What is the best way to travel from Buffalo, NY to Chicago?
Looking for a trip? Check and compare all the available Flights and Buses to Chicago from Buffalo, NY. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from Buffalo, NY?
You can reach Chicago with just £52 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 22/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 23/03/2026 08:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 25h 5m
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 22/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 22/03/2026 20:05:00. 50 Economy ticket for £58 per person are available. Travel duration is 13h 10m
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Frontier Airlines17h 34m021:47Buffalo AirportBuffalo Airport14:21Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 21:47:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 23/03/2026 14:21:00. 50 Economy ticket for £95 per person are available. Travel duration is 17h 34m
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Frontier Airlines28h 2m020:42Buffalo AirportBuffalo Airport23:44Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 20:42:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 23:44:00. 50 Economy ticket for £95 per person are available. Travel duration is 28h 2m
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Frontier Airlines18h 38m021:47Buffalo AirportBuffalo Airport15:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 21:47:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 15:25:00. 50 Economy ticket for £95 per person are available. Travel duration is 18h 38m
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Frontier Airlines10h 34m012:45Buffalo AirportBuffalo Airport22:19Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 12:45:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 22/03/2026 22:19:00. 50 Economy ticket for £139 per person are available. Travel duration is 10h 34m
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 22/03/2026 11:25:00. 50 Economy ticket for £168 per person are available. Travel duration is 6h 25m
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Frontier Airlines8h 2m012:45Buffalo AirportBuffalo Airport19:47Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 12:45:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 22/03/2026 19:47:00. 50 Economy ticket for £210 per person are available. Travel duration is 8h 2m
Cheapest Buses Sunday
Cheapest Flights Sunday
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 11:25:00. 50 Economy ticket for £66 per person are available. Travel duration is 6h 25m
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Frontier Airlines21h 24m011:59Buffalo AirportBuffalo Airport08:23Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 11:59:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 24/03/2026 08:23:00. 50 Economy ticket for £67 per person are available. Travel duration is 21h 24m
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 08:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 0m
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Skyscanner2h 8m013:52Buffalo AirportBuffalo Airport15:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 13:52:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 15:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 8m
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Allegiant Air24h 3m021:00Niagara Falls AirportNiagara Falls Airport20:03Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 23/03/2026 21:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 24/03/2026 20:03:00. 50 Economy ticket for £156 per person are available. Travel duration is 24h 3m
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Allegiant Air19h 33m021:00Niagara Falls AirportNiagara Falls Airport15:33Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 23/03/2026 21:00:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 24/03/2026 15:33:00. 50 Economy ticket for £162 per person are available. Travel duration is 19h 33m
Cheapest Flights Monday
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to Canal & Van Buren, Chicago (USA) arriving at 25/03/2026 08:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 25h 5m
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 24/03/2026 20:05:00. 50 Economy ticket for £55 per person are available. Travel duration is 13h 10m
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Greyhound US16h 40m007:55Buffalo, NYCentral Coach Station23:35Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to 95th Red Line Station, Chicago (USA) arriving at 24/03/2026 23:35:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 40m
Cheapest Buses Tuesday
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 25/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 26/03/2026 08:00:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 5m
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 25/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 25/03/2026 20:05:00. 50 Economy ticket for £52 per person are available. Travel duration is 13h 10m
Cheapest Buses Wednesday
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 08:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 0m
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Skyscanner2h 11m017:29Buffalo AirportBuffalo Airport18:40Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 17:29:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 18:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 11m
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Frontier Airlines10h 49m012:50Buffalo AirportBuffalo Airport22:39Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 12:50:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 22:39:00. 50 Economy ticket for £119 per person are available. Travel duration is 10h 49m
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 11:25:00. 50 Economy ticket for £140 per person are available. Travel duration is 6h 25m
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Allegiant Air11h 42m010:00Niagara Falls AirportNiagara Falls Airport20:42Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 26/03/2026 10:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 20:42:00. 50 Economy ticket for £264 per person are available. Travel duration is 11h 42m
Cheapest Flights Thursday
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 27/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 27/03/2026 20:05:00. 50 Economy ticket for £55 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 27/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 28/03/2026 08:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 25h 5m
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 08:00:00. 50 Economy ticket for £97 per person are available. Travel duration is 2h 0m
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Skyscanner2h 8m013:52Buffalo AirportBuffalo Airport15:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 13:52:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 15:00:00. 50 Economy ticket for £122 per person are available. Travel duration is 2h 8m
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Skyscanner2h 11m017:29Buffalo AirportBuffalo Airport18:40Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 17:29:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 18:40:00. 50 Economy ticket for £122 per person are available. Travel duration is 2h 11m
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Frontier Airlines10h 49m012:50Buffalo AirportBuffalo Airport22:39Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 12:50:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 22:39:00. 50 Economy ticket for £194 per person are available. Travel duration is 10h 49m
Cheapest Buses Friday
Cheapest Flights Friday
What are the fastest trips from Buffalo, NY to Chicago?
