What is the best way to travel from La Serena to Santiago, RM?
Looking for a trip? Check and compare all the available Flights and Buses to Santiago, RM from La Serena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 14 available companies to find your perfect trip!
What is the cheapest way to reach Santiago, RM from La Serena?
You can reach Santiago, RM with just £7 by taking a Bus from Buses Romani, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Pluss Chile7h 15m009:50La SerenaCentral Coach Station17:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 22/03/2026 09:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/03/2026 17:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 15m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 22/03/2026 09:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 15:00:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 0m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 22/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 16:20:00. 50 Business ticket for £11 per person are available. Travel duration is 6h 20m
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Cikbus Elité7h 5m014:55La SerenaCentral Coach Station22:00Santiago, RMTerminal San Borja0BusinessA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 22/03/2026 14:55:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 22:00:00. 50 Business ticket for £11 per person are available. Travel duration is 7h 5m
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Cormar Bus6h 30m014:15La SerenaCentral Coach Station20:45Santiago, RMTerminal San Borja0BusinessA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 22/03/2026 14:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 20:45:00. 50 Business ticket for £11 per person are available. Travel duration is 6h 30m
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LAN Perú0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 10:35:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 55m
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Sky Airline1h 4m020:48La Florida, La Serena AirportLa Florida, La Serena Airport21:52Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 20:48:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 21:52:00. 50 Economy ticket for £39 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 10:35:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m014:35La Florida, La Serena AirportLa Florida, La Serena Airport15:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 14:35:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 15:30:00. 50 Economy ticket for £45 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m015:37La Florida, La Serena AirportLa Florida, La Serena Airport16:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 15:37:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 16:36:00. 50 Economy ticket for £47 per person are available. Travel duration is 0h 59m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 06:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 23/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/03/2026 16:20:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Condor Bus6h 15m016:50La SerenaCentral Coach Station23:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 23/03/2026 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 23:05:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 15m
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Sky Airline1h 4m012:21La Florida, La Serena AirportLa Florida, La Serena Airport13:25Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 12:21:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 13:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 1h 4m
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LAN Perú0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 10:35:00. 50 Economy ticket for £54 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 10:35:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m013:04La Florida, La Serena AirportLa Florida, La Serena Airport13:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 13:04:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 13:59:00. 50 Economy ticket for £58 per person are available. Travel duration is 0h 55m
Cheapest Buses Monday
Cheapest Flights Monday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Condor Bus6h 30m003:15La SerenaCentral Coach Station09:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 24/03/2026 03:15:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 09:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Turbus6h 30m003:15La SerenaAvda. Fco de Aguirre Station09:45Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 24/03/2026 03:15:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 24/03/2026 09:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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Sky Airline1h 4m010:28La Florida, La Serena AirportLa Florida, La Serena Airport11:32Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 10:28:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 11:32:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m009:47La Florida, La Serena AirportLa Florida, La Serena Airport10:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 09:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 10:46:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 59m
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LAN Perú0h 55m009:45La Florida, La Serena AirportLa Florida, La Serena Airport10:40Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 09:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 10:40:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m013:38La Florida, La Serena AirportLa Florida, La Serena Airport14:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 13:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 14:33:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m013:38La Florida, La Serena AirportLa Florida, La Serena Airport14:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 13:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 14:33:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 25/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 25/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 25/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 25/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
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FlixBus6h 5m015:15La SerenaCentral Coach Station21:20Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 25/03/2026 15:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 21:20:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Sky Airline1h 4m010:25La Florida, La Serena AirportLa Florida, La Serena Airport11:29Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 10:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 11:29:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 4m
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LAN Perú0h 55m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 10:36:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 10:36:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m012:48La Florida, La Serena AirportLa Florida, La Serena Airport13:47Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 12:48:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 13:47:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 55m015:49La Florida, La Serena AirportLa Florida, La Serena Airport16:44Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 15:49:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 16:44:00. 50 Economy ticket for £44 per person are available. Travel duration is 0h 55m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 26/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 26/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 26/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 26/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 16:20:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 26/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
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Sky Airline1h 4m013:52La Florida, La Serena AirportLa Florida, La Serena Airport14:56Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 13:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 14:56:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m019:38La Florida, La Serena AirportLa Florida, La Serena Airport20:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 19:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 20:37:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 55m015:09La Florida, La Serena AirportLa Florida, La Serena Airport16:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 15:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 16:04:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m015:09La Florida, La Serena AirportLa Florida, La Serena Airport16:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 15:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 16:04:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 55m
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LAN Perú0h 56m020:45La Florida, La Serena AirportLa Florida, La Serena Airport21:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 20:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 21:41:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 56m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 27/03/2026 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Turbus6h 5m006:55La SerenaAvda. Fco de Aguirre Station13:00Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 27/03/2026 06:55:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 27/03/2026 13:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 27/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 27/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 19:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 7h 15m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 27/03/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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JetSmart0h 59m016:31La Florida, La Serena AirportLa Florida, La Serena Airport17:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 16:31:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 17:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 56m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:21Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 23:21:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m021:30La Florida, La Serena AirportLa Florida, La Serena Airport22:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 21:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 22:26:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 56m
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LATAM Brasil0h 56m021:30La Florida, La Serena AirportLa Florida, La Serena Airport22:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 21:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 22:26:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 56m
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Sky Airline1h 4m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:44Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 10:44:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 4m
Cheapest Buses Friday
Cheapest Flights Friday
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 28/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 28/03/2026 06:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 28/03/2026 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Turbus6h 35m016:35La SerenaAvda. Fco de Aguirre Station23:10Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 28/03/2026 16:35:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 28/03/2026 23:10:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 35m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 28/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 28/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
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Sky Airline1h 4m009:30La Florida, La Serena AirportLa Florida, La Serena Airport10:34Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 09:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 10:34:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m012:41La Florida, La Serena AirportLa Florida, La Serena Airport13:40Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 12:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 13:40:00. 50 Economy ticket for £29 per person are available. Travel duration is 0h 59m
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LAN Perú0h 55m009:42La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 09:42:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 10:37:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m012:17La Florida, La Serena AirportLa Florida, La Serena Airport13:12Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 12:17:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 13:12:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 55m
Cheapest Buses Saturday
Cheapest Flights Saturday
What are the fastest trips from La Serena to Santiago, RM?
