What is the best way to travel from Lyon to Prague?
Looking for a trip? Check and compare all the available Buses and Flights to Prague from Lyon. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can reach Prague with just £45 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 09:20:00. 50 Economy ticket for £58 per person are available. Travel duration is 15h 5m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 06/12/2025 08:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 14h 40m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 13:55:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 14:05:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 5m
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FlixBus16h 30m005:20LyonPerrache Bus Stop21:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 30m
Cheapest Buses Friday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 07/12/2025 08:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 09:20:00. 50 Economy ticket for £54 per person are available. Travel duration is 15h 5m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 07/12/2025 06:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 06:15:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 45m
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £56 per person are available. Travel duration is 18h 45m
Cheapest Buses Saturday
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 15:25:00. 50 Economy ticket for £54 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 08/12/2025 16:10:00. 50 Economy ticket for £54 per person are available. Travel duration is 18h 10m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 08:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 09:20:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 08/12/2025 13:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 16h 55m
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Air Bagan28h 0m014:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 14:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 18:20:00. 50 Economy ticket for £67 per person are available. Travel duration is 28h 0m
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Volotea17h 35m020:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:40Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 20:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 13:40:00. 50 Economy ticket for £85 per person are available. Travel duration is 17h 35m
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Air Nostrum12h 45m006:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:55Prague AirportPrague Airport - T1/20EconomyA Flight from Air Nostrum goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 06:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 07/12/2025 18:55:00. 50 Economy ticket for £100 per person are available. Travel duration is 12h 45m
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EasyJet Airline8h 25m012:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station21:15Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 12:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 07/12/2025 21:15:00. 50 Economy ticket for £104 per person are available. Travel duration is 8h 25m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 08:50:00. 50 Economy ticket for £146 per person are available. Travel duration is 13h 35m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus17h 35m005:20LyonPerrache Bus Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 22:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
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FlixBus19h 5m005:20LyonPerrache Bus Stop00:25PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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STARSHIPPER SAS21h 15m016:40Lyons St. Exupery AirportLyons St. Exupery Airport13:55PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 08/12/2025 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 13:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 21h 15m
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BlaBlaCar Bus21h 45m012:00LyonPerrache Bus Stop09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 09/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 45m
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EasyJet Airline7h 50m010:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:40Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 10:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 18:40:00. 50 Economy ticket for £92 per person are available. Travel duration is 7h 50m
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Air Nostrum8h 45m006:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station14:55Prague AirportPrague Airport - T1/20EconomyA Flight from Air Nostrum goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 06:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 14:55:00. 50 Economy ticket for £124 per person are available. Travel duration is 8h 45m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 17:15:00. 50 Economy ticket for £146 per person are available. Travel duration is 6h 5m
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 22:25:00. 50 Economy ticket for £153 per person are available. Travel duration is 4h 0m
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Lufthansa9h 20m013:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 13:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 22:25:00. 50 Economy ticket for £155 per person are available. Travel duration is 9h 20m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 22:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 45m
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FlixBus19h 5m005:20LyonPerrache Bus Stop00:25PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 13:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 55m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 09:20:00. 50 Economy ticket for £45 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 14:05:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 5m
Cheapest Buses Tuesday
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FlixBus20h 30m002:25LyonPerrache Bus Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 02:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 10/12/2025 22:55:00. 50 Economy ticket for £49 per person are available. Travel duration is 20h 30m
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FlixBus23h 35m007:20LyonPerrache Bus Stop06:55PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 06:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 23h 35m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 14:05:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 11/12/2025 13:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 55m
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FlixBus24h 20m007:20LyonPerrache Bus Stop07:40PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 11/12/2025 07:40:00. 50 Economy ticket for £59 per person are available. Travel duration is 24h 20m