You can get to Chicago from Buffalo, NY in just 2h 0m with a Flight from United Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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United Airlines2h 3m006:51Buffalo AirportBuffalo Airport07:54Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 06:51:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 22/03/2026 07:54:00. 50 Economy ticket for £277 per person are available. Travel duration is 2h 3m
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 22/03/2026 11:25:00. 50 Economy ticket for £168 per person are available. Travel duration is 6h 25m
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Frontier Airlines8h 2m012:45Buffalo AirportBuffalo Airport19:47Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 12:45:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 22/03/2026 19:47:00. 50 Economy ticket for £210 per person are available. Travel duration is 8h 2m
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JetBlue Airways8h 30m009:54Buffalo AirportBuffalo Airport17:24Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 09:54:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 22/03/2026 17:24:00. 50 Economy ticket for £232 per person are available. Travel duration is 8h 30m
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Frontier Airlines10h 34m012:45Buffalo AirportBuffalo Airport22:19Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 12:45:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 22/03/2026 22:19:00. 50 Economy ticket for £139 per person are available. Travel duration is 10h 34m
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Frontier Airlines17h 34m021:47Buffalo AirportBuffalo Airport14:21Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 22/03/2026 21:47:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 23/03/2026 14:21:00. 50 Economy ticket for £95 per person are available. Travel duration is 17h 34m
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 22/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 22/03/2026 20:05:00. 50 Economy ticket for £58 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 22/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 23/03/2026 08:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 25h 5m
Fastest Flights Sunday
Fastest Buses Sunday
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 08:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 0m
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Skyscanner2h 8m013:52Buffalo AirportBuffalo Airport15:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 13:52:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 15:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 8m
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 23/03/2026 11:25:00. 50 Economy ticket for £66 per person are available. Travel duration is 6h 25m
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Allegiant Air19h 33m021:00Niagara Falls AirportNiagara Falls Airport15:33Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 23/03/2026 21:00:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 24/03/2026 15:33:00. 50 Economy ticket for £162 per person are available. Travel duration is 19h 33m
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Frontier Airlines21h 24m011:59Buffalo AirportBuffalo Airport08:23Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 23/03/2026 11:59:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 24/03/2026 08:23:00. 50 Economy ticket for £67 per person are available. Travel duration is 21h 24m
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Allegiant Air24h 3m021:00Niagara Falls AirportNiagara Falls Airport20:03Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 23/03/2026 21:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 24/03/2026 20:03:00. 50 Economy ticket for £156 per person are available. Travel duration is 24h 3m
Fastest Flights Monday
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 24/03/2026 20:05:00. 50 Economy ticket for £55 per person are available. Travel duration is 13h 10m
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Greyhound US16h 40m007:55Buffalo, NYCentral Coach Station23:35Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to 95th Red Line Station, Chicago (USA) arriving at 24/03/2026 23:35:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 40m
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 24/03/2026 07:55:00 to Canal & Van Buren, Chicago (USA) arriving at 25/03/2026 08:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 25h 5m
Fastest Buses Tuesday
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 25/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 25/03/2026 20:05:00. 50 Economy ticket for £52 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 25/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 26/03/2026 08:00:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 5m
Fastest Buses Wednesday
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 08:00:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 0m
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Skyscanner2h 11m017:29Buffalo AirportBuffalo Airport18:40Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 17:29:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 18:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 2h 11m
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JetBlue Airways6h 25m006:00Buffalo AirportBuffalo Airport11:25Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 06:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 11:25:00. 50 Economy ticket for £140 per person are available. Travel duration is 6h 25m
