Which bus from La Serena to Santiago, RM is the cheapest?

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Which bus from La Serena to Santiago, RM is the best?

Check the bus schedule for La Serena to Santiago, RM. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus, Turbus or Pullman San Andres. To see the full timetable for all coaches just use or search and compare.

today
£11
tomorrow
£8
Wednesday
£8
Thursday
£8
Friday
£8
Saturday
£8
Sunday
£10

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Condor Bus 6h 15m 16:50 La Serena Central Coach Station 23:05 Santiago, RM Sur Bus Station  Premium Economy £11
Turbus 7h 10m 11:30 La Serena Avda. Fco de Aguirre Station 18:40 Santiago, RM Terminal Alameda  Premium Economy £11
Cormar Bus 6h 20m 11:50 La Serena Central Coach Station 18:10 Santiago, RM Terminal San Borja  Premium Economy £12
Pullman Bus 7h 30m 11:00 La Serena El Sto, 1060 18:30 Santiago, RM Terminal San Borja  First Class £12
Cikbus Elité 7h 5m 09:55 La Serena Central Coach Station 17:00 Santiago, RM Sur Bus Station  Premium Economy £12
  • Did you know that if you travel from La Serena to Santiago, RM via Coquimbo, you can save more than £1? You will find the corresponding connections below.
    • Save more than 9%
      5h 50m
      La Serena
      11 km
      17:15
      Coquimbo
      Coach Station
      23:05
      Santiago, RM
      Sur Bus Station
      0 km
      Premium Economy
      £10

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Buses Romani 6h 30m 00:45 La Serena Central Coach Station 07:15 Santiago, RM Sur Bus Station  Premium Economy £8
Condor Bus 6h 15m 00:45 La Serena Central Coach Station 07:00 Santiago, RM Sur Bus Station  Premium Economy £10
Turbus 6h 15m 05:35 La Serena Avda. Fco de Aguirre Station 11:50 Santiago, RM Terminal Alameda  Premium Economy £10
Cormar Bus 6h 45m 00:30 La Serena Central Coach Station 07:15 Santiago, RM Terminal San Borja  Premium Economy £11
FlixBus 6h 30m 08:00 La Serena Central Coach Station 14:30 Santiago, RM Terminal San Borja  Economy £11

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Buses Romani 6h 30m 00:45 La Serena Central Coach Station 07:15 Santiago, RM Sur Bus Station  Premium Economy £8
Condor Bus 6h 15m 16:50 La Serena Central Coach Station 23:05 Santiago, RM Sur Bus Station  Premium Economy £10
Turbus 6h 15m 02:30 La Serena Avda. Fco de Aguirre Station 08:45 Santiago, RM Terminal Alameda  Premium Economy £10
Cormar Bus 6h 45m 00:30 La Serena Central Coach Station 07:15 Santiago, RM Terminal San Borja  Premium Economy £11
Cikbus Elité 7h 5m 09:55 La Serena Central Coach Station 17:00 Santiago, RM Sur Bus Station  Premium Economy £12

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Buses Romani 6h 30m 00:45 La Serena Central Coach Station 07:15 Santiago, RM Sur Bus Station  Premium Economy £8
Condor Bus 6h 35m 00:45 La Serena Central Coach Station 07:20 Santiago, RM Sur Bus Station  Premium Economy £10
Turbus 6h 15m 02:30 La Serena Avda. Fco de Aguirre Station 08:45 Santiago, RM Terminal Alameda  Premium Economy £10
FlixBus 6h 30m 08:00 La Serena Central Coach Station 14:30 Santiago, RM Terminal San Borja  Economy £11
Cormar Bus 6h 10m 23:50 La Serena Central Coach Station 06:00 Santiago, RM Terminal San Borja  Premium Economy £11

