What is the best way to travel from Santiago, RM to La Serena?
Looking for a trip? Check and compare all the available Flights and Buses to La Serena from Santiago, RM. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 17 available companies to find your perfect trip!
What is the cheapest way to reach La Serena from Santiago, RM?
You can reach La Serena with just £7 by taking a Bus from Buses Romani, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 21/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 30m022:55Santiago, RMTerminal San Borja05:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 22:55:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 05:25:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 20m012:30Santiago, RMSur Bus Station18:50La SerenaCentral Coach Station0First ClassA Bus from Buses Paravias goes from Sur Bus Station, Santiago, RM (Chile) at 21/03/2026 12:30:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 18:50:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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FlixBus6h 10m014:15Santiago, RMTerminal San Borja20:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 14:15:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 20:25:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 10m
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Pullman San Andres6h 15m020:30Santiago, RMTerminal San Borja02:45La SerenaCentral Coach Station0Premium EconomyA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 20:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 02:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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Sky Airline1h 11m007:50Santiago de Chile AirportSantiago de Chile Airport09:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 07:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 09:01:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m017:35Santiago de Chile AirportSantiago de Chile Airport18:46La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 17:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 18:46:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 11m
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JetSmart1h 10m016:55Santiago de Chile AirportSantiago de Chile Airport18:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 16:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 18:05:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 10m
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LAN Perú1h 5m018:00Santiago de Chile AirportSantiago de Chile Airport19:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 18:00:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 19:05:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 5m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 50m012:00Santiago, RMTerminal San Borja18:50La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 22/03/2026 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 50m
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Buses Paravias6h 20m012:30Santiago, RMSur Bus Station18:50La SerenaCentral Coach Station0First ClassA Bus from Buses Paravias goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 12:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 18:50:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Pullman San Andres6h 15m015:30Santiago, RMTerminal San Borja21:45La SerenaCentral Coach Station0Premium EconomyA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 22/03/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 21:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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JetSmart1h 10m019:17Santiago de Chile AirportSantiago de Chile Airport20:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 19:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 20:27:00. 50 Economy ticket for £19 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m014:05Santiago de Chile AirportSantiago de Chile Airport15:16La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 14:05:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 15:16:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 11m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 08:55:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 8m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 08:55:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 8m
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LAN Airlines1h 7m011:31Santiago de Chile AirportSantiago de Chile Airport12:38La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 11:31:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 12:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 7m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 23/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 23/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Condor Bus7h 40m022:00Santiago, RMSur Bus Station05:40La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 22:00:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 05:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 40m
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FlixBus6h 10m006:15Santiago, RMTerminal San Borja12:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 23/03/2026 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Sky Airline1h 11m010:35Santiago de Chile AirportSantiago de Chile Airport11:46La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 10:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 11:46:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 11m
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LAN Perú1h 5m016:24Santiago de Chile AirportSantiago de Chile Airport17:29La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 16:24:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 17:29:00. 50 Economy ticket for £33 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 5m016:24Santiago de Chile AirportSantiago de Chile Airport17:29La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 16:24:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 17:29:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 7m011:17Santiago de Chile AirportSantiago de Chile Airport12:24La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 11:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 12:24:00. 50 Economy ticket for £37 per person are available. Travel duration is 1h 7m
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JetSmart41h 5m015:55Santiago de Chile AirportSantiago de Chile Airport09:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 15:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 09:00:00. 50 Economy ticket for £140 per person are available. Travel duration is 41h 5m
Cheapest Buses Monday
Cheapest Flights Monday
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 23:55:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 25m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 24/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 24/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Condor Bus6h 40m018:00Santiago, RMSur Bus Station00:40La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 18:00:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 00:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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FlixBus6h 10m007:30Santiago, RMTerminal San Borja13:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 24/03/2026 07:30:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 13:40:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Sky Airline1h 11m014:21Santiago de Chile AirportSantiago de Chile Airport15:32La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 14:21:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 15:32:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 11m
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JetSmart1h 10m015:50Santiago de Chile AirportSantiago de Chile Airport17:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 15:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 17:00:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 10m
