What is the best way to travel from Santiago, RM to La Serena?
Looking for a trip? Check and compare all the available Flights and Buses to La Serena from Santiago, RM. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 15 available companies to find your perfect trip!
What is the cheapest way to reach La Serena from Santiago, RM?
You can reach La Serena with just £10 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 04/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 04/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Pullman San Andres6h 15m019:00Santiago, RMTerminal San Borja01:15La SerenaCentral Coach Station0First ClassA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 04/02/2026 19:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 01:15:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 15m
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FlixBus5h 35m018:45Santiago, RMLos Libertadores Bus Stop00:20La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Los Libertadores Bus Stop, Santiago, RM (Chile) at 04/02/2026 18:45:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 00:20:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 35m
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Pluss Chile6h 20m010:45Santiago, RMSur Bus Station17:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 04/02/2026 10:45:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 17:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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LATAM Brasil1h 7m012:20Santiago de Chile AirportSantiago de Chile Airport13:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 12:20:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 13:27:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 7m
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Sky Airline1h 11m011:32Santiago de Chile AirportSantiago de Chile Airport12:43La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 11:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 12:43:00. 50 Economy ticket for £78 per person are available. Travel duration is 1h 11m
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JetSmart1h 10m013:32Santiago de Chile AirportSantiago de Chile Airport14:42La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 13:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 14:42:00. 50 Economy ticket for £96 per person are available. Travel duration is 1h 10m
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LAN Perú1h 5m019:40Santiago de Chile AirportSantiago de Chile Airport20:45La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 19:40:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 20:45:00. 50 Economy ticket for £136 per person are available. Travel duration is 1h 5m
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LAN Airlines12h 41m020:29Santiago de Chile AirportSantiago de Chile Airport09:10La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 20:29:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 09:10:00. 50 Economy ticket for £252 per person are available. Travel duration is 12h 41m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 05/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0BusinessA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 17:00:00. 50 Business ticket for £14 per person are available. Travel duration is 7h 0m
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FlixBus6h 10m018:10Santiago, RMTerminal San Borja00:20La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 18:10:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 00:20:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 05/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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JetSmart1h 10m017:11Santiago de Chile AirportSantiago de Chile Airport18:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 17:11:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 18:21:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m010:44Santiago de Chile AirportSantiago de Chile Airport11:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 10:44:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 11:55:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 11m
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LAN Perú1h 5m017:43Santiago de Chile AirportSantiago de Chile Airport18:48La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 17:43:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 18:48:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 5m015:04Santiago de Chile AirportSantiago de Chile Airport16:09La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 15:04:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 16:09:00. 50 Economy ticket for £85 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 7m013:52Santiago de Chile AirportSantiago de Chile Airport14:59La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 13:52:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 14:59:00. 50 Economy ticket for £88 per person are available. Travel duration is 1h 7m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Cormar Bus6h 30m017:30Santiago, RMTerminal San Borja00:00La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 00:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 30m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 06/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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FlixBus6h 50m012:15Santiago, RMTerminal San Borja19:05La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 12:15:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 19:05:00. 50 Economy ticket for £17 per person are available. Travel duration is 6h 50m
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Sky Airline1h 11m008:10Santiago de Chile AirportSantiago de Chile Airport09:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 08:10:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 09:21:00. 50 Economy ticket for £48 per person are available. Travel duration is 1h 11m
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LAN Perú1h 7m010:34Santiago de Chile AirportSantiago de Chile Airport11:41La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 10:34:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 11:41:00. 50 Economy ticket for £49 per person are available. Travel duration is 1h 7m
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JetSmart1h 10m012:42Santiago de Chile AirportSantiago de Chile Airport13:52La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 12:42:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 13:52:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 10m
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LATAM Brasil1h 7m013:58Santiago de Chile AirportSantiago de Chile Airport15:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 13:58:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 15:05:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 7m
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LAN Airlines1h 7m013:58Santiago de Chile AirportSantiago de Chile Airport15:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 13:58:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 15:05:00. 50 Economy ticket for £85 per person are available. Travel duration is 1h 7m
Cheapest Buses Friday
Cheapest Flights Friday
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FlixBus6h 45m015:30Santiago, RMTerminal San Borja22:15La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 22:15:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 45m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
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Cormar Bus6h 30m022:55Santiago, RMTerminal San Borja05:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 22:55:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 05:25:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 6h 30m
