What is the best way to travel from Lyon to Prague?
Looking for a trip? Check and compare all the available Buses and Flights to Prague from Lyon. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can reach Prague with just £54 by taking a Flight from Volotea, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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BlaBlaCar Bus21h 0m012:45LyonPerrache Train Station09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/12/2025 12:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 0m
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BlaBlaCar Bus21h 0m012:45LyonPerrache Bus Stop09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 12:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 0m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 20/12/2025 16:10:00. 50 Economy ticket for £106 per person are available. Travel duration is 18h 10m
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FlixBus22h 15m017:55Lyons St. Exupery AirportLyons St. Exupery Airport16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 19/12/2025 17:55:00 to Černý Most, Prague (Czech Republic) arriving at 20/12/2025 16:10:00. 50 Economy ticket for £109 per person are available. Travel duration is 22h 15m
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STARSHIPPER SAS21h 15m016:40Lyons St. Exupery AirportLyons St. Exupery Airport13:55PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 19/12/2025 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £139 per person are available. Travel duration is 21h 15m
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Volotea1h 40m016:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 16:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 18:20:00. 50 Economy ticket for £77 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 15:55:00. 50 Economy ticket for £100 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 15:55:00. 50 Economy ticket for £117 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 08:50:00. 50 Economy ticket for £184 per person are available. Travel duration is 13h 35m
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KLM - Royal Dutch Airlines5h 25m014:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:35Prague AirportPrague Airport - T1/20EconomyA Flight from KLM - Royal Dutch Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 19:35:00. 50 Economy ticket for £193 per person are available. Travel duration is 5h 25m
Cheapest Buses Friday
Cheapest Flights Friday
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RegioJet15h 55m014:35LyonPerrache Bus Stop06:30PragueÚAN Florenc0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 06:30:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 55m
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RegioJet15h 50m014:35LyonPerrache Bus Stop06:25PragueTrain station Wilsonova0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to Train station Wilsonova, Prague (Czech Republic) arriving at 21/12/2025 06:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 50m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 21/12/2025 08:55:00. 50 Economy ticket for £91 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:20:00. 50 Economy ticket for £91 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 15:25:00. 50 Economy ticket for £94 per person are available. Travel duration is 17h 25m
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Volotea1h 40m014:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:50Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 14:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 15:50:00. 50 Economy ticket for £111 per person are available. Travel duration is 1h 40m
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EasyJet Airline28h 10m014:30Lyons St. Exupery AirportLyons St. Exupery Airport18:40Prague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 20/12/2025 14:30:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 21/12/2025 18:40:00. 50 Economy ticket for £152 per person are available. Travel duration is 28h 10m
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Aer Lingus7h 5m017:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station00:15Prague AirportPrague Airport - T1/20EconomyA Flight from Aer Lingus goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 17:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 00:15:00. 50 Economy ticket for £175 per person are available. Travel duration is 7h 5m
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Air France7h 5m006:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:45Prague AirportPrague Airport - T1/20EconomyA Flight from Air France goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 13:45:00. 50 Economy ticket for £204 per person are available. Travel duration is 7h 5m
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Hop!25h 45m017:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:35Prague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 17:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 19:35:00. 50 Economy ticket for £204 per person are available. Travel duration is 25h 45m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 22/12/2025 08:55:00. 50 Economy ticket for £83 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 09:20:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 5m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 06:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 06:15:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 45m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 13:55:00. 50 Economy ticket for £96 per person are available. Travel duration is 16h 55m
Cheapest Buses Sunday
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Volotea1h 40m009:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station11:35Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 09:55:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 11:35:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m011:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 11:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 13:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 17:15:00. 50 Economy ticket for £143 per person are available. Travel duration is 6h 5m
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 22:25:00. 50 Economy ticket for £152 per person are available. Travel duration is 4h 0m
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Brussels Airlines3h 50m007:00Lyons St. Exupery AirportAéroport St Exupéry Coach Station10:50Prague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 07:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 10:50:00. 50 Economy ticket for £158 per person are available. Travel duration is 3h 50m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 06:00:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 06:15:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 45m
