Bus and Coach from Palermo to Milan: Compare all prices

Compare all timetables for the bus from Palermo to Milan

Here is a selection of the cheapest bus trips from the schedule from Palermo to Milan from various bus operators like FlixBus or Autoservizi Salemi for the next days.

today

£76

tomorrow

£91

Monday

£82

Tuesday

£63

Wednesday

Thursday

£71

Friday

£89

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	25h 5m	17:25	Palermo	Via Tommaso Fazello Bus Stop	18:30	Milan	San Donato Bus Station	Economy	£76	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 20/12/2025 17:25:00 to San Donato Bus Station, Milan (Italy) arriving at 21/12/2025 18:30:00. 50 Economy ticket for £76 per person are available. Travel duration is 25h 5m
FlixBus	23h 45m	17:25	Palermo	Via Tommaso Fazello Bus Stop	17:10	Milan	Lampugnano Bus Station	Economy	£77	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 20/12/2025 17:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/12/2025 17:10:00. 50 Economy ticket for £77 per person are available. Travel duration is 23h 45m
FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station	Economy	£81	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 20/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 21/12/2025 14:35:00. 50 Economy ticket for £81 per person are available. Travel duration is 23h 10m
Autoservizi Salemi	19h 10m	18:00	Palermo	Via Tommaso Fazello Bus Stop	13:10	Milan	San Donato Bus Station	Basic	£103	A Bus from Autoservizi Salemi goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 20/12/2025 18:00:00 to San Donato Bus Station, Milan (Italy) arriving at 21/12/2025 13:10:00. 50 Basic ticket for £103 per person are available. Travel duration is 19h 10m
Autoservizi Salemi	19h 50m	18:00	Palermo	Via Tommaso Fazello Bus Stop	13:50	Milan	Lampugnano Bus Station	Basic	£103	A Bus from Autoservizi Salemi goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 20/12/2025 18:00:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/12/2025 13:50:00. 50 Basic ticket for £103 per person are available. Travel duration is 19h 50m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	24h 0m	17:10	Palermo	Via Tommaso Fazello Bus Stop	17:10	Milan	Lampugnano Bus Station	Economy	£91	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 21/12/2025 17:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/12/2025 17:10:00. 50 Economy ticket for £91 per person are available. Travel duration is 24h 0m
FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station	Economy	£95	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 21/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 22/12/2025 14:35:00. 50 Economy ticket for £95 per person are available. Travel duration is 23h 10m
FlixBus	25h 20m	17:10	Palermo	Via Tommaso Fazello Bus Stop	18:30	Milan	San Donato Bus Station	Economy	£95	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 21/12/2025 17:10:00 to San Donato Bus Station, Milan (Italy) arriving at 22/12/2025 18:30:00. 50 Economy ticket for £95 per person are available. Travel duration is 25h 20m
FlixBus	22h 15m	15:25	Palermo	Via Tommaso Fazello Bus Stop	13:40	Milan	Lampugnano Bus Station	Economy	£106	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 21/12/2025 15:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/12/2025 13:40:00. 50 Economy ticket for £106 per person are available. Travel duration is 22h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	24h 0m	17:10	Palermo	Via Tommaso Fazello Bus Stop	17:10	Milan	Lampugnano Bus Station	Economy	£82	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 22/12/2025 17:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/12/2025 17:10:00. 50 Economy ticket for £82 per person are available. Travel duration is 24h 0m
FlixBus	25h 20m	17:10	Palermo	Via Tommaso Fazello Bus Stop	18:30	Milan	San Donato Bus Station	Economy	£85	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 22/12/2025 17:10:00 to San Donato Bus Station, Milan (Italy) arriving at 23/12/2025 18:30:00. 50 Economy ticket for £85 per person are available. Travel duration is 25h 20m
FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station	Economy	£88	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 22/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 23/12/2025 14:35:00. 50 Economy ticket for £88 per person are available. Travel duration is 23h 10m
FlixBus	22h 15m	15:25	Palermo	Via Tommaso Fazello Bus Stop	13:40	Milan	Lampugnano Bus Station	Economy	£95	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 22/12/2025 15:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/12/2025 13:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 22h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	25h 25m	17:10	Palermo	Via Tommaso Fazello Bus Stop	18:35	Milan	Lampugnano Bus Station	Economy	£63	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 23/12/2025 17:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/12/2025 18:35:00. 50 Economy ticket for £63 per person are available. Travel duration is 25h 25m
FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station	Economy	£72	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 23/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 24/12/2025 14:35:00. 50 Economy ticket for £72 per person are available. Travel duration is 23h 10m
FlixBus	29h 50m	17:10	Palermo	Via Tommaso Fazello Bus Stop	23:00	Milan	San Donato Bus Station	Economy	£76	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 23/12/2025 17:10:00 to San Donato Bus Station, Milan (Italy) arriving at 24/12/2025 23:00:00. 50 Economy ticket for £76 per person are available. Travel duration is 29h 50m
FlixBus	22h 15m	15:25	Palermo	Via Tommaso Fazello Bus Stop	13:40	Milan	Lampugnano Bus Station	Economy	£91	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 23/12/2025 15:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/12/2025 13:40:00. 50 Economy ticket for £91 per person are available. Travel duration is 22h 15m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station		Economy	£71	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 25/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 26/12/2025 14:35:00. 50 Economy ticket for £71 per person are available. Travel duration is 23h 10m
	FlixBus	22h 15m	15:25	Palermo	Via Tommaso Fazello Bus Stop	13:40	Milan	Lampugnano Bus Station		Economy	£76	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 25/12/2025 15:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 26/12/2025 13:40:00. 50 Economy ticket for £76 per person are available. Travel duration is 22h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 10m	15:25	Palermo	Via Tommaso Fazello Bus Stop	14:35	Milan	San Donato Bus Station	Economy	£89	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 26/12/2025 15:25:00 to San Donato Bus Station, Milan (Italy) arriving at 27/12/2025 14:35:00. 50 Economy ticket for £89 per person are available. Travel duration is 23h 10m
FlixBus	25h 20m	17:10	Palermo	Via Tommaso Fazello Bus Stop	18:30	Milan	San Donato Bus Station	Economy	£95	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 26/12/2025 17:10:00 to San Donato Bus Station, Milan (Italy) arriving at 27/12/2025 18:30:00. 50 Economy ticket for £95 per person are available. Travel duration is 25h 20m
FlixBus	22h 15m	15:25	Palermo	Via Tommaso Fazello Bus Stop	13:40	Milan	Lampugnano Bus Station	Economy	£95	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 26/12/2025 15:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 27/12/2025 13:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 22h 15m
FlixBus	24h 0m	17:10	Palermo	Via Tommaso Fazello Bus Stop	17:10	Milan	Lampugnano Bus Station	Economy	£99	A Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 26/12/2025 17:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 27/12/2025 17:10:00. 50 Economy ticket for £99 per person are available. Travel duration is 24h 0m

Best Price Offer: The price for the cheapest coach from Palermo to Milan is £56 on 16/12/2025. Flexible travellers save on ticket prices.

Frequency of bus connections between Palermo and Milan

See here how frequent the connections between Palermo and Milan are, during different times and days of the week.

Saturday is the busiest day, with more than 6 daily coaches from Palermo to Milan. Thursday has instead the fewest connections, with only 2 daily coaches between Palermo and Milan.

The busiest time of the day is the Afternoon, with 22 coaches from Palermo to Milan, while Evening sees the fewest connections between Palermo and Milan, with 2 offers.

Facts about coaches from Palermo to Milan

Compare all providers like FlixBus and Autoservizi Salemi that travel 4 times every day by bus from Palermo to Milan in one click! Book your bus ticket from Palermo to Milan starting from £56!

Cheapest Bus	£56
Fastest Bus	19h 10m
Earliest Coach	15:25
Latest Coach	17:10
Daily Bus Connections	4 Ø
Distance	887.2 km
Coach Companies	FlixBus and Autoservizi Salemi

Cheapest coach connections from Palermo to Milan

Every day, 4 buses from 2 coach companies leave Palermo for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 20/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 15/12

Tuesday 16/12

Wednesday 17/12

Thursday 18/12

Friday 19/12

Saturday 20/12

£76

Sunday 21/12

£91

Monday 22/12

£82

Tuesday 23/12

£63

Wednesday 24/12

Thursday 25/12

£71

Friday 26/12

£89

Saturday 27/12

£109

Sunday 28/12

£102

Monday 29/12

£95

Tuesday 30/12

£94

Wednesday 31/12

Thursday 01/01

Friday 02/01

£106

Saturday 03/01

£116

Sunday 04/01

£128

Monday 05/01

£120

Tuesday 06/01

£63

Wednesday 07/01

£109

Thursday 08/01

£69

Friday 09/01

£59

Saturday 10/01

£59

Sunday 11/01

The cheapest time to travel from Palermo to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Palermo to Milan, for the next 30 days.

With a price starting from £38, Monday is the cheapest day for a coach from Palermo to Milan. Tuesday instead is the most expensive day with prices starting from £63.

Afternoon is the cheapest day time for bus tickets from Palermo to Milan, with £63. Evening is the most expensive time of the day with prices starting from £102.

How to save money travelling from Palermo to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Palermo to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Palermo to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Palermo to Milan are also emptier.

Beloved bus companies from Palermo to Milan

These are the most booked bus companies between Palermo to Milan from our users.

Autoservizi Salemi from Palermo to Milan

Here you will find the key facts about the Autoservizi Salemi bus route Palermo to Milan:

Cheapest Price	£103
Fastest Coach	19h 10m
Earliest Coach	18:00
Last Coach	18:00
Daily Connections	2 Ø
Found on	12/12/2025

All bus stations and stops in Palermo and Milan

The map below shows you where to find all the bus stations in Palermo and Milan.

Oreto Orsi Bus Stop

Via Oreto 389

Piazza Cairoli Bus Station

Piazza Cairoli Piazza Cairoli

Piazza Indipendenza Station

Piazza Indipendenza Palazzo Reale

Via Tommaso Fazello Bus Stop

Via Tommaso Fazello

Via della Libertà

Via della Libertà 163

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Central Station - Piazza Luigi di Savoia

Piazza Duca D'Aosta 16

Central Bus Station

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Palermo to Milan? Compare all modes of transports from Palermo to Milan.

Service and Comfort on the bus from Palermo to Milan

Want to know which seat classes are available on the coaches from Palermo to Milan? Or which bus companies serve the route Palermo to Milan? Below you will find answers to your questions.

FAQs about the Palermo to Milan bus

How much does a Palermo - Milan coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Palermo - Milan bus trip is available from £56 and takes 25h 25m. Compare offers and save money!

How much could I save by comparing buses from Palermo to Milan?

The connection Palermo to Milan is offered by 2 companies with ticket prices ranging from £56 to £106. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Palermo - Milan route on average every day?

Each day, the bus route from Palermo to Milan is offered by roughly 4 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Milan from Palermo take?

The quickest coach from Palermo to Milan is provided by Autoservizi Salemi and takes 19h 10m. Coach tickets for this connection cost £103. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Palermo to Milan?

The earliest bus to Milan departs from Palermo at 15:25. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Palermo to Milan?

The latest bus to Milan departs from Palermo at 17:10. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Palermo - Milan route?

Passengers looking to travel from Palermo to Milan can travel with FlixBus and Autoservizi Salemi. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Palermo and Milan?

You can check all the direct connections between Palermo and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Autoservizi Salemi.

What can I take with me on the bus to Milan from Palermo?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Palermo Milan bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Palermo Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Palermo to Milan on your planned travel date.

How does CheckMyBus find the best bus deals from Palermo to Milan?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Palermo and Milan. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Palermo to Milan?

Prices and availability for 4 trips between Palermo and Milan change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Palermo to Milan

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Palermo and to Milan

Here’s an overview of the most popular bus routes to Palermo and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!