How to get from St. Louis, MO to Chicago

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What is the best way to travel from St. Louis, MO to Chicago?

Looking for a trip? Check and compare all the available Buses and Flights to Chicago from St. Louis, MO. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
5h 50m
£25
£34
14
Flight
1h 23m
£45
£73
7

What is the cheapest way to reach Chicago from St. Louis, MO?

You can reach Chicago with just £25 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.

Friday
from £26
Saturday
from £25
Sunday
from £27
Monday
from £26
Tuesday
Wednesday
from £36
Thursday
from £27

    Cheapest Buses Friday

  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £26
  • FlixBus
    5h 50m
    0
    16:00
    St. Louis, MO
    Gateway Station
    21:50
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £28
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £29
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £41
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £41

    Cheapest Buses Saturday

  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £25
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £26
  • FlixBus
    6h 15m
    0
    16:00
    St. Louis, MO
    Gateway Station
    22:15
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £27
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £38
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £41
  • Cheapest Flights Saturday

  • Frontier Airlines
    15h 25m
    0
    19:43
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    11:08
    Chicago Midway Airport
    Chicago Midway Airport
    0
    Frontier Airlines
    Economy
    from £45
  • Skyscanner
    1h 29m
    0
    06:30
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    07:59
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • Skyscanner
    1h 29m
    0
    08:00
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    09:29
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • Skyscanner
    1h 30m
    0
    13:00
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    14:30
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • United Airlines
    1h 23m
    0
    17:27
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    18:50
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    United Airlines
    Economy
    from £64
  • Frontier Airlines
    25h 57m
    0
    15:30
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    17:27
    Chicago Midway Airport
    Chicago Midway Airport
    0
    Frontier Airlines
    Economy
    from £136

    Cheapest Buses Sunday

  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £27
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £29
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £41
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £42

    Cheapest Buses Monday

  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £26
  • FlixBus
    6h 15m
    0
    16:00
    St. Louis, MO
    Gateway Station
    22:15
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £28
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £39
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £45

    Cheapest Buses Wednesday

  • Greyhound US
    9h 5m
    0
    13:55
    St. Louis, MO
    Gateway Station
    23:00
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £36
  • Greyhound US
    11h 40m
    0
    02:00
    St. Louis, MO
    Gateway Station
    13:40
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £37
  • Greyhound US
    13h 40m
    0
    08:45
    St. Louis, MO
    Gateway Station
    22:25
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £37
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £42
  • Greyhound US
    12h 35m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:35
    Chicago
    Downtown Coach Station
    0
    Greyhound US
    Economy
    £42

    Cheapest Buses Thursday

  • Greyhound US
    9h 5m
    0
    13:55
    St. Louis, MO
    Gateway Station
    23:00
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £27
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £29
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £31

What are the fastest trips from St. Louis, MO to Chicago?

You can get to Chicago from St. Louis, MO in just 1h 23m with a Flight from United Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.

Friday
from 5h 50m
Saturday
from 1h 23m
Sunday
from 6h 25m
Monday
from 6h 15m
Tuesday
Wednesday
from 9h 5m
Thursday
from 6h 25m

    Fastest Buses Friday

  • FlixBus
    5h 50m
    0
    16:00
    St. Louis, MO
    Gateway Station
    21:50
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £28
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £29
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £26
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £41
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £41

    Fastest Flights Saturday

  • United Airlines
    1h 23m
    0
    17:27
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    18:50
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    United Airlines
    Economy
    from £64
  • Skyscanner
    1h 29m
    0
    06:30
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    07:59
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • Skyscanner
    1h 29m
    0
    08:00
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    09:29
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • Skyscanner
    1h 30m
    0
    13:00
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    14:30
    Chicago O'Hare Airport
    Chicago O'Hare Airport - Bus/Shuttle Center
    0
    Skyscanner
    Economy
    from £64
  • Frontier Airlines
    15h 25m
    0
    19:43
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    11:08
    Chicago Midway Airport
    Chicago Midway Airport
    0
    Frontier Airlines
    Economy
    from £45
  • Frontier Airlines
    25h 57m
    0
    15:30
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    17:27
    Chicago Midway Airport
    Chicago Midway Airport
    0
    Frontier Airlines
    Economy
    from £136
  • Fastest Buses Saturday

  • FlixBus
    6h 15m
    0
    16:00
    St. Louis, MO
    Gateway Station
    22:15
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £27
  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £26
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £25
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £38
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £41

    Fastest Buses Sunday

  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £29
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £27
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £41
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £42

    Fastest Buses Monday

  • FlixBus
    6h 15m
    0
    16:00
    St. Louis, MO
    Gateway Station
    22:15
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £28
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £26
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Canal & Van Buren
    0
    Greyhound US
    Economy
    £39
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £45

    Fastest Buses Wednesday

  • Greyhound US
    9h 5m
    0
    13:55
    St. Louis, MO
    Gateway Station
    23:00
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £36
  • Greyhound US
    11h 40m
    0
    02:00
    St. Louis, MO
    Gateway Station
    13:40
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £37
  • Greyhound US
    12h 10m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:10
    Chicago
    Union Station
    0
    Greyhound US
    Economy
    £42
  • Greyhound US
    12h 35m
    0
    02:00
    St. Louis, MO
    Gateway Station
    14:35
    Chicago
    Downtown Coach Station
    0
    Greyhound US
    Economy
    £42
  • Greyhound US
    13h 40m
    0
    08:45
    St. Louis, MO
    Gateway Station
    22:25
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £37

    Fastest Buses Thursday

  • FlixBus
    6h 25m
    0
    09:30
    St. Louis, MO
    Gateway Station
    15:55
    Chicago
    95th Red Line Station
    0
    FlixBus
    Economy
    £31
  • FlixBus
    7h 0m
    0
    09:30
    St. Louis, MO
    Gateway Station
    16:30
    Chicago
    Downtown Coach Station
    0
    FlixBus
    Economy
    £29
  • Greyhound US
    9h 5m
    0
    13:55
    St. Louis, MO
    Gateway Station
    23:00
    Chicago
    95th Red Line Station
    0
    Greyhound US
    Economy
    £27
Here you will find all operators and timetables for a Bus from St. Louis, MO to Chicago

What are the most popular stations in St. Louis, MO and Chicago?

In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in Chicago you will be arriving at California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to Chicago from St. Louis, MO? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and Chicago, you can pay as low as £25 with a Bus from FlixBus.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 1h 23m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and Chicago are FlixBus, Greyhound US and Skyscanner, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in St. Louis, MO and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Cicero, IL, and look at flights from St. Louis Lambert Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from St. Louis, MO to Chicago?

The most popular companies between St. Louis, MO and Chicago, are FlixBus, Greyhound US and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: FlixBus and Greyhound US

Airlines: Skyscanner, Frontier Airlines and United Airlines

All you need to know when you travel from St. Louis, MO to Chicago

Check all information on comfort and services on all modes of transports from St. Louis, MO to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from St. Louis, MO to Chicago

How can I reach Chicago from St. Louis, MO?

Every day, there are on average 6 connections between Bus and Flight, with which you can get to Chicago from St. Louis, MO.

How far is Chicago from St. Louis, MO?

The distance between St. Louis, MO and Chicago is 422.1 km.

What is the most ecofriendly mode of transport between St. Louis, MO and Chicago?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 15 kgs, a car 72 kgs, and a flight 104 kgs.

What is the cheapest mode of transport from St. Louis, MO to Chicago?

You can get to Chicago with just £25 by taking a Bus from FlixBus.

What is the fastest way to get from St. Louis, MO to Chicago?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 1h 23m with a Flight from United Airlines.

More routes to St. Louis, MO and to Chicago

Looking for more options? Here you can see the most popular routes to St. Louis, MO and to Chicago. Simply click on a connection, and you’ll find all the details about the route!

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