What is the best way to travel from Rome to Lyon?
Looking for a trip? Check and compare all the available Flights and Buses to Lyon from Rome. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Rome?
You can reach Lyon with just £22 by taking a Bus from Itabus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 12:55:00. 50 Premium Economy ticket for £31 per person are available. Travel duration is 15h 10m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 11/03/2026 12:55:00. 50 Premium Economy ticket for £38 per person are available. Travel duration is 15h 10m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 12:00:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 0m
-
FlixBus17h 40m022:45RomeTiburtina Bus Station16:25LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 22:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 16:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 17h 40m
Cheapest Buses Tuesday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 12/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 12:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 10m
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 23:45:00. 50 Economy ticket for £45 per person are available. Travel duration is 14h 55m
-
FlixBus18h 20m012:10RomeTiburtina Bus Station06:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 12:10:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 06:30:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 20m
Cheapest Buses Wednesday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 00:25:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 16h 25m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 04:55:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 15h 55m
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 22:40:00. 50 Economy ticket for £41 per person are available. Travel duration is 14h 55m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 13/03/2026 12:00:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 0m
Cheapest Buses Thursday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus16h 25m008:00RomeTiburtina Coach Station00:25LyonPerrache Bus Stop0BasicA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 13/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 00:25:00. 50 Basic ticket for £23 per person are available. Travel duration is 16h 25m
-
Itabus15h 25m009:00RomeTiburtina Coach Station00:25LyonPerrache Bus Stop0BasicA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 13/03/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 00:25:00. 50 Basic ticket for £23 per person are available. Travel duration is 15h 25m
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 13/03/2026 22:40:00. 50 Economy ticket for £42 per person are available. Travel duration is 14h 55m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 14/03/2026 12:00:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 0m
-
EasyJet Airline1h 40m009:15Rome Fiumicino AirportRome Fiumicino Airport10:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 09:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 13/03/2026 10:55:00. 50 Economy ticket for £27 per person are available. Travel duration is 1h 40m
-
Ryanair11h 5m020:30Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 20:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 07:35:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 5m
-
LC Perú13h 15m019:20Rome Fiumicino AirportRome Fiumicino Airport08:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 19:20:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 08:35:00. 50 Economy ticket for £52 per person are available. Travel duration is 13h 15m
-
Wizz Air9h 30m022:35Rome Fiumicino AirportRome Fiumicino Airport08:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 22:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 08:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 9h 30m
-
Iberia10h 20m013:25Rome Fiumicino AirportRome Fiumicino Airport23:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Iberia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 13:25:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 13/03/2026 23:45:00. 50 Economy ticket for £75 per person are available. Travel duration is 10h 20m
Cheapest Buses Friday
Cheapest Flights Friday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 00:25:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 16h 25m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 04:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 55m
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 14/03/2026 23:45:00. 50 Economy ticket for £45 per person are available. Travel duration is 14h 55m
-
FlixBus16h 45m016:00RomeTiburtina Bus Station08:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 15/03/2026 08:45:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 45m
-
LC Perú9h 25m022:35Rome Fiumicino AirportRome Fiumicino Airport08:00Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 22:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 08:00:00. 50 Economy ticket for £35 per person are available. Travel duration is 9h 25m
-
Vueling Airlines11h 5m020:30Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 20:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 07:35:00. 50 Economy ticket for £49 per person are available. Travel duration is 11h 5m
-
Skyscanner11h 55m019:40Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 07:35:00. 50 Economy ticket for £54 per person are available. Travel duration is 11h 55m
-
EasyJet Airline1h 40m010:30Rome Fiumicino AirportRome Fiumicino Airport12:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 10:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 12:10:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 40m
-
Air Malta23h 40m021:00Rome Fiumicino AirportRome Fiumicino Airport20:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Malta goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 21:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 20:40:00. 50 Economy ticket for £86 per person are available. Travel duration is 23h 40m
Cheapest Buses Saturday
Cheapest Flights Saturday
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 00:25:00. 50 Premium Economy ticket for £27 per person are available. Travel duration is 16h 25m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 12:55:00. 50 Premium Economy ticket for £31 per person are available. Travel duration is 15h 10m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 04:55:00. 50 Premium Economy ticket for £35 per person are available. Travel duration is 15h 55m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 12:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 0m
-
FlixBus16h 20m022:45RomeTiburtina Bus Station15:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 22:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 15:05:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 20m
Cheapest Buses Sunday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 17/03/2026 12:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 10m
-
Itabus14h 30m007:00RomeTiburtina Bus Station21:30LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 21:30:00. 50 Premium Economy ticket for £32 per person are available. Travel duration is 14h 30m
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 22:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 14h 55m
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 23:45:00. 50 Economy ticket for £41 per person are available. Travel duration is 14h 55m
Cheapest Buses Monday
What are the fastest trips from Rome to Lyon?