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Buses Romani 6h 15m 00:45 La Serena Central Coach Station 07:00 Santiago, RM Sur Bus Station  Premium Economy £8
Pullman Bus 8h 0m 13:00 La Serena El Sto, 1060 21:00 Santiago, RM Terminal San Borja  First Class £9
Turbus 6h 15m 02:30 La Serena Avda. Fco de Aguirre Station 08:45 Santiago, RM Terminal Alameda  Premium Economy £10
FlixBus 6h 30m 08:00 La Serena Central Coach Station 14:30 Santiago, RM Terminal San Borja  Business £11
Cormar Bus 6h 45m 00:30 La Serena Central Coach Station 07:15 Santiago, RM Terminal San Borja  Premium Economy £11

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Buses Romani 6h 15m 00:45 La Serena Central Coach Station 07:00 Santiago, RM Sur Bus Station  Premium Economy £8
Condor Bus 6h 15m 16:50 La Serena Central Coach Station 23:05 Santiago, RM Sur Bus Station  Premium Economy £10
Turbus 6h 15m 04:50 La Serena Avda. Fco de Aguirre Station 11:05 Santiago, RM Terminal Alameda  Premium Economy £10
FlixBus 6h 30m 08:00 La Serena Central Coach Station 14:30 Santiago, RM Terminal San Borja  Economy £11
Cormar Bus 6h 45m 00:30 La Serena Central Coach Station 07:15 Santiago, RM Terminal San Borja  Premium Economy £11

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Condor Bus 6h 50m 03:15 La Serena Central Coach Station 10:05 Santiago, RM Sur Bus Station  Premium Economy £10
Turbus 6h 15m 02:30 La Serena Avda. Fco de Aguirre Station 08:45 Santiago, RM Terminal Alameda  Premium Economy £10
Cormar Bus 6h 35m 00:15 La Serena Central Coach Station 06:50 Santiago, RM Terminal San Borja  Premium Economy £11
FlixBus 6h 5m 06:00 La Serena Central Coach Station 12:05 Santiago, RM Terminal San Borja  Economy £12
Pullman Bus 7h 45m 22:15 La Serena El Sto, 1060 06:00 Santiago, RM Terminal San Borja  First Class £13

Best Price Offer: The price for the cheapest coach from La Serena to Santiago, RM is £8 on 04/08/2026. Flexible travellers save on ticket prices.


What is the best day and time to travel by bus between La Serena and Santiago, RM?

Here is the frequency of all coach connections from La Serena to Santiago, RM. See on which day of the week you have more travel options and what time you have more bus trips to choose from.
Thursday is the busiest day, with more than 278 daily coaches from La Serena to Santiago, RM. Monday has instead the fewest connections, with only 98 daily coaches between La Serena and Santiago, RM.
The busiest time of the day is the Night, with 441 coaches from La Serena to Santiago, RM, while Evening sees the fewest connections between La Serena and Santiago, RM, with 190 offers.

All facts for La Serena to Santiago, RM bus at a glance

Compare all coach operators like FlixBus, Turbus and Pullman San Andres that travel daily 184 times by bus from La Serena to Santiago, RM in one click. Book your La Serena to Santiago, RM bus ticket starting from £8!

Cheapest Bus £8
Fastest Bus 5h 40m
Earliest Coach 05:20
Latest Coach 23:59
Daily Bus Connections 184 Ø
Distance 397.3 km
Coach Companies FlixBus, Turbus, Pullman San Andres, Cikbus Elité, Pluss Chile, Pullman Bus, Condor Bus, Buses Romani, Cormar Bus, Nueva Andimar Vip and 2 more.

What are the cheapest coach tickets from La Serena to Santiago, RM?

Every day, 184 buses from 12 coach companies leave La Serena for Santiago, RM. Check the table below to find the cheapest prices for coach tickets for this route, starting from 03/08/2026 and for the following days. Make sure get the cheapest bus ticket!

