What is the best way to travel from Chicago to St. Louis, MO?
Looking for a trip? Check and compare all the available Buses and Flights to St. Louis, MO from Chicago. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Chicago?
You can reach St. Louis, MO with just £30 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
Greyhound US9h 5m022:50ChicagoDowntown Coach Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 22:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 14/12/2025 07:55:00. 50 Economy ticket for £39 per person are available. Travel duration is 9h 5m
-
Greyhound US8h 45m023:10ChicagoUnion Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 13/12/2025 23:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 14/12/2025 07:55:00. 50 Economy ticket for £39 per person are available. Travel duration is 8h 45m
-
FlixBus5h 50m009:45ChicagoDowntown Coach Station15:35St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 09:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 15:35:00. 50 Economy ticket for £39 per person are available. Travel duration is 5h 50m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 15:20:00. 50 Economy ticket for £40 per person are available. Travel duration is 9h 10m
Cheapest Buses Saturday
-
Skyscanner1h 31m009:30Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:01St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 09:30:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 11:01:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 31m
-
Skyscanner1h 25m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 12:15:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
Skyscanner1h 25m013:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:25St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 13:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 14:25:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
United Airlines1h 26m014:14Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:40St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 14:14:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 15:40:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 26m
Cheapest Flights Sunday
-
FlixBus5h 45m000:40Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 15/12/2025 00:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 15/12/2025 06:25:00. 50 Economy ticket for £33 per person are available. Travel duration is 5h 45m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 15/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 15/12/2025 23:10:00. 50 Economy ticket for £37 per person are available. Travel duration is 6h 40m
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 15/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 8h 15m
-
Skyscanner1h 25m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 12:15:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
Skyscanner1h 28m015:35Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center17:03St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 15:35:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 17:03:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 28m
-
Skyscanner1h 27m017:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:17St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 17:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 19:17:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 27m
-
United Airlines1h 23m013:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:23St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 13:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 14:23:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 23m
-
United Airlines1h 26m014:14Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:40St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 14:14:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 15:40:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 26m
Cheapest Buses Monday
Cheapest Flights Monday
-
Greyhound US9h 15m014:10Chicago95th Red Line Station23:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 14:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 23:25:00. 50 Economy ticket for £33 per person are available. Travel duration is 9h 15m
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 07:55:00. 50 Economy ticket for £33 per person are available. Travel duration is 8h 15m
-
FlixBus9h 55m005:25Chicago95th Red Line Station15:20St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 05:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 15:20:00. 50 Economy ticket for £34 per person are available. Travel duration is 9h 55m
-
FlixBus15h 30m023:50Chicago95th Red Line Station15:20St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 23:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 15:20:00. 50 Economy ticket for £34 per person are available. Travel duration is 15h 30m
Cheapest Buses Tuesday
-
Greyhound US9h 15m014:10Chicago95th Red Line Station23:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 17/12/2025 14:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 23:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 9h 15m
-
Greyhound US7h 55m022:30Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 17/12/2025 22:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 7h 55m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 17/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 15:20:00. 50 Economy ticket for £32 per person are available. Travel duration is 9h 10m
-
Greyhound US8h 45m021:40ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 17/12/2025 21:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £32 per person are available. Travel duration is 8h 45m
-
Greyhound US8h 25m022:00ChicagoCanal & Van Buren06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 17/12/2025 22:00:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £32 per person are available. Travel duration is 8h 25m
Cheapest Buses Wednesday
-
FlixBus6h 10m000:15ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 00:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 10m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
FlixBus5h 50m009:45ChicagoDowntown Coach Station15:35St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 09:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 15:35:00. 50 Economy ticket for £37 per person are available. Travel duration is 5h 50m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 15:20:00. 50 Economy ticket for £41 per person are available. Travel duration is 9h 10m
-
Greyhound US9h 5m022:50ChicagoDowntown Coach Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 22:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 9h 5m
-
Skyscanner1h 37m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:27St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 12:27:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 37m
-
Skyscanner1h 30m012:56Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:26St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 12:56:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 14:26:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 30m
-
Skyscanner1h 27m015:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center16:27St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 15:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 16:27:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 27m
-
Skyscanner1h 30m016:24Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center17:54St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 16:24:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 17:54:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 30m
-
Skyscanner1h 28m017:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:18St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 17:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 19:18:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 28m
Cheapest Buses Thursday
Cheapest Flights Thursday
-
FlixBus6h 10m000:15ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 19/12/2025 00:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 06:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 10m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 19/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
FlixBus5h 45m000:40Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 19/12/2025 00:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 06:25:00. 50 Economy ticket for £35 per person are available. Travel duration is 5h 45m
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 19/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 20/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 8h 15m
Cheapest Buses Friday
What are the fastest trips from Chicago to St. Louis, MO?