You can get to Santiago, RM from La Serena in just 0h 55m with a Flight from LAN Perú. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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LAN Perú0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 10:35:00. 50 Economy ticket for £38 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 10:35:00. 50 Economy ticket for £43 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m014:35La Florida, La Serena AirportLa Florida, La Serena Airport15:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 14:35:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 15:30:00. 50 Economy ticket for £45 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m015:37La Florida, La Serena AirportLa Florida, La Serena Airport16:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 15:37:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 16:36:00. 50 Economy ticket for £47 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m020:48La Florida, La Serena AirportLa Florida, La Serena Airport21:52Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/03/2026 20:48:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/03/2026 21:52:00. 50 Economy ticket for £39 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 22/03/2026 09:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 15:00:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 0m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 22/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 16:20:00. 50 Business ticket for £11 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 30m014:15La SerenaCentral Coach Station20:45Santiago, RMTerminal San Borja0BusinessA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 22/03/2026 14:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 20:45:00. 50 Business ticket for £11 per person are available. Travel duration is 6h 30m
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Cikbus Elité7h 5m014:55La SerenaCentral Coach Station22:00Santiago, RMTerminal San Borja0BusinessA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 22/03/2026 14:55:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/03/2026 22:00:00. 50 Business ticket for £11 per person are available. Travel duration is 7h 5m
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Pluss Chile7h 15m009:50La SerenaCentral Coach Station17:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 22/03/2026 09:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/03/2026 17:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 15m
Fastest Flights Sunday
Fastest Buses Sunday
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LAN Perú0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 10:35:00. 50 Economy ticket for £54 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:35Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 10:35:00. 50 Economy ticket for £55 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m013:04La Florida, La Serena AirportLa Florida, La Serena Airport13:59Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 13:04:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 13:59:00. 50 Economy ticket for £58 per person are available. Travel duration is 0h 55m
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Sky Airline1h 4m012:21La Florida, La Serena AirportLa Florida, La Serena Airport13:25Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/03/2026 12:21:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/03/2026 13:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 1h 4m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Condor Bus6h 15m016:50La SerenaCentral Coach Station23:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 23/03/2026 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 23:05:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 15m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 23/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/03/2026 16:20:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/03/2026 06:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 23/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
Fastest Flights Monday
Fastest Buses Monday
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LAN Perú0h 55m009:45La Florida, La Serena AirportLa Florida, La Serena Airport10:40Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 09:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 10:40:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m013:38La Florida, La Serena AirportLa Florida, La Serena Airport14:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 13:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 14:33:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m013:38La Florida, La Serena AirportLa Florida, La Serena Airport14:33Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 13:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 14:33:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m009:47La Florida, La Serena AirportLa Florida, La Serena Airport10:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 09:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 10:46:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m010:28La Florida, La Serena AirportLa Florida, La Serena Airport11:32Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/03/2026 10:28:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/03/2026 11:32:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 4m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Condor Bus6h 30m003:15La SerenaCentral Coach Station09:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 24/03/2026 03:15:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 09:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Turbus6h 30m003:15La SerenaAvda. Fco de Aguirre Station09:45Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 24/03/2026 03:15:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 24/03/2026 09:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 24/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
Fastest Flights Tuesday
Fastest Buses Tuesday
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LAN Perú0h 55m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 10:36:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:36Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 10:36:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m015:49La Florida, La Serena AirportLa Florida, La Serena Airport16:44Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 15:49:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 16:44:00. 50 Economy ticket for £44 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m012:48La Florida, La Serena AirportLa Florida, La Serena Airport13:47Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 12:48:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 13:47:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m010:25La Florida, La Serena AirportLa Florida, La Serena Airport11:29Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/03/2026 10:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/03/2026 11:29:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 4m
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FlixBus6h 5m015:15La SerenaCentral Coach Station21:20Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 25/03/2026 15:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 21:20:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 25/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 25/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 25/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 25/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Airlines0h 55m015:09La Florida, La Serena AirportLa Florida, La Serena Airport16:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 15:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 16:04:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 55m015:09La Florida, La Serena AirportLa Florida, La Serena Airport16:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 15:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 16:04:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 55m