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 03/08
£12
Tuesday 04/08
£11
Wednesday 05/08
£10
Thursday 06/08
£8
Friday 07/08
£9
Saturday 08/08
£8
Sunday 09/08
£10
Monday 10/08
£11
Tuesday 11/08
£10
Wednesday 12/08
£9
Thursday 13/08
£11
Friday 14/08
£8
Saturday 15/08
£8
Sunday 16/08
£9
Monday 17/08
£8
Tuesday 18/08
£9
Wednesday 19/08
£9
Thursday 20/08
£9
Friday 21/08
£9
Saturday 22/08
£9
Sunday 23/08
£9
Monday 24/08
£9
Tuesday 25/08
£10
Wednesday 26/08
£8
Thursday 27/08
£10
Friday 28/08
£9
Saturday 29/08
£9
Sunday 30/08

The cheapest time to travel from La Serena to Santiago, RM

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Santiago, RM, for the next 30 days.
With a price starting from £8, Tuesday is the cheapest day for a coach from La Serena to Santiago, RM. Sunday instead is the most expensive day with prices starting from £9.
Morning is the cheapest day time for bus tickets from La Serena to Santiago, RM, with £8. Evening is the most expensive time of the day with prices starting from £10.

How to save money travelling from La Serena to Santiago, RM

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying higher prices for your trip? Plan your bus trips smartly. Here are a few hacks to save money on your coach journey.

Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from La Serena to Santiago, RM are also emptier.

Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.

What are the most popular bus companies from La Serena to Santiago, RM?

These are the most booked bus companies by our users on the La Serena to Santiago, RM timetable.

FlixBus from La Serena to Santiago, RM

FlixBus

Here you will find the key facts about the FlixBus bus route La Serena to Santiago, RM:

Cheapest Price £11
Fastest Coach 5h 40m
Earliest Coach 06:00
Last Coach 23:59
Daily Connections 31 Ø
Found on 03/08/2026
In total 12 operators offer buses for this route. Find all bus timetables for them. Each coach company has a dedicated cancellation policy and possibilities for transport luggage on the bus. Check also special conditions to travel with kids or coach cards with rebates.

Latest reviews for coach companies on the route La Serena - Santiago, RM

FlixBus
Risa Manabe , 17/04/2026
Por lo general viajamos con mi pareja de serena a Santiago y nos acomoda el terminal los libertadores En dos ocasiones hemos tenido problemas con el bus y al cambiarnos no nos dan ninguna solución p ... Por lo general viajamos con mi pareja de serena a Santiago y nos acomoda el terminal los libertadores En dos ocasiones hemos tenido problemas con el bus y al cambiarnos no nos dan ninguna solución para llegar al mismo terminal ya que por eso compramos hacia terminal los libertadores y me parece de muy mal gusto que nos coloquen en otro bus al terminal Borja ,el problema no es el bus ni que nos cambien de bus por emergencia ,el problema es que no se reubiquen a los pasajeros del bus al mismo destino que uno saca el pasaje En este caso el destino era los libertadores y a mí pareja le cambiaron el bus y lo dejaron el el terminal Borja ...es la segunda vez que ocurre
Pluss Chile
carolina saavedra, 14/04/2026

Pésimo servicio,.los auxiliares maleducados, sin aire, parecía un sauna, los auxiliares prepotentes, pésima atención

Cormar Bus
Ana Riveros, 17/12/2025
El bus salió 1 hora atrasado Debía llegara la 8.15 a Santiago Y llegara a las 10 y yo debía estar a las 9.30 por un tema médico. Esto significa que perdí mi hora y el viaje. Por culpa de su neglige ... El bus salió 1 hora atrasado Debía llegara la 8.15 a Santiago Y llegara a las 10 y yo debía estar a las 9.30 por un tema médico. Esto significa que perdí mi hora y el viaje. Por culpa de su negligencia. Estaba acostumbrada a la puntualidad que siempre entregaban.
Pluss Chile
Claudia , 23/10/2025

El bus venía de Calama y salió con una hora de retraso.

Pluss Chile
Luis ig, 05/10/2025
Viaje en salón cama de la serena a Santiago y el bus salió una hora más tarde adema la máquina estaba hedionda y el asiento de reclinaba solo y el posa piernas estaba vencido por lo que todo el viaje ... Viaje en salón cama de la serena a Santiago y el bus salió una hora más tarde adema la máquina estaba hedionda y el asiento de reclinaba solo y el posa piernas estaba vencido por lo que todo el viaje me estuvo golpeando las piernas, pésimo el viaje.
Pluss Chile
Esteban Guerrero, 29/01/2025

Compré un pasaje de 6 horas en salón premium adelante en el parabrisas no había nada de espacio. Ultima vez que viajo en plus chile

All bus stations and stops in La Serena and Santiago, RM

Here is a map with all coach stations in La Serena and Santiago, RM. Compare which stop is closest to your destination to save time to find the fastest buses and connections.

All you need to know when you travel by bus from La Serena to Santiago, RM

Check all information on comfort and services on the coaches from La Serena to Santiago, RM. Which seat classes are available or what are the amenities of operators on your coach trip? Below you´ll find answers to your questions.

FAQs for La Serena to Santiago, RM bus

How much does a La Serena Santiago, RM coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the La Serena Santiago, RM bus trip is available from £8 and takes 6h 30m. Compare offers and save money!

How much could I save by comparing buses from La Serena to Santiago, RM?

This connection is offered by 12 companies with ticket prices ranging from £8 to £26. Therefore, we suggest booking your ticket as soon as possible to ensure you’ll get the cheapest bus trip to Santiago, RM.

How many connections are available for the La Serena Santiago, RM route on average every day?

Each day, the bus route from La Serena to Santiago, RM is offered by roughly 184 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Santiago, RM from La Serena take?

The quickest coach from La Serena to Santiago, RM is provided by FlixBus and takes 5h 40m. Coach tickets for this connection cost £16. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from La Serena to Santiago, RM?

The earliest bus to Santiago, RM departs from La Serena at 05:20. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from La Serena to Santiago, RM?

The latest bus to Santiago, RM departs from La Serena at 23:59. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the La Serena Santiago, RM route?

Passengers looking to travel from La Serena to Santiago, RM can travel with FlixBus, Turbus and Pullman San Andres. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between La Serena and Santiago, RM?

You can check all the direct connections between La Serena and Santiago, RM by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Turbus and Pullman San Andres.

What can I take with me on the bus to Santiago, RM from La Serena?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the La Serena Santiago, RM bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Santiago, RM bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Santiago, RM on your planned travel date.

How does CheckMyBus find the best coach deals from La Serena to Santiago, RM?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 184 daily trips between La Serena and Santiago, RM. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from La Serena to Santiago, RM?

Prices and availability for 184 trips between La Serena and Santiago, RM change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route La Serena to Santiago, RM

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business
Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

First Class
First

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to La Serena and to Santiago, RM

Here’s an overview of the most popular bus routes to La Serena and to Santiago, RM. Simply click on the connection of your choice, and you’ll find all the details about your bus route!
Curicó to La Serena bus Curicó to La Serena bus
Coaches Valdivia to La Serena Coaches Valdivia to La Serena
Coaches Diego de Almagro to La Serena Coaches Diego de Almagro to La Serena
Bus Talca, ML to La Serena Bus Talca, ML to La Serena
Coach from Purén to Santiago, RM Coach from Purén to Santiago, RM
Coach Curanilahue to Santiago, RM Coach Curanilahue to Santiago, RM
Buses Matanzas to Santiago, RM Buses Matanzas to Santiago, RM
Coach to Santiago, RM from Quillota Coach to Santiago, RM from Quillota
Popular Airport Transfers to La Serena and to Santiago, RM
CheckMyBus › Coaches in Chile › Coach to La Serena › Coach to Santiago, RM

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