You can get to St. Louis, MO from Chicago in just 1h 23m with a Flight from United Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
-
FlixBus5h 50m009:45ChicagoDowntown Coach Station15:35St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 09:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 15:35:00. 50 Economy ticket for £39 per person are available. Travel duration is 5h 50m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
Greyhound US8h 45m023:10ChicagoUnion Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 13/12/2025 23:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 14/12/2025 07:55:00. 50 Economy ticket for £39 per person are available. Travel duration is 8h 45m
-
Greyhound US9h 5m022:50ChicagoDowntown Coach Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 22:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 14/12/2025 07:55:00. 50 Economy ticket for £39 per person are available. Travel duration is 9h 5m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 13/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 13/12/2025 15:20:00. 50 Economy ticket for £40 per person are available. Travel duration is 9h 10m
Fastest Buses Saturday
-
Skyscanner1h 25m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 12:15:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
Skyscanner1h 25m013:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:25St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 13:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 14:25:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
United Airlines1h 26m014:14Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:40St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 14:14:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 15:40:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 26m
-
Skyscanner1h 31m009:30Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:01St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 14/12/2025 09:30:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 14/12/2025 11:01:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 31m
Fastest Flights Sunday
-
United Airlines1h 23m013:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:23St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 13:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 14:23:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 23m
-
Skyscanner1h 25m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 12:15:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 25m
-
United Airlines1h 26m014:14Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:40St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 14:14:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 15:40:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 26m
-
Skyscanner1h 27m017:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:17St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 17:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 19:17:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 27m
-
Skyscanner1h 28m015:35Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center17:03St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 15/12/2025 15:35:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 15/12/2025 17:03:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 28m
-
FlixBus5h 45m000:40Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 15/12/2025 00:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 15/12/2025 06:25:00. 50 Economy ticket for £33 per person are available. Travel duration is 5h 45m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 15/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 15/12/2025 23:10:00. 50 Economy ticket for £37 per person are available. Travel duration is 6h 40m
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 15/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 8h 15m
Fastest Flights Monday
Fastest Buses Monday
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 07:55:00. 50 Economy ticket for £33 per person are available. Travel duration is 8h 15m
-
Greyhound US9h 15m014:10Chicago95th Red Line Station23:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 14:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 23:25:00. 50 Economy ticket for £33 per person are available. Travel duration is 9h 15m
-
FlixBus9h 55m005:25Chicago95th Red Line Station15:20St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 05:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 16/12/2025 15:20:00. 50 Economy ticket for £34 per person are available. Travel duration is 9h 55m
-
FlixBus15h 30m023:50Chicago95th Red Line Station15:20St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 16/12/2025 23:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 15:20:00. 50 Economy ticket for £34 per person are available. Travel duration is 15h 30m
Fastest Buses Tuesday
-
Greyhound US7h 55m022:30Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 17/12/2025 22:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 7h 55m
-
Greyhound US8h 25m022:00ChicagoCanal & Van Buren06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 17/12/2025 22:00:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £32 per person are available. Travel duration is 8h 25m
-
Greyhound US8h 45m021:40ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 17/12/2025 21:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £32 per person are available. Travel duration is 8h 45m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 17/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 15:20:00. 50 Economy ticket for £32 per person are available. Travel duration is 9h 10m
-
