus | 18h 10m | 22:00 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 16:10 | Prague | Černý Most | Economy | £59 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 21/06/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 22/06/2026 16:10:00. 50 Economy ticket for £59 per person are available. Travel duration is 18h 10m
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| FlixBus | 17h 5m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:35 | Prague | Wilsonova Coach Station | Economy | £62 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 21/06/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/06/2026 14:35:00. 50 Economy ticket for £62 per person are available. Travel duration is 17h 5m
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| FlixBus | 16h 30m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 21:50 | Prague | ÚAN Florenc | Economy | £62 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 21/06/2026 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/06/2026 21:50:00. 50 Economy ticket for £62 per person are available. Travel duration is 16h 30m
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| FlixBus | 17h 15m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:45 | Prague | ÚAN Florenc | Economy | £62 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 21/06/2026 21:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/06/2026 14:45:00. 50 Economy ticket for £62 per person are available. Travel duration is 17h 15m
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FlixBus20h 55m017:40LyonLyon Avenue Tony Garnier Coach Stop21:10LausanneP+R Vélodrome0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 20/06/2026 17:40:00 to P+R Vélodrome, Lausanne (Switzerland) arriving at 20/06/2026 21:10:00. 50 Economy ticket for £13 per person are available. Travel duration is 3h 30m
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FlixBus13h 40m000:55LausanneP+R Vélodrome14:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from P+R Vélodrome, Lausanne (Switzerland) at 21/06/2026 00:55:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 21/06/2026 14:35:00. 50 Economy ticket for £40 per person are available. Travel duration is 13h 40m
Waiting Time 3h 45m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 19h 5m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £48 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 22/06/2026 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/06/2026 00:25:00. 50 Economy ticket for £48 per person are available. Travel duration is 19h 5m
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| FlixBus | 17h 15m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 11:20 | Prague | Wilsonova Coach Station | Economy | £48 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 22/06/2026 18:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/06/2026 11:20:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 15m
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| FlixBus | 17h 5m | 21:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 14:35 | Prague | Wilsonova Coach Station | Economy | £48 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 22/06/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/06/2026 14:35:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
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| BlaBlaCar Bus | 21h 45m | 12:00 | Lyon | Perrache Train Station | 09:45 | Prague | ÚAN Florenc | Economy | £69 |
A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 22/06/2026 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/06/2026 09:45:00. 50 Economy ticket for £69 per person are available. Travel duration is 21h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 45m | 03:30 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 22:15 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/06/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/06/2026 22:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 45m
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| FlixBus | 19h 5m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/06/2026 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/06/2026 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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| FlixBus | 17h 15m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 11:20 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/06/2026 18:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/06/2026 11:20:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 15m
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| FlixBus | 17h 35m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 22:55 | Prague | Na Knížecí Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/06/2026 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 23/06/2026 22:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
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| FlixBus | 19h 45m | 12:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 07:50 | Prague | ÚAN Florenc | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/06/2026 12:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/06/2026 07:50:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 19h 5m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 00:25 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/06/2026 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/06/2026 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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| FlixBus | 17h 15m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 11:20 | Prague | Wilsonova Coach Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/06/2026 18:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/06/2026 11:20:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 15m
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| FlixBus | 17h 35m | 05:20 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 22:55 | Prague | Na Knížecí Station | Economy | £45 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/06/2026 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/06/2026 22:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
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| FlixBus | 14h 50m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 08:55 | Prague | Na Knížecí Station | Economy | £47 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/06/2026 18:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 25/06/2026 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 14h 50m
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| FlixBus | 15h 15m | 18:05 | Lyon | Lyon Avenue Tony Garnier Coach Stop | 09:20 | Prague | ÚAN Florenc | Economy | £47 |
A Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/06/2026 18:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/06/2026 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 15m
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Best Price Offer: The price for the cheapest coach from Lyon to Prague is £45 on 23/06/2026. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between Lyon and Prague?
All facts for Lyon to Prague bus at a glance
Compare all coach operators like FlixBus and BlaBlaCar Bus that travel daily 13 times by bus from Lyon to Prague in one click. Book your Lyon to Prague bus ticket starting from £45!
| Cheapest Bus | £45 |
| Fastest Bus | 14h 50m |
| Earliest Coach | 05:20 |
| Latest Coach | 22:00 |
| Daily Bus Connections | 13 Ø |
| Distance | 860.7 km |
| Coach Companies | FlixBus and BlaBlaCar Bus |
What are the cheapest coach tickets from Lyon to Prague?
Every day, 13 buses from 2 coach companies leave Lyon for Prague. Check the table below to find the cheapest prices for coach tickets for this route, starting from 18/06/2026 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from Lyon to Prague
How to save money travelling from Lyon to Prague
Book the ticket from Lyon to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Lyon to Prague, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Lyon to Prague are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
Latest reviews for coach companies on the route Lyon - Prague
All bus stations and stops in Lyon and Prague
Here is a map with all coach stations in Lyon and Prague. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
All you need to know when you travel by bus from Lyon to Prague
FAQs for Lyon to Prague bus
How much does a Lyon Prague coach trip cost?
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Which bus companies serve the Lyon Prague route?
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Available seat classes which are offered on the bus route Lyon to Prague
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Lyon and to Prague
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