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Buses Romani6h 30m011:30Santiago, RMTerminal San Borja18:00La SerenaCentral Coach Station0BusinessA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 11:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 18:00:00. 50 Business ticket for £16 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 07/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Sky Airline1h 11m009:15Santiago de Chile AirportSantiago de Chile Airport10:26La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 09:15:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 10:26:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m017:50Santiago de Chile AirportSantiago de Chile Airport19:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 17:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 19:01:00. 50 Economy ticket for £58 per person are available. Travel duration is 1h 11m
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LATAM Brasil1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 08:55:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 08:55:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 9m
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LAN Perú1h 5m017:50Santiago de Chile AirportSantiago de Chile Airport18:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 17:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 18:55:00. 50 Economy ticket for £65 per person are available. Travel duration is 1h 5m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus6h 45m017:30Santiago, RMTerminal San Borja00:15La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 00:15:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 45m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 08/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Cormar Bus6h 40m023:45Santiago, RMTerminal San Borja06:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 23:45:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 06:25:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 40m
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Serena Mar7h 0m023:30Santiago, RMTerminal San Borja06:30La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 23:30:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 06:30:00. 50 First Class ticket for £15 per person are available. Travel duration is 7h 0m
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Nueva Andimar Vip6h 0m008:50Santiago, RMTerminal San Borja14:50La SerenaCentral Coach Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 08:50:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 14:50:00. 50 Economy ticket for £17 per person are available. Travel duration is 6h 0m
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LAN Perú1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 08:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 9m
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Sky Airline1h 11m016:02Santiago de Chile AirportSantiago de Chile Airport17:13La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 16:02:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 17:13:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 11m
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LAN Airlines1h 7m013:31Santiago de Chile AirportSantiago de Chile Airport14:38La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 13:31:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 14:38:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 7m
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LATAM Brasil1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 08:55:00. 50 Economy ticket for £38 per person are available. Travel duration is 1h 9m
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JetSmart1h 10m019:09Santiago de Chile AirportSantiago de Chile Airport20:19La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 19:09:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 20:19:00. 50 Economy ticket for £51 per person are available. Travel duration is 1h 10m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus6h 10m019:15Santiago, RMTerminal San Borja01:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 19:15:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 01:25:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 30m023:15Santiago, RMTerminal San Borja05:45La SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 23:15:00 to El Sto, 1060, La Serena (Chile) arriving at 10/02/2026 05:45:00. 50 First Class ticket for £11 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 09/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Sky Airline1h 11m016:14Santiago de Chile AirportSantiago de Chile Airport17:25La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:14:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:25:00. 50 Economy ticket for £48 per person are available. Travel duration is 1h 11m
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LATAM Brasil1h 5m016:03Santiago de Chile AirportSantiago de Chile Airport17:08La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:03:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:08:00. 50 Economy ticket for £53 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 5m016:48Santiago de Chile AirportSantiago de Chile Airport17:53La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:53:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 5m
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JetSmart1h 10m011:02Santiago de Chile AirportSantiago de Chile Airport12:12La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 11:02:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 12:12:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 10m
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LAN Perú1h 5m016:03Santiago de Chile AirportSantiago de Chile Airport17:08La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:03:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:08:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 5m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus6h 45m015:30Santiago, RMTerminal San Borja22:15La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 22:15:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 45m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
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Buses Romani6h 30m011:30Santiago, RMTerminal San Borja18:00La SerenaCentral Coach Station0BusinessA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 11:30:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 18:00:00. 50 Business ticket for £16 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 10/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Sky Airline1h 11m017:47Santiago de Chile AirportSantiago de Chile Airport18:58La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 17:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 18:58:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 11m
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LATAM Brasil1h 5m015:56Santiago de Chile AirportSantiago de Chile Airport17:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:56:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 17:01:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Perú1h 5m018:55Santiago de Chile AirportSantiago de Chile Airport20:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 18:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 20:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 5m015:56Santiago de Chile AirportSantiago de Chile Airport17:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:56:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 17:01:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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JetSmart1h 10m015:41Santiago de Chile AirportSantiago de Chile Airport16:51La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:41:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 16:51:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 10m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
What are the fastest trips from Santiago, RM to La Serena?
