What is the best way to travel from Lyon to Prague?
Looking for a trip? Check and compare all the available Buses and Flights to Prague from Lyon. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can reach Prague with just £43 by taking a Flight from Volotea, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
-
FlixBus16h 15m017:05Lyons St. Exupery AirportLyons St. Exupery Airport09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 17:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/03/2026 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 15m
-
FlixBus15h 50m017:05Lyons St. Exupery AirportLyons St. Exupery Airport08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 17:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 23/03/2026 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 50m
-
FlixBus16h 30m005:20LyonLyon Avenue Tony Garnier Coach Stop21:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 22/03/2026 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/03/2026 21:50:00. 50 Economy ticket for £65 per person are available. Travel duration is 16h 30m
-
STARSHIPPER SAS21h 55m016:40Lyons St. Exupery AirportLyons St. Exupery Airport14:35PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/03/2026 14:35:00. 50 Economy ticket for £70 per person are available. Travel duration is 21h 55m
-
EasyJet Airline10h 15m007:50Lyons St. Exupery AirportLyons St. Exupery Airport18:05Prague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 07:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 18:05:00. 50 Economy ticket for £76 per person are available. Travel duration is 10h 15m
-
Lufthansa7h 55m006:10Lyons St. Exupery AirportLyons St. Exupery Airport14:05Prague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 06:10:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 14:05:00. 50 Economy ticket for £125 per person are available. Travel duration is 7h 55m
-
Vueling Airlines18h 5m023:20Lyons St. Exupery AirportLyons St. Exupery Airport17:25Prague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 23:20:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 23/03/2026 17:25:00. 50 Economy ticket for £136 per person are available. Travel duration is 18h 5m
-
Volotea17h 0m020:55Lyons St. Exupery AirportLyons St. Exupery Airport13:55Prague AirportPrague Airport0EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 20:55:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 23/03/2026 13:55:00. 50 Economy ticket for £137 per person are available. Travel duration is 17h 0m
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 16:00:00. 50 Economy ticket for £154 per person are available. Travel duration is 3h 10m
Cheapest Buses Sunday
Cheapest Flights Sunday
-
Volotea1h 40m007:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:55Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 07:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 08:55:00. 50 Economy ticket for £43 per person are available. Travel duration is 1h 40m
-
EasyJet Airline9h 5m009:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 09:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 18:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 9h 5m
-
LC Perú6h 0m016:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:05Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 16:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 22:05:00. 50 Economy ticket for £82 per person are available. Travel duration is 6h 0m
-
Vueling Airlines24h 10m020:15Lyons St. Exupery AirportLyons St. Exupery Airport20:25Prague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 23/03/2026 20:15:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 24/03/2026 20:25:00. 50 Economy ticket for £101 per person are available. Travel duration is 24h 10m
-
LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 17:15:00. 50 Economy ticket for £107 per person are available. Travel duration is 6h 5m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/03/2026 09:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 15h 5m
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/03/2026 15:25:00. 50 Economy ticket for £50 per person are available. Travel duration is 17h 25m
-
FlixBus14h 40m018:15LyonLyon Avenue Tony Garnier Coach Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/03/2026 08:55:00. 50 Economy ticket for £50 per person are available. Travel duration is 14h 40m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 24/03/2026 16:10:00. 50 Economy ticket for £50 per person are available. Travel duration is 18h 10m
-
FlixBus19h 0m003:15LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 03:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/03/2026 22:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 0m
Cheapest Flights Monday
Cheapest Buses Monday
-
FlixBus20h 15m013:05LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 13:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/03/2026 09:20:00. 50 Economy ticket for £44 per person are available. Travel duration is 20h 15m
-
FlixBus22h 0m009:00LyonLyon Avenue Tony Garnier Coach Stop07:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 09:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/03/2026 07:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 22h 0m
-
FlixBus23h 35m013:05LyonLyon Avenue Tony Garnier Coach Stop12:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 13:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/03/2026 12:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 23h 35m
