Which bus from La Serena to Santiago, RM is the best?
Check the bus schedule for La Serena to Santiago, RM. Here is a selection of the cheapest coach trips for the next days from bus operators like Pluss Chile, Turbus or FlixBus. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 40m | 10:21 | La Serena | Central Coach Station | 17:01 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 01/11/2026 10:21:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 01/11/2026 17:01:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 35m | 16:35 | La Serena | Avda. Fco de Aguirre Station | 23:10 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 01/11/2026 16:35:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 01/11/2026 23:10:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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| Cikbus Elité | 7h 5m | 09:55 | La Serena | Central Coach Station | 17:00 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 01/11/2026 09:55:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 01/11/2026 17:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 5m
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| Cormar Bus | 6h 30m | 22:50 | La Serena | Central Coach Station | 05:20 | Santiago, RM | Terminal San Borja | Premium Economy | £12 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 01/11/2026 22:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 02/11/2026 05:20:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 30m
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| Pullman Bus | 7h 45m | 22:15 | La Serena | El Sto, 1060 | 06:00 | Santiago, RM | Terminal San Borja | First Class | £12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 01/11/2026 22:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 02/11/2026 06:00:00. 50 First Class ticket for £12 per person are available. Travel duration is 7h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 30m | 00:05 | La Serena | Central Coach Station | 06:35 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 02/11/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 02/11/2026 06:35:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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| Turbus | 6h 20m | 04:45 | La Serena | Avda. Fco de Aguirre Station | 11:05 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 02/11/2026 04:45:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 02/11/2026 11:05:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 20m
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| Condor Bus | 6h 35m | 04:15 | La Serena | Central Coach Station | 10:50 | Santiago, RM | Sur Bus Station | Premium Economy | £10 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 02/11/2026 04:15:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 02/11/2026 10:50:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 35m
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| Cikbus Elité | 7h 5m | 09:55 | La Serena | Central Coach Station | 17:00 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 02/11/2026 09:55:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 02/11/2026 17:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 5m
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| Cormar Bus | 6h 30m | 23:30 | La Serena | Central Coach Station | 06:00 | Santiago, RM | Terminal San Borja | Premium Economy | £11 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 02/11/2026 23:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 03/11/2026 06:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 40m | 00:05 | La Serena | Central Coach Station | 06:45 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 03/11/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 03/11/2026 06:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 5m | 06:55 | La Serena | Avda. Fco de Aguirre Station | 13:00 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 03/11/2026 06:55:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 03/11/2026 13:00:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 5m
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| Condor Bus | 6h 35m | 00:45 | La Serena | Central Coach Station | 07:20 | Santiago, RM | Sur Bus Station | Premium Economy | £10 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 03/11/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 03/11/2026 07:20:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 35m
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| Cikbus Elité | 7h 5m | 09:55 | La Serena | Central Coach Station | 17:00 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 03/11/2026 09:55:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 03/11/2026 17:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 5m
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| Cormar Bus | 6h 30m | 23:30 | La Serena | Central Coach Station | 06:00 | Santiago, RM | Terminal San Borja | Premium Economy | £11 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 03/11/2026 23:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/11/2026 06:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 40m | 00:05 | La Serena | Central Coach Station | 06:45 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 04/11/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 04/11/2026 06:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 5m | 06:55 | La Serena | Avda. Fco de Aguirre Station | 13:00 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 04/11/2026 06:55:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 04/11/2026 13:00:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 5m
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| Condor Bus | 6h 50m | 03:15 | La Serena | Central Coach Station | 10:05 | Santiago, RM | Sur Bus Station | Premium Economy | £10 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 04/11/2026 03:15:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 04/11/2026 10:05:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 50m
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| Pullman Bus | 6h 0m | 01:30 | La Serena | El Sto, 1060 | 07:30 | Santiago, RM | Terminal San Borja | Premium Economy | £10 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 04/11/2026 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/11/2026 07:30:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 0m
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| FlixBus | 6h 30m | 08:00 | La Serena | Central Coach Station | 14:30 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 04/11/2026 08:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/11/2026 14:30:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 40m | 00:05 | La Serena | Central Coach Station | 06:45 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 05/11/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 05/11/2026 06:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 15m | 02:30 | La Serena | Avda. Fco de Aguirre Station | 08:45 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 05/11/2026 02:30:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 05/11/2026 08:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 15m