Greyhound US9h 15m014:10Chicago95th Red Line Station23:25St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 17/12/2025 14:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 17/12/2025 23:25:00. 50 Economy ticket for £30 per person are available. Travel duration is 9h 15m
Fastest Buses Wednesday
-
Skyscanner1h 27m015:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center16:27St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 15:00:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 16:27:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 27m
-
Skyscanner1h 28m017:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:18St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 17:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 19:18:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 28m
-
Skyscanner1h 30m012:56Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center14:26St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 12:56:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 14:26:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 30m
-
Skyscanner1h 30m016:24Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center17:54St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 16:24:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 17:54:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 30m
-
Skyscanner1h 37m010:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:27St. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 18/12/2025 10:50:00 to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 18/12/2025 12:27:00. 50 Economy ticket for £229 per person are available. Travel duration is 1h 37m
-
FlixBus5h 50m009:45ChicagoDowntown Coach Station15:35St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 09:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 15:35:00. 50 Economy ticket for £37 per person are available. Travel duration is 5h 50m
-
FlixBus6h 10m000:15ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 00:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 06:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 10m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
Greyhound US9h 5m022:50ChicagoDowntown Coach Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 22:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 9h 5m
-
Greyhound US9h 10m006:10ChicagoDowntown Coach Station15:20St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 18/12/2025 06:10:00 to Gateway Station, St. Louis, MO (USA) arriving at 18/12/2025 15:20:00. 50 Economy ticket for £41 per person are available. Travel duration is 9h 10m
Fastest Flights Thursday
Fastest Buses Thursday
-
FlixBus5h 45m000:40Chicago95th Red Line Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 19/12/2025 00:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 06:25:00. 50 Economy ticket for £35 per person are available. Travel duration is 5h 45m
-
FlixBus6h 10m000:15ChicagoDowntown Coach Station06:25St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 19/12/2025 00:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 06:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 10m
-
FlixBus6h 40m016:30ChicagoDowntown Coach Station23:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 19/12/2025 16:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 19/12/2025 23:10:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 40m
-
Greyhound US8h 15m023:40Chicago95th Red Line Station07:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 19/12/2025 23:40:00 to Gateway Station, St. Louis, MO (USA) arriving at 20/12/2025 07:55:00. 50 Economy ticket for £41 per person are available. Travel duration is 8h 15m
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Chicago to St. Louis, MO
What are the most popular stations in Chicago and St. Louis, MO?
In Chicago, you will usually depart from California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Chicago? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and St. Louis, MO, you can pay as low as £30 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 1h 23m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and St. Louis, MO are Greyhound US, FlixBus and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to Sauget, IL, and look at flights from Chicago Midway Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to St. Louis, MO?
The most popular companies between Chicago and St. Louis, MO, are Greyhound US, FlixBus and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Skyscanner and United Airlines
All you need to know when you travel from Chicago to St. Louis, MO
Check all information on comfort and services on all modes of transports from Chicago to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to St. Louis, MO
How can I reach St. Louis, MO from Chicago?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to St. Louis, MO from Chicago.
How far is St. Louis, MO from Chicago?
The distance between Chicago and St. Louis, MO is 422.1 km.
What is the most ecofriendly mode of transport between Chicago and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 15 kgs, a car 72 kgs, and a flight 104 kgs.
What is the cheapest mode of transport from Chicago to St. Louis, MO?
You can get to St. Louis, MO with just £30 by taking a Bus from Greyhound US.
What is the fastest way to get from Chicago to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 1h 23m with a Flight from United Airlines.
More routes to Chicago and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Chicago and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Pearson Toronto Airport to Chicago
- Philadelphia, PA to Chicago
- Phoenix, AZ to Chicago
- San Antonio, TX to Chicago
- San Luis Potosí to Chicago
- Santiago de Queretaro to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago

