How to get from La Serena to Santiago, RM

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What is the best way to travel from La Serena to Santiago, RM?

Looking for a trip? Check and compare all the available Buses and Flights to Santiago, RM from La Serena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 14 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
5h 40m
£7
£11
277
Flight
0h 57m
£23
£44
44

What is the cheapest way to reach Santiago, RM from La Serena?

You can reach Santiago, RM with just £7 by taking a Bus from Buses Romani, but there are many more cheap offers: we have selected the best ones for you for the next few days here.

Sunday
from £13
Monday
from £7
Tuesday
from £8
Wednesday
from £8
Thursday
from £10
Friday
from £7
Saturday
from £8

    Cheapest Buses Sunday

  • Nueva Andimar Vip
    5h 40m
    0
    13:55
    La Serena
    Central Coach Station
    19:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • FlixBus
    6h 50m
    0
    14:00
    La Serena
    Central Coach Station
    20:50
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £13
  • Buses Romani
    7h 0m
    0
    13:00
    La Serena
    Central Coach Station
    20:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    £13
  • Turbus
    6h 55m
    0
    12:00
    La Serena
    Avda. Fco de Aguirre Station
    18:55
    Santiago, RM
    Terminal San Borja
    0
    Turbus
    Premium Economy
    £13
  • Cikbus Elité
    7h 5m
    0
    12:45
    La Serena
    Central Coach Station
    19:50
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £14
  • Cheapest Flights Sunday

  • LATAM Brasil
    0h 58m
    0
    12:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £32
  • LAN Perú
    0h 58m
    0
    12:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £34
  • LAN Airlines
    0h 58m
    0
    13:51
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:49
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £34
  • Sky Airline
    1h 4m
    0
    17:51
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    18:55
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £36
  • JetSmart
    19h 5m
    0
    21:21
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    16:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £143

    Cheapest Buses Monday

  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £7
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Cormar Bus
    6h 20m
    0
    11:50
    La Serena
    Central Coach Station
    18:10
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • Cheapest Flights Monday

  • LATAM Brasil
    0h 57m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £35
  • LAN Perú
    0h 57m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £36
  • JetSmart
    0h 59m
    0
    09:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £39
  • LAN Airlines
    0h 58m
    0
    13:29
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:27
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £56
  • Sky Airline
    21h 17m
    0
    12:29
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    09:46
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £230

    Cheapest Buses Tuesday

  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Nueva Andimar Vip
    5h 40m
    0
    15:55
    La Serena
    Central Coach Station
    21:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • Cikbus Elité
    6h 30m
    0
    02:00
    La Serena
    Central Coach Station
    08:30
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £14
  • Cheapest Flights Tuesday

  • LATAM Brasil
    0h 58m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £36
  • JetSmart
    0h 59m
    0
    15:25
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    16:24
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £36
  • LAN Perú
    0h 58m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £36
  • Sky Airline
    1h 4m
    0
    10:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:42
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £39
  • LAN Airlines
    0h 58m
    0
    13:45
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:43
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £103

    Cheapest Buses Wednesday

  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Central Coach Station
    07:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • Pullman Bus
    6h 30m
    0
    01:30
    La Serena
    El Sto, 1060
    08:00
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £9
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £12
  • Cormar Bus
    6h 10m
    0
    23:50
    La Serena
    Central Coach Station
    06:00
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12
  • Nueva Andimar Vip
    5h 40m
    0
    15:55
    La Serena
    Central Coach Station
    21:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • Cheapest Flights Wednesday

  • Sky Airline
    1h 4m
    0
    21:15
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:19
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £23
  • LATAM Brasil
    0h 57m
    0
    19:09
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    20:06
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 57m
    0
    19:09
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    20:06
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £25
  • LAN Airlines
    0h 57m
    0
    14:56
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    15:53
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £48
  • JetSmart
    15h 55m
    0
    21:03
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:58
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £76

    Cheapest Buses Thursday

  • Pullman Bus
    6h 30m
    0
    01:30
    La Serena
    Central Coach Station
    08:00
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    Business
    £10
  • FlixBus
    6h 5m
    0
    15:15
    La Serena
    Central Coach Station
    21:20
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Cormar Bus
    6h 10m
    0
    23:50
    La Serena
    Central Coach Station
    06:00
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12
  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • Nueva Andimar Vip
    7h 15m
    0
    10:20
    La Serena
    Central Coach Station
    17:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • Cheapest Flights Thursday