You can get to La Serena from Santiago, RM in just 1h 5m with a Flight from LAN Perú. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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LAN Perú1h 5m019:40Santiago de Chile AirportSantiago de Chile Airport20:45La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 19:40:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 20:45:00. 50 Economy ticket for £136 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 7m012:20Santiago de Chile AirportSantiago de Chile Airport13:27La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 12:20:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 13:27:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 7m
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JetSmart1h 10m013:32Santiago de Chile AirportSantiago de Chile Airport14:42La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 13:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 14:42:00. 50 Economy ticket for £96 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m011:32Santiago de Chile AirportSantiago de Chile Airport12:43La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 11:32:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 04/02/2026 12:43:00. 50 Economy ticket for £78 per person are available. Travel duration is 1h 11m
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LAN Airlines12h 41m020:29Santiago de Chile AirportSantiago de Chile Airport09:10La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 04/02/2026 20:29:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 09:10:00. 50 Economy ticket for £252 per person are available. Travel duration is 12h 41m
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FlixBus5h 35m018:45Santiago, RMLos Libertadores Bus Stop00:20La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Los Libertadores Bus Stop, Santiago, RM (Chile) at 04/02/2026 18:45:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 00:20:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 35m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 04/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pullman San Andres6h 15m019:00Santiago, RMTerminal San Borja01:15La SerenaCentral Coach Station0First ClassA Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 04/02/2026 19:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 01:15:00. 50 First Class ticket for £13 per person are available. Travel duration is 6h 15m
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Pluss Chile6h 20m010:45Santiago, RMSur Bus Station17:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 04/02/2026 10:45:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 17:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 04/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 04/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Perú1h 5m017:43Santiago de Chile AirportSantiago de Chile Airport18:48La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 17:43:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 18:48:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 5m015:04Santiago de Chile AirportSantiago de Chile Airport16:09La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 15:04:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 16:09:00. 50 Economy ticket for £85 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 7m013:52Santiago de Chile AirportSantiago de Chile Airport14:59La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 13:52:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 14:59:00. 50 Economy ticket for £88 per person are available. Travel duration is 1h 7m
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JetSmart1h 10m017:11Santiago de Chile AirportSantiago de Chile Airport18:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 17:11:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 18:21:00. 50 Economy ticket for £45 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m010:44Santiago de Chile AirportSantiago de Chile Airport11:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 05/02/2026 10:44:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 05/02/2026 11:55:00. 50 Economy ticket for £63 per person are available. Travel duration is 1h 11m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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FlixBus6h 10m018:10Santiago, RMTerminal San Borja00:20La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 18:10:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 00:20:00. 50 Premium Economy ticket for £15 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 05/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 05/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0BusinessA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 05/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 05/02/2026 17:00:00. 50 Business ticket for £14 per person are available. Travel duration is 7h 0m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Perú1h 7m010:34Santiago de Chile AirportSantiago de Chile Airport11:41La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 10:34:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 11:41:00. 50 Economy ticket for £49 per person are available. Travel duration is 1h 7m
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LATAM Brasil1h 7m013:58Santiago de Chile AirportSantiago de Chile Airport15:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 13:58:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 15:05:00. 50 Economy ticket for £62 per person are available. Travel duration is 1h 7m
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LAN Airlines1h 7m013:58Santiago de Chile AirportSantiago de Chile Airport15:05La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 13:58:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 15:05:00. 50 Economy ticket for £85 per person are available. Travel duration is 1h 7m
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JetSmart1h 10m012:42Santiago de Chile AirportSantiago de Chile Airport13:52La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 12:42:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 13:52:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m008:10Santiago de Chile AirportSantiago de Chile Airport09:21La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 06/02/2026 08:10:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 06/02/2026 09:21:00. 50 Economy ticket for £48 per person are available. Travel duration is 1h 11m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 06/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Cormar Bus6h 30m017:30Santiago, RMTerminal San Borja00:00La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 00:00:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 30m