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Frontier Airlines10h 49m012:50Buffalo AirportBuffalo Airport22:39Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 26/03/2026 12:50:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 22:39:00. 50 Economy ticket for £119 per person are available. Travel duration is 10h 49m
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Allegiant Air11h 42m010:00Niagara Falls AirportNiagara Falls Airport20:42Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 26/03/2026 10:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 26/03/2026 20:42:00. 50 Economy ticket for £264 per person are available. Travel duration is 11h 42m
Fastest Flights Thursday
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United Airlines2h 0m007:00Buffalo AirportBuffalo Airport08:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 07:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 08:00:00. 50 Economy ticket for £97 per person are available. Travel duration is 2h 0m
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Skyscanner2h 8m013:52Buffalo AirportBuffalo Airport15:00Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 13:52:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 15:00:00. 50 Economy ticket for £122 per person are available. Travel duration is 2h 8m
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Skyscanner2h 11m017:29Buffalo AirportBuffalo Airport18:40Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 17:29:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 18:40:00. 50 Economy ticket for £122 per person are available. Travel duration is 2h 11m
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Frontier Airlines10h 49m012:50Buffalo AirportBuffalo Airport22:39Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 27/03/2026 12:50:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 27/03/2026 22:39:00. 50 Economy ticket for £194 per person are available. Travel duration is 10h 49m
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Greyhound US13h 10m007:55Buffalo, NYCentral Coach Station20:05ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 27/03/2026 07:55:00 to Downtown Coach Station, Chicago (USA) arriving at 27/03/2026 20:05:00. 50 Economy ticket for £55 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m007:55Buffalo, NYCentral Coach Station08:00ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Buffalo, NY (USA) at 27/03/2026 07:55:00 to Union Station, Chicago (USA) arriving at 28/03/2026 08:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 25h 5m
Fastest Flights Friday
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Buffalo, NY to Chicago
What are the most popular stations in Buffalo, NY and Chicago?
In Buffalo, NY, you will usually depart from Central Coach Station, Exchange Street Train Station or Maple Road Gulf, while in Chicago you will be arriving at California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from Buffalo, NY? With 6 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Buffalo, NY and Chicago, you can pay as low as £52 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 2h 0m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Buffalo, NY and Chicago are Frontier Airlines, Greyhound US and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Buffalo, NY and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sloan, NY or to Cicero, IL, and look at flights from Niagara Falls Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Buffalo, NY to Chicago?
The most popular companies between Buffalo, NY and Chicago, are Frontier Airlines, Greyhound US and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Frontier Airlines, United Airlines, Allegiant Air and 2 more.
All you need to know when you travel from Buffalo, NY to Chicago
Check all information on comfort and services on all modes of transports from Buffalo, NY to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Buffalo, NY to Chicago
How can I reach Chicago from Buffalo, NY?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Chicago from Buffalo, NY.
How far is Chicago from Buffalo, NY?
The distance between Buffalo, NY and Chicago is 728.4 km.
What is the most ecofriendly mode of transport between Buffalo, NY and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 25 kgs, a car 124 kgs, and a flight 179 kgs.
What is the cheapest mode of transport from Buffalo, NY to Chicago?
You can get to Chicago with just £52 by taking a Bus from Greyhound US.
What is the fastest way to get from Buffalo, NY to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 2h 0m with a Flight from United Airlines.
More routes to Buffalo, NY and to Chicago
Looking for more options? Here you can see the most popular routes to Buffalo, NY and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Buffalo, NY
- Atlanta, GA to Buffalo, NY
- Birmingham, AL to Buffalo, NY
- New York to Buffalo, NY
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Cincinnati to Chicago
- Ciudad Juárez to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Houston to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Matamoros to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- New York to Chicago
- Oklahoma City, OK to Chicago
- Philadelphia, PA to Chicago
- Phoenix, AZ to Chicago
- Santiago de Queretaro to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