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FlixBus19h 0m003:15LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 03:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 22:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 19h 0m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 15:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 23/12/2025 16:10:00. 50 Economy ticket for £83 per person are available. Travel duration is 18h 10m
Cheapest Flights Monday
Cheapest Buses Monday
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Volotea1h 40m006:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:10Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 06:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/12/2025 08:10:00. 50 Economy ticket for £72 per person are available. Travel duration is 1h 40m
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EasyJet Airline18h 35m013:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:25Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 13:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 08:25:00. 50 Economy ticket for £93 per person are available. Travel duration is 18h 35m
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Wizz Air17h 50m022:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:35Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 22:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 16:35:00. 50 Economy ticket for £123 per person are available. Travel duration is 17h 50m
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Hop!12h 5m020:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:25Prague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 20:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 08:25:00. 50 Economy ticket for £138 per person are available. Travel duration is 12h 5m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/12/2025 17:15:00. 50 Economy ticket for £143 per person are available. Travel duration is 6h 5m
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FlixBus17h 45m017:05LyonPerrache Bus Stop10:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 10:50:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 45m
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 22:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/12/2025 08:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 14h 40m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 13:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 55m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/12/2025 09:20:00. 50 Economy ticket for £81 per person are available. Travel duration is 15h 5m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 25/12/2025 08:55:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 40m
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FlixBus17h 45m017:05LyonPerrache Bus Stop10:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/12/2025 10:50:00. 50 Economy ticket for £72 per person are available. Travel duration is 17h 45m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 09:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 15:25:00. 50 Economy ticket for £81 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 25/12/2025 16:10:00. 50 Economy ticket for £81 per person are available. Travel duration is 18h 10m
Cheapest Buses Wednesday
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Volotea1h 40m019:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station21:25Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 19:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 21:25:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 40m
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Air Bagan23h 30m014:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station14:00Prague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 14:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 26/12/2025 14:00:00. 50 Economy ticket for £97 per person are available. Travel duration is 23h 30m
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LC Perú7h 15m009:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:45Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 09:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 16:45:00. 50 Economy ticket for £99 per person are available. Travel duration is 7h 15m
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EasyJet Airline1h 40m018:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 18:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 19:55:00. 50 Economy ticket for £102 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 12:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 16:00:00. 50 Economy ticket for £154 per person are available. Travel duration is 3h 10m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/12/2025 08:55:00. 50 Economy ticket for £74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 09:20:00. 50 Economy ticket for £74 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 15:25:00. 50 Economy ticket for £74 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 26/12/2025 16:10:00. 50 Economy ticket for £74 per person are available. Travel duration is 18h 10m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/12/2025 13:55:00. 50 Economy ticket for £76 per person are available. Travel duration is 16h 55m
Cheapest Flights Thursday
Cheapest Buses Thursday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from Volotea. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Volotea1h 40m016:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station18:20Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 16:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 18:20:00. 50 Economy ticket for £77 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 15:55:00. 50 Economy ticket for £100 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m014:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:55Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 15:55:00. 50 Economy ticket for £117 per person are available. Travel duration is 1h 40m
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KLM - Royal Dutch Airlines5h 25m014:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:35Prague AirportPrague Airport - T1/20EconomyA Flight from KLM - Royal Dutch Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 14:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 19:35:00. 50 Economy ticket for £193 per person are available. Travel duration is 5h 25m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m019:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:50Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 19/12/2025 19:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 08:50:00. 50 Economy ticket for £184 per person are available. Travel duration is 13h 35m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 20/12/2025 16:10:00. 50 Economy ticket for £106 per person are available. Travel duration is 18h 10m
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BlaBlaCar Bus21h 0m012:45LyonPerrache Train Station09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 19/12/2025 12:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 0m
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BlaBlaCar Bus21h 0m012:45LyonPerrache Bus Stop09:45PragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 19/12/2025 12:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 09:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 0m
