What is the best way to travel from Siena to Milan?
Looking for a trip? Check and compare all the available Carpool and Buses to Milan from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Milan from Siena?
You can reach Milan with just £9 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus6h 49m014:51SienaBus Stop21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 03/02/2026 14:51:00 to Lampugnano Bus Station, Milan (Italy) arriving at 03/02/2026 21:40:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 49m
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FlixBus6h 35m015:05SienaTrain Station21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/02/2026 15:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 03/02/2026 21:40:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 35m
Cheapest Buses Tuesday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 05/02/2026 05:15:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 30m
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 05:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 10m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 13:45:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 05/02/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 16:40:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 05/02/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 06:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 50m
Cheapest Buses Thursday
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FlixBus5h 15m009:20SienaTrain Station14:35MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 09:20:00 to San Donato Bus Station, Milan (Italy) arriving at 06/02/2026 14:35:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 15m
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FlixBus4h 50m016:05SienaTrain Station20:55MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 16:05:00 to San Donato Bus Station, Milan (Italy) arriving at 06/02/2026 20:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 50m
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FlixBus6h 0m009:20SienaTrain Station15:20MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 09:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 15:20:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 0m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 06/02/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 06/02/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 06:55:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 5h 50m
Cheapest Buses Friday
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FlixBus5h 19m018:40SienaTrain Station23:59MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 18:40:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 23:59:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 19m
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 05:55:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 10m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 11:55:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 45m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 13:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 55m
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FlixBus6h 0m009:20SienaTrain Station15:20MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 09:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 15:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 0m
Cheapest Buses Sunday
What are the fastest trips from Siena to Milan?
You can get to Milan from Siena in just 4h 30m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus6h 35m015:05SienaTrain Station21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/02/2026 15:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 03/02/2026 21:40:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 35m
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FlixBus6h 49m014:51SienaBus Stop21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 03/02/2026 14:51:00 to Lampugnano Bus Station, Milan (Italy) arriving at 03/02/2026 21:40:00. 50 Economy ticket for £14 per person are available. Travel duration is 6h 49m
Fastest Buses Tuesday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 05/02/2026 05:15:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 30m
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 05:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 10m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 05/02/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 16:40:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 05/02/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 06:55:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 50m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 05/02/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 05/02/2026 13:45:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 55m
Fastest Buses Thursday
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FlixBus4h 50m016:05SienaTrain Station20:55MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 16:05:00 to San Donato Bus Station, Milan (Italy) arriving at 06/02/2026 20:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 4h 50m
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FlixBus5h 15m009:20SienaTrain Station14:35MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 09:20:00 to San Donato Bus Station, Milan (Italy) arriving at 06/02/2026 14:35:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 06/02/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 06/02/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 06:55:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 5h 50m
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FlixBus6h 0m009:20SienaTrain Station15:20MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/02/2026 09:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 06/02/2026 15:20:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 0m
Fastest Buses Friday
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FlixBus5h 10m000:45SienaTrain Station05:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 00:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 05:55:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 10m
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FlixBus5h 19m018:40SienaTrain Station23:59MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 18:40:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 23:59:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 19m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 11:55:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 45m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 13:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 55m
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FlixBus6h 0m009:20SienaTrain Station15:20MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 08/02/2026 09:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 08/02/2026 15:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 0m
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Siena to Milan
What are the most popular stations in Siena and Milan?
In Siena, you will usually depart from Central Bus Station, Train Station or Bus Stop, while in Milan you will be arriving at Lampugnano Bus Station, Cadorna Train Station or Central Station - Piazza Luigi di Savoia, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Milan from Siena? With 4 connections between 2 Carpool and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Milan, you can pay as low as £9 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Milan in just 4h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Milan are FlixBus and Itabus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Milan is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Corsico, and look at flights from , and landing at Bergamo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Milan?
The most popular companies between Siena and Milan, are FlixBus and Itabus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Itabus
All you need to know when you travel from Siena to Milan
Check all information on comfort and services on all modes of transports from Siena to Milan. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Milan
How can I reach Milan from Siena?
Every day, there are on average 4 connections between Carpool and Bus, with which you can get to Milan from Siena.
How far is Milan from Siena?
The distance between Siena and Milan is 293.3 km.
What is the most ecofriendly mode of transport between Siena and Milan?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 8 kgs of CO2, a train 10 kgs, a car 50 kgs, and a flight 72 kgs.
What is the cheapest mode of transport from Siena to Milan?
You can get to Milan with just £9 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Milan?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Milan in just 4h 30m with a Bus from FlixBus.
More routes to Siena and to Milan
Looking for more options? Here you can see the most popular routes to Siena and to Milan. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Avellino to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Florence Airport to Siena
- Florence to Siena
- Frosinone to Siena
- Grosseto to Siena
- Milan to Siena
- Naples to Siena
- Padua to Siena
- Parma to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Prato to Siena
- Rome to Siena
- Trips to Milan
- Antey-Saint-Andrè to Milan
- Aosta to Milan
- Bergamo to Milan
- Cosenza to Milan
- Crotone to Milan
- Florence to Milan
- Geneva to Milan
- Genoa to Milan
- Innsbruck to Milan
- Latisana to Milan
- Lyon to Milan
- Milan Malpensa Airport to Milan
- Munich to Milan
- Naples to Milan
- Paris to Milan
- Pont-Saint-Martin to Milan
- Reggio Calabria to Milan
- Rome to Milan
- Turin to Milan
- Venice to Milan
- Vibo Valentia to Milan
- Zurich to Milan