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FlixBus6h 50m012:15Santiago, RMTerminal San Borja19:05La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 12:15:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 19:05:00. 50 Economy ticket for £17 per person are available. Travel duration is 6h 50m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 06/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 06/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
Fastest Flights Friday
Fastest Buses Friday
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LAN Perú1h 5m017:50Santiago de Chile AirportSantiago de Chile Airport18:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 17:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 18:55:00. 50 Economy ticket for £65 per person are available. Travel duration is 1h 5m
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LATAM Brasil1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 08:55:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 08:55:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 9m
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Sky Airline1h 11m009:15Santiago de Chile AirportSantiago de Chile Airport10:26La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 09:15:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 10:26:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m017:50Santiago de Chile AirportSantiago de Chile Airport19:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 07/02/2026 17:50:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 07/02/2026 19:01:00. 50 Economy ticket for £58 per person are available. Travel duration is 1h 11m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 07/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Cormar Bus6h 30m022:55Santiago, RMTerminal San Borja05:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 22:55:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 05:25:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 6h 30m
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Buses Romani6h 30m011:30Santiago, RMTerminal San Borja18:00La SerenaCentral Coach Station0BusinessA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 11:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 18:00:00. 50 Business ticket for £16 per person are available. Travel duration is 6h 30m
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FlixBus6h 45m015:30Santiago, RMTerminal San Borja22:15La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 22:15:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 6h 45m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 07/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 07/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Airlines1h 7m013:31Santiago de Chile AirportSantiago de Chile Airport14:38La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 13:31:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 14:38:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 7m
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LAN Perú1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 08:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 9m007:46Santiago de Chile AirportSantiago de Chile Airport08:55La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 07:46:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 08:55:00. 50 Economy ticket for £38 per person are available. Travel duration is 1h 9m
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JetSmart1h 10m019:09Santiago de Chile AirportSantiago de Chile Airport20:19La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 19:09:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 20:19:00. 50 Economy ticket for £51 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m016:02Santiago de Chile AirportSantiago de Chile Airport17:13La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 08/02/2026 16:02:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 08/02/2026 17:13:00. 50 Economy ticket for £30 per person are available. Travel duration is 1h 11m
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Nueva Andimar Vip6h 0m008:50Santiago, RMTerminal San Borja14:50La SerenaCentral Coach Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 08:50:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 14:50:00. 50 Economy ticket for £17 per person are available. Travel duration is 6h 0m
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Buses Romani6h 25m017:30Santiago, RMSur Bus Station23:55La SerenaCentral Coach Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 08/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 08/02/2026 23:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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Cormar Bus6h 40m023:45Santiago, RMTerminal San Borja06:25La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 23:45:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 06:25:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 40m
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FlixBus6h 45m017:30Santiago, RMTerminal San Borja00:15La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 17:30:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 00:15:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 45m
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Serena Mar7h 0m023:30Santiago, RMTerminal San Borja06:30La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 08/02/2026 23:30:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 06:30:00. 50 First Class ticket for £15 per person are available. Travel duration is 7h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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LATAM Brasil1h 5m016:03Santiago de Chile AirportSantiago de Chile Airport17:08La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:03:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:08:00. 50 Economy ticket for £53 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 5m016:48Santiago de Chile AirportSantiago de Chile Airport17:53La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:48:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:53:00. 50 Economy ticket for £55 per person are available. Travel duration is 1h 5m
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LAN Perú1h 5m016:03Santiago de Chile AirportSantiago de Chile Airport17:08La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:03:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:08:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 5m