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STARSHIPPER SAS21h 15m016:40Lyons St. Exupery AirportLyons St. Exupery Airport13:55PragueWilsonova Coach Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 19/12/2025 16:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £139 per person are available. Travel duration is 21h 15m
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FlixBus22h 15m017:55Lyons St. Exupery AirportLyons St. Exupery Airport16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 19/12/2025 17:55:00 to Černý Most, Prague (Czech Republic) arriving at 20/12/2025 16:10:00. 50 Economy ticket for £109 per person are available. Travel duration is 22h 15m
Fastest Flights Friday
Fastest Buses Friday
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Volotea1h 40m014:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station15:50Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 14:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 15:50:00. 50 Economy ticket for £111 per person are available. Travel duration is 1h 40m
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Aer Lingus7h 5m017:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station00:15Prague AirportPrague Airport - T1/20EconomyA Flight from Aer Lingus goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 17:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 00:15:00. 50 Economy ticket for £175 per person are available. Travel duration is 7h 5m
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Air France7h 5m006:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:45Prague AirportPrague Airport - T1/20EconomyA Flight from Air France goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 13:45:00. 50 Economy ticket for £204 per person are available. Travel duration is 7h 5m
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Hop!25h 45m017:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:35Prague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 20/12/2025 17:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 19:35:00. 50 Economy ticket for £204 per person are available. Travel duration is 25h 45m
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EasyJet Airline28h 10m014:30Lyons St. Exupery AirportLyons St. Exupery Airport18:40Prague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 20/12/2025 14:30:00 to Prague Airport, Prague Airport (Czech Republic) arriving at 21/12/2025 18:40:00. 50 Economy ticket for £152 per person are available. Travel duration is 28h 10m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 21/12/2025 08:55:00. 50 Economy ticket for £91 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:20:00. 50 Economy ticket for £91 per person are available. Travel duration is 15h 5m
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RegioJet15h 50m014:35LyonPerrache Bus Stop06:25PragueTrain station Wilsonova0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to Train station Wilsonova, Prague (Czech Republic) arriving at 21/12/2025 06:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 50m
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RegioJet15h 55m014:35LyonPerrache Bus Stop06:30PragueÚAN Florenc0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 14:35:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 06:30:00. 50 Economy ticket for £79 per person are available. Travel duration is 15h 55m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 20/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 15:25:00. 50 Economy ticket for £94 per person are available. Travel duration is 17h 25m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 22/12/2025 08:55:00. 50 Economy ticket for £83 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 09:20:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 13:55:00. 50 Economy ticket for £96 per person are available. Travel duration is 16h 55m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 06:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 21/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 06:15:00. 50 Economy ticket for £95 per person are available. Travel duration is 20h 45m
Fastest Buses Sunday
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Volotea1h 40m009:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station11:35Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 09:55:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 11:35:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m011:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station13:20Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 11:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 13:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 1h 40m
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Brussels Airlines3h 50m007:00Lyons St. Exupery AirportAéroport St Exupéry Coach Station10:50Prague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 07:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 10:50:00. 50 Economy ticket for £158 per person are available. Travel duration is 3h 50m
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Lufthansa CityLine4h 0m018:25Lyons St. Exupery AirportAéroport St Exupéry Coach Station22:25Prague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 18:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 22:25:00. 50 Economy ticket for £152 per person are available. Travel duration is 4h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 22/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 17:15:00. 50 Economy ticket for £143 per person are available. Travel duration is 6h 5m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 15:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 23/12/2025 16:10:00. 50 Economy ticket for £83 per person are available. Travel duration is 18h 10m
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FlixBus19h 0m003:15LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 03:15:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 22:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 19h 0m
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FlixBus20h 30m009:30LyonPerrache Bus Stop06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 06:00:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30LyonPerrache Bus Stop06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 22/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 06:15:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 45m
Fastest Flights Monday
Fastest Buses Monday
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Volotea1h 40m006:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:10Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 06:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/12/2025 08:10:00. 50 Economy ticket for £72 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station17:15Prague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 11:10:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 23/12/2025 17:15:00. 50 Economy ticket for £143 per person are available. Travel duration is 6h 5m