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LATAM Brasil1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 08:56:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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LAN Perú1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 08:56:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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LAN Airlines1h 5m015:16Santiago de Chile AirportSantiago de Chile Airport16:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 15:16:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 16:21:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 5m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 25/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 25/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 25/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 25/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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FlixBus6h 10m009:30Santiago, RMTerminal San Borja15:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 25/03/2026 09:30:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 15:40:00. 50 Economy ticket for £8 per person are available. Travel duration is 6h 10m
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Cormar Bus6h 50m012:00Santiago, RMTerminal San Borja18:50La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 25/03/2026 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 50m
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Sky Airline1h 11m009:32Santiago de Chile AirportSantiago de Chile Airport10:43La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 09:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 10:43:00. 50 Economy ticket for £22 per person are available. Travel duration is 1h 11m
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JetSmart1h 10m011:20Santiago de Chile AirportSantiago de Chile Airport12:30La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 11:20:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 12:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 10m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 08:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 8m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 08:55:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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LAN Airlines1h 5m014:04Santiago de Chile AirportSantiago de Chile Airport15:09La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 14:04:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 15:09:00. 50 Economy ticket for £36 per person are available. Travel duration is 1h 5m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 26/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Turbus6h 20m006:10Santiago, RMTerminal Alameda12:30La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 26/03/2026 06:10:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 26/03/2026 12:30:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Condor Bus7h 0m019:00Santiago, RMSur Bus Station02:00La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 26/03/2026 19:00:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 02:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 0m
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FlixBus6h 10m007:30Santiago, RMTerminal San Borja13:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 26/03/2026 07:30:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 13:40:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Nueva Andimar Vip6h 50m013:15Santiago, RMTerminal San Borja20:05La SerenaCentral Coach Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 26/03/2026 13:15:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 20:05:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 50m
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JetSmart1h 10m008:05Santiago de Chile AirportSantiago de Chile Airport09:15La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 08:05:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 09:15:00. 50 Economy ticket for £27 per person are available. Travel duration is 1h 10m
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LATAM Brasil1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 08:56:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 8m
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LATAM Brasil1h 7m013:17Santiago de Chile AirportSantiago de Chile Airport14:24La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 13:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 14:24:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 7m
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LAN Perú1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 08:56:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 8m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 27/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 27/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Condor Bus7h 5m014:30Santiago, RMSur Bus Station21:35La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 14:30:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 21:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 5m
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FlixBus6h 10m006:15Santiago, RMTerminal San Borja12:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 27/03/2026 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Sky Airline1h 11m015:16Santiago de Chile AirportSantiago de Chile Airport16:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 15:16:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 16:27:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 11m
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JetSmart1h 10m014:43Santiago de Chile AirportSantiago de Chile Airport15:53La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 14:43:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 15:53:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 10m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 08:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 8m
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LAN Airlines1h 5m020:35Santiago de Chile AirportSantiago de Chile Airport21:40La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 20:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 21:40:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 08:55:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 8m
Cheapest Buses Friday
Cheapest Flights Friday
What are the fastest trips from Santiago, RM to La Serena?
You can get to La Serena from Santiago, RM in just 1h 5m with a Flight from LAN Perú. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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LAN Perú1h 5m018:00Santiago de Chile AirportSantiago de Chile Airport19:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 18:00:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 19:05:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 5m
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JetSmart1h 10m016:55Santiago de Chile AirportSantiago de Chile Airport18:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 16:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 18:05:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m007:50Santiago de Chile AirportSantiago de Chile Airport09:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 07:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 09:01:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m017:35Santiago de Chile AirportSantiago de Chile Airport18:46La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 21/03/2026 17:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 21/03/2026 18:46:00. 50 Economy ticket for £25 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m014:15Santiago, RMTerminal San Borja20:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 14:15:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 20:25:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 10m