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JetSmart1h 10m011:02Santiago de Chile AirportSantiago de Chile Airport12:12La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 11:02:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 12:12:00. 50 Economy ticket for £56 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m016:14Santiago de Chile AirportSantiago de Chile Airport17:25La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 09/02/2026 16:14:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 09/02/2026 17:25:00. 50 Economy ticket for £48 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m019:15Santiago, RMTerminal San Borja01:25La SerenaCentral Coach Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 19:15:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 01:25:00. 50 Economy ticket for £11 per person are available. Travel duration is 6h 10m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 09/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Pullman Bus6h 30m023:15Santiago, RMTerminal San Borja05:45La SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 23:15:00 to El Sto, 1060, La Serena (Chile) arriving at 10/02/2026 05:45:00. 50 First Class ticket for £11 per person are available. Travel duration is 6h 30m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 09/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 09/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
Fastest Flights Monday
Fastest Buses Monday
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LATAM Brasil1h 5m015:56Santiago de Chile AirportSantiago de Chile Airport17:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:56:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 17:01:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Perú1h 5m018:55Santiago de Chile AirportSantiago de Chile Airport20:00La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 18:55:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 20:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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LAN Airlines1h 5m015:56Santiago de Chile AirportSantiago de Chile Airport17:01La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:56:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 17:01:00. 50 Economy ticket for £34 per person are available. Travel duration is 1h 5m
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JetSmart1h 10m015:41Santiago de Chile AirportSantiago de Chile Airport16:51La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 15:41:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 16:51:00. 50 Economy ticket for £40 per person are available. Travel duration is 1h 10m
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Sky Airline1h 11m017:47Santiago de Chile AirportSantiago de Chile Airport18:58La Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 10/02/2026 17:47:00 to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 10/02/2026 18:58:00. 50 Economy ticket for £28 per person are available. Travel duration is 1h 11m
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Cormar Bus6h 10m013:00Santiago, RMTerminal San Borja19:10La SerenaCentral Coach Station0Premium EconomyA Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 19:10:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m007:45Santiago, RMSur Bus Station14:05La SerenaCentral Coach Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 10/02/2026 07:45:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 14:05:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m011:30Santiago, RMTerminal San Borja18:00La SerenaCentral Coach Station0BusinessA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 11:30:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 18:00:00. 50 Business ticket for £16 per person are available. Travel duration is 6h 30m
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FlixBus6h 45m015:30Santiago, RMTerminal San Borja22:15La SerenaCentral Coach Station0Premium EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 22:15:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 45m
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Serena Mar7h 0m010:00Santiago, RMTerminal San Borja17:00La SerenaCentral Coach Station0First ClassA Bus from Serena Mar goes from Terminal San Borja, Santiago, RM (Chile) at 10/02/2026 10:00:00 to Central Coach Station, La Serena (Chile) arriving at 10/02/2026 17:00:00. 50 First Class ticket for £14 per person are available. Travel duration is 7h 0m
Fastest Flights Tuesday
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Santiago, RM to La Serena
What are the most popular stations in Santiago, RM and La Serena?
In Santiago, RM, you will usually depart from Terminal Alameda, Terminal San Borja or Sur Bus Station, while in La Serena you will be arriving at Avda. Fco de Aguirre Station, Central Coach Station or El Sto, 1060, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to La Serena from Santiago, RM? With 10 connections between 15 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Santiago, RM and La Serena, you can pay as low as £10 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to La Serena in just 1h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Santiago, RM and La Serena are Sky Airline, LAN Perú and Cormar Bus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Santiago, RM and La Serena is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Lo Prado or to La Florida, La Serena Airport, and look at flights from Santiago de Chile Airport, and landing at La Florida, La Serena Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Santiago, RM to La Serena?
The most popular companies between Santiago, RM and La Serena, are Sky Airline, LAN Perú and Cormar Bus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Cormar Bus, FlixBus, Buses Romani and 5 more.
Airlines: Sky Airline, LAN Perú, LATAM Brasil and 2 more.
All you need to know when you travel from Santiago, RM to La Serena
Check all information on comfort and services on all modes of transports from Santiago, RM to La Serena. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Santiago, RM to La Serena
How can I reach La Serena from Santiago, RM?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to La Serena from Santiago, RM.
How far is La Serena from Santiago, RM?
The distance between Santiago, RM and La Serena is 397.3 km.
What is the most ecofriendly mode of transport between Santiago, RM and La Serena?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from Santiago, RM to La Serena?
You can get to La Serena with just £10 by taking a Bus from FlixBus.
What is the fastest way to get from Santiago, RM to La Serena?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to La Serena in just 1h 5m with a Flight from LAN Perú.
More routes to Santiago, RM and to La Serena
Looking for more options? Here you can see the most popular routes to Santiago, RM and to La Serena. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Santiago, RM
- Alto Hospicio to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Bariloche to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Coronel to Santiago, RM
- Iquique to Santiago, RM
- La Serena to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM