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LAN Perú0h 56m020:45La Florida, La Serena AirportLa Florida, La Serena Airport21:41Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 20:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 21:41:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m019:38La Florida, La Serena AirportLa Florida, La Serena Airport20:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 19:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 20:37:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m013:52La Florida, La Serena AirportLa Florida, La Serena Airport14:56Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/03/2026 13:52:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/03/2026 14:56:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 4m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 26/03/2026 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/03/2026 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Serena Mar6h 20m010:00La SerenaCentral Coach Station16:20Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 26/03/2026 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 16:20:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 26/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 40m000:05La SerenaCentral Coach Station06:45Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 26/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/03/2026 06:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 26/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Airlines0h 56m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:21Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 23:21:00. 50 Economy ticket for £31 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m021:30La Florida, La Serena AirportLa Florida, La Serena Airport22:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 21:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 22:26:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 56m
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LATAM Brasil0h 56m021:30La Florida, La Serena AirportLa Florida, La Serena Airport22:26Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 21:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 22:26:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m016:31La Florida, La Serena AirportLa Florida, La Serena Airport17:30Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 16:31:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 17:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:44Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 27/03/2026 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 27/03/2026 10:44:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 4m
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Turbus6h 5m006:55La SerenaAvda. Fco de Aguirre Station13:00Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 27/03/2026 06:55:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 27/03/2026 13:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 5m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 27/03/2026 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 27/03/2026 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 35m000:15La SerenaCentral Coach Station06:50Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 27/03/2026 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 06:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 35m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 27/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 27/03/2026 19:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 7h 15m
Fastest Flights Friday
Fastest Buses Friday
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LAN Perú0h 55m009:42La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 09:42:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 10:37:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m012:17La Florida, La Serena AirportLa Florida, La Serena Airport13:12Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 12:17:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 13:12:00. 50 Economy ticket for £30 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m012:41La Florida, La Serena AirportLa Florida, La Serena Airport13:40Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 12:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 13:40:00. 50 Economy ticket for £29 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m009:30La Florida, La Serena AirportLa Florida, La Serena Airport10:34Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 28/03/2026 09:30:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 28/03/2026 10:34:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 4m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 28/03/2026 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 30m000:05La SerenaCentral Coach Station06:35Santiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Coach Station, La Serena (Chile) at 28/03/2026 00:05:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 28/03/2026 06:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 30m001:50La SerenaCentral Coach Station08:20Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 28/03/2026 01:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 08:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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Turbus6h 35m016:35La SerenaAvda. Fco de Aguirre Station23:10Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 28/03/2026 16:35:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 28/03/2026 23:10:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 35m
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Nueva Andimar Vip7h 15m011:50La SerenaCentral Coach Station19:05Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 28/03/2026 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 28/03/2026 19:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 7h 15m
Fastest Flights Saturday
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Here you will find all operators and timetables for a
Bus from La Serena to Santiago, RM
What are the most popular stations in La Serena and Santiago, RM?
In La Serena, you will usually depart from Central Coach Station, El Sto, 1060 or Avda. Fco de Aguirre Station, while in Santiago, RM you will be arriving at Terminal San Borja, Sur Bus Station or Terminal Alameda, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 14 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as £7 with a Bus from Buses Romani.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to Santiago, RM in just 0h 55m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LAN Perú, Sky Airline and Buses Romani, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from La Serena to Santiago, RM?
The most popular companies between La Serena and Santiago, RM, are LAN Perú, Sky Airline and Buses Romani. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Buses Romani, Cormar Bus, Pluss Chile and 6 more.
Airlines: LAN Perú, Sky Airline, JetSmart and 2 more.
All you need to know when you travel from La Serena to Santiago, RM
Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from La Serena to Santiago, RM
How can I reach Santiago, RM from La Serena?
Every day, there are on average 10 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.
How far is Santiago, RM from La Serena?
The distance between La Serena and Santiago, RM is 397.3 km.
What is the most ecofriendly mode of transport between La Serena and Santiago, RM?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from La Serena to Santiago, RM?
You can get to Santiago, RM with just £7 by taking a Bus from Buses Romani.
What is the fastest way to get from La Serena to Santiago, RM?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 55m with a Flight from LAN Perú.
More routes to La Serena and to Santiago, RM
Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!
- Trips to La Serena
- Antofagasta to La Serena
- Arica, AP to La Serena
- Calama to La Serena
- Concepción to La Serena
- Iquique to La Serena
- Mendoza to La Serena
- San Juan, SJ to La Serena
- Santiago, RM to La Serena
- Trips to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Castro to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Iquique to Santiago, RM
- Los Ángeles, BI to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- São Paulo to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Viña del Mar to Santiago, RM
