What is the best way to travel from La Serena to Santiago, RM?
Looking for a trip? Check and compare all the available Flights and Buses to Santiago, RM from La Serena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 15 available companies to find your perfect trip!
What is the cheapest way to reach Santiago, RM from La Serena?
You can reach Santiago, RM with just £9 by taking a Bus from Pullman Bus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Pullman Bus6h 30m016:00La SerenaEl Sto, 106022:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 04/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 22:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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Pullman San Andres6h 10m023:20La SerenaCentral Coach Station05:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman San Andres goes from Central Coach Station, La Serena (Chile) at 04/02/2026 23:20:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 05:30:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 10m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 04/02/2026 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 06:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 10m
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FlixBus6h 50m016:00La SerenaCentral Coach Station22:50Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 04/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 22:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 50m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 04/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
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JetSmart0h 59m010:52La Florida, La Serena AirportLa Florida, La Serena Airport11:51Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 10:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:51:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:33La Florida, La Serena AirportLa Florida, La Serena Airport12:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:33:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 12:37:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 56m011:03La Florida, La Serena AirportLa Florida, La Serena Airport11:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:59:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m011:03La Florida, La Serena AirportLa Florida, La Serena Airport11:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:59:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m014:18La Florida, La Serena AirportLa Florida, La Serena Airport15:14Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 14:18:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 15:14:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 56m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Pullman Bus6h 30m002:30La SerenaEl Sto, 106009:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 05/02/2026 02:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 09:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 05/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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FlixBus6h 50m016:00La SerenaCentral Coach Station22:50Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 05/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 22:50:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 50m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 05/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 05/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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Sky Airline1h 4m013:22La Florida, La Serena AirportLa Florida, La Serena Airport14:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 13:22:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 14:26:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 56m011:19La Florida, La Serena AirportLa Florida, La Serena Airport12:15Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 11:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 12:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m011:19La Florida, La Serena AirportLa Florida, La Serena Airport12:15Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 11:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 12:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m018:59La Florida, La Serena AirportLa Florida, La Serena Airport19:58Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 18:59:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 19:58:00. 50 Economy ticket for £69 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 54m015:39La Florida, La Serena AirportLa Florida, La Serena Airport16:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 15:39:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 16:33:00. 50 Economy ticket for £72 per person are available. Travel duration is 0h 54m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Pullman Bus6h 30m014:30La SerenaEl Sto, 106021:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 06/02/2026 14:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 21:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 06/02/2026 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/02/2026 15:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 06/02/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 08:20:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 30m
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FlixBus6h 5m007:15La SerenaCentral Coach Station13:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 06/02/2026 07:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 13:20:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 6h 5m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 06/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
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Sky Airline1h 4m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:45Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 10:45:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 56m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 13:23:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 13:23:00. 50 Economy ticket for £36 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m010:53La Florida, La Serena AirportLa Florida, La Serena Airport11:52Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 10:53:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 11:52:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 54m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:19Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 23:19:00. 50 Economy ticket for £40 per person are available. Travel duration is 0h 54m
Cheapest Buses Friday
Cheapest Flights Friday
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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FlixBus6h 30m017:15La SerenaCentral Coach Station23:45Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 07/02/2026 17:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/02/2026 23:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 30m
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Buses Romani6h 15m000:30La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 06:45:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 15m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 07/02/2026 16:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 23:10:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 40m