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EasyJet Airline1h 40m013:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 13:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 15:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m013:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:20Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 13:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 15:20:00. 50 Economy ticket for £81 per person are available. Travel duration is 1h 40m
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Cityjet11h 15m020:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station07:25Prague AirportPrague Airport - T1/20EconomyA Flight from Cityjet goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 20:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2025 07:25:00. 50 Economy ticket for £94 per person are available. Travel duration is 11h 15m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2025 08:50:00. 50 Economy ticket for £146 per person are available. Travel duration is 13h 35m
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 22:25:00. 50 Economy ticket for £153 per person are available. Travel duration is 4h 0m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 5m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 12/12/2025 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 14h 40m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 14:05:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 12/12/2025 13:55:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 55m
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FlixBus15h 50m017:05Lyons St. Exupery AirportLyons St. Exupery Airport08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/12/2025 17:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 12/12/2025 08:55:00. 50 Economy ticket for £48 per person are available. Travel duration is 15h 50m
Cheapest Buses Thursday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from EasyJet Airline. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 06/12/2025 08:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 09:20:00. 50 Economy ticket for £58 per person are available. Travel duration is 15h 5m
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FlixBus16h 30m005:20LyonPerrache Bus Stop21:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 05:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 30m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 13:55:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 05/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 06/12/2025 14:05:00. 50 Economy ticket for £59 per person are available. Travel duration is 17h 5m
Fastest Buses Friday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 07/12/2025 08:55:00. 50 Economy ticket for £54 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 09:20:00. 50 Economy ticket for £54 per person are available. Travel duration is 15h 5m
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £56 per person are available. Travel duration is 18h 45m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 07/12/2025 06:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 06/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 07/12/2025 06:15:00. 50 Economy ticket for £55 per person are available. Travel duration is 20h 45m
Fastest Buses Saturday
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EasyJet Airline8h 25m012:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station21:15Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 12:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 07/12/2025 21:15:00. 50 Economy ticket for £104 per person are available. Travel duration is 8h 25m
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Air Nostrum12h 45m006:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:55Prague AirportPrague Airport - T1/20EconomyA Flight from Air Nostrum goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 06:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 07/12/2025 18:55:00. 50 Economy ticket for £100 per person are available. Travel duration is 12h 45m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 08:50:00. 50 Economy ticket for £146 per person are available. Travel duration is 13h 35m
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Volotea17h 35m020:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:40Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 20:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 13:40:00. 50 Economy ticket for £85 per person are available. Travel duration is 17h 35m
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Air Bagan28h 0m014:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 07/12/2025 14:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 18:20:00. 50 Economy ticket for £67 per person are available. Travel duration is 28h 0m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 08:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 09:20:00. 50 Economy ticket for £56 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 08/12/2025 13:55:00. 50 Economy ticket for £58 per person are available. Travel duration is 16h 55m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 08/12/2025 15:25:00. 50 Economy ticket for £54 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 07/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 08/12/2025 16:10:00. 50 Economy ticket for £54 per person are available. Travel duration is 18h 10m
Fastest Flights Sunday
Fastest Buses Sunday
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 22:25:00. 50 Economy ticket for £153 per person are available. Travel duration is 4h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 17:15:00. 50 Economy ticket for £146 per person are available. Travel duration is 6h 5m
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EasyJet Airline7h 50m010:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:40Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 10:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 18:40:00. 50 Economy ticket for £92 per person are available. Travel duration is 7h 50m
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Air Nostrum8h 45m006:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station14:55Prague AirportPrague Airport - T1/20EconomyA Flight from Air Nostrum goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 06:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 14:55:00. 50 Economy ticket for £124 per person are available. Travel duration is 8h 45m
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Lufthansa9h 20m013:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 08/12/2025 13:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 08/12/2025 22:25:00. 50 Economy ticket for £155 per person are available. Travel duration is 9h 20m
