Which bus from La Serena to Santiago, RM is the best?
Check the bus schedule for La Serena to Santiago, RM. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus, Pullman Bus or Cikbus Elité. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £10 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 05/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 16:30:00. 50 Business ticket for £10 per person are available. Travel duration is 7h 0m
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| Serena Mar | 6h 0m | 10:00 | La Serena | Central Coach Station | 16:00 | Santiago, RM | Terminal San Borja | First Class | £10 |
A Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 05/12/2025 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 16:00:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 0m
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| FlixBus | 6h 5m | 06:00 | La Serena | Central Coach Station | 12:05 | Santiago, RM | Terminal San Borja | Premium Economy | £11 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 05/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 12:05:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 5m
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| Pullman Bus | 6h 30m | 05:30 | La Serena | El Sto, 1060 | 12:00 | Santiago, RM | Terminal San Borja | First Class | £12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 05/12/2025 05:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 12:00:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 40m | 00:15 | La Serena | Central Coach Station | 06:55 | Santiago, RM | Terminal San Borja | Premium Economy | £12 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 05/12/2025 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 06:55:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 40m
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Save more than 1%5h 30mLa Serena11 km10:30CoquimboCoach Station16:00Santiago, RMTerminal San Borja0 kmFirst ClassA Bus from goes from Coach Station, Coquimbo (Chile) at 05/12/2025 10:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/12/2025 16:00:00. 50 First Class ticket for £10 per person are available. Travel duration is 5h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 00:45 | La Serena | Central Coach Station | 07:00 | Santiago, RM | Sur Bus Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 06/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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| FlixBus | 6h 5m | 11:00 | La Serena | Central Coach Station | 17:05 | Santiago, RM | Terminal San Borja | Economy | £9 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 06/12/2025 11:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/12/2025 17:05:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 5m
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| Cormar Bus | 6h 10m | 13:20 | La Serena | Central Coach Station | 19:30 | Santiago, RM | Terminal San Borja | First Class | £11 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 06/12/2025 13:20:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/12/2025 19:30:00. 50 First Class ticket for £11 per person are available. Travel duration is 6h 10m
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| Condor Bus | 6h 15m | 16:50 | La Serena | Central Coach Station | 23:05 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 06/12/2025 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/12/2025 23:05:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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| Turbus | 6h 25m | 12:00 | La Serena | Avda. Fco de Aguirre Station | 18:25 | Santiago, RM | Terminal Alameda | Premium Economy | £12 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 06/12/2025 12:00:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 06/12/2025 18:25:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 25m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 0m | 09:00 | La Serena | Central Coach Station | 15:00 | Santiago, RM | Terminal San Borja | Business | £8 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 07/12/2025 09:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/12/2025 15:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 0m
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| FlixBus | 6h 5m | 15:30 | La Serena | Central Coach Station | 21:35 | Santiago, RM | Terminal San Borja | Economy | £9 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 07/12/2025 15:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/12/2025 21:35:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 5m
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| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £10 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 07/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/12/2025 16:30:00. 50 Business ticket for £10 per person are available. Travel duration is 7h 0m
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| Serena Mar | 6h 0m | 10:00 | La Serena | Central Coach Station | 16:00 | Santiago, RM | Terminal San Borja | First Class | £10 |
A Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 07/12/2025 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/12/2025 16:00:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 0m
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| Condor Bus | 6h 35m | 01:45 | La Serena | Central Coach Station | 08:20 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 07/12/2025 01:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/12/2025 08:20:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 35m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 00:45 | La Serena | Central Coach Station | 07:00 | Santiago, RM | Sur Bus Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 08/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 08/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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| Turbus | 6h 15m | 02:30 | La Serena | Avda. Fco de Aguirre Station | 08:45 | Santiago, RM | Terminal Alameda | Premium Economy | £8 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 08/12/2025 02:30:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 08/12/2025 08:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 15m
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| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £10 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 08/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/12/2025 16:30:00. 50 Business ticket for £10 per person are available. Travel duration is 7h 0m
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| Serena Mar | 6h 0m | 10:00 | La Serena | Central Coach Station | 16:00 | Santiago, RM | Terminal San Borja | First Class | £10 |
A Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 08/12/2025 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/12/2025 16:00:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 0m
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| Cormar Bus | 6h 10m | 13:20 | La Serena | Central Coach Station | 19:30 | Santiago, RM | Terminal San Borja | First Class | £12 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 08/12/2025 13:20:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/12/2025 19:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 0m | 09:00 | La Serena | Central Coach Station | 15:00 | Santiago, RM | Sur Bus Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 09/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 09/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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| Cormar Bus | 6h 10m | 23:50 | La Serena | Central Coach Station | 06:00 | Santiago, RM | Terminal San Borja | Premium Economy | £8 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 09/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/12/2025 06:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 10m