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 06:35:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 30m
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JetSmart0h 59m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 13:26:00. 50 Economy ticket for £48 per person are available. Travel duration is 0h 59m
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LATAM Brasil0h 55m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 11:42:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 11:42:00. 50 Economy ticket for £56 per person are available. Travel duration is 0h 55m
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Sky Airline1h 4m011:01La Florida, La Serena AirportLa Florida, La Serena Airport12:05Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 11:01:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 12:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 1h 4m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 08/02/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 18:10:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 20m
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Pullman Bus7h 10m008:15La SerenaEl Sto, 106015:25Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 08/02/2026 08:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 15:25:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 10m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 08/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 12:05:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 5m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 08/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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Pluss Chile6h 30m002:16La SerenaCentral Coach Station08:46Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 08/02/2026 02:16:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 08/02/2026 08:46:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 30m
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Sky Airline1h 4m013:53La Florida, La Serena AirportLa Florida, La Serena Airport14:57Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 13:53:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 14:57:00. 50 Economy ticket for £41 per person are available. Travel duration is 1h 4m
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LAN Perú0h 55m009:50La Florida, La Serena AirportLa Florida, La Serena Airport10:45Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 09:50:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 10:45:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 56m013:54La Florida, La Serena AirportLa Florida, La Serena Airport14:50Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 13:54:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 14:50:00. 50 Economy ticket for £62 per person are available. Travel duration is 0h 56m
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LATAM Brasil0h 56m012:28La Florida, La Serena AirportLa Florida, La Serena Airport13:24Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 12:28:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 13:24:00. 50 Economy ticket for £65 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m011:14La Florida, La Serena AirportLa Florida, La Serena Airport12:13Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 11:14:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 12:13:00. 50 Economy ticket for £69 per person are available. Travel duration is 0h 59m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Turbus6h 25m021:20La SerenaAvda. Fco de Aguirre Station03:45Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 09/02/2026 21:20:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 10/02/2026 03:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 25m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 09/02/2026 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 09/02/2026 15:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 09/02/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 18:10:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 20m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 09/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 12:05:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 5m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 09/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 56m012:52La Florida, La Serena AirportLa Florida, La Serena Airport13:48Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:48:00. 50 Economy ticket for £74 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:52La Florida, La Serena AirportLa Florida, La Serena Airport13:48Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:48:00. 50 Economy ticket for £77 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:26:00. 50 Economy ticket for £79 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 56m013:34La Florida, La Serena AirportLa Florida, La Serena Airport14:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 13:34:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 14:30:00. 50 Economy ticket for £87 per person are available. Travel duration is 0h 56m
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Sky Airline5h 16m018:00La Florida, La Serena AirportLa Florida, La Serena Airport23:16Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 18:00:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 23:16:00. 50 Economy ticket for £219 per person are available. Travel duration is 5h 16m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 10/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/02/2026 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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Buses Romani6h 15m000:30La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 06:45:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 15m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 10/02/2026 16:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 23:10:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 40m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 06:45:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 40m
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Sky Airline1h 4m020:34La Florida, La Serena AirportLa Florida, La Serena Airport21:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 20:34:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 21:38:00. 50 Economy ticket for £41 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m017:29La Florida, La Serena AirportLa Florida, La Serena Airport18:28Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:28:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 54m017:47La Florida, La Serena AirportLa Florida, La Serena Airport18:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:41:00. 50 Economy ticket for £45 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 54m017:47La Florida, La Serena AirportLa Florida, La Serena Airport18:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:41:00. 50 Economy ticket for £47 per person are available. Travel duration is 0h 54m
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LAN Perú0h 56m014:15La Florida, La Serena AirportLa Florida, La Serena Airport15:11Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 14:15:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 15:11:00. 50 Economy ticket for £48 per person are available. Travel duration is 0h 56m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
What are the fastest trips from La Serena to Santiago, RM?