  • LATAM Brasil
    0h 58m
    0
    09:41
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 58m
    0
    09:41
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £24
  • Sky Airline
    1h 4m
    0
    11:58
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:02
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £25
  • LAN Airlines
    0h 57m
    0
    14:49
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    15:46
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £25
  • JetSmart
    0h 59m
    0
    13:05
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:04
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £27

    Cheapest Buses Friday

  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £7
  • Condor Bus
    6h 15m
    0
    16:50
    La Serena
    Central Coach Station
    23:05
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    £8
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • Cheapest Flights Friday

  • LATAM Brasil
    0h 57m
    0
    21:26
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:23
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 57m
    0
    21:26
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:23
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £24
  • LAN Airlines
    0h 57m
    0
    22:25
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    23:22
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £24
  • Sky Airline
    1h 4m
    0
    09:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:42
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £25
  • JetSmart
    0h 59m
    0
    13:08
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:07
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £25

    Cheapest Buses Saturday

  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Central Coach Station
    07:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • Cikbus Elité
    7h 0m
    0
    09:30
    La Serena
    Central Coach Station
    16:30
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    £10
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £10
  • Cormar Bus
    6h 10m
    0
    13:20
    La Serena
    Central Coach Station
    19:30
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Business
    £12
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Cheapest Flights Saturday

  • Sky Airline
    1h 4m
    0
    11:06
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:10
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £23
  • LAN Perú
    0h 58m
    0
    09:36
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:34
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £25
  • JetSmart
    0h 59m
    0
    11:31
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:30
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £25
  • LAN Perú
    0h 57m
    0
    16:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    17:25
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £69

What are the fastest trips from La Serena to Santiago, RM?

You can get to Santiago, RM from La Serena in just 0h 57m with a Flight from LATAM Brasil. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.

Sunday
from 0h 58m
Monday
from 0h 57m
Tuesday
from 0h 58m
Wednesday
from 0h 57m
Thursday
from 0h 57m
Friday
from 0h 57m
Saturday
from 0h 57m

    Fastest Flights Sunday

  • LATAM Brasil
    0h 58m
    0
    12:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £32
  • LAN Perú
    0h 58m
    0
    12:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £34
  • LAN Airlines
    0h 58m
    0
    13:51
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:49
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £34
  • Sky Airline
    1h 4m
    0
    17:51
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    18:55
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £36
  • JetSmart
    19h 5m
    0
    21:21
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    16:26
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £143
  • Fastest Buses Sunday

  • Nueva Andimar Vip
    5h 40m
    0
    13:55
    La Serena
    Central Coach Station
    19:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • FlixBus
    6h 50m
    0
    14:00
    La Serena
    Central Coach Station
    20:50
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £13
  • Turbus
    6h 55m
    0
    12:00
    La Serena
    Avda. Fco de Aguirre Station
    18:55
    Santiago, RM
    Terminal San Borja
    0
    Turbus
    Premium Economy
    £13
  • Buses Romani
    7h 0m
    0
    13:00
    La Serena
    Central Coach Station
    20:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    £13
  • Cikbus Elité
    7h 5m
    0
    12:45
    La Serena
    Central Coach Station
    19:50
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £14

    Fastest Flights Monday

  • LATAM Brasil
    0h 57m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £35
  • LAN Perú
    0h 57m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £36
  • LAN Airlines
    0h 58m
    0
    13:29
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:27
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £56
  • JetSmart
    0h 59m
    0
    09:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £39
  • Sky Airline
    21h 17m
    0
    12:29
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    09:46
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £230
  • Fastest Buses Monday

  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £7
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Cormar Bus
    6h 20m
    0
    11:50
    La Serena
    Central Coach Station
    18:10
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12

    Fastest Flights Tuesday

  • LATAM Brasil
    0h 58m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £36
  • LAN Perú
    0h 58m
    0
    09:40
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £36
  • LAN Airlines
    0h 58m
    0
    13:45
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:43
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £103
  • JetSmart
    0h 59m
    0
    15:25
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    16:24
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £36
  • Sky Airline
    1h 4m
    0
    10:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:42
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £39
  • Fastest Buses Tuesday

  • Nueva Andimar Vip
    5h 40m
    0
    15:55
    La Serena
    Central Coach Station
    21:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Cikbus Elité
    6h 30m
    0
    02:00
    La Serena
    Central Coach Station
    08:30
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £14

    Fastest Flights Wednesday

  • LATAM Brasil
    0h 57m
    0
    19:09
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    20:06
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 57m
    0
    19:09
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    20:06
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £25
  • LAN Airlines
    0h 57m
    0
    14:56
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    15:53
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £48
  • Sky Airline
    1h 4m
    0
    21:15
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:19
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £23
  • JetSmart
    15h 55m
    0
    21:03
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:58
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £76
  • Fastest Buses Wednesday

  • Nueva Andimar Vip
    5h 40m
    0
    15:55
    La Serena
    Central Coach Station
    21:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £12
  • Cormar Bus
    6h 10m
    0
    23:50
    La Serena
    Central Coach Station
    06:00
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Central Coach Station
    07:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • Pullman Bus
    6h 30m
    0
    01:30
    La Serena
    El Sto, 1060
    08:00
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £9

    Fastest Flights Thursday

  • LAN Airlines
    0h 57m
    0
    14:49
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    15:46
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £25
  • LATAM Brasil
    0h 58m
    0
    09:41
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 58m
    0
    09:41
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £24
  • JetSmart
    0h 59m
    0
    13:05
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:04
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £27
  • Sky Airline
    1h 4m
    0
    11:58
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    13:02
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £25
  • Fastest Buses Thursday

  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • FlixBus
    6h 5m
    0
    15:15
    La Serena
    Central Coach Station
    21:20
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Cormar Bus
    6h 10m
    0
    23:50
    La Serena
    Central Coach Station
    06:00
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    £12
  • Pullman Bus
    6h 30m
    0
    01:30
    La Serena
    Central Coach Station
    08:00
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    Business
    £10
  • Nueva Andimar Vip
    7h 15m
    0
    10:20
    La Serena
    Central Coach Station
    17:35
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    £13

    Fastest Flights Friday

  • LATAM Brasil
    0h 57m
    0
    21:26
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:23
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from £24
  • LAN Perú
    0h 57m
    0
    21:26
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    22:23
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £24
  • LAN Airlines
    0h 57m
    0
    22:25
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    23:22
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from £24
  • JetSmart
    0h 59m
    0
    13:08
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    14:07
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £25
  • Sky Airline
    1h 4m
    0
    09:38
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:42
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £25
  • Fastest Buses Friday

  • Buses Romani
    6h 0m
    0
    09:00
    La Serena
    Central Coach Station
    15:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £7
  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • Serena Mar
    6h 0m
    0
    10:00
    La Serena
    Central Coach Station
    16:00
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    £13
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £11
  • Condor Bus
    6h 15m
    0
    16:50
    La Serena
    Central Coach Station
    23:05
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    £8

    Fastest Flights Saturday

  • LAN Perú
    0h 57m
    0
    16:28
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    17:25
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £69
  • LAN Perú
    0h 58m
    0
    09:36
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:34
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from £25
  • JetSmart
    0h 59m
    0
    11:31
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:30
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from £25
  • Sky Airline
    1h 4m
    0
    11:06
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:10
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from £23
  • Fastest Buses Saturday

  • Pullman Bus
    6h 0m
    0
    08:30
    La Serena
    El Sto, 1060
    14:30
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    £12
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Central Coach Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £10
  • Cormar Bus
    6h 10m
    0
    13:20
    La Serena
    Central Coach Station
    19:30
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Business
    £12
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Central Coach Station
    07:00
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    £8
  • Cikbus Elité
    7h 0m
    0
    09:30
    La Serena
    Central Coach Station
    16:30
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    £10
Here you will find all operators and timetables for a Bus from La Serena to Santiago, RM

What are the most popular stations in La Serena and Santiago, RM?

In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Coach Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 9 connections between 14 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as £7 with a Bus from Buses Romani.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LATAM Brasil: you will get to Santiago, RM in just 0h 57m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LAN Perú, FlixBus and Sky Airline, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from La Serena to Santiago, RM?

The most popular companies between La Serena and Santiago, RM, are LAN Perú, FlixBus and Sky Airline. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: FlixBus, Buses Romani, Pullman Bus and 6 more.

Airlines: LAN Perú, Sky Airline, JetSmart and 2 more.

All you need to know when you travel from La Serena to Santiago, RM

Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from La Serena to Santiago, RM

How can I reach Santiago, RM from La Serena?

Every day, there are on average 9 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.

How far is Santiago, RM from La Serena?

The distance between La Serena and Santiago, RM is 397.3 km.

What is the most ecofriendly mode of transport between La Serena and Santiago, RM?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.

What is the cheapest mode of transport from La Serena to Santiago, RM?

You can get to Santiago, RM with just £7 by taking a Bus from Buses Romani.

What is the fastest way to get from La Serena to Santiago, RM?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 57m with a Flight from LATAM Brasil.

More routes to La Serena and to Santiago, RM

Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!

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