Bus and Coach from Siena to Milan: Compare all prices

Compare all timetables for the bus from Siena to Milan

Here is a selection of the cheapest bus trips from the schedule from Siena to Milan from various bus operators like FlixBus or Itabus for the next days.

today

tomorrow

Sunday

£9

Monday

Tuesday

£11

Wednesday

£6

Thursday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	4h 50m	06:40	Siena	Train Station	11:30	Milan	San Donato Bus Station	Economy	£9	A Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 11:30:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 50m
FlixBus	5h 45m	06:10	Siena	Train Station	11:55	Milan	Lampugnano Bus Station	Economy	£9	A Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 11:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 45m
Itabus	5h 50m	01:05	Siena	Train Station	06:55	Milan	Lampugnano Bus Station	Premium Economy	£9	A Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 06:55:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 50m
Itabus	5h 14m	18:35	Siena	Train Station	23:49	Milan	San Donato Bus Station	Premium Economy	£9	A Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 23:49:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 14m
Itabus	5h 45m	10:55	Siena	Train Station	16:40	Milan	Lampugnano Bus Station	Premium Economy	£9	A Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55	Siena	Train Station	16:40	Milan	Lampugnano Bus Station	Premium Economy	£11	A Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 16:40:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 5h 45m
Itabus	5h 50m	01:05	Siena	Train Station	06:55	Milan	Lampugnano Bus Station	Premium Economy	£22	A Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 06:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 5h 50m
Itabus	7h 5m	01:05	Siena	Train Station	08:10	Milan	San Donato Bus Station	Premium Economy	£37	A Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 08:10:00. 50 Premium Economy ticket for £37 per person are available. Travel duration is 7h 5m
Itabus	6h 30m	01:05	Siena	Train Station	07:35	Milan	San Donato Bus Station	Premium Economy	£46	A Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 07:35:00. 50 Premium Economy ticket for £46 per person are available. Travel duration is 6h 30m
Itabus	6h 0m	01:05	Siena	Train Station	07:05	Milan	San Donato Bus Station	Premium Economy	£50	A Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 07:05:00. 50 Premium Economy ticket for £50 per person are available. Travel duration is 6h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	4h 30m	00:45	Siena	Train Station	05:15	Milan	San Donato Bus Station	Economy	£6	A Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 05:15:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 30m
FlixBus	5h 10m	00:45	Siena	Train Station	05:55	Milan	Lampugnano Bus Station	Economy	£6	A Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 05:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 10m
FlixBus	5h 45m	06:10	Siena	Train Station	11:55	Milan	Lampugnano Bus Station	Economy	£6	A Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 11:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 45m
Itabus	6h 0m	01:05	Siena	Train Station	07:05	Milan	San Donato Bus Station	Premium Economy	£8	A Bus from Itabus goes from Train Station, Siena (Italy) at 25/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 07:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 0m

Best Price Offer: The price for the cheapest coach from Siena to Milan is £6 on 25/03/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between Siena and Milan

See here how frequent the connections between Siena and Milan are, during different times and days of the week.

Sunday is the busiest day, with more than 29 daily coaches from Siena to Milan. Tuesday has instead the fewest connections, with only 6 daily coaches between Siena and Milan.

The busiest time of the day is the Night, with 16 coaches from Siena to Milan, while Evening sees the fewest connections between Siena and Milan, with 3 offers.

Facts about coaches from Siena to Milan

Compare all providers like FlixBus and Itabus that travel 14 times every day by bus from Siena to Milan in one click! Book your bus ticket from Siena to Milan starting from £6!

Cheapest Bus	£6
Fastest Bus	4h 30m
Earliest Coach	00:45
Latest Coach	15:05
Daily Bus Connections	14 Ø
Distance	293.3 km
Coach Companies	FlixBus and Itabus

Cheapest coach connections from Siena to Milan

Every day, 14 buses from 2 coach companies leave Siena for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 20/03/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 16/03

Tuesday 17/03

Wednesday 18/03

Thursday 19/03

Friday 20/03

Saturday 21/03

Sunday 22/03

£10

Monday 23/03

Tuesday 24/03

£6

Wednesday 25/03

£6

Thursday 26/03

Friday 27/03

£13

Saturday 28/03

£14

Sunday 29/03

Monday 30/03

£13

Tuesday 31/03

£14

Wednesday 01/04

Thursday 02/04

£16

Friday 03/04

Saturday 04/04

£22

Sunday 05/04

£6

Monday 06/04

£19

Tuesday 07/04

£38

Wednesday 08/04

£8

Thursday 09/04

£15

Friday 10/04

£10

Saturday 11/04

£15

Sunday 12/04

The cheapest time to travel from Siena to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Siena to Milan, for the next 30 days.

With a price starting from £6, Tuesday is the cheapest day for a coach from Siena to Milan. Sunday instead is the most expensive day with prices starting from £6.

Night is the cheapest day time for bus tickets from Siena to Milan, with £6. Afternoon is the most expensive time of the day with prices starting from £9.

How to save money travelling from Siena to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Siena to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Siena to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Siena to Milan are also emptier.

All bus stations and stops in Siena and Milan

The map below shows you where to find all the bus stations in Siena and Milan.

Piazza Antonio Gramsci

Central Bus Station

Bus Stop

Via Fiorentina 99

Colonna San Marco

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Duomo Bus Stop

Piazza del Duomo

Central Bus Station

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Siena to Milan? Compare all modes of transports from Siena to Milan.

Service and Comfort on the bus from Siena to Milan

Want to know which seat classes are available on the coaches from Siena to Milan? Or which bus companies serve the route Siena to Milan? Below you will find answers to your questions.

FAQs about the Siena to Milan bus

How much does a Siena - Milan coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Siena - Milan bus trip is available from £6 and takes 4h 30m. Compare offers and save money!

How much could I save by comparing buses from Siena to Milan?

The connection Siena to Milan is offered by 2 companies with ticket prices ranging from £6 to £55. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Siena - Milan route on average every day?

Each day, the bus route from Siena to Milan is offered by roughly 14 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Milan from Siena take?

The quickest coach from Siena to Milan is provided by FlixBus and takes 4h 30m. Coach tickets for this connection cost £10. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Siena to Milan?

The earliest bus to Milan departs from Siena at 00:45. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Siena to Milan?

The latest bus to Milan departs from Siena at 15:05. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Siena - Milan route?

Passengers looking to travel from Siena to Milan can travel with FlixBus and Itabus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Siena and Milan?

You can check all the direct connections between Siena and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Itabus.

What can I take with me on the bus to Milan from Siena?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Siena Milan bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Siena Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Siena to Milan on your planned travel date.

How does CheckMyBus find the best bus deals from Siena to Milan?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 14 daily trips between Siena and Milan. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Siena to Milan?

Prices and availability for 14 trips between Siena and Milan change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Siena to Milan

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Siena and to Milan

Here’s an overview of the most popular bus routes to Siena and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!