You can get to Santiago, RM from La Serena in just 0h 54m with a Flight from LAN Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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LATAM Brasil0h 56m011:03La Florida, La Serena AirportLa Florida, La Serena Airport11:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:59:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m011:03La Florida, La Serena AirportLa Florida, La Serena Airport11:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:59:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m014:18La Florida, La Serena AirportLa Florida, La Serena Airport15:14Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 14:18:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 15:14:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m010:52La Florida, La Serena AirportLa Florida, La Serena Airport11:51Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 10:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 11:51:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:33La Florida, La Serena AirportLa Florida, La Serena Airport12:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 04/02/2026 11:33:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 04/02/2026 12:37:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 4m
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Pullman San Andres6h 10m023:20La SerenaCentral Coach Station05:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman San Andres goes from Central Coach Station, La Serena (Chile) at 04/02/2026 23:20:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 05:30:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 10m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 04/02/2026 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 06:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 30m016:00La SerenaEl Sto, 106022:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 04/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 22:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 04/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
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FlixBus6h 50m016:00La SerenaCentral Coach Station22:50Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 04/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 04/02/2026 22:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 50m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Airlines0h 54m015:39La Florida, La Serena AirportLa Florida, La Serena Airport16:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 15:39:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 16:33:00. 50 Economy ticket for £72 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 56m011:19La Florida, La Serena AirportLa Florida, La Serena Airport12:15Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 11:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 12:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m011:19La Florida, La Serena AirportLa Florida, La Serena Airport12:15Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 11:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 12:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m018:59La Florida, La Serena AirportLa Florida, La Serena Airport19:58Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 18:59:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 19:58:00. 50 Economy ticket for £69 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m013:22La Florida, La Serena AirportLa Florida, La Serena Airport14:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 05/02/2026 13:22:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 05/02/2026 14:26:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 4m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 05/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 30m002:30La SerenaEl Sto, 106009:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 05/02/2026 02:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 09:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 05/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 05/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
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FlixBus6h 50m016:00La SerenaCentral Coach Station22:50Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 05/02/2026 16:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 05/02/2026 22:50:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 50m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Airlines0h 54m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:19Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 23:19:00. 50 Economy ticket for £40 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 56m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 13:23:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 13:23:00. 50 Economy ticket for £36 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m010:53La Florida, La Serena AirportLa Florida, La Serena Airport11:52Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 10:53:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 11:52:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:45Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 06/02/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 06/02/2026 10:45:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 06/02/2026 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 06/02/2026 15:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m007:15La SerenaCentral Coach Station13:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 06/02/2026 07:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 13:20:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 6h 5m
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Pullman Bus6h 30m014:30La SerenaEl Sto, 106021:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 06/02/2026 14:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 21:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 06/02/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 08:20:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 06/02/2026 16:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 06/02/2026 23:10:00. 50 Economy ticket for £15 per person are available. Travel duration is 6h 40m
Fastest Flights Friday
Fastest Buses Friday
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LATAM Brasil0h 55m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 11:42:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 11:42:00. 50 Economy ticket for £56 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 13:26:00. 50 Economy ticket for £48 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:01La Florida, La Serena AirportLa Florida, La Serena Airport12:05Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 07/02/2026 11:01:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 07/02/2026 12:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 1h 4m
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Buses Romani6h 15m000:30La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 06:45:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 15m
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FlixBus6h 30m017:15La SerenaCentral Coach Station23:45Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 07/02/2026 17:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/02/2026 23:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 06:35:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 07/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 07/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 07/02/2026 16:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 07/02/2026 23:10:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 40m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Perú0h 55m009:50La Florida, La Serena AirportLa Florida, La Serena Airport10:45Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 09:50:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 10:45:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 56m013:54La Florida, La Serena AirportLa Florida, La Serena Airport14:50Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 13:54:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 14:50:00. 50 Economy ticket for £62 per person are available. Travel duration is 0h 56m