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FlixBus17h 35m005:20LyonPerrache Bus Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 08/12/2025 22:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 35m
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FlixBus19h 5m005:20LyonPerrache Bus Stop00:25PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
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STARSHIPPER SAS21h 15m016:40Lyons St. Exupery AirportLyons St. Exupery Airport13:55PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 08/12/2025 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 13:55:00. 50 Economy ticket for £56 per person are available. Travel duration is 21h 15m
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BlaBlaCar Bus21h 45m012:00LyonPerrache Bus Stop09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 08/12/2025 12:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 09/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 45m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 09:20:00. 50 Economy ticket for £45 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 13:55:00. 50 Economy ticket for £45 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 10/12/2025 14:05:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 5m
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 09/12/2025 22:15:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 45m
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FlixBus19h 5m005:20LyonPerrache Bus Stop00:25PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 09/12/2025 05:20:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 10/12/2025 00:25:00. 50 Economy ticket for £45 per person are available. Travel duration is 19h 5m
Fastest Buses Tuesday
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EasyJet Airline1h 40m013:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 13:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 15:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m013:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:20Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 13:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 15:20:00. 50 Economy ticket for £81 per person are available. Travel duration is 1h 40m
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 10/12/2025 22:25:00. 50 Economy ticket for £153 per person are available. Travel duration is 4h 0m
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Cityjet11h 15m020:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station07:25Prague AirportPrague Airport - T1/20EconomyA Flight from Cityjet goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 20:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2025 07:25:00. 50 Economy ticket for £94 per person are available. Travel duration is 11h 15m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 10/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2025 08:50:00. 50 Economy ticket for £146 per person are available. Travel duration is 13h 35m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 11/12/2025 13:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 14:05:00. 50 Economy ticket for £53 per person are available. Travel duration is 17h 5m
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FlixBus20h 30m002:25LyonPerrache Bus Stop22:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 02:25:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 10/12/2025 22:55:00. 50 Economy ticket for £49 per person are available. Travel duration is 20h 30m
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FlixBus23h 35m007:20LyonPerrache Bus Stop06:55PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2025 06:55:00. 50 Economy ticket for £53 per person are available. Travel duration is 23h 35m
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FlixBus24h 20m007:20LyonPerrache Bus Stop07:40PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 10/12/2025 07:20:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 11/12/2025 07:40:00. 50 Economy ticket for £59 per person are available. Travel duration is 24h 20m
Fastest Flights Wednesday
Fastest Buses Wednesday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 12/12/2025 08:55:00. 50 Economy ticket for £47 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 09:20:00. 50 Economy ticket for £47 per person are available. Travel duration is 15h 5m
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FlixBus15h 50m017:05Lyons St. Exupery AirportLyons St. Exupery Airport08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/12/2025 17:05:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 12/12/2025 08:55:00. 50 Economy ticket for £48 per person are available. Travel duration is 15h 50m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 12/12/2025 13:55:00. 50 Economy ticket for £48 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m021:00LyonPerrache Bus Stop14:05PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 11/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 12/12/2025 14:05:00. 50 Economy ticket for £48 per person are available. Travel duration is 17h 5m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, while in Prague you will be arriving at Wilsonova Coach Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 7 connections between 3 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as £45 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, EasyJet Airline and LOT Polish Airlines / Polskie Linie Lotnicze, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, EasyJet Airline and LOT Polish Airlines / Polskie Linie Lotnicze. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, STARSHIPPER SAS and BlaBlaCar Bus
Airlines: EasyJet Airline, LOT Polish Airlines / Polskie Linie Lotnicze, Air Nostrum and 6 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 860.7 km.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just £45 by taking a Bus from FlixBus.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from EasyJet Airline.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Avignon to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Bordeaux to Lyon
- Caen to Lyon
- Dijon to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Lisbon to Lyon
- Lloret de Mar to Lyon
- London to Lyon
- Lyons St. Exupery Airport to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nancy to Lyon
- Paris to Lyon
- Rome to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Venice to Lyon
- Trips to Prague
- Berlin to Prague
- Birmingham to Prague
- Bologna to Prague
- Braunschweig to Prague
- Chisinau to Prague
- Dresden to Prague
- Florence to Prague
- Hamburg to Prague
- Humpolec to Prague
- Jihlava to Prague
- Kosice to Prague
- Leipzig to Prague
- Linz to Prague
- London to Prague
- Louny to Prague
- Milan to Prague
- Minsk to Prague
- Munich to Prague
- Ostrava to Prague
- Pelhřimov to Prague
- Rome to Prague
- Vienna to Prague
- Vilnius to Prague
- Zurich to Prague