-
FlixBus22h 10m009:00LyonLyon Avenue Tony Garnier Coach Stop07:10PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 09:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/03/2026 07:10:00. 50 Economy ticket for £45 per person are available. Travel duration is 22h 10m
-
FlixBus18h 45m003:30LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/03/2026 22:15:00. 50 Economy ticket for £46 per person are available. Travel duration is 18h 45m
Cheapest Buses Tuesday
-
FlixBus25h 30m021:25LyonLyon Avenue Tony Garnier Coach Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 21:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/03/2026 22:55:00. 50 Economy ticket for £46 per person are available. Travel duration is 25h 30m
-
FlixBus24h 45m010:45LyonLyon Avenue Tony Garnier Coach Stop11:30PragueZličín0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 10:45:00 to Zličín, Prague (Czech Republic) arriving at 26/03/2026 11:30:00. 50 Economy ticket for £46 per person are available. Travel duration is 24h 45m
-
FlixBus26h 55m008:35LyonLyon Avenue Tony Garnier Coach Stop11:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 08:35:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 11:30:00. 50 Economy ticket for £52 per person are available. Travel duration is 26h 55m
-
FlixBus23h 50m010:45LyonLyon Avenue Tony Garnier Coach Stop10:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 10:45:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 10:35:00. 50 Economy ticket for £53 per person are available. Travel duration is 23h 50m
-
FlixBus24h 25m002:25LyonLyon Avenue Tony Garnier Coach Stop02:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 02:25:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 02:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 24h 25m
Cheapest Buses Wednesday
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 27/03/2026 15:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 17h 25m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 27/03/2026 16:10:00. 50 Economy ticket for £56 per person are available. Travel duration is 18h 10m
-
FlixBus19h 55m002:25LyonLyon Avenue Tony Garnier Coach Stop22:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 02:25:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/03/2026 22:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 19h 55m
-
FlixBus20h 30m002:25LyonLyon Avenue Tony Garnier Coach Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 02:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/03/2026 22:55:00. 50 Economy ticket for £62 per person are available. Travel duration is 20h 30m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 27/03/2026 09:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 15h 5m
-
EasyJet Airline1h 40m013:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:25Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 26/03/2026 13:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 26/03/2026 15:25:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 40m
-
LC Perú24h 30m021:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:00Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 26/03/2026 21:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 22:00:00. 50 Economy ticket for £67 per person are available. Travel duration is 24h 30m
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 16:00:00. 50 Economy ticket for £123 per person are available. Travel duration is 3h 10m
-
Lufthansa7h 30m014:55Lyons St. Exupery AirportLyons St. Exupery Airport22:25Prague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 14:55:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 22:25:00. 50 Economy ticket for £147 per person are available. Travel duration is 7h 30m
-
Brussels Airlines13h 55m007:00Lyons St. Exupery AirportLyons St. Exupery Airport20:55Prague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 07:00:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £147 per person are available. Travel duration is 13h 55m
Cheapest Buses Thursday
Cheapest Flights Thursday
-
BlaBlaCar Bus21h 45m012:00LyonPerrache Train Station09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 27/03/2026 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 28/03/2026 09:45:00. 50 Economy ticket for £51 per person are available. Travel duration is 21h 45m
-
FlixBus14h 40m018:15LyonLyon Avenue Tony Garnier Coach Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 28/03/2026 08:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 40m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 28/03/2026 09:20:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 5m
-
FlixBus17h 5m021:30LyonLyon Avenue Tony Garnier Coach Stop14:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 28/03/2026 14:35:00. 50 Economy ticket for £61 per person are available. Travel duration is 17h 5m
-
Volotea1h 40m007:30Lyons St. Exupery AirportLyons St. Exupery Airport09:10Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 27/03/2026 07:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 09:10:00. 50 Economy ticket for £81 per person are available. Travel duration is 1h 40m
-
EasyJet Airline1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 15:55:00. 50 Economy ticket for £98 per person are available. Travel duration is 1h 40m
-
LC Perú12h 0m010:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:05Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 10:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 22:05:00. 50 Economy ticket for £107 per person are available. Travel duration is 12h 0m