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LATAM Brasil0h 56m012:28La Florida, La Serena AirportLa Florida, La Serena Airport13:24Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 12:28:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 13:24:00. 50 Economy ticket for £65 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m011:14La Florida, La Serena AirportLa Florida, La Serena Airport12:13Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 11:14:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 12:13:00. 50 Economy ticket for £69 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m013:53La Florida, La Serena AirportLa Florida, La Serena Airport14:57Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 08/02/2026 13:53:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 08/02/2026 14:57:00. 50 Economy ticket for £41 per person are available. Travel duration is 1h 4m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 08/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 08/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 12:05:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 08/02/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 18:10:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 30m002:16La SerenaCentral Coach Station08:46Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 08/02/2026 02:16:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 08/02/2026 08:46:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 30m
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Pullman Bus7h 10m008:15La SerenaEl Sto, 106015:25Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 08/02/2026 08:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 08/02/2026 15:25:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 10m
Fastest Flights Sunday
Fastest Buses Sunday
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LATAM Brasil0h 56m012:52La Florida, La Serena AirportLa Florida, La Serena Airport13:48Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:48:00. 50 Economy ticket for £74 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:52La Florida, La Serena AirportLa Florida, La Serena Airport13:48Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:48:00. 50 Economy ticket for £77 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m013:34La Florida, La Serena AirportLa Florida, La Serena Airport14:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 13:34:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 14:30:00. 50 Economy ticket for £87 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m012:27La Florida, La Serena AirportLa Florida, La Serena Airport13:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 12:27:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 13:26:00. 50 Economy ticket for £79 per person are available. Travel duration is 0h 59m
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Sky Airline5h 16m018:00La Florida, La Serena AirportLa Florida, La Serena Airport23:16Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 09/02/2026 18:00:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 09/02/2026 23:16:00. 50 Economy ticket for £219 per person are available. Travel duration is 5h 16m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 09/02/2026 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 09/02/2026 15:00:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 09/02/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 16:00:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 09/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 12:05:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 09/02/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 09/02/2026 18:10:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 20m
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Turbus6h 25m021:20La SerenaAvda. Fco de Aguirre Station03:45Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 09/02/2026 21:20:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 10/02/2026 03:45:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 25m
Fastest Flights Monday
Fastest Buses Monday
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LAN Airlines0h 54m017:47La Florida, La Serena AirportLa Florida, La Serena Airport18:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:41:00. 50 Economy ticket for £45 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 54m017:47La Florida, La Serena AirportLa Florida, La Serena Airport18:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:41:00. 50 Economy ticket for £47 per person are available. Travel duration is 0h 54m
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LAN Perú0h 56m014:15La Florida, La Serena AirportLa Florida, La Serena Airport15:11Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 14:15:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 15:11:00. 50 Economy ticket for £48 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m017:29La Florida, La Serena AirportLa Florida, La Serena Airport18:28Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 17:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 18:28:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m020:34La Florida, La Serena AirportLa Florida, La Serena Airport21:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 10/02/2026 20:34:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 10/02/2026 21:38:00. 50 Economy ticket for £41 per person are available. Travel duration is 1h 4m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 10/02/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/02/2026 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m000:30La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 06:45:00. 50 First Class ticket for £15 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 10/02/2026 06:50:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 35m
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Buses Paravias6h 40m016:30La SerenaCentral Coach Station23:10Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Paravias goes from Central Coach Station, La Serena (Chile) at 10/02/2026 16:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 23:10:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 40m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 10/02/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 10/02/2026 06:45:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 40m
Fastest Flights Tuesday
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from La Serena to Santiago, RM
What are the most popular stations in La Serena and Santiago, RM?
In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Coach Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 15 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as £9 with a Bus from Pullman Bus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Airlines: you will get to Santiago, RM in just 0h 54m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are JetSmart, Cormar Bus and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from La Serena to Santiago, RM?
The most popular companies between La Serena and Santiago, RM, are JetSmart, Cormar Bus and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Cormar Bus, FlixBus, Buses Paravias and 6 more.
Airlines: JetSmart, Sky Airline, LATAM Brasil and 2 more.
All you need to know when you travel from La Serena to Santiago, RM
Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from La Serena to Santiago, RM
How can I reach Santiago, RM from La Serena?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to Santiago, RM from La Serena.
How far is Santiago, RM from La Serena?
The distance between La Serena and Santiago, RM is 397.3 km.
What is the most ecofriendly mode of transport between La Serena and Santiago, RM?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from La Serena to Santiago, RM?
You can get to Santiago, RM with just £9 by taking a Bus from Pullman Bus.
What is the fastest way to get from La Serena to Santiago, RM?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 54m with a Flight from LAN Airlines.
More routes to La Serena and to Santiago, RM
Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!
- Trips to La Serena
- Antofagasta to La Serena
- Arica, AP to La Serena
- Calama to La Serena
- Concepción to La Serena
- Iquique to La Serena
- Mendoza to La Serena
- San Juan, SJ to La Serena
- Santiago, RM to La Serena
- Trips to Santiago, RM
- Alto Hospicio to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Bariloche to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Iquique to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Pitrufquén to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM
