Bus and Coach from Rome to Isernia: Compare all prices

Compare all timetables for the bus from Rome to Isernia

Here is a selection of the cheapest bus trips from the schedule from Rome to Isernia from various bus operators like FlixBus for the next days.

today

tomorrow

£22

Sunday

Monday

Tuesday

Wednesday

Thursday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	6h 14m	05:10	Rome	Tiburtina Bus Station	11:24	Isernia	Central Bus Station		Economy	£22	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 06/12/2025 05:10:00 to Central Bus Station, Isernia (Italy) arriving at 06/12/2025 11:24:00. 50 Economy ticket for £22 per person are available. Travel duration is 6h 14m

Did you know that if you travel from Rome to Isernia via Caserta, you can save more than £8? You can find the corresponding connections below.
- Distribusion
  
  4h 14m
  
  0
  
  07:10
  
  Rome
  Tiburtina Bus Station
  
  09:30
  
  Caserta
  Train Station
  
  0
  
  Premium Economy
  
  £6
  
  A Bus from Distribusion goes from Tiburtina Bus Station, Rome (Italy) at 08/12/2025 07:10:00 to Train Station, Caserta (Italy) arriving at 08/12/2025 09:30:00. 50 Premium Economy ticket for £6 per person are available. Travel duration is 2h 20m
- FlixBus
  
  1h 14m
  
  0
  
  10:10
  
  Caserta
  Train Station
  
  11:24
  
  Isernia
  Central Bus Station
  
  0
  
  Economy
  
  £8
  
  A Bus from FlixBus goes from Train Station, Caserta (Italy) at 08/12/2025 10:10:00 to Central Bus Station, Isernia (Italy) arriving at 08/12/2025 11:24:00. 50 Economy ticket for £8 per person are available. Travel duration is 1h 14m
Travel Time is 2h 0m shorter, and you will save £8

Best Price Offer: The price for the cheapest coach from Rome to Isernia is £22 on 06/12/2025. Flexible travellers save on ticket prices.

Facts about coaches from Rome to Isernia

Compare all providers like FlixBus that travel 1 times every day by bus from Rome to Isernia in one click! Book your bus ticket from Rome to Isernia starting from £22!

Cheapest Bus	£22
Fastest Bus	6h 14m
Earliest Coach	05:10
Latest Coach	05:10
Daily Bus Connections	1 Ø
Distance	147.8 km
Coach Companies	FlixBus

Cheapest coach connections from Rome to Isernia

Every day, 1 buses from 1 coach companies leave Rome for Isernia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 01/12

Tuesday 02/12

Wednesday 03/12

Thursday 04/12

Friday 05/12

Saturday 06/12

£22

Sunday 07/12

Monday 08/12

Tuesday 09/12

Wednesday 10/12

Thursday 11/12

Friday 12/12

Saturday 13/12

Sunday 14/12

Monday 15/12

Tuesday 16/12

Wednesday 17/12

Thursday 18/12

Friday 19/12

Saturday 20/12

Sunday 21/12

Monday 22/12

Tuesday 23/12

Wednesday 24/12

Thursday 25/12

Friday 26/12

Saturday 27/12

Sunday 28/12

How to save money travelling from Rome to Isernia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Isernia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Isernia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Rome to Isernia are also emptier.

All bus stations and stops in Rome and Isernia

The map below shows you where to find all the bus stations in Rome and Isernia.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Largo Guido Mazzoni 4

Tiburtina Coach Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Central Bus Station

Train Station

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Isernia? Compare all modes of transports from Rome to Isernia.

Service and Comfort on the bus from Rome to Isernia

Want to know which seat classes are available on the coaches from Rome to Isernia? Or which bus companies serve the route Rome to Isernia? Below you will find answers to your questions.

FAQs about the Rome to Isernia bus

How much does a Rome - Isernia coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Rome - Isernia bus trip is available from £22 and takes 6h 14m. Compare offers and save money!

How much could I save by comparing buses from Rome to Isernia?

The connection Rome to Isernia is offered by 1 companies with ticket prices ranging from £22 to £22. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Rome - Isernia route on average every day?

Each day, the bus route from Rome to Isernia is offered by roughly 1 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Isernia from Rome take?

The quickest coach from Rome to Isernia is provided by FlixBus and takes 6h 14m. Coach tickets for this connection cost £22. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Rome to Isernia?

The earliest bus to Isernia departs from Rome at 05:10. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Rome to Isernia?

The latest bus to Isernia departs from Rome at 05:10. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Rome - Isernia route?

Passengers looking to travel from Rome to Isernia can travel with FlixBus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Rome and Isernia?

You can check all the direct connections between Rome and Isernia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the bus to Isernia from Rome?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Rome Isernia bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Isernia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Isernia on your planned travel date.

Available seat classes which are offered on the bus route Rome to Isernia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Isernia

Here’s an overview of the most popular bus routes to Rome and to Isernia. Simply click on the connection of your choice, and you will find all the details about your bus route!