What is the best way to travel from La Serena to Santiago, RM?
Looking for a trip? Check and compare all the available Buses and Flights to Santiago, RM from La Serena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 14 available companies to find your perfect trip!
What is the cheapest way to reach Santiago, RM from La Serena?
You can reach Santiago, RM with just £7 by taking a Bus from Buses Romani, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus5h 40m011:00La SerenaCentral Coach Station16:40Santiago, RMLos Libertadores Bus Stop0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 20/12/2025 11:00:00 to Los Libertadores Bus Stop, Santiago, RM (Chile) arriving at 20/12/2025 16:40:00. 50 Economy ticket for £11 per person are available. Travel duration is 5h 40m
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Pullman Bus7h 30m011:00La SerenaEl Sto, 106018:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 20/12/2025 11:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 20/12/2025 18:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 7h 30m
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Nueva Andimar Vip5h 40m013:55La SerenaCentral Coach Station19:35Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 20/12/2025 13:55:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 20/12/2025 19:35:00. 50 Economy ticket for £13 per person are available. Travel duration is 5h 40m
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Buses Romani6h 0m010:30La SerenaCentral Coach Station16:30Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 20/12/2025 10:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 20/12/2025 16:30:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 0m
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Condor Bus7h 10m021:45La SerenaCentral Coach Station04:55Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 20/12/2025 21:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 21/12/2025 04:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 7h 10m
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JetSmart0h 59m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 11:46:00. 50 Economy ticket for £39 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:06La Florida, La Serena AirportLa Florida, La Serena Airport12:10Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 11:06:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 12:10:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 57m016:19La Florida, La Serena AirportLa Florida, La Serena Airport17:16Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 16:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 17:16:00. 50 Economy ticket for £60 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 58m012:20La Florida, La Serena AirportLa Florida, La Serena Airport13:18Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 12:20:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 13:18:00. 50 Economy ticket for £82 per person are available. Travel duration is 0h 58m
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LAN Perú0h 57m019:45La Florida, La Serena AirportLa Florida, La Serena Airport20:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 19:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 20:42:00. 50 Economy ticket for £82 per person are available. Travel duration is 0h 57m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 21/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 21/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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Turbus6h 15m001:45La SerenaAvda. Fco de Aguirre Station08:00Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 21/12/2025 01:45:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 21/12/2025 08:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 21/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 21/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 21/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 21/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 21/12/2025 12:05:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 5m
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JetSmart0h 59m010:39La Florida, La Serena AirportLa Florida, La Serena Airport11:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 10:39:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 11:38:00. 50 Economy ticket for £28 per person are available. Travel duration is 0h 59m
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LAN Perú0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 10:38:00. 50 Economy ticket for £29 per person are available. Travel duration is 0h 58m
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LATAM Brasil0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 58m013:51La Florida, La Serena AirportLa Florida, La Serena Airport14:49Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 13:51:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 14:49:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 58m
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Sky Airline1h 4m017:51La Florida, La Serena AirportLa Florida, La Serena Airport18:55Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 17:51:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 18:55:00. 50 Economy ticket for £36 per person are available. Travel duration is 1h 4m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 22/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 22/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 22/12/2025 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 18:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 20m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 22/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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Cikbus Elité6h 0m000:30La SerenaCentral Coach Station06:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 22/12/2025 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/12/2025 06:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 58m013:29La Florida, La Serena AirportLa Florida, La Serena Airport14:27Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 13:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 14:27:00. 50 Economy ticket for £28 per person are available. Travel duration is 0h 58m
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LAN Perú0h 57m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 10:37:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 57m
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JetSmart0h 59m009:38La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 09:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 10:37:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 58m013:29La Florida, La Serena AirportLa Florida, La Serena Airport14:27Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 13:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 14:27:00. 50 Economy ticket for £44 per person are available. Travel duration is 0h 58m
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Sky Airline21h 17m012:29La Florida, La Serena AirportLa Florida, La Serena Airport09:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 12:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 09:46:00. 50 Economy ticket for £205 per person are available. Travel duration is 21h 17m
Cheapest Buses Monday
Cheapest Flights Monday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 23/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 23/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/12/2025 12:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 23/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 23/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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Cikbus Elité6h 30m002:00La SerenaCentral Coach Station08:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 23/12/2025 02:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/12/2025 08:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 30m