You can get to Lyon from Rome in just 1h 40m with a Flight from EasyJet Airline. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 12:55:00. 50 Premium Economy ticket for £31 per person are available. Travel duration is 15h 10m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 11/03/2026 12:55:00. 50 Premium Economy ticket for £38 per person are available. Travel duration is 15h 10m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 12:00:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 0m
-
FlixBus17h 40m022:45RomeTiburtina Bus Station16:25LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 10/03/2026 22:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 16:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 17h 40m
Fastest Buses Tuesday
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 11/03/2026 23:45:00. 50 Economy ticket for £45 per person are available. Travel duration is 14h 55m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 12/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 12:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 10m
-
FlixBus18h 20m012:10RomeTiburtina Bus Station06:30LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/03/2026 12:10:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 06:30:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 20m
Fastest Buses Wednesday
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 12/03/2026 22:40:00. 50 Economy ticket for £41 per person are available. Travel duration is 14h 55m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 04:55:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 15h 55m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 13/03/2026 12:00:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 0m
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 12/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 13/03/2026 00:25:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 16h 25m
Fastest Buses Thursday
-
EasyJet Airline1h 40m009:15Rome Fiumicino AirportRome Fiumicino Airport10:55Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 09:15:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 13/03/2026 10:55:00. 50 Economy ticket for £27 per person are available. Travel duration is 1h 40m
-
Wizz Air9h 30m022:35Rome Fiumicino AirportRome Fiumicino Airport08:05Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 22:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 08:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 9h 30m
-
Iberia10h 20m013:25Rome Fiumicino AirportRome Fiumicino Airport23:45Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Iberia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 13:25:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 13/03/2026 23:45:00. 50 Economy ticket for £75 per person are available. Travel duration is 10h 20m
-
Ryanair11h 5m020:30Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 20:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 07:35:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 5m
-
LC Perú13h 15m019:20Rome Fiumicino AirportRome Fiumicino Airport08:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 13/03/2026 19:20:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 08:35:00. 50 Economy ticket for £52 per person are available. Travel duration is 13h 15m
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 13/03/2026 22:40:00. 50 Economy ticket for £42 per person are available. Travel duration is 14h 55m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus15h 25m009:00RomeTiburtina Coach Station00:25LyonPerrache Bus Stop0BasicA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 13/03/2026 09:00:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 00:25:00. 50 Basic ticket for £23 per person are available. Travel duration is 15h 25m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 13/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 14/03/2026 12:00:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 0m
-
Itabus16h 25m008:00RomeTiburtina Coach Station00:25LyonPerrache Bus Stop0BasicA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 13/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 14/03/2026 00:25:00. 50 Basic ticket for £23 per person are available. Travel duration is 16h 25m
Fastest Flights Friday
Fastest Buses Friday
-
EasyJet Airline1h 40m010:30Rome Fiumicino AirportRome Fiumicino Airport12:10Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 10:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 14/03/2026 12:10:00. 50 Economy ticket for £60 per person are available. Travel duration is 1h 40m
-
LC Perú9h 25m022:35Rome Fiumicino AirportRome Fiumicino Airport08:00Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 22:35:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 08:00:00. 50 Economy ticket for £35 per person are available. Travel duration is 9h 25m
-
Vueling Airlines11h 5m020:30Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 20:30:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 07:35:00. 50 Economy ticket for £49 per person are available. Travel duration is 11h 5m
-
Skyscanner11h 55m019:40Rome Fiumicino AirportRome Fiumicino Airport07:35Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 19:40:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 07:35:00. 50 Economy ticket for £54 per person are available. Travel duration is 11h 55m
-
Air Malta23h 40m021:00Rome Fiumicino AirportRome Fiumicino Airport20:40Lyons St. Exupery AirportAéroport St Exupéry Coach Station0EconomyA Flight from Air Malta goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 14/03/2026 21:00:00 to Aéroport St Exupéry Coach Station, Lyons St. Exupery Airport (France) arriving at 15/03/2026 20:40:00. 50 Economy ticket for £86 per person are available. Travel duration is 23h 40m