-
LOT Polish Airlines / Polskie Linie Lotnicze22h 0m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 28/03/2026 17:15:00. 50 Economy ticket for £137 per person are available. Travel duration is 22h 0m
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 27/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 27/03/2026 16:00:00. 50 Economy ticket for £139 per person are available. Travel duration is 3h 10m
Cheapest Buses Friday
Cheapest Flights Friday
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop16:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 29/03/2026 16:25:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 25m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop17:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 29/03/2026 17:10:00. 50 Economy ticket for £51 per person are available. Travel duration is 18h 10m
-
FlixBus17h 5m021:30LyonLyon Avenue Tony Garnier Coach Stop15:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 29/03/2026 15:35:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 5m
-
FlixBus17h 15m021:30LyonLyon Avenue Tony Garnier Coach Stop15:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 21:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 29/03/2026 15:45:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 15m
-
FlixBus18h 45m003:30LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 28/03/2026 22:15:00. 50 Economy ticket for £55 per person are available. Travel duration is 18h 45m
Cheapest Buses Saturday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from Volotea. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 16:00:00. 50 Economy ticket for £154 per person are available. Travel duration is 3h 10m
-
Lufthansa7h 55m006:10Lyons St. Exupery AirportLyons St. Exupery Airport14:05Prague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 06:10:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 14:05:00. 50 Economy ticket for £125 per person are available. Travel duration is 7h 55m
-
EasyJet Airline10h 15m007:50Lyons St. Exupery AirportLyons St. Exupery Airport18:05Prague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 07:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 22/03/2026 18:05:00. 50 Economy ticket for £76 per person are available. Travel duration is 10h 15m
-
Volotea17h 0m020:55Lyons St. Exupery AirportLyons St. Exupery Airport13:55Prague AirportPrague Airport0EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 20:55:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 23/03/2026 13:55:00. 50 Economy ticket for £137 per person are available. Travel duration is 17h 0m
-
Vueling Airlines18h 5m023:20Lyons St. Exupery AirportLyons St. Exupery Airport17:25Prague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 23:20:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 23/03/2026 17:25:00. 50 Economy ticket for £136 per person are available. Travel duration is 18h 5m
-
FlixBus15h 50m017:05Lyons St. Exupery AirportLyons St. Exupery Airport08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 17:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 23/03/2026 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 50m
-
FlixBus16h 15m017:05Lyons St. Exupery AirportLyons St. Exupery Airport09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 17:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/03/2026 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 16h 15m
-
FlixBus16h 30m005:20LyonLyon Avenue Tony Garnier Coach Stop21:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 22/03/2026 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/03/2026 21:50:00. 50 Economy ticket for £65 per person are available. Travel duration is 16h 30m
-
STARSHIPPER SAS21h 55m016:40Lyons St. Exupery AirportLyons St. Exupery Airport14:35PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 22/03/2026 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/03/2026 14:35:00. 50 Economy ticket for £70 per person are available. Travel duration is 21h 55m
Fastest Flights Sunday
Fastest Buses Sunday
-
Volotea1h 40m007:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:55Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 07:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 08:55:00. 50 Economy ticket for £43 per person are available. Travel duration is 1h 40m
-
LC Perú6h 0m016:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:05Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 16:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 22:05:00. 50 Economy ticket for £82 per person are available. Travel duration is 6h 0m
-
LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 17:15:00. 50 Economy ticket for £107 per person are available. Travel duration is 6h 5m
-
EasyJet Airline9h 5m009:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/03/2026 09:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/03/2026 18:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 9h 5m
-
Vueling Airlines24h 10m020:15Lyons St. Exupery AirportLyons St. Exupery Airport20:25Prague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 23/03/2026 20:15:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 24/03/2026 20:25:00. 50 Economy ticket for £101 per person are available. Travel duration is 24h 10m
-
FlixBus14h 40m018:15LyonLyon Avenue Tony Garnier Coach Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/03/2026 08:55:00. 50 Economy ticket for £50 per person are available. Travel duration is 14h 40m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/03/2026 09:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 15h 5m
