What is the best way to travel from Rome to Isernia?
Looking for a trip? Check and compare all the available Buses and Carpool to Isernia from Rome. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Isernia from Rome?
You can reach Isernia with just £4 by taking a Bus from MarinoBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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MarinoBus2h 30m016:30RomeTiburtina Bus Station19:00IserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 26/06/2026 16:30:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 19:00:00. 50 Economy ticket for £4 per person are available. Travel duration is 2h 30m
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FlixBus2h 25m014:50RomeTiburtina Bus Station17:15IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/06/2026 14:50:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 17:15:00. 50 Economy ticket for £12 per person are available. Travel duration is 2h 25m
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 26/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 11:44:00. 50 Economy ticket for £25 per person are available. Travel duration is 6h 29m
Cheapest Buses Friday
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MarinoBus2h 30m016:30RomeTiburtina Bus Station19:00IserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 27/06/2026 16:30:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 19:00:00. 50 Economy ticket for £4 per person are available. Travel duration is 2h 30m
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FlixBus2h 25m014:50RomeTiburtina Bus Station17:15IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 27/06/2026 14:50:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 17:15:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 25m
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 27/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 11:44:00. 50 Economy ticket for £23 per person are available. Travel duration is 6h 29m
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 27/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 11:44:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 4m
Cheapest Buses Saturday
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 28/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 11:44:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 29m
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 28/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 11:44:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 4m
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FlixBus7h 39m010:25Rome Fiumicino AirportRome Fiumicino Airport18:04IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 28/06/2026 10:25:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 18:04:00. 50 Economy ticket for £42 per person are available. Travel duration is 7h 39m
Cheapest Buses Sunday
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 30/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 30/06/2026 11:44:00. 50 Economy ticket for £27 per person are available. Travel duration is 7h 4m
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FlixBus7h 39m010:25Rome Fiumicino AirportRome Fiumicino Airport18:04IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 30/06/2026 10:25:00 to Central Bus Station, Isernia (Italy) arriving at 30/06/2026 18:04:00. 50 Economy ticket for £39 per person are available. Travel duration is 7h 39m
Cheapest Buses Tuesday
What are the fastest trips from Rome to Isernia?
You can get to Isernia from Rome in just 2h 25m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus2h 25m014:50RomeTiburtina Bus Station17:15IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/06/2026 14:50:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 17:15:00. 50 Economy ticket for £12 per person are available. Travel duration is 2h 25m
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MarinoBus2h 30m016:30RomeTiburtina Bus Station19:00IserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 26/06/2026 16:30:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 19:00:00. 50 Economy ticket for £4 per person are available. Travel duration is 2h 30m
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 26/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 26/06/2026 11:44:00. 50 Economy ticket for £25 per person are available. Travel duration is 6h 29m
Fastest Buses Friday
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FlixBus2h 25m014:50RomeTiburtina Bus Station17:15IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 27/06/2026 14:50:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 17:15:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 25m
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MarinoBus2h 30m016:30RomeTiburtina Bus Station19:00IserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 27/06/2026 16:30:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 19:00:00. 50 Economy ticket for £4 per person are available. Travel duration is 2h 30m
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 27/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 11:44:00. 50 Economy ticket for £23 per person are available. Travel duration is 6h 29m
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 27/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 27/06/2026 11:44:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 4m
Fastest Buses Saturday
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FlixBus6h 29m005:15Rome Ciampino AirportRome Ciampino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 28/06/2026 05:15:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 11:44:00. 50 Economy ticket for £26 per person are available. Travel duration is 6h 29m
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 28/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 11:44:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 4m
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FlixBus7h 39m010:25Rome Fiumicino AirportRome Fiumicino Airport18:04IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 28/06/2026 10:25:00 to Central Bus Station, Isernia (Italy) arriving at 28/06/2026 18:04:00. 50 Economy ticket for £42 per person are available. Travel duration is 7h 39m
Fastest Buses Sunday
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FlixBus7h 4m004:40Rome Fiumicino AirportRome Fiumicino Airport11:44IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 30/06/2026 04:40:00 to Central Bus Station, Isernia (Italy) arriving at 30/06/2026 11:44:00. 50 Economy ticket for £27 per person are available. Travel duration is 7h 4m
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FlixBus7h 39m010:25Rome Fiumicino AirportRome Fiumicino Airport18:04IserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 30/06/2026 10:25:00 to Central Bus Station, Isernia (Italy) arriving at 30/06/2026 18:04:00. 50 Economy ticket for £39 per person are available. Travel duration is 7h 39m
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Rome to Isernia
What are the most popular stations in Rome and Isernia?
In Rome, you will usually depart from Termini Bus Station, Termini Central Station or Ostiense Train Station, while in Isernia you will be arriving at Central Bus Station or Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Isernia from Rome? With 3 connections between 2 Carpool and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Isernia, you can pay as low as £4 with a Bus from MarinoBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Isernia in just 2h 25m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Isernia are FlixBus and MarinoBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Isernia is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Carpinone, and look at flights from Rome Ciampino Airport, and landing at . Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Isernia?
The most popular companies between Rome and Isernia, are FlixBus and MarinoBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and MarinoBus
All you need to know when you travel from Rome to Isernia
Check all information on comfort and services on all modes of transports from Rome to Isernia. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Isernia
How can I reach Isernia from Rome?
Every day, there are on average 3 connections between Carpool and Bus, with which you can get to Isernia from Rome.
How far is Isernia from Rome?
The distance between Rome and Isernia is 147.8 km.
What is the most ecofriendly mode of transport between Rome and Isernia?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 4 kgs of CO2, a train 5 kgs, a car 25 kgs, and a flight 36 kgs.
What is the cheapest mode of transport from Rome to Isernia?
You can get to Isernia with just £4 by taking a Bus from MarinoBus.
What is the fastest way to get from Rome to Isernia?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Isernia in just 2h 25m with a Bus from FlixBus.
More routes to Rome and to Isernia
Looking for more options? Here you can see the most popular routes to Rome and to Isernia. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Ancona to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Chieti to Rome
- Ciampino to Rome
- Civitavecchia to Rome
- Deruta to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Perugia to Rome
- Pescara to Rome
- Porto D'Ascoli to Rome
- Porto San Giorgio to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Teramo to Rome
- Termoli to Rome
- Trips to Isernia
- Naples to Isernia
- Pescara to Isernia