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| Cormar Bus | 6h 30m | 23:30 | La Serena | Central Coach Station | 06:00 | Santiago, RM | Terminal San Borja | Premium Economy | £10 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 05/11/2026 23:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/11/2026 06:00:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 30m
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| Andimar | 7h 15m | 10:10 | La Serena | Central Coach Station | 17:25 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from Andimar goes from Central Coach Station, La Serena (Chile) at 05/11/2026 10:10:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/11/2026 17:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
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| FlixBus | 6h 30m | 01:15 | La Serena | Central Coach Station | 07:45 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 05/11/2026 01:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/11/2026 07:45:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 40m | 00:05 | La Serena | Central Coach Station | 06:45 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 06/11/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/11/2026 06:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 15m | 05:35 | La Serena | Avda. Fco de Aguirre Station | 11:50 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 06/11/2026 05:35:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 06/11/2026 11:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 15m
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| FlixBus | 6h 5m | 06:00 | La Serena | Central Coach Station | 12:05 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 06/11/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/11/2026 12:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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| Andimar | 5h 40m | 13:55 | La Serena | Central Coach Station | 19:35 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from Andimar goes from Central Coach Station, La Serena (Chile) at 06/11/2026 13:55:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/11/2026 19:35:00. 50 Economy ticket for £10 per person are available. Travel duration is 5h 40m
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| Cikbus Elité | 7h 5m | 09:55 | La Serena | Central Coach Station | 17:00 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 06/11/2026 09:55:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/11/2026 17:00:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 30m | 02:30 | La Serena | Central Coach Station | 09:00 | Santiago, RM | Sur Bus Station | Premium Economy | £9 |
A Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 07/11/2026 02:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/11/2026 09:00:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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| Turbus | 7h 15m | 08:20 | La Serena | Avda. Fco de Aguirre Station | 15:35 | Santiago, RM | Terminal Alameda | Premium Economy | £9 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 07/11/2026 08:20:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 07/11/2026 15:35:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 7h 15m
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| Pullman Bus | 6h 0m | 01:30 | La Serena | El Sto, 1060 | 07:30 | Santiago, RM | Terminal San Borja | Premium Economy | £10 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 07/11/2026 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/11/2026 07:30:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 0m
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| FlixBus | 6h 30m | 08:00 | La Serena | Central Coach Station | 14:30 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 07/11/2026 08:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/11/2026 14:30:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 30m
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| Andimar | 7h 15m | 10:10 | La Serena | Central Coach Station | 17:25 | Santiago, RM | Terminal San Borja | Economy | £10 |
A Bus from Andimar goes from Central Coach Station, La Serena (Chile) at 07/11/2026 10:10:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/11/2026 17:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
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Best Price Offer: The price for the cheapest coach from La Serena to Santiago, RM is £8 on 27/10/2026. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between La Serena and Santiago, RM?
All facts for La Serena to Santiago, RM bus at a glance
Compare all coach operators like Pluss Chile, Turbus and FlixBus that travel daily 178 times by bus from La Serena to Santiago, RM in one click. Book your La Serena to Santiago, RM bus ticket starting from £8!
| Cheapest Bus | £8 |
| Fastest Bus | 5h 35m |
| Earliest Coach | 08:10 |
| Latest Coach | 23:59 |
| Daily Bus Connections | 178 Ø |
| Distance | 397.3 km |
| Coach Companies | Pluss Chile, Turbus, FlixBus, Cikbus Elité, Pullman San Andres, Andimar, Buses Romani, Cormar Bus, Pullman Bus, Condor Bus and 2 more. |
What are the cheapest coach tickets from La Serena to Santiago, RM?
Every day, 178 buses from 12 coach companies leave La Serena for Santiago, RM. Check the table below to find the cheapest prices for coach tickets for this route, starting from 01/11/2026 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from La Serena to Santiago, RM
How to save money travelling from La Serena to Santiago, RM
Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from La Serena to Santiago, RM are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
What are the most popular bus companies from La Serena to Santiago, RM?
FlixBus from La Serena to Santiago, RM
Here you will find the key facts about the FlixBus bus route La Serena to Santiago, RM:
| Cheapest Price | £10 |
| Fastest Coach | 5h 40m |
| Earliest Coach | 10:00 |
| Last Coach | 23:50 |
| Daily Connections | 23 Ø |
| Found on | 01/11/2026 |
Latest reviews for coach companies on the route La Serena - Santiago, RM
All bus stations and stops in La Serena and Santiago, RM
Here is a map with all coach stations in La Serena and Santiago, RM. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from La Serena to Santiago, RM
FAQs for La Serena to Santiago, RM bus
How much does a La Serena Santiago, RM coach trip cost?
How much could I save by comparing buses from La Serena to Santiago, RM?
How many connections are available for the La Serena Santiago, RM route on average every day?
How long does a bus to Santiago, RM from La Serena take?
What time is the first bus from La Serena to Santiago, RM?
What time is the last coach from La Serena to Santiago, RM?
Which bus companies serve the La Serena Santiago, RM route?
Is there a direct bus between La Serena and Santiago, RM?
What can I take with me on the bus to Santiago, RM from La Serena?
What equipment is available for the La Serena Santiago, RM bus route?
How does CheckMyBus find the best coach deals from La Serena to Santiago, RM?
How does CheckMyBus technology work for trips from La Serena to Santiago, RM?
Available seat classes which are offered on the bus route La Serena to Santiago, RM
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
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