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Sky Airline1h 4m010:38La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 10:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 11:42:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m015:25La Florida, La Serena AirportLa Florida, La Serena Airport16:24Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 15:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 16:24:00. 50 Economy ticket for £36 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 58m013:45La Florida, La Serena AirportLa Florida, La Serena Airport14:43Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 13:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 14:43:00. 50 Economy ticket for £61 per person are available. Travel duration is 0h 58m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 24/12/2025 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Pullman Bus6h 30m001:30La SerenaEl Sto, 106008:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 24/12/2025 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 08:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 24/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 30m009:10La SerenaCentral Coach Station15:40Santiago, RMTerminal San Borja0First ClassA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 24/12/2025 09:10:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 15:40:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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Cikbus Elité6h 45m004:45La SerenaCentral Coach Station11:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 24/12/2025 04:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/12/2025 11:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 45m
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Sky Airline1h 4m021:15La Florida, La Serena AirportLa Florida, La Serena Airport22:19Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 21:15:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 22:19:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 57m019:09La Florida, La Serena AirportLa Florida, La Serena Airport20:06Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 19:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 20:06:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m019:09La Florida, La Serena AirportLa Florida, La Serena Airport20:06Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 19:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 20:06:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m014:56La Florida, La Serena AirportLa Florida, La Serena Airport15:53Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 14:56:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 15:53:00. 50 Economy ticket for £42 per person are available. Travel duration is 0h 57m
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JetSmart15h 55m021:03La Florida, La Serena AirportLa Florida, La Serena Airport12:58Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 21:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 12:58:00. 50 Economy ticket for £75 per person are available. Travel duration is 15h 55m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Pullman Bus6h 30m001:30La SerenaCentral Coach Station08:00Santiago, RMTerminal San Borja0BusinessA Bus from Pullman Bus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 08:00:00. 50 Business ticket for £10 per person are available. Travel duration is 6h 30m
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FlixBus6h 5m007:15La SerenaCentral Coach Station13:20Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 07:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 13:20:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Cikbus Elité7h 20m001:10La SerenaCentral Coach Station08:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 25/12/2025 01:10:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/12/2025 08:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 7h 20m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 25/12/2025 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 16:00:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 58m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:39Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 10:39:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:39Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 10:39:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 57m014:49La Florida, La Serena AirportLa Florida, La Serena Airport15:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 14:49:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 15:46:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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Sky Airline1h 4m011:58La Florida, La Serena AirportLa Florida, La Serena Airport13:02Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 11:58:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 13:02:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m013:05La Florida, La Serena AirportLa Florida, La Serena Airport14:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 13:05:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 14:04:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 59m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 26/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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Condor Bus6h 15m016:50La SerenaCentral Coach Station23:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/12/2025 23:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 15m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 12:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 40m000:15La SerenaCentral Coach Station06:55Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 06:55:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 40m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 26/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 57m021:26La Florida, La Serena AirportLa Florida, La Serena Airport22:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 21:26:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 22:23:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m021:26La Florida, La Serena AirportLa Florida, La Serena Airport22:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 21:26:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 22:23:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:22Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 23:22:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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Sky Airline1h 4m009:38La Florida, La Serena AirportLa Florida, La Serena Airport10:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 09:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 10:42:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m013:08La Florida, La Serena AirportLa Florida, La Serena Airport14:07Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 13:08:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 14:07:00. 50 Economy ticket for £25 per person are available. Travel duration is 0h 59m
Cheapest Buses Friday
Cheapest Flights Friday
What are the fastest trips from La Serena to Santiago, RM?
You can get to Santiago, RM from La Serena in just 0h 57m with a Flight from LATAM Brasil. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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LATAM Brasil0h 57m016:19La Florida, La Serena AirportLa Florida, La Serena Airport17:16Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 16:19:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 17:16:00. 50 Economy ticket for £60 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m019:45La Florida, La Serena AirportLa Florida, La Serena Airport20:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 19:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 20:42:00. 50 Economy ticket for £82 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 58m012:20La Florida, La Serena AirportLa Florida, La Serena Airport13:18Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 12:20:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 13:18:00. 50 Economy ticket for £82 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m010:47La Florida, La Serena AirportLa Florida, La Serena Airport11:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 10:47:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 11:46:00. 50 Economy ticket for £39 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:06La Florida, La Serena AirportLa Florida, La Serena Airport12:10Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 20/12/2025 11:06:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 20/12/2025 12:10:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 4m
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FlixBus5h 40m011:00La SerenaCentral Coach Station16:40Santiago, RMLos Libertadores Bus Stop0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 20/12/2025 11:00:00 to Los Libertadores Bus Stop, Santiago, RM (Chile) arriving at 20/12/2025 16:40:00. 50 Economy ticket for £11 per person are available. Travel duration is 5h 40m
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Nueva Andimar Vip5h 40m013:55La SerenaCentral Coach Station19:35Santiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Coach Station, La Serena (Chile) at 20/12/2025 13:55:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 20/12/2025 19:35:00. 50 Economy ticket for £13 per person are available. Travel duration is 5h 40m
