Bus and Coach from Mendoza to La Serena: Compare all prices

Compare all timetables for the bus from Mendoza to La Serena

Here is a selection of the cheapest bus trips from the schedule from Mendoza to La Serena from various bus operators like CATA Internacional for the next days.

today

£69

tomorrow

Thursday

£69

Friday

Saturday

£69

Sunday

Monday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	CATA Internacional	11h 45m	20:15	Mendoza	Bus Station	08:00	La Serena	Central Coach Station		Premium Economy	£69	A Bus from CATA Internacional goes from Bus Station, Mendoza (Argentina) at 03/02/2026 20:15:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 08:00:00. 50 Premium Economy ticket for £69 per person are available. Travel duration is 11h 45m

Did you know that if you travel from Mendoza to La Serena via Santiago, RM, you can save more than £35? You can find the corresponding connections below.
- Plataforma 10
  
  14h 15m
  
  0
  
  10:00
  
  Mendoza
  Bus Station
  
  18:00
  
  Santiago, RM
  Sur Bus Station
  
  0
  
  Premium Economy
  
  £23
  
  A Bus from Plataforma 10 goes from Bus Station, Mendoza (Argentina) at 04/02/2026 10:00:00 to Sur Bus Station, Santiago, RM (Chile) arriving at 04/02/2026 18:00:00. 50 Premium Economy ticket for £23 per person are available. Travel duration is 8h 0m
- FlixBus
  
  6h 10m
  
  0
  
  18:05
  
  Santiago, RM
  Los Libertadores Bus Stop
  
  00:15
  
  La Serena
  Central Coach Station
  
  0
  
  Economy
  
  £11
  
  A Bus from FlixBus goes from Los Libertadores Bus Stop, Santiago, RM (Chile) at 04/02/2026 18:05:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 00:15:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 10m
Travel time is 2h 30m longer, but you will save £35

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	CATA Internacional	11h 45m	20:15	Mendoza	Bus Station	08:00	La Serena	Central Coach Station		Premium Economy	£69	A Bus from CATA Internacional goes from Bus Station, Mendoza (Argentina) at 05/02/2026 20:15:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 08:00:00. 50 Premium Economy ticket for £69 per person are available. Travel duration is 11h 45m

Did you know that if you travel from Mendoza to La Serena via Santiago, RM, you can save more than £39? You can find the corresponding connections below.
- Voyenbus
  
  16h 15m
  
  0
  
  07:45
  
  Mendoza
  Bus Station
  
  14:45
  
  Santiago, RM
  Los Héroes Station
  
  0
  
  Basic
  
  £18
  
  A Bus from Voyenbus goes from Bus Station, Mendoza (Argentina) at 06/02/2026 07:45:00 to Los Héroes Station, Santiago, RM (Chile) arriving at 06/02/2026 14:45:00. 50 Basic ticket for £18 per person are available. Travel duration is 7h 0m
- kupos.cl
  
  6h 30m
  
  0
  
  17:30
  
  Santiago, RM
  Terminal San Borja
  
  00:00
  
  La Serena
  Central Coach Station
  
  0
  
  Premium Economy
  
  £12
  
  A Bus from kupos.cl goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 00:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 30m
Travel time is 4h 30m longer, but you will save £39

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	CATA Internacional	11h 45m	20:15	Mendoza	Bus Station	08:00	La Serena	Central Coach Station		Premium Economy	£69	A Bus from CATA Internacional goes from Bus Station, Mendoza (Argentina) at 07/02/2026 20:15:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 08:00:00. 50 Premium Economy ticket for £69 per person are available. Travel duration is 11h 45m
	CATA Internacional	11h 45m	20:16	Mendoza	Bus Station	08:01	La Serena	Avda. Fco de Aguirre Station		Business	£69	A Bus from CATA Internacional goes from Bus Station, Mendoza (Argentina) at 07/02/2026 20:16:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 08/02/2026 08:01:00. 50 Business ticket for £69 per person are available. Travel duration is 11h 45m

Did you know that if you travel from Mendoza to La Serena via Santiago, RM, you can save more than £39? You can find the corresponding connections below.
- Voyenbus
  
  16h 15m
  
  0
  
  07:45
  
  Mendoza
  Bus Station
  
  14:45
  
  Santiago, RM
  Los Héroes Station
  
  0
  
  Basic
  
  £18
  
  A Bus from Voyenbus goes from Bus Station, Mendoza (Argentina) at 06/02/2026 07:45:00 to Los Héroes Station, Santiago, RM (Chile) arriving at 06/02/2026 14:45:00. 50 Basic ticket for £18 per person are available. Travel duration is 7h 0m
- kupos.cl
  
  6h 30m
  
  0
  
  17:30
  
  Santiago, RM
  Terminal San Borja
  
  00:00
  
  La Serena
  Central Coach Station
  
  0
  
  Premium Economy
  
  £12
  
  A Bus from kupos.cl goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 00:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 30m
Travel time is 4h 30m longer, but you will save £39

Best Price Offer: The price for the cheapest coach from Mendoza to La Serena is £69 on 03/02/2026. Flexible travellers save on ticket prices.

Facts about coaches from Mendoza to La Serena

Compare all providers like CATA Internacional that travel 6 times every day by bus from Mendoza to La Serena in one click! Book your bus ticket from Mendoza to La Serena starting from £69!

Cheapest Bus	£69
Fastest Bus	11h 45m
Earliest Coach	20:15
Latest Coach	20:16
Daily Bus Connections	6 Ø
Distance	403.0 km
Coach Companies	CATA Internacional

Cheapest coach connections from Mendoza to La Serena

Every day, 6 buses from 1 coach companies leave Mendoza for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/02/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 02/02

Tuesday 03/02

£69

Wednesday 04/02

Thursday 05/02

£69

Friday 06/02

Saturday 07/02

£69

Sunday 08/02

Monday 09/02

Tuesday 10/02

£69

Wednesday 11/02

Thursday 12/02

£69

Friday 13/02

Saturday 14/02

£69

Sunday 15/02

Monday 16/02

Tuesday 17/02

£69

Wednesday 18/02

Thursday 19/02

Friday 20/02

Saturday 21/02

£69

Sunday 22/02

Monday 23/02

Tuesday 24/02

£69

Wednesday 25/02

Thursday 26/02

Friday 27/02

Saturday 28/02

£69

Sunday 01/03

How to save money travelling from Mendoza to La Serena

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mendoza to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mendoza to La Serena, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Mendoza to La Serena are also emptier.

All bus stations and stops in Mendoza and La Serena

The map below shows you where to find all the bus stations in Mendoza and La Serena.

Bus Station

Juan B. Alberdi s/n

Hotel Internacional

Av. Sarmiento 720

Hotel NH Cordillera

1324 1324

Casa Juri

Centro Informacion Turistica

de Julio 9

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Coach Station

Avenida El Santo 1475

El Sto, 1060

terminal de buses covalle bus

Rotonda

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Mendoza to La Serena? Compare all modes of transports from Mendoza to La Serena.

Service and Comfort on the bus from Mendoza to La Serena

Want to know which seat classes are available on the coaches from Mendoza to La Serena? Or which bus companies serve the route Mendoza to La Serena? Below you will find answers to your questions.

FAQs about the Mendoza to La Serena bus

How much does a Mendoza - La Serena coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Mendoza - La Serena bus trip is available from £69 and takes 11h 45m. Compare offers and save money!

How much could I save by comparing buses from Mendoza to La Serena?

The connection Mendoza to La Serena is offered by 1 companies with ticket prices ranging from £69 to £88. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Mendoza - La Serena route on average every day?

Each day, the bus route from Mendoza to La Serena is offered by roughly 6 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to La Serena from Mendoza take?

The quickest coach from Mendoza to La Serena is provided by CATA Internacional and takes 11h 45m. Coach tickets for this connection cost £83. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Mendoza to La Serena?

The earliest bus to La Serena departs from Mendoza at 20:15. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Mendoza to La Serena?

The latest bus to La Serena departs from Mendoza at 20:16. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Mendoza - La Serena route?

Passengers looking to travel from Mendoza to La Serena can travel with CATA Internacional. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Mendoza and La Serena?

You can check all the direct connections between Mendoza and La Serena by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: CATA Internacional.

What can I take with me on the bus to La Serena from Mendoza?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Mendoza La Serena bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Mendoza La Serena bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mendoza to La Serena on your planned travel date.

How does CheckMyBus find the best bus deals from Mendoza to La Serena?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Mendoza and La Serena. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mendoza to La Serena?

Prices and availability for 6 trips between Mendoza and La Serena change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mendoza to La Serena

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

More bus routes to Mendoza and to La Serena

Here’s an overview of the most popular bus routes to Mendoza and to La Serena. Simply click on the connection of your choice, and you will find all the details about your bus route!