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Hop!12h 5m020:20Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:25Prague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 20:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 08:25:00. 50 Economy ticket for £138 per person are available. Travel duration is 12h 5m
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Wizz Air17h 50m022:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:35Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 22:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 16:35:00. 50 Economy ticket for £123 per person are available. Travel duration is 17h 50m
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EasyJet Airline18h 35m013:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station08:25Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 23/12/2025 13:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 24/12/2025 08:25:00. 50 Economy ticket for £93 per person are available. Travel duration is 18h 35m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 24/12/2025 08:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 24/12/2025 09:20:00. 50 Economy ticket for £81 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 13:55:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 55m
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FlixBus17h 45m017:05LyonPerrache Bus Stop10:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 24/12/2025 10:50:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 45m
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FlixBus18h 45m003:30LyonPerrache Bus Stop22:15PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 23/12/2025 03:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 22:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
Fastest Flights Tuesday
Fastest Buses Tuesday
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 25/12/2025 08:55:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 09:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 25/12/2025 15:25:00. 50 Economy ticket for £81 per person are available. Travel duration is 17h 25m
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FlixBus17h 45m017:05LyonPerrache Bus Stop10:50PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 25/12/2025 10:50:00. 50 Economy ticket for £72 per person are available. Travel duration is 17h 45m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 24/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 25/12/2025 16:10:00. 50 Economy ticket for £81 per person are available. Travel duration is 18h 10m
Fastest Buses Wednesday
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Volotea1h 40m019:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station21:25Prague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 19:45:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 21:25:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m018:15Lyons St. Exupery AirportAéroport St Exupéry Coach Station19:55Prague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 18:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 19:55:00. 50 Economy ticket for £102 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 12:50:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 16:00:00. 50 Economy ticket for £154 per person are available. Travel duration is 3h 10m
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LC Perú7h 15m009:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station16:45Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 09:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 25/12/2025 16:45:00. 50 Economy ticket for £99 per person are available. Travel duration is 7h 15m
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Air Bagan23h 30m014:30Lyons St. Exupery AirportAéroport St Exupéry Coach Station14:00Prague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) at 25/12/2025 14:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 26/12/2025 14:00:00. 50 Economy ticket for £97 per person are available. Travel duration is 23h 30m
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FlixBus14h 40m018:15LyonPerrache Bus Stop08:55PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 26/12/2025 08:55:00. 50 Economy ticket for £74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m018:15LyonPerrache Bus Stop09:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 18:15:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 09:20:00. 50 Economy ticket for £74 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m021:00LyonPerrache Bus Stop13:55PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 26/12/2025 13:55:00. 50 Economy ticket for £76 per person are available. Travel duration is 16h 55m
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FlixBus17h 25m022:00LyonPerrache Bus Stop15:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 26/12/2025 15:25:00. 50 Economy ticket for £74 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m022:00LyonPerrache Bus Stop16:10PragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 25/12/2025 22:00:00 to Černý Most, Prague (Czech Republic) arriving at 26/12/2025 16:10:00. 50 Economy ticket for £74 per person are available. Travel duration is 18h 10m
Fastest Flights Thursday
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, while in Prague you will be arriving at Wilsonova Coach Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 8 connections between 3 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as £54 with a Flight from Volotea.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, Volotea and EasyJet Airline, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, Volotea and EasyJet Airline. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, BlaBlaCar Bus, RegioJet and 1 more.
Airlines: Volotea, EasyJet Airline, LOT Polish Airlines / Polskie Linie Lotnicze and 11 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 8 connections between Bus and Flight, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 860.7 km.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just £54 by taking a Flight from Volotea.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from Volotea.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Bayonne to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Braga to Lyon
- Caen to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Lille to Lyon
- Lisbon to Lyon
- London to Lyon
- Lyons St. Exupery Airport to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nancy to Lyon
- Paris to Lyon
- Rome to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Trips to Prague
- Belgrade to Prague
- Berlin to Prague
- Bologna to Prague
- Bremen to Prague
- Budapest to Prague
- Dresden to Prague
- Florence to Prague
- Hamburg to Prague
- Humpolec to Prague
- Jihlava to Prague
- Kosice to Prague
- Krakow to Prague
- Leipzig to Prague
- Limburg an der Lahn to Prague
- Linz to Prague
- Minsk to Prague
- Mladá Boleslav to Prague
- Munich to Prague
- Ostrava to Prague
- Pelhřimov to Prague
- Pilsen to Prague
- Turin to Prague
- Uherske Hradiste to Prague
- Vienna to Prague