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 14/03/2026 23:45:00. 50 Economy ticket for £45 per person are available. Travel duration is 14h 55m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 21:45:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 12:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 15h 10m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 04:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 55m
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 15/03/2026 00:25:00. 50 Premium Economy ticket for £25 per person are available. Travel duration is 16h 25m
-
FlixBus16h 45m016:00RomeTiburtina Bus Station08:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 14/03/2026 16:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 15/03/2026 08:45:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 45m
Fastest Flights Saturday
Fastest Buses Saturday
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 12:55:00. 50 Premium Economy ticket for £31 per person are available. Travel duration is 15h 10m
-
Itabus15h 55m013:00RomeTiburtina Bus Station04:55LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 13:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 04:55:00. 50 Premium Economy ticket for £35 per person are available. Travel duration is 15h 55m
-
FlixBus16h 0m020:00RomeTiburtina Bus Station12:00LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 20:00:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 12:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 0m
-
FlixBus16h 20m022:45RomeTiburtina Bus Station15:05LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 22:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 15:05:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 20m
-
Itabus16h 25m008:00RomeTiburtina Bus Station00:25LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 15/03/2026 08:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 00:25:00. 50 Premium Economy ticket for £27 per person are available. Travel duration is 16h 25m
Fastest Buses Sunday
-
Itabus14h 30m007:00RomeTiburtina Bus Station21:30LyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 07:00:00 to Perrache Bus Stop, Lyon (France) arriving at 16/03/2026 21:30:00. 50 Premium Economy ticket for £32 per person are available. Travel duration is 14h 30m
-
FlixBus14h 55m007:45RomeTiburtina Bus Station22:40LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 07:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 22:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 14h 55m
-
FlixBus14h 55m008:50RomeTiburtina Bus Station23:45LyonLyon Avenue Tony Garnier Coach Stop0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 08:50:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 16/03/2026 23:45:00. 50 Economy ticket for £41 per person are available. Travel duration is 14h 55m
-
Itabus15h 10m021:45RomeTiburtina Bus Station12:55LyonLyon Avenue Tony Garnier Coach Stop0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 16/03/2026 21:45:00 to Lyon Avenue Tony Garnier Coach Stop, Lyon (France) arriving at 17/03/2026 12:55:00. 50 Premium Economy ticket for £26 per person are available. Travel duration is 15h 10m
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Rome to Lyon
What are the most popular stations in Rome and Lyon?
In Rome, you will usually depart from Termini Central Station, Ostiense Train Station or Termini Bus Station, while in Lyon you will be arriving at Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Rome? With 6 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Lyon, you can pay as low as £22 with a Bus from Itabus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Lyon in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Lyon are Itabus, FlixBus and EasyJet Airline, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Caluire-et-Cuire, and look at flights from Rome Ciampino Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Lyon?
The most popular companies between Rome and Lyon, are Itabus, FlixBus and EasyJet Airline. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Itabus and FlixBus
Airlines: EasyJet Airline, LC Perú, Ryanair and 5 more.
All you need to know when you travel from Rome to Lyon
Check all information on comfort and services on all modes of transports from Rome to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Lyon
How can I reach Lyon from Rome?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Lyon from Rome.
How far is Lyon from Rome?
The distance between Rome and Lyon is 749.0 km.
What is the most ecofriendly mode of transport between Rome and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 127 kgs, and a flight 184 kgs.
What is the cheapest mode of transport from Rome to Lyon?
You can get to Lyon with just £22 by taking a Bus from Itabus.
What is the fastest way to get from Rome to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 40m with a Flight from EasyJet Airline.
More routes to Rome and to Lyon
Looking for more options? Here you can see the most popular routes to Rome and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Caserta to Rome
- Catanzaro to Rome
- Chieti to Rome
- Civitanova to Rome
- Grottaminarda to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Lanciano to Rome
- Lecce to Rome
- Marseille to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Perugia to Rome
- Pescara to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Venice to Rome
- Trips to Lyon
- Alicante to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Béziers to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Dijon to Lyon
- Geneva to Lyon
- Grenoble to Lyon
- Karlsruhe to Lyon
- London to Lyon
- Marseille to Lyon
- Milan to Lyon
- Montpellier to Lyon
- Naples to Lyon
- Nice to Lyon
- Paris to Lyon
- Poitiers to Lyon
- Sallanches to Lyon
- Toulon to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Vienna to Lyon
