What is the best way to travel from Siena to Milan?
Looking for a trip? Check and compare all the available Carpool, Trains and Buses to Milan from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Milan from Siena?
You can reach Milan with just £6 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 11:30:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 50m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 11:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 23:49:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 14m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 06:55:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 50m
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Trenitalia8h 14m015:18SienaTrain Station23:32MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 15:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 23:32:00. 50 Economy ticket for £31 per person are available. Travel duration is 8h 14m
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Trenitalia8h 22m013:18SienaTrain Station21:40MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 13:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 21:40:00. 50 Economy ticket for £34 per person are available. Travel duration is 8h 22m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 23:17:00. 50 Economy ticket for £38 per person are available. Travel duration is 5h 59m
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Trenitalia5h 57m018:18SienaTrain Station00:15MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 18:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 23/03/2026 00:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 5h 57m
Cheapest Buses Sunday
Cheapest Trains Sunday
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 16:40:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 06:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 5h 50m
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Itabus7h 5m001:05SienaTrain Station08:10MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 08:10:00. 50 Premium Economy ticket for £37 per person are available. Travel duration is 7h 5m
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Itabus6h 30m001:05SienaTrain Station07:35MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 07:35:00. 50 Premium Economy ticket for £46 per person are available. Travel duration is 6h 30m
Cheapest Buses Tuesday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 05:15:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 30m
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 05:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 10m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 11:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 45m
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Itabus6h 0m001:05SienaTrain Station07:05MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 25/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 07:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 0m
Cheapest Buses Wednesday
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 23:49:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 14m
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Itabus6h 30m001:05SienaTrain Station07:35MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 07:35:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 6h 30m
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Itabus6h 0m001:05SienaTrain Station07:05MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 07:05:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 6h 0m
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Itabus7h 5m001:05SienaTrain Station08:10MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 08:10:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 7h 5m
Cheapest Buses Friday
What are the fastest trips from Siena to Milan?
You can get to Milan from Siena in just 4h 30m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 11:30:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 50m
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 22/03/2026 23:49:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 14m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 22/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 11:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/03/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/03/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Trenitalia5h 57m018:18SienaTrain Station00:15MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 18:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 23/03/2026 00:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 5h 57m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 23:17:00. 50 Economy ticket for £38 per person are available. Travel duration is 5h 59m
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Trenitalia7h 11m008:48SienaTrain Station15:59MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 08:48:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 15:59:00. 50 Economy ticket for £42 per person are available. Travel duration is 7h 11m
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Trenitalia8h 14m015:18SienaTrain Station23:32MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 22/03/2026 15:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 22/03/2026 23:32:00. 50 Economy ticket for £31 per person are available. Travel duration is 8h 14m
Fastest Buses Sunday
Fastest Trains Sunday
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 16:40:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/03/2026 06:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 5h 50m
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Itabus6h 30m001:05SienaTrain Station07:35MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 07:35:00. 50 Premium Economy ticket for £46 per person are available. Travel duration is 6h 30m
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Itabus7h 5m001:05SienaTrain Station08:10MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 24/03/2026 08:10:00. 50 Premium Economy ticket for £37 per person are available. Travel duration is 7h 5m
Fastest Buses Tuesday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 05:15:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 30m
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 05:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 10m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 25/03/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/03/2026 11:55:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 45m
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Itabus6h 0m001:05SienaTrain Station07:05MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 25/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 25/03/2026 07:05:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 0m
Fastest Buses Wednesday
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 23:49:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 14m
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Itabus6h 0m001:05SienaTrain Station07:05MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 07:05:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 6h 0m
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Itabus6h 30m001:05SienaTrain Station07:35MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 07:35:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 6h 30m
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Itabus6h 35m001:05SienaTrain Station07:40MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 27/03/2026 01:05:00 to San Donato Bus Station, Milan (Italy) arriving at 27/03/2026 07:40:00. 50 Premium Economy ticket for £19 per person are available. Travel duration is 6h 35m
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Siena to Milan
What are the most popular stations in Siena and Milan?
In Siena, you will usually depart from Bus Stop, Train Station or Central Bus Station, while in Milan you will be arriving at Central Station - Piazza Luigi di Savoia, Lampugnano Bus Station or Cadorna Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Milan from Siena? With 6 connections between 3 Carpool, Train and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Milan, you can pay as low as £6 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Milan in just 4h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Milan are Itabus, FlixBus and Trenitalia, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Milan is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Corsico, and look at flights from , and landing at Bergamo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Milan?
The most popular companies between Siena and Milan, are Itabus, FlixBus and Trenitalia. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Itabus and FlixBus
Train companies: Trenitalia
All you need to know when you travel from Siena to Milan
Check all information on comfort and services on all modes of transports from Siena to Milan. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Milan
How can I reach Milan from Siena?
Every day, there are on average 6 connections between Carpool, Train and Bus, with which you can get to Milan from Siena.
How far is Milan from Siena?
The distance between Siena and Milan is 293.3 km.
What is the most ecofriendly mode of transport between Siena and Milan?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 8 kgs of CO2, a train 10 kgs, a car 50 kgs, and a flight 72 kgs.
What is the cheapest mode of transport from Siena to Milan?
You can get to Milan with just £6 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Milan?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Milan in just 4h 30m with a Bus from FlixBus.
More routes to Siena and to Milan
Looking for more options? Here you can see the most popular routes to Siena and to Milan. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Assisi to Siena
- Avellino to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Florence to Siena
- Frosinone to Siena
- Lucca to Siena
- Milan to Siena
- Naples to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Potenza to Siena
- Prato to Siena
- Rimini to Siena
- Rome to Siena
- Salerno to Siena
- Turin to Siena
- Trips to Milan
- Amsterdam to Milan
- Aosta to Milan
- Bergamo Airport to Milan
- Brescia to Milan
- Carisolo to Milan
- Cosenza to Milan
- Crotone to Milan
- Geneva to Milan
- Lamezia Terme to Milan
- Lugano to Milan
- Lyon to Milan
- Milan Malpensa Airport to Milan
- Munich to Milan
- Naples to Milan
- Paris to Milan
- Pisa to Milan
- Pont-Saint-Martin to Milan
- Reggio Calabria to Milan
- Rome to Milan
- Turin to Milan
- Vibo Valentia to Milan
- Zurich to Milan