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Pullman San Andres6h 15m020:30Santiago, RMTerminal San Borja02:45La SerenaCentral Coach Station0Premium EconomyA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 20:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 02:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 21/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Paravias6h 20m012:30Santiago, RMSur Bus Station18:50La SerenaCentral Coach Station0First ClassA Bus from Buses Paravias goes from Sur Bus Station, Santiago, RM (Chile) at 21/03/2026 12:30:00 to Central Coach Station, La Serena (Chile) arriving at 21/03/2026 18:50:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 30m022:55Santiago, RMTerminal San Borja05:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 21/03/2026 22:55:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 05:25:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 30m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Airlines1h 7m011:31Santiago de Chile AirportSantiago de Chile Airport12:38La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 11:31:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 12:38:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 7m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 08:55:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 8m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 08:55:00. 50 Economy ticket for £32 per person are available. Travel duration is 1h 8m
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JetSmart1h 10m019:17Santiago de Chile AirportSantiago de Chile Airport20:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 19:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 20:27:00. 50 Economy ticket for £19 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m014:05Santiago de Chile AirportSantiago de Chile Airport15:16La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 22/03/2026 14:05:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 22/03/2026 15:16:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 11m
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Pullman San Andres6h 15m015:30Santiago, RMTerminal San Borja21:45La SerenaCentral Coach Station0Premium EconomyA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 22/03/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 21:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Paravias6h 20m012:30Santiago, RMSur Bus Station18:50La SerenaCentral Coach Station0First ClassA Bus from Buses Paravias goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 12:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 18:50:00. 50 First Class ticket for £10 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 22/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 50m012:00Santiago, RMTerminal San Borja18:50La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 22/03/2026 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 22/03/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 50m
Fastest Flights Sunday
Fastest Buses Sunday
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LAN Perú1h 5m016:24Santiago de Chile AirportSantiago de Chile Airport17:29La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 16:24:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 17:29:00. 50 Economy ticket for £33 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 5m016:24Santiago de Chile AirportSantiago de Chile Airport17:29La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 16:24:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 17:29:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 7m011:17Santiago de Chile AirportSantiago de Chile Airport12:24La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 11:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 12:24:00. 50 Economy ticket for £37 per person are available. Travel duration is 1h 7m
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Sky Airline1h 11m010:35Santiago de Chile AirportSantiago de Chile Airport11:46La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 10:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 23/03/2026 11:46:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 11m
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JetSmart41h 5m015:55Santiago de Chile AirportSantiago de Chile Airport09:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 23/03/2026 15:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 09:00:00. 50 Economy ticket for £140 per person are available. Travel duration is 41h 5m
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FlixBus6h 10m006:15Santiago, RMTerminal San Borja12:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 23/03/2026 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 23/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 23/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 23/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Condor Bus7h 40m022:00Santiago, RMSur Bus Station05:40La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 23/03/2026 22:00:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 05:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 40m
Fastest Flights Monday
Fastest Buses Monday
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LAN Airlines1h 5m015:16Santiago de Chile AirportSantiago de Chile Airport16:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 15:16:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 16:21:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 08:56:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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LAN Perú1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 08:56:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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JetSmart1h 10m015:50Santiago de Chile AirportSantiago de Chile Airport17:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 15:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 17:00:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m014:21Santiago de Chile AirportSantiago de Chile Airport15:32La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 24/03/2026 14:21:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 24/03/2026 15:32:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m007:30Santiago, RMTerminal San Borja13:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 24/03/2026 07:30:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 13:40:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 24/03/2026 23:55:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 25m
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Condor Bus6h 40m018:00Santiago, RMSur Bus Station00:40La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 24/03/2026 18:00:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 00:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 40m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 24/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 24/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
Fastest Flights Tuesday
Fastest Buses Tuesday
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LAN Airlines1h 5m014:04Santiago de Chile AirportSantiago de Chile Airport15:09La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 14:04:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 15:09:00. 50 Economy ticket for £36 per person are available. Travel duration is 1h 5m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 08:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 8m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 08:55:00. 50 Economy ticket for £31 per person are available. Travel duration is 1h 8m
