What is the best way to travel from Siena to Milan?
Looking for a trip? Check and compare all the available Trains and Buses to Milan from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Milan from Siena?
You can reach Milan with just £6 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 18/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 13:45:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 55m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 18/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 18/06/2026 18:50:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 18/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
Cheapest Buses Thursday
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 11:30:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 19/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/06/2026 16:40:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 5h 45m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 19/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
Cheapest Buses Friday
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 11:30:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/06/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
Cheapest Buses Saturday
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 21/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus5h 15m009:20SienaTrain Station14:35MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 09:20:00 to San Donato Bus Station, Milan (Italy) arriving at 21/06/2026 14:35:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 15m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 21/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/06/2026 16:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 5h 45m
Cheapest Buses Sunday
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/06/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 22/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/06/2026 06:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 5h 50m
Cheapest Buses Monday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 05:15:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 30m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus5h 15m006:30SienaTrain Station11:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 06:30:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 11:45:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 23/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/06/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 23/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 4h 55m
Cheapest Buses Tuesday
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 16:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 24/06/2026 12:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 13:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 50m
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 24/06/2026 05:15:00. 50 Economy ticket for £10 per person are available. Travel duration is 4h 30m
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Itabus5h 45m010:55SienaPiazza Antonio Gramsci16:40MilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 24/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 16:40:00. 50 Economy ticket for £13 per person are available. Travel duration is 5h 45m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:17:00. 50 Economy ticket for £24 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m017:41SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 17:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:17:00. 50 Economy ticket for £24 per person are available. Travel duration is 5h 36m
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Trenitalia6h 41m016:41SienaTrain Station23:22MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 16:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:22:00. 50 Economy ticket for £27 per person are available. Travel duration is 6h 41m
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Trenitalia7h 45m006:25SienaTrain Station14:10MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 06:25:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 14:10:00. 50 Economy ticket for £29 per person are available. Travel duration is 7h 45m
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Trenitalia6h 7m013:18SienaTrain Station19:25MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 13:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 19:25:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 7m
Cheapest Buses Wednesday
Cheapest Trains Wednesday
What are the fastest trips from Siena to Milan?
You can get to Milan from Siena in just 4h 30m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 18/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 18/06/2026 18:50:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 18/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 18/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus5h 55m007:50SienaTrain Station13:45MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 07:50:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 13:45:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 55m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 18/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 18/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
Fastest Buses Thursday
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 11:30:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 50m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 19/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 19/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/06/2026 16:40:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 19/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 19/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
Fastest Buses Friday
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FlixBus4h 50m006:40SienaTrain Station11:30MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:40:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 11:30:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 50m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 20/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/06/2026 16:40:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 20/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 20/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
Fastest Buses Saturday
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FlixBus5h 15m009:20SienaTrain Station14:35MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 09:20:00 to San Donato Bus Station, Milan (Italy) arriving at 21/06/2026 14:35:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 21/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/06/2026 16:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 21/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 21/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/06/2026 13:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 6h 50m
Fastest Buses Sunday
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 22/06/2026 18:50:00. 50 Premium Economy ticket for £16 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/06/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m
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Itabus5h 50m001:05SienaTrain Station06:55MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 22/06/2026 01:05:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/06/2026 06:55:00. 50 Premium Economy ticket for £22 per person are available. Travel duration is 5h 50m
Fastest Buses Monday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 05:15:00. 50 Economy ticket for £6 per person are available. Travel duration is 4h 30m
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Itabus4h 55m013:55SienaTrain Station18:50MilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 23/06/2026 13:55:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 18:50:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 4h 55m
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FlixBus5h 15m006:30SienaTrain Station11:45MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 06:30:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 11:45:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 23/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/06/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 23/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 23/06/2026 12:00:00. 50 Economy ticket for £6 per person are available. Travel duration is 5h 50m
Fastest Buses Tuesday
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FlixBus4h 30m000:45SienaTrain Station05:15MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 00:45:00 to San Donato Bus Station, Milan (Italy) arriving at 24/06/2026 05:15:00. 50 Economy ticket for £10 per person are available. Travel duration is 4h 30m
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Itabus5h 45m010:55SienaTrain Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 24/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 16:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55SienaPiazza Antonio Gramsci16:40MilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 24/06/2026 10:55:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 16:40:00. 50 Economy ticket for £13 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m006:10SienaTrain Station12:00MilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 06:10:00 to San Donato Bus Station, Milan (Italy) arriving at 24/06/2026 12:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m006:10SienaTrain Station13:00MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 24/06/2026 06:10:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/06/2026 13:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 50m
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Trenitalia5h 36m017:41SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 17:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:17:00. 50 Economy ticket for £24 per person are available. Travel duration is 5h 36m
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Trenitalia5h 59m017:18SienaTrain Station23:17MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 17:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:17:00. 50 Economy ticket for £24 per person are available. Travel duration is 5h 59m
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Trenitalia6h 7m013:18SienaTrain Station19:25MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 13:18:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 19:25:00. 50 Economy ticket for £29 per person are available. Travel duration is 6h 7m
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Trenitalia6h 41m016:41SienaTrain Station23:22MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 16:41:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 23:22:00. 50 Economy ticket for £27 per person are available. Travel duration is 6h 41m
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Trenitalia7h 45m006:25SienaTrain Station14:10MilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 24/06/2026 06:25:00 to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 24/06/2026 14:10:00. 50 Economy ticket for £29 per person are available. Travel duration is 7h 45m
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Here you will find all operators and timetables for a
Bus from Siena to Milan
What are the most popular stations in Siena and Milan?
In Siena, you will usually depart from Bus Stop, Train Station or Central Bus Station, while in Milan you will be arriving at Central Station - Piazza Luigi di Savoia, Lampugnano Bus Station or Cadorna Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Milan from Siena? With 5 connections between 3 Train and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Milan, you can pay as low as £6 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Milan in just 4h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Milan are FlixBus, Itabus and Trenitalia, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Milan is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Corsico, and look at flights from , and landing at Bergamo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Milan?
The most popular companies between Siena and Milan, are FlixBus, Itabus and Trenitalia. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Itabus
Train companies: Trenitalia
All you need to know when you travel from Siena to Milan
Check all information on comfort and services on all modes of transports from Siena to Milan. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Milan
How can I reach Milan from Siena?
Every day, there are on average 5 connections between Train and Bus, with which you can get to Milan from Siena.
How far is Milan from Siena?
The distance between Siena and Milan is 293.3 km.
What is the most ecofriendly mode of transport between Siena and Milan?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 8 kgs of CO2, a train 10 kgs, a car 50 kgs, and a flight 72 kgs.
What is the cheapest mode of transport from Siena to Milan?
You can get to Milan with just £6 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Milan?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Milan in just 4h 30m with a Bus from FlixBus.
More routes to Siena and to Milan
Looking for more options? Here you can see the most popular routes to Siena and to Milan. Simply click on a connection, and you’ll find all the details about the route!