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| Turbus | 6h 5m | 06:55 | La Serena | Avda. Fco de Aguirre Station | 13:00 | Santiago, RM | Terminal Alameda | Premium Economy | £8 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 09/12/2025 06:55:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 09/12/2025 13:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 5m
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| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £10 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 09/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/12/2025 16:30:00. 50 Business ticket for £10 per person are available. Travel duration is 7h 0m
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| Condor Bus | 6h 15m | 16:50 | La Serena | Central Coach Station | 23:05 | Santiago, RM | Sur Bus Station | Premium Economy | £11 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 09/12/2025 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 09/12/2025 23:05:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 00:45 | La Serena | Central Coach Station | 07:00 | Santiago, RM | Sur Bus Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 10/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £7 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 10/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/12/2025 16:30:00. 50 Business ticket for £7 per person are available. Travel duration is 7h 0m
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| Condor Bus | 6h 50m | 03:15 | La Serena | Central Coach Station | 10:05 | Santiago, RM | Sur Bus Station | Premium Economy | £8 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 10/12/2025 03:15:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/12/2025 10:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 50m
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| Cormar Bus | 6h 20m | 11:50 | La Serena | Central Coach Station | 18:10 | Santiago, RM | Terminal San Borja | Premium Economy | £8 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 10/12/2025 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/12/2025 18:10:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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| FlixBus | 6h 5m | 06:00 | La Serena | Central Coach Station | 12:05 | Santiago, RM | Terminal San Borja | Economy | £8 |
A Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 10/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/12/2025 12:05:00. 50 Economy ticket for £8 per person are available. Travel duration is 6h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 00:45 | La Serena | Central Coach Station | 07:00 | Santiago, RM | Sur Bus Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 11/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 11/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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| Cikbus Elité | 7h 0m | 09:30 | La Serena | Central Coach Station | 16:30 | Santiago, RM | Terminal San Borja | Business | £7 |
A Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 11/12/2025 09:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 11/12/2025 16:30:00. 50 Business ticket for £7 per person are available. Travel duration is 7h 0m
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| Condor Bus | 7h 10m | 21:45 | La Serena | Central Coach Station | 04:55 | Santiago, RM | Sur Bus Station | Premium Economy | £8 |
A Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 11/12/2025 21:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 12/12/2025 04:55:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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| Turbus | 6h 40m | 21:20 | La Serena | Avda. Fco de Aguirre Station | 04:00 | Santiago, RM | Terminal Alameda | Premium Economy | £8 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 11/12/2025 21:20:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 12/12/2025 04:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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| Cormar Bus | 6h 10m | 23:50 | La Serena | Central Coach Station | 06:00 | Santiago, RM | Terminal San Borja | Premium Economy | £8 |
A Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 11/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 12/12/2025 06:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 10m
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Best Price Offer: The price for the cheapest coach from La Serena to Santiago, RM is £6 on 25/12/2025. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between La Serena and Santiago, RM?
All facts for La Serena to Santiago, RM bus at a glance
Compare all coach operators like FlixBus, Pullman Bus and Cikbus Elité that travel daily 272 times by bus from La Serena to Santiago, RM in one click. Book your La Serena to Santiago, RM bus ticket starting from £6!
| Cheapest Bus | £6 |
| Fastest Bus | 5h 40m |
| Earliest Coach | 00:05 |
| Latest Coach | 23:59 |
| Daily Bus Connections | 272 Ø |
| Distance | 397.3 km |
| Coach Companies | FlixBus, Pullman Bus, Cikbus Elité, Turbus, Pullman San Andres, Pluss Chile, Buses Romani, Condor Bus, Cormar Bus, Nueva Andimar Vip and 2 more. |
What are the cheapest coach tickets from La Serena to Santiago, RM?
Every day, 272 buses from 12 coach companies leave La Serena for Santiago, RM. Check the table below to find the cheapest prices for coach tickets for this route, starting from 05/12/2025 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from La Serena to Santiago, RM
How to save money travelling from La Serena to Santiago, RM
Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from La Serena to Santiago, RM are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
What are the most popular bus companies from La Serena to Santiago, RM?
Pluss Chile from La Serena to Santiago, RM
Here you will find the key facts about the Pluss Chile bus route La Serena to Santiago, RM:
| Cheapest Price | £13 |
| Fastest Coach | 6h 30m |
| Earliest Coach | 00:05 |
| Last Coach | 22:20 |
| Daily Connections | 32 Ø |
| Found on | 04/12/2025 |
Cormar Bus from La Serena to Santiago, RM
Here you will find the key facts about the Cormar Bus bus route La Serena to Santiago, RM:
| Cheapest Price | £8 |
| Fastest Coach | 5h 40m |
| Earliest Coach | 00:15 |
| Last Coach | 23:50 |
| Daily Connections | 13 Ø |
| Found on | 04/12/2025 |
Serena Mar from La Serena to Santiago, RM
Here you will find the key facts about the Serena Mar bus route La Serena to Santiago, RM:
| Cheapest Price | £10 |
| Fastest Coach | 6h 0m |
| Earliest Coach | 00:45 |
| Last Coach | 10:00 |
| Daily Connections | 3 Ø |
| Found on | 05/12/2025 |
Latest reviews for coach companies on the route La Serena - Santiago, RM
All bus stations and stops in La Serena and Santiago, RM
Here is a map with all coach stations in La Serena and Santiago, RM. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from La Serena to Santiago, RM
FAQs for La Serena to Santiago, RM bus
How much does a La Serena Santiago, RM coach trip cost?
How much could I save by comparing buses from La Serena to Santiago, RM?
How many connections are available for the La Serena Santiago, RM route on average every day?
How long does a bus to Santiago, RM from La Serena take?
What time is the first bus from La Serena to Santiago, RM?
What time is the last coach from La Serena to Santiago, RM?
Which bus companies serve the La Serena Santiago, RM route?
Is there a direct bus between La Serena and Santiago, RM?
What can I take with me on the bus to Santiago, RM from La Serena?
What equipment is available for the La Serena Santiago, RM bus route?
Available seat classes which are offered on the bus route La Serena to Santiago, RM
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Comfortable seating, food and drink service, accompanied generally by ticket flexibility.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
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