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/03/2026 15:25:00. 50 Economy ticket for £50 per person are available. Travel duration is 17h 25m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 24/03/2026 16:10:00. 50 Economy ticket for £50 per person are available. Travel duration is 18h 10m
-
FlixBus19h 0m003:15LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 23/03/2026 03:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/03/2026 22:15:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 0m
Fastest Flights Monday
Fastest Buses Monday
-
FlixBus18h 45m003:30LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/03/2026 22:15:00. 50 Economy ticket for £46 per person are available. Travel duration is 18h 45m
-
FlixBus20h 15m013:05LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 13:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/03/2026 09:20:00. 50 Economy ticket for £44 per person are available. Travel duration is 20h 15m
-
FlixBus22h 0m009:00LyonLyon Avenue Tony Garnier Coach Stop07:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 09:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/03/2026 07:00:00. 50 Economy ticket for £45 per person are available. Travel duration is 22h 0m
-
FlixBus22h 10m009:00LyonLyon Avenue Tony Garnier Coach Stop07:10PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 09:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/03/2026 07:10:00. 50 Economy ticket for £45 per person are available. Travel duration is 22h 10m
-
FlixBus23h 35m013:05LyonLyon Avenue Tony Garnier Coach Stop12:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 24/03/2026 13:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/03/2026 12:40:00. 50 Economy ticket for £45 per person are available. Travel duration is 23h 35m
Fastest Buses Tuesday
-
FlixBus23h 50m010:45LyonLyon Avenue Tony Garnier Coach Stop10:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 10:45:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 10:35:00. 50 Economy ticket for £53 per person are available. Travel duration is 23h 50m
-
FlixBus24h 25m002:25LyonLyon Avenue Tony Garnier Coach Stop02:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 02:25:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 02:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 24h 25m
-
FlixBus24h 45m010:45LyonLyon Avenue Tony Garnier Coach Stop11:30PragueZličín0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 10:45:00 to Zličín, Prague (Czech Republic) arriving at 26/03/2026 11:30:00. 50 Economy ticket for £46 per person are available. Travel duration is 24h 45m
-
FlixBus25h 30m021:25LyonLyon Avenue Tony Garnier Coach Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 21:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/03/2026 22:55:00. 50 Economy ticket for £46 per person are available. Travel duration is 25h 30m
-
FlixBus26h 55m008:35LyonLyon Avenue Tony Garnier Coach Stop11:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 25/03/2026 08:35:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/03/2026 11:30:00. 50 Economy ticket for £52 per person are available. Travel duration is 26h 55m
Fastest Buses Wednesday
-
EasyJet Airline1h 40m013:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:25Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 26/03/2026 13:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 26/03/2026 15:25:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 40m
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 16:00:00. 50 Economy ticket for £123 per person are available. Travel duration is 3h 10m
-
Lufthansa7h 30m014:55Lyons St. Exupery AirportLyons St. Exupery Airport22:25Prague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 14:55:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 22:25:00. 50 Economy ticket for £147 per person are available. Travel duration is 7h 30m
-
Brussels Airlines13h 55m007:00Lyons St. Exupery AirportLyons St. Exupery Airport20:55Prague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 26/03/2026 07:00:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 26/03/2026 20:55:00. 50 Economy ticket for £147 per person are available. Travel duration is 13h 55m
-
LC Perú24h 30m021:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:00Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 26/03/2026 21:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 22:00:00. 50 Economy ticket for £67 per person are available. Travel duration is 24h 30m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 27/03/2026 09:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 15h 5m
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 27/03/2026 15:25:00. 50 Economy ticket for £56 per person are available. Travel duration is 17h 25m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 27/03/2026 16:10:00. 50 Economy ticket for £56 per person are available. Travel duration is 18h 10m
-
FlixBus19h 55m002:25LyonLyon Avenue Tony Garnier Coach Stop22:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 02:25:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/03/2026 22:20:00. 50 Economy ticket for £62 per person are available. Travel duration is 19h 55m
-
FlixBus20h 30m002:25LyonLyon Avenue Tony Garnier Coach Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 26/03/2026 02:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/03/2026 22:55:00. 50 Economy ticket for £62 per person are available. Travel duration is 20h 30m
Fastest Flights Thursday
Fastest Buses Thursday
-
Volotea1h 40m007:30Lyons St. Exupery AirportLyons St. Exupery Airport09:10Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 27/03/2026 07:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 09:10:00. 50 Economy ticket for £81 per person are available. Travel duration is 1h 40m
-
EasyJet Airline1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 15:55:00. 50 Economy ticket for £98 per person are available. Travel duration is 1h 40m
-
Austrian Airlines3h 10m012:50Lyons St. Exupery AirportLyons St. Exupery Airport16:00Prague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 27/03/2026 12:50:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 27/03/2026 16:00:00. 50 Economy ticket for £139 per person are available. Travel duration is 3h 10m
-
LC Perú12h 0m010:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:05Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 10:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 27/03/2026 22:05:00. 50 Economy ticket for £107 per person are available. Travel duration is 12h 0m
-
LOT Polish Airlines / Polskie Linie Lotnicze22h 0m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 27/03/2026 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 28/03/2026 17:15:00. 50 Economy ticket for £137 per person are available. Travel duration is 22h 0m
-
FlixBus14h 40m018:15LyonLyon Avenue Tony Garnier Coach Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 28/03/2026 08:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 40m
-
FlixBus15h 5m018:15LyonLyon Avenue Tony Garnier Coach Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 28/03/2026 09:20:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 5m
-
FlixBus17h 5m021:30LyonLyon Avenue Tony Garnier Coach Stop14:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 27/03/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 28/03/2026 14:35:00. 50 Economy ticket for £61 per person are available. Travel duration is 17h 5m
-
BlaBlaCar Bus21h 45m012:00LyonPerrache Train Station09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 27/03/2026 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 28/03/2026 09:45:00. 50 Economy ticket for £51 per person are available. Travel duration is 21h 45m
Fastest Flights Friday
Fastest Buses Friday
-
FlixBus17h 5m021:30LyonLyon Avenue Tony Garnier Coach Stop15:35PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 21:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 29/03/2026 15:35:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 5m
-
FlixBus17h 15m021:30LyonLyon Avenue Tony Garnier Coach Stop15:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 21:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 29/03/2026 15:45:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 15m
-
FlixBus17h 25m022:00LyonLyon Avenue Tony Garnier Coach Stop16:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 29/03/2026 16:25:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 25m
-
FlixBus18h 10m022:00LyonLyon Avenue Tony Garnier Coach Stop17:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 29/03/2026 17:10:00. 50 Economy ticket for £51 per person are available. Travel duration is 18h 10m
-
FlixBus18h 45m003:30LyonLyon Avenue Tony Garnier Coach Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Coach Stop, Lyon (France) at 28/03/2026 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 28/03/2026 22:15:00. 50 Economy ticket for £55 per person are available. Travel duration is 18h 45m
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Perrache Train Station or Part-Dieu Train Station, while in Prague you will be arriving at Wilsonova Coach Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 7 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as £43 with a Flight from Volotea.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, EasyJet Airline and Volotea, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, EasyJet Airline and Volotea. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, STARSHIPPER SAS and BlaBlaCar Bus
Airlines: EasyJet Airline, Volotea, Austrian Airlines and 5 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 7 connections between Flight and Bus, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 860.7 km.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just £43 by taking a Flight from Volotea.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from Volotea.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Avignon to Lyon
- Barcelona to Lyon
- Birmingham to Lyon
- Bordeaux to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Grenoble to Lyon
- Lille to Lyon
- London to Lyon
- Madrid to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nantes to Lyon
- Nice to Lyon
- Paris Orly Airport to Lyon
- Paris to Lyon
- Rome to Lyon
- Saint-Étienne to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Trips to Prague
- Berlin to Prague
- Bielsko-Biala to Prague
- Bologna to Prague
- Budapest to Prague
- Český Krumlov to Prague
- Cologne/Bonn Airport to Prague
- Dortmund to Prague
- Dresden to Prague
- Hamburg to Prague
- Humpolec to Prague
- Jihlava to Prague
- Kosice to Prague
- Leipzig to Prague
- London to Prague
- Munich to Prague
- Oldenburg to Prague
- Ostrava to Prague
- Salzburg to Prague
- St. Gallen to Prague
- Stockholm to Prague
- Venice to Prague
- Vienna to Prague
- Warsaw to Prague
- Wroclaw to Prague
