What is the best way to travel from St. Louis, MO to Chicago?
Looking for a trip? Check and compare all the available Buses and Flights to Chicago from St. Louis, MO. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from St. Louis, MO?
You can reach Chicago with just £25 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 05/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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FlixBus5h 50m016:00St. Louis, MOGateway Station21:50Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 16:00:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 5h 50m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 05/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 05/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
Cheapest Buses Friday
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 16:30:00. 50 Economy ticket for £25 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 06/12/2025 15:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 25m
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FlixBus6h 15m016:00St. Louis, MOGateway Station22:15ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £27 per person are available. Travel duration is 6h 15m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 06/12/2025 14:10:00. 50 Economy ticket for £38 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 06/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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Frontier Airlines15h 25m019:43St. Louis Lambert AirportSt. Louis Lambert Airport11:08Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 19:43:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 07/12/2025 11:08:00. 50 Economy ticket for £45 per person are available. Travel duration is 15h 25m
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Skyscanner1h 29m006:30St. Louis Lambert AirportSt. Louis Lambert Airport07:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 06:30:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 07:59:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 29m
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Skyscanner1h 29m008:00St. Louis Lambert AirportSt. Louis Lambert Airport09:29Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 08:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 09:29:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 29m
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Skyscanner1h 30m013:00St. Louis Lambert AirportSt. Louis Lambert Airport14:30Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 13:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 14:30:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 30m
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United Airlines1h 23m017:27St. Louis Lambert AirportSt. Louis Lambert Airport18:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 17:27:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 18:50:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 23m
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Frontier Airlines25h 57m015:30St. Louis Lambert AirportSt. Louis Lambert Airport17:27Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 15:30:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 07/12/2025 17:27:00. 50 Economy ticket for £136 per person are available. Travel duration is 25h 57m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 07/12/2025 16:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 07/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 10m
Cheapest Buses Sunday
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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FlixBus6h 15m016:00St. Louis, MOGateway Station22:15ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 15m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 08/12/2025 14:10:00. 50 Economy ticket for £39 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 08/12/2025 14:10:00. 50 Economy ticket for £45 per person are available. Travel duration is 12h 10m
Cheapest Buses Monday
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Greyhound US9h 5m013:55St. Louis, MOGateway Station23:00Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 23:00:00. 50 Economy ticket for £36 per person are available. Travel duration is 9h 5m
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Greyhound US11h 40m002:00St. Louis, MOGateway Station13:40Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 13:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 11h 40m
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Greyhound US13h 40m008:45St. Louis, MOGateway Station22:25Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 08:45:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 22:25:00. 50 Economy ticket for £37 per person are available. Travel duration is 13h 40m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 10/12/2025 14:10:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 10m
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Greyhound US12h 35m002:00St. Louis, MOGateway Station14:35ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Downtown Coach Station, Chicago (USA) arriving at 10/12/2025 14:35:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 35m
Cheapest Buses Wednesday
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Greyhound US9h 5m013:55St. Louis, MOGateway Station23:00Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 23:00:00. 50 Economy ticket for £27 per person are available. Travel duration is 9h 5m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 11/12/2025 16:30:00. 50 Economy ticket for £29 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 15:55:00. 50 Economy ticket for £31 per person are available. Travel duration is 6h 25m
Cheapest Buses Thursday
What are the fastest trips from St. Louis, MO to Chicago?
You can get to Chicago from St. Louis, MO in just 1h 23m with a Flight from United Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus5h 50m016:00St. Louis, MOGateway Station21:50Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 16:00:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 21:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 5h 50m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 05/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 05/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 05/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 05/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
Fastest Buses Friday
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United Airlines1h 23m017:27St. Louis Lambert AirportSt. Louis Lambert Airport18:50Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 17:27:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 18:50:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 23m
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Skyscanner1h 29m006:30St. Louis Lambert AirportSt. Louis Lambert Airport07:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 06:30:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 07:59:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 29m
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Skyscanner1h 29m008:00St. Louis Lambert AirportSt. Louis Lambert Airport09:29Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 08:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 09:29:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 29m
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Skyscanner1h 30m013:00St. Louis Lambert AirportSt. Louis Lambert Airport14:30Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 13:00:00 to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 06/12/2025 14:30:00. 50 Economy ticket for £64 per person are available. Travel duration is 1h 30m
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Frontier Airlines15h 25m019:43St. Louis Lambert AirportSt. Louis Lambert Airport11:08Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 19:43:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 07/12/2025 11:08:00. 50 Economy ticket for £45 per person are available. Travel duration is 15h 25m
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Frontier Airlines25h 57m015:30St. Louis Lambert AirportSt. Louis Lambert Airport17:27Chicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 06/12/2025 15:30:00 to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 07/12/2025 17:27:00. 50 Economy ticket for £136 per person are available. Travel duration is 25h 57m
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FlixBus6h 15m016:00St. Louis, MOGateway Station22:15ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 22:15:00. 50 Economy ticket for £27 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 06/12/2025 15:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 06/12/2025 16:30:00. 50 Economy ticket for £25 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 06/12/2025 14:10:00. 50 Economy ticket for £38 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 06/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 07/12/2025 15:55:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 07/12/2025 16:30:00. 50 Economy ticket for £27 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £41 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 07/12/2025 14:10:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 10m
Fastest Buses Sunday
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FlixBus6h 15m016:00St. Louis, MOGateway Station22:15ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 16:00:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 15m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 08/12/2025 16:30:00. 50 Economy ticket for £26 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 02:00:00 to Canal & Van Buren, Chicago (USA) arriving at 08/12/2025 14:10:00. 50 Economy ticket for £39 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 08/12/2025 14:10:00. 50 Economy ticket for £45 per person are available. Travel duration is 12h 10m
Fastest Buses Monday
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Greyhound US9h 5m013:55St. Louis, MOGateway Station23:00Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 23:00:00. 50 Economy ticket for £36 per person are available. Travel duration is 9h 5m
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Greyhound US11h 40m002:00St. Louis, MOGateway Station13:40Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 13:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 11h 40m
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Greyhound US12h 10m002:00St. Louis, MOGateway Station14:10ChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Union Station, Chicago (USA) arriving at 10/12/2025 14:10:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 10m
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Greyhound US12h 35m002:00St. Louis, MOGateway Station14:35ChicagoDowntown Coach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 02:00:00 to Downtown Coach Station, Chicago (USA) arriving at 10/12/2025 14:35:00. 50 Economy ticket for £42 per person are available. Travel duration is 12h 35m
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Greyhound US13h 40m008:45St. Louis, MOGateway Station22:25Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/12/2025 08:45:00 to 95th Red Line Station, Chicago (USA) arriving at 10/12/2025 22:25:00. 50 Economy ticket for £37 per person are available. Travel duration is 13h 40m
Fastest Buses Wednesday
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FlixBus6h 25m009:30St. Louis, MOGateway Station15:55Chicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 15:55:00. 50 Economy ticket for £31 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m009:30St. Louis, MOGateway Station16:30ChicagoDowntown Coach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 09:30:00 to Downtown Coach Station, Chicago (USA) arriving at 11/12/2025 16:30:00. 50 Economy ticket for £29 per person are available. Travel duration is 7h 0m
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Greyhound US9h 5m013:55St. Louis, MOGateway Station23:00Chicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 11/12/2025 13:55:00 to 95th Red Line Station, Chicago (USA) arriving at 11/12/2025 23:00:00. 50 Economy ticket for £27 per person are available. Travel duration is 9h 5m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to Chicago
What are the most popular stations in St. Louis, MO and Chicago?
In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in Chicago you will be arriving at California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from St. Louis, MO? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and Chicago, you can pay as low as £25 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 1h 23m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and Chicago are FlixBus, Greyhound US and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Cicero, IL, and look at flights from St. Louis Lambert Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to Chicago?
The most popular companies between St. Louis, MO and Chicago, are FlixBus, Greyhound US and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: Skyscanner, Frontier Airlines and United Airlines
All you need to know when you travel from St. Louis, MO to Chicago
Check all information on comfort and services on all modes of transports from St. Louis, MO to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to Chicago
How can I reach Chicago from St. Louis, MO?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to Chicago from St. Louis, MO.
How far is Chicago from St. Louis, MO?
The distance between St. Louis, MO and Chicago is 422.1 km.
What is the most ecofriendly mode of transport between St. Louis, MO and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 15 kgs, a car 72 kgs, and a flight 104 kgs.
What is the cheapest mode of transport from St. Louis, MO to Chicago?
You can get to Chicago with just £25 by taking a Bus from FlixBus.
What is the fastest way to get from St. Louis, MO to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 1h 23m with a Flight from United Airlines.
More routes to St. Louis, MO and to Chicago
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to St. Louis, MO
- Atlanta, GA to St. Louis, MO
- Ciudad Juárez to St. Louis, MO
- Dallas to St. Louis, MO
- Mexico City to St. Louis, MO
- Monterrey, NL to St. Louis, MO
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Dallas to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- Louisville, KY to Chicago
- McAllen, TX to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Mississauga, ON to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Oklahoma City, OK to Chicago
- Pearson Toronto Airport to Chicago
- Phoenix, AZ to Chicago
- Pittsburgh to Chicago
- San Antonio, TX to Chicago
- San Luis Potosí to Chicago
- Santiago de Queretaro to Chicago
- Toronto, ON to Chicago