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Buses Romani6h 0m010:30La SerenaCentral Coach Station16:30Santiago, RMSur Bus Station0First ClassA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 20/12/2025 10:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 20/12/2025 16:30:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 0m
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Condor Bus7h 10m021:45La SerenaCentral Coach Station04:55Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 20/12/2025 21:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 21/12/2025 04:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 7h 10m
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Pullman Bus7h 30m011:00La SerenaEl Sto, 106018:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 20/12/2025 11:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 20/12/2025 18:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 7h 30m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Perú0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 10:38:00. 50 Economy ticket for £29 per person are available. Travel duration is 0h 58m
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LATAM Brasil0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 58m013:51La Florida, La Serena AirportLa Florida, La Serena Airport14:49Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 13:51:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 14:49:00. 50 Economy ticket for £34 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m010:39La Florida, La Serena AirportLa Florida, La Serena Airport11:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 10:39:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 11:38:00. 50 Economy ticket for £28 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m017:51La Florida, La Serena AirportLa Florida, La Serena Airport18:55Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 21/12/2025 17:51:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 21/12/2025 18:55:00. 50 Economy ticket for £36 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 21/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 21/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 21/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 21/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 21/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 21/12/2025 12:05:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 21/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Turbus6h 15m001:45La SerenaAvda. Fco de Aguirre Station08:00Santiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 21/12/2025 01:45:00 to Terminal Alameda, Santiago, RM (Chile) arriving at 21/12/2025 08:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 15m
Fastest Flights Sunday
Fastest Buses Sunday
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LAN Perú0h 57m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 10:37:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 58m013:29La Florida, La Serena AirportLa Florida, La Serena Airport14:27Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 13:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 14:27:00. 50 Economy ticket for £28 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 58m013:29La Florida, La Serena AirportLa Florida, La Serena Airport14:27Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 13:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 14:27:00. 50 Economy ticket for £44 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m009:38La Florida, La Serena AirportLa Florida, La Serena Airport10:37Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 09:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 22/12/2025 10:37:00. 50 Economy ticket for £33 per person are available. Travel duration is 0h 59m
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Sky Airline21h 17m012:29La Florida, La Serena AirportLa Florida, La Serena Airport09:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 22/12/2025 12:29:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 09:46:00. 50 Economy ticket for £205 per person are available. Travel duration is 21h 17m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 22/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 22/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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Cikbus Elité6h 0m000:30La SerenaCentral Coach Station06:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 22/12/2025 00:30:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 22/12/2025 06:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 22/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 20m011:50La SerenaCentral Coach Station18:10Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 22/12/2025 11:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 22/12/2025 18:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 20m
Fastest Flights Monday
Fastest Buses Monday
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LATAM Brasil0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m009:40La Florida, La Serena AirportLa Florida, La Serena Airport10:38Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 09:40:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 10:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 58m013:45La Florida, La Serena AirportLa Florida, La Serena Airport14:43Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 13:45:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 14:43:00. 50 Economy ticket for £61 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m015:25La Florida, La Serena AirportLa Florida, La Serena Airport16:24Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 15:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 16:24:00. 50 Economy ticket for £36 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m010:38La Florida, La Serena AirportLa Florida, La Serena Airport11:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 23/12/2025 10:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 23/12/2025 11:42:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 4m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 23/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 23/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 23/12/2025 12:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 23/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 23/12/2025 00:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/12/2025 07:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 15m
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Cikbus Elité6h 30m002:00La SerenaCentral Coach Station08:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 23/12/2025 02:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 23/12/2025 08:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 30m
Fastest Flights Tuesday
Fastest Buses Tuesday
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LATAM Brasil0h 57m019:09La Florida, La Serena AirportLa Florida, La Serena Airport20:06Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 19:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 20:06:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m019:09La Florida, La Serena AirportLa Florida, La Serena Airport20:06Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 19:09:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 20:06:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m014:56La Florida, La Serena AirportLa Florida, La Serena Airport15:53Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 14:56:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 15:53:00. 50 Economy ticket for £42 per person are available. Travel duration is 0h 57m
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Sky Airline1h 4m021:15La Florida, La Serena AirportLa Florida, La Serena Airport22:19Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 21:15:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 24/12/2025 22:19:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 4m
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JetSmart15h 55m021:03La Florida, La Serena AirportLa Florida, La Serena Airport12:58Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 24/12/2025 21:03:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 12:58:00. 50 Economy ticket for £75 per person are available. Travel duration is 15h 55m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 24/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 12:05:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m000:45La SerenaCentral Coach Station07:00Santiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 24/12/2025 00:45:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 07:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 15m