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JetSmart1h 10m011:20Santiago de Chile AirportSantiago de Chile Airport12:30La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 11:20:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 12:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m009:32Santiago de Chile AirportSantiago de Chile Airport10:43La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 25/03/2026 09:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 25/03/2026 10:43:00. 50 Economy ticket for £22 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m009:30Santiago, RMTerminal San Borja15:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 25/03/2026 09:30:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 15:40:00. 50 Economy ticket for £8 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 25/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 25/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 50m012:00Santiago, RMTerminal San Borja18:50La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 25/03/2026 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 25/03/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 50m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 25/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 25/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LATAM Brasil1h 7m013:17Santiago de Chile AirportSantiago de Chile Airport14:24La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 13:17:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 14:24:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 7m
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LATAM Brasil1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 08:56:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 8m
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LAN Perú1h 8m007:48Santiago de Chile AirportSantiago de Chile Airport08:56La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 07:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 08:56:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 8m
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JetSmart1h 10m008:05Santiago de Chile AirportSantiago de Chile Airport09:15La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 26/03/2026 08:05:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 26/03/2026 09:15:00. 50 Economy ticket for £27 per person are available. Travel duration is 1h 10m
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FlixBus6h 10m007:30Santiago, RMTerminal San Borja13:40La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 26/03/2026 07:30:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 13:40:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Turbus6h 20m006:10Santiago, RMTerminal Alameda12:30La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 26/03/2026 06:10:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 26/03/2026 12:30:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 26/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Nueva Andimar Vip6h 50m013:15Santiago, RMTerminal San Borja20:05La SerenaCentral Coach Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 26/03/2026 13:15:00 to Central Coach Station, La Serena (Chile) arriving at 26/03/2026 20:05:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 50m
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Condor Bus7h 0m019:00Santiago, RMSur Bus Station02:00La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 26/03/2026 19:00:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 02:00:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 0m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Airlines1h 5m020:35Santiago de Chile AirportSantiago de Chile Airport21:40La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 20:35:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 21:40:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 5m
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LAN Perú1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 08:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 1h 8m
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LATAM Brasil1h 8m007:47Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 07:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 08:55:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 8m
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JetSmart1h 10m014:43Santiago de Chile AirportSantiago de Chile Airport15:53La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 14:43:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 15:53:00. 50 Economy ticket for £24 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m015:16Santiago de Chile AirportSantiago de Chile Airport16:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 27/03/2026 15:16:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 27/03/2026 16:27:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m006:15Santiago, RMTerminal San Borja12:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 27/03/2026 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30Santiago, RMSur Bus Station17:00La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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Condor Bus7h 5m014:30Santiago, RMSur Bus Station21:35La SerenaCentral Coach Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 27/03/2026 14:30:00 to Central Coach Station, La Serena (Chile) arriving at 27/03/2026 21:35:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 5m
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Turbus7h 10m006:55Santiago, RMTerminal Alameda14:05La SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 27/03/2026 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 27/03/2026 14:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 7h 10m
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Here you will find all operators and timetables for a
Bus from Santiago, RM to La Serena
What are the most popular stations in Santiago, RM and La Serena?
In Santiago, RM, you will usually depart from Terminal Alameda, Terminal San Borja or Sur Bus Station, while in La Serena you will be arriving at El Sto, 1060, Central Coach Station or Avda. Fco de Aguirre Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to La Serena from Santiago, RM? With 10 connections between 17 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Santiago, RM and La Serena, you can pay as low as £7 with a Bus from Buses Romani.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to La Serena in just 1h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Santiago, RM and La Serena are JetSmart, Sky Airline and LAN Perú, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Santiago, RM and La Serena is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Lo Prado or to La Florida, La Serena Airport, and look at flights from Santiago de Chile Airport, and landing at La Florida, La Serena Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Santiago, RM to La Serena?
The most popular companies between Santiago, RM and La Serena, are JetSmart, Sky Airline and LAN Perú. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Pluss Chile, FlixBus, Buses Romani and 6 more.
Airlines: JetSmart, Sky Airline, LAN Perú and 2 more.
All you need to know when you travel from Santiago, RM to La Serena
Check all information on comfort and services on all modes of transports from Santiago, RM to La Serena. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Santiago, RM to La Serena
How can I reach La Serena from Santiago, RM?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to La Serena from Santiago, RM.
How far is La Serena from Santiago, RM?
The distance between Santiago, RM and La Serena is 397.3 km.
What is the most ecofriendly mode of transport between Santiago, RM and La Serena?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from Santiago, RM to La Serena?
You can get to La Serena with just £7 by taking a Bus from Buses Romani.
What is the fastest way to get from Santiago, RM to La Serena?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to La Serena in just 1h 5m with a Flight from LAN Perú.
More routes to Santiago, RM and to La Serena
Looking for more options? Here you can see the most popular routes to Santiago, RM and to La Serena. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Santiago, RM
- Alto Hospicio to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Bariloche to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Castro to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Iquique to Santiago, RM
- La Serena to Santiago, RM
- Los Ángeles, BI to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Pitrufquén to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Santiago de Chile Airport to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM
