What is the best way to travel from Siena to Milan?
Looking for a trip? Check and compare all the available Buses, Trains and Carpool to Milan from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Milan from Siena?
You can reach Milan with just £11 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus5h 15m006:30SienaTrain Station11:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 06:30:00 to San Donato Bus Station, Milan (Italy) arriving at 16/12/2025 11:45:00. 50 Economy ticket for £11 per person are available. Travel duration is 5h 15m
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FlixBus6h 35m015:05SienaTrain Station21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 15:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 21:40:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 35m
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FlixBus6h 49m014:51SienaBus Stop21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 16/12/2025 14:51:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 21:40:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 49m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 11:55:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 45m
Cheapest Buses Tuesday
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FlixBus5h 0m019:45SienaTrain Station00:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 19:45:00 to San Donato Bus Station, Milan (Italy) arriving at 19/12/2025 00:45:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 0m
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FlixBus5h 34m019:45SienaTrain Station01:19MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 19:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/12/2025 01:19:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 34m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/12/2025 11:55:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 45m
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FlixBus7h 35m011:20SienaTrain Station18:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 11:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/12/2025 18:55:00. 50 Economy ticket for £16 per person are available. Travel duration is 7h 35m
Cheapest Buses Thursday
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FlixBus5h 0m019:45SienaTrain Station00:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 19:45:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 00:45:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 0m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/12/2025 11:55:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 45m
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FlixBus5h 34m019:45SienaTrain Station01:19MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 19:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 01:19:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 34m
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Itabus5h 14m018:35SienaCentral Bus Station23:49MilanSan Donato Bus Station0BasicA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 19/12/2025 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 19/12/2025 23:49:00. 50 Basic ticket for £16 per person are available. Travel duration is 5h 14m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 23:17:00. 50 Economy ticket for £21 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m017:41SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 17:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 23:17:00. 50 Economy ticket for £21 per person are available. Travel duration is 5h 36m
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Trenitalia6h 7m013:18SienaTrain Station19:25MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 13:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 19:25:00. 50 Economy ticket for £25 per person are available. Travel duration is 6h 7m
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Trenitalia6h 37m015:18SienaTrain Station21:55MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 15:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 21:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 37m
Cheapest Buses Friday
Cheapest Trains Friday
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FlixBus4h 50m016:05SienaTrain Station20:55MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/12/2025 16:05:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 20:55:00. 50 Economy ticket for £16 per person are available. Travel duration is 4h 50m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 11:55:00. 50 Economy ticket for £16 per person are available. Travel duration is 5h 45m
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FlixBus7h 20m014:25SienaTrain Station21:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/12/2025 14:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 21:45:00. 50 Economy ticket for £16 per person are available. Travel duration is 7h 20m
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/12/2025 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 23:49:00. 50 Premium Economy ticket for £53 per person are available. Travel duration is 5h 14m
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Trenitalia3h 54m015:18SienaTrain Station19:12MilanPorta Garibaldi Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 15:18:00 to Porta Garibaldi Train Station, Milan (Italy) arriving at 20/12/2025 19:12:00. 50 Economy ticket for £28 per person are available. Travel duration is 3h 54m
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Trenitalia3h 54m018:18SienaTrain Station22:12MilanPorta Garibaldi Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 18:18:00 to Porta Garibaldi Train Station, Milan (Italy) arriving at 20/12/2025 22:12:00. 50 Economy ticket for £28 per person are available. Travel duration is 3h 54m
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Trenitalia4h 9m014:41SienaTrain Station18:50MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 14:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 20/12/2025 18:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 4h 9m
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Trenitalia6h 37m015:18SienaTrain Station21:55MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 15:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 20/12/2025 21:55:00. 50 Economy ticket for £28 per person are available. Travel duration is 6h 37m
Cheapest Buses Saturday
Cheapest Trains Saturday
What are the fastest trips from Siena to Milan?
You can get to Milan from Siena in just 3h 54m with a Train from Trenitalia. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus5h 15m006:30SienaTrain Station11:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 06:30:00 to San Donato Bus Station, Milan (Italy) arriving at 16/12/2025 11:45:00. 50 Economy ticket for £11 per person are available. Travel duration is 5h 15m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 11:55:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m007:50SienaTrain Station13:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 13:40:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 50m
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FlixBus6h 35m015:05SienaTrain Station21:40MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 16/12/2025 15:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 16/12/2025 21:40:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 35m
Fastest Buses Tuesday
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FlixBus5h 0m019:45SienaTrain Station00:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 19:45:00 to San Donato Bus Station, Milan (Italy) arriving at 19/12/2025 00:45:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 0m
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FlixBus5h 34m019:45SienaTrain Station01:19MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 19:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/12/2025 01:19:00. 50 Economy ticket for £14 per person are available. Travel duration is 5h 34m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/12/2025 11:55:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 45m
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FlixBus7h 20m014:25SienaTrain Station21:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/12/2025 14:25:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/12/2025 21:45:00. 50 Economy ticket for £16 per person are available. Travel duration is 7h 20m
Fastest Buses Thursday
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FlixBus5h 0m019:45SienaTrain Station00:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 19:45:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 00:45:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 0m
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Itabus5h 14m018:35SienaCentral Bus Station23:49MilanSan Donato Bus Station0BasicA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 19/12/2025 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 19/12/2025 23:49:00. 50 Basic ticket for £16 per person are available. Travel duration is 5h 14m
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FlixBus5h 34m019:45SienaTrain Station01:19MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 19:45:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 01:19:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 34m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/12/2025 11:55:00. 50 Economy ticket for £15 per person are available. Travel duration is 5h 45m
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Trenitalia5h 36m017:41SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 17:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 23:17:00. 50 Economy ticket for £21 per person are available. Travel duration is 5h 36m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 23:17:00. 50 Economy ticket for £21 per person are available. Travel duration is 5h 59m
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Trenitalia6h 7m013:18SienaTrain Station19:25MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 13:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 19:25:00. 50 Economy ticket for £25 per person are available. Travel duration is 6h 7m
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Trenitalia6h 37m015:18SienaTrain Station21:55MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 19/12/2025 15:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 19/12/2025 21:55:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 37m
Fastest Buses Friday
Fastest Trains Friday
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Trenitalia3h 54m015:18SienaTrain Station19:12MilanPorta Garibaldi Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 15:18:00 to Porta Garibaldi Train Station, Milan (Italy) arriving at 20/12/2025 19:12:00. 50 Economy ticket for £28 per person are available. Travel duration is 3h 54m
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Trenitalia3h 54m018:18SienaTrain Station22:12MilanPorta Garibaldi Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 18:18:00 to Porta Garibaldi Train Station, Milan (Italy) arriving at 20/12/2025 22:12:00. 50 Economy ticket for £28 per person are available. Travel duration is 3h 54m
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Trenitalia4h 9m014:41SienaTrain Station18:50MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 14:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 20/12/2025 18:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 4h 9m
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Trenitalia4h 32m017:18SienaTrain Station21:50MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 20/12/2025 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 20/12/2025 21:50:00. 50 Economy ticket for £28 per person are available. Travel duration is 4h 32m
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FlixBus4h 50m016:05SienaTrain Station20:55MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/12/2025 16:05:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 20:55:00. 50 Economy ticket for £16 per person are available. Travel duration is 4h 50m
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Itabus5h 14m018:35SienaTrain Station23:49MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/12/2025 18:35:00 to San Donato Bus Station, Milan (Italy) arriving at 20/12/2025 23:49:00. 50 Premium Economy ticket for £53 per person are available. Travel duration is 5h 14m
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FlixBus5h 45m006:10SienaTrain Station11:55MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/12/2025 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 11:55:00. 50 Economy ticket for £16 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaCentral Bus Station06:55MilanLampugnano Bus Station0BasicA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 20/12/2025 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/12/2025 06:55:00. 50 Basic ticket for £53 per person are available. Travel duration is 5h 50m
Fastest Trains Saturday
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from Siena to Milan
What are the most popular stations in Siena and Milan?
In Siena, you will usually depart from Central Bus Station, Train Station or Bus Stop, while in Milan you will be arriving at Central Station - Piazza Luigi di Savoia, Lampugnano Bus Station or Cadorna Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Milan from Siena? With 7 connections between 3 Bus, Train and Carpool operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Milan, you can pay as low as £11 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Train from Trenitalia: you will get to Milan in just 3h 54m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Milan are FlixBus, Trenitalia and Itabus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Milan is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Corsico, and look at flights from , and landing at Bergamo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Milan?
The most popular companies between Siena and Milan, are FlixBus, Trenitalia and Itabus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Itabus
Train companies: Trenitalia
All you need to know when you travel from Siena to Milan
Check all information on comfort and services on all modes of transports from Siena to Milan. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Milan
How can I reach Milan from Siena?
Every day, there are on average 7 connections between Bus, Train and Carpool, with which you can get to Milan from Siena.
How far is Milan from Siena?
The distance between Siena and Milan is 293.3 km.
What is the most ecofriendly mode of transport between Siena and Milan?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 8 kgs of CO2, a train 10 kgs, a car 50 kgs, and a flight 72 kgs.
What is the cheapest mode of transport from Siena to Milan?
You can get to Milan with just £11 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Milan?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Milan in just 3h 54m with a Train from Trenitalia.
More routes to Siena and to Milan
Looking for more options? Here you can see the most popular routes to Siena and to Milan. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Avellino to Siena
- Bari to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Florence to Siena
- Frosinone to Siena
- Grosseto to Siena
- Grottaminarda to Siena
- Lucca to Siena
- Milan to Siena
- Naples to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Prato to Siena
- Rome to Siena
- Verona to Siena
- Trips to Milan
- Bari to Milan
- Basel to Milan
- Bergamo to Milan
- Bologna to Milan
- Breuil-Cervinia to Milan
- Como to Milan
- Cosenza to Milan
- Courmayeur to Milan
- Ferrara to Milan
- Florence to Milan
- Foggia to Milan
- Geneva to Milan
- Genoa to Milan
- Latisana to Milan
- Lecce to Milan
- Lindau to Milan
- Lugano to Milan
- Marseille to Milan
- Messina to Milan
- Milan Linate Airport to Milan
- Palermo to Milan
- Rimini to Milan
- Venice to Milan
- Verrès to Milan