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Pullman Bus6h 30m001:30La SerenaEl Sto, 106008:00Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 24/12/2025 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 08:00:00. 50 First Class ticket for £9 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 30m009:10La SerenaCentral Coach Station15:40Santiago, RMTerminal San Borja0First ClassA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 24/12/2025 09:10:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 24/12/2025 15:40:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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Cikbus Elité6h 45m004:45La SerenaCentral Coach Station11:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 24/12/2025 04:45:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 24/12/2025 11:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 45m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Airlines0h 57m014:49La Florida, La Serena AirportLa Florida, La Serena Airport15:46Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 14:49:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 15:46:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 58m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:39Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 10:39:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m009:41La Florida, La Serena AirportLa Florida, La Serena Airport10:39Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 09:41:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 10:39:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m013:05La Florida, La Serena AirportLa Florida, La Serena Airport14:04Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 13:05:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 14:04:00. 50 Economy ticket for £27 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:58La Florida, La Serena AirportLa Florida, La Serena Airport13:02Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 25/12/2025 11:58:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 25/12/2025 13:02:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 4m
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Serena Mar6h 0m010:00La SerenaCentral Coach Station16:00Santiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Coach Station, La Serena (Chile) at 25/12/2025 10:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 16:00:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m007:15La SerenaCentral Coach Station13:20Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 07:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 13:20:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m023:50La SerenaCentral Coach Station06:00Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 23:50:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 06:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 30m001:30La SerenaCentral Coach Station08:00Santiago, RMTerminal San Borja0BusinessA Bus from Pullman Bus goes from Central Coach Station, La Serena (Chile) at 25/12/2025 01:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 25/12/2025 08:00:00. 50 Business ticket for £10 per person are available. Travel duration is 6h 30m
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Cikbus Elité7h 20m001:10La SerenaCentral Coach Station08:30Santiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Coach Station, La Serena (Chile) at 25/12/2025 01:10:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 25/12/2025 08:30:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 7h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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LATAM Brasil0h 57m021:26La Florida, La Serena AirportLa Florida, La Serena Airport22:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 21:26:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 22:23:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m021:26La Florida, La Serena AirportLa Florida, La Serena Airport22:23Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 21:26:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 22:23:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m022:25La Florida, La Serena AirportLa Florida, La Serena Airport23:22Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 22:25:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 23:22:00. 50 Economy ticket for £24 per person are available. Travel duration is 0h 57m
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JetSmart0h 59m013:08La Florida, La Serena AirportLa Florida, La Serena Airport14:07Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 13:08:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 14:07:00. 50 Economy ticket for £25 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m009:38La Florida, La Serena AirportLa Florida, La Serena Airport10:42Santiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 26/12/2025 09:38:00 to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 26/12/2025 10:42:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m009:00La SerenaCentral Coach Station15:00Santiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Coach Station, La Serena (Chile) at 26/12/2025 09:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/12/2025 15:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 0m008:30La SerenaEl Sto, 106014:30Santiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 26/12/2025 08:30:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 14:30:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m006:00La SerenaCentral Coach Station12:05Santiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 06:00:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 12:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 5m
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Condor Bus6h 15m016:50La SerenaCentral Coach Station23:05Santiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 16:50:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 26/12/2025 23:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 40m000:15La SerenaCentral Coach Station06:55Santiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Coach Station, La Serena (Chile) at 26/12/2025 00:15:00 to Terminal San Borja, Santiago, RM (Chile) arriving at 26/12/2025 06:55:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 40m
Fastest Flights Friday
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from La Serena to Santiago, RM
What are the most popular stations in La Serena and Santiago, RM?
In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Coach Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 14 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as £7 with a Bus from Buses Romani.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LATAM Brasil: you will get to Santiago, RM in just 0h 57m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LATAM Brasil, FlixBus and Pullman Bus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from La Serena to Santiago, RM?
The most popular companies between La Serena and Santiago, RM, are LATAM Brasil, FlixBus and Pullman Bus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Pullman Bus, Buses Romani and 6 more.
Airlines: LATAM Brasil, JetSmart, Sky Airline and 2 more.
All you need to know when you travel from La Serena to Santiago, RM
Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from La Serena to Santiago, RM
How can I reach Santiago, RM from La Serena?
Every day, there are on average 10 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.
How far is Santiago, RM from La Serena?
The distance between La Serena and Santiago, RM is 397.3 km.
What is the most ecofriendly mode of transport between La Serena and Santiago, RM?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from La Serena to Santiago, RM?
You can get to Santiago, RM with just £7 by taking a Bus from Buses Romani.
What is the fastest way to get from La Serena to Santiago, RM?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 57m with a Flight from LATAM Brasil.
More routes to La Serena and to Santiago, RM
Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!
- Trips to La Serena
- Antofagasta to La Serena
- Arica, AP to La Serena
- Calama to La Serena
- Concepción to La Serena
- Iquique to La Serena
- Mendoza to La Serena
- San Juan, SJ to La Serena
- Santiago, RM to La Serena
- Trips to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Castro to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Coronel to Santiago, RM
- Freire to Santiago, RM
- Iquique to Santiago, RM
- Los Ángeles, BI to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Porto Alegre, RS to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM
