Bus and Coach from Prague to Brussels: Compare all prices

Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus or European Sleeper for the next days.

today

£51

tomorrow

£40

Sunday

£50

Monday

£40

Tuesday

£39

Wednesday

£37

Thursday

£38

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 0m	01:45	Prague	Wilsonova Coach Station	18:45	Brussels	North Station	Economy	£51	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 05/12/2025 01:45:00 to North Station, Brussels (Belgium) arriving at 05/12/2025 18:45:00. 50 Economy ticket for £51 per person are available. Travel duration is 17h 0m
FlixBus	15h 35m	17:45	Prague	Na Knížecí Station	09:20	Brussels	North Station	Economy	£51	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 05/12/2025 17:45:00 to North Station, Brussels (Belgium) arriving at 06/12/2025 09:20:00. 50 Economy ticket for £51 per person are available. Travel duration is 15h 35m
FlixBus	19h 50m	05:50	Prague	Wilsonova Coach Station	01:40	Brussels	Midi Bus Station	Economy	£51	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 05/12/2025 05:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 06/12/2025 01:40:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 50m
FlixBus	19h 20m	20:15	Prague	ÚAN Florenc	15:35	Brussels	Midi Bus Station	Economy	£51	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 05/12/2025 20:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 06/12/2025 15:35:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 20m
FlixBus	18h 55m	20:40	Prague	Na Knížecí Station	15:35	Brussels	Midi Bus Station	Economy	£51	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 05/12/2025 20:40:00 to Midi Bus Station, Brussels (Belgium) arriving at 06/12/2025 15:35:00. 50 Economy ticket for £51 per person are available. Travel duration is 18h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 40m	13:05	Prague	Wilsonova Coach Station	06:45	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 13:05:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 06:45:00. 50 Economy ticket for £40 per person are available. Travel duration is 17h 40m
FlixBus	17h 45m	14:45	Prague	Wilsonova Coach Station	08:30	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 14:45:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 08:30:00. 50 Economy ticket for £40 per person are available. Travel duration is 17h 45m
FlixBus	17h 5m	15:45	Prague	Wilsonova Coach Station	08:50	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 15:45:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 08:50:00. 50 Economy ticket for £40 per person are available. Travel duration is 17h 5m
FlixBus	15h 55m	17:30	Prague	Wilsonova Coach Station	09:25	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 06/12/2025 17:30:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 09:25:00. 50 Economy ticket for £40 per person are available. Travel duration is 15h 55m
FlixBus	15h 35m	17:45	Prague	Na Knížecí Station	09:20	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 06/12/2025 17:45:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 09:20:00. 50 Economy ticket for £40 per person are available. Travel duration is 15h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 0m	01:45	Prague	Wilsonova Coach Station	18:45	Brussels	North Station	Economy	£50	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 07/12/2025 01:45:00 to North Station, Brussels (Belgium) arriving at 07/12/2025 18:45:00. 50 Economy ticket for £50 per person are available. Travel duration is 17h 0m
FlixBus	18h 25m	12:55	Prague	Zličín	07:20	Brussels	Midi Bus Station	Economy	£50	A Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 07/12/2025 12:55:00 to Midi Bus Station, Brussels (Belgium) arriving at 08/12/2025 07:20:00. 50 Economy ticket for £50 per person are available. Travel duration is 18h 25m
FlixBus	19h 0m	17:45	Prague	Na Knížecí Station	12:45	Brussels	Midi Bus Station	Economy	£50	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 07/12/2025 17:45:00 to Midi Bus Station, Brussels (Belgium) arriving at 08/12/2025 12:45:00. 50 Economy ticket for £50 per person are available. Travel duration is 19h 0m
European Sleeper	15h 25m	18:02	Prague	Wilsonova Coach Station	09:27	Brussels	Midi Bus Station	Economy	£214	A Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 07/12/2025 18:02:00 to Midi Bus Station, Brussels (Belgium) arriving at 08/12/2025 09:27:00. 50 Economy ticket for £214 per person are available. Travel duration is 15h 25m

Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than £12? You can find the corresponding connections below.
- RegioJet
  
  15h 40m
  
  0
  
  23:00
  
  Prague
  ÚAN Florenc
  
  08:05
  
  Cologne/Bonn Airport
  Cologne/Bonn Airport - Bus Station
  
  0
  
  Economy
  
  £26
  
  A Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 23:00:00 to Cologne/Bonn Airport - Bus Station, Cologne/Bonn Airport (Germany) arriving at 09/12/2025 08:05:00. 50 Economy ticket for £26 per person are available. Travel duration is 9h 5m
- FlixBus
  
  4h 30m
  
  0
  
  10:10
  
  Cologne/Bonn Airport
  Cologne/Bonn Airport - Bus Station
  
  14:40
  
  Brussels
  North Station
  
  0
  
  Economy
  
  £12
  
  A Bus from FlixBus goes from Cologne/Bonn Airport - Bus Station, Cologne/Bonn Airport (Germany) at 09/12/2025 10:10:00 to North Station, Brussels (Belgium) arriving at 09/12/2025 14:40:00. 50 Economy ticket for £12 per person are available. Travel duration is 4h 30m
Travel time is 0h 15m longer, but you will save £12

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 5m	17:15	Prague	ÚAN Florenc	09:20	Brussels	North Station	Economy	£40	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 17:15:00 to North Station, Brussels (Belgium) arriving at 09/12/2025 09:20:00. 50 Economy ticket for £40 per person are available. Travel duration is 16h 5m
FlixBus	17h 45m	16:15	Prague	ÚAN Florenc	10:00	Brussels	Midi Bus Station	Economy	£40	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 08/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 09/12/2025 10:00:00. 50 Economy ticket for £40 per person are available. Travel duration is 17h 45m
FlixBus	15h 35m	17:45	Prague	Na Knížecí Station	09:20	Brussels	North Station	Economy	£41	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 08/12/2025 17:45:00 to North Station, Brussels (Belgium) arriving at 09/12/2025 09:20:00. 50 Economy ticket for £41 per person are available. Travel duration is 15h 35m
FlixBus	18h 0m	20:40	Prague	Na Knížecí Station	14:40	Brussels	North Station	Economy	£41	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 08/12/2025 20:40:00 to North Station, Brussels (Belgium) arriving at 09/12/2025 14:40:00. 50 Economy ticket for £41 per person are available. Travel duration is 18h 0m
FlixBus	20h 0m	22:15	Prague	Na Knížecí Station	18:15	Brussels	North Station	Economy	£41	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 08/12/2025 22:15:00 to North Station, Brussels (Belgium) arriving at 09/12/2025 18:15:00. 50 Economy ticket for £41 per person are available. Travel duration is 20h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 25m	17:15	Prague	Wilsonova Coach Station	14:40	Brussels	North Station	Economy	£39	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 09/12/2025 17:15:00 to North Station, Brussels (Belgium) arriving at 10/12/2025 14:40:00. 50 Economy ticket for £39 per person are available. Travel duration is 21h 25m
FlixBus	18h 40m	20:00	Prague	ÚAN Florenc	14:40	Brussels	North Station	Economy	£39	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 09/12/2025 20:00:00 to North Station, Brussels (Belgium) arriving at 10/12/2025 14:40:00. 50 Economy ticket for £39 per person are available. Travel duration is 18h 40m
FlixBus	21h 5m	09:40	Prague	Na Knížecí Station	06:45	Brussels	North Station	Economy	£39	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 09/12/2025 09:40:00 to North Station, Brussels (Belgium) arriving at 10/12/2025 06:45:00. 50 Economy ticket for £39 per person are available. Travel duration is 21h 5m
European Sleeper	16h 37m	18:02	Prague	Wilsonova Coach Station	10:39	Brussels	Midi Bus Station	Economy	£233	A Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 09/12/2025 18:02:00 to Midi Bus Station, Brussels (Belgium) arriving at 10/12/2025 10:39:00. 50 Economy ticket for £233 per person are available. Travel duration is 16h 37m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 25m	17:15	Prague	Wilsonova Coach Station	14:40	Brussels	North Station	Economy	£37	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 10/12/2025 17:15:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 14:40:00. 50 Economy ticket for £37 per person are available. Travel duration is 21h 25m
FlixBus	20h 10m	21:55	Prague	ÚAN Florenc	18:05	Brussels	North Station	Economy	£37	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 10/12/2025 21:55:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 18:05:00. 50 Economy ticket for £37 per person are available. Travel duration is 20h 10m
FlixBus	21h 5m	09:40	Prague	Na Knížecí Station	06:45	Brussels	North Station	Economy	£37	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 10/12/2025 09:40:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 06:45:00. 50 Economy ticket for £37 per person are available. Travel duration is 21h 5m
FlixBus	18h 15m	22:15	Prague	Na Knížecí Station	16:30	Brussels	North Station	Economy	£37	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 10/12/2025 22:15:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 16:30:00. 50 Economy ticket for £37 per person are available. Travel duration is 18h 15m
FlixBus	15h 55m	17:30	Prague	Wilsonova Coach Station	09:25	Brussels	North Station	Economy	£38	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 10/12/2025 17:30:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 09:25:00. 50 Economy ticket for £38 per person are available. Travel duration is 15h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 30m	12:50	Prague	Hradčanská	07:20	Brussels	Midi Bus Station	Economy	£38	A Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 11/12/2025 12:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 07:20:00. 50 Economy ticket for £38 per person are available. Travel duration is 18h 30m
FlixBus	18h 30m	04:00	Prague	Wilsonova Coach Station	22:30	Brussels	North Station	Economy	£39	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 11/12/2025 04:00:00 to North Station, Brussels (Belgium) arriving at 11/12/2025 22:30:00. 50 Economy ticket for £39 per person are available. Travel duration is 18h 30m
FlixBus	18h 40m	14:10	Prague	Wilsonova Coach Station	08:50	Brussels	North Station	Economy	£39	A Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 11/12/2025 14:10:00 to North Station, Brussels (Belgium) arriving at 12/12/2025 08:50:00. 50 Economy ticket for £39 per person are available. Travel duration is 18h 40m
European Sleeper	15h 25m	18:02	Prague	Wilsonova Coach Station	09:27	Brussels	Midi Bus Station	Economy	£184	A Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 11/12/2025 18:02:00 to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 09:27:00. 50 Economy ticket for £184 per person are available. Travel duration is 15h 25m

Best Price Offer: The price for the cheapest coach from Prague to Brussels is £36 on 17/12/2025. Flexible travellers save on ticket prices.

Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.

Sunday is the busiest day, with more than 40 daily coaches from Prague to Brussels. Tuesday has instead the fewest connections, with only 23 daily coaches between Prague and Brussels.

The busiest time of the day is the Afternoon, with 92 coaches from Prague to Brussels, while Morning sees the fewest connections between Prague and Brussels, with 33 offers.

Facts about coaches from Prague to Brussels

Compare all providers like FlixBus and European Sleeper that travel 32 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from £36!

Cheapest Bus	£36
Fastest Bus	13h 55m
Earliest Coach	01:45
Latest Coach	22:15
Daily Bus Connections	32 Ø
Distance	718.5 km
Coach Companies	FlixBus and European Sleeper

Cheapest coach connections from Prague to Brussels

Every day, 32 buses from 2 coach companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 01/12

Tuesday 02/12

Wednesday 03/12

Thursday 04/12

Friday 05/12

£51

Saturday 06/12

£40

Sunday 07/12

£50

Monday 08/12

£40

Tuesday 09/12

£39

Wednesday 10/12

£37

Thursday 11/12

£38

Friday 12/12

£42

Saturday 13/12

£38

Sunday 14/12

£44

Monday 15/12

£37

Tuesday 16/12

£37

Wednesday 17/12

£36

Thursday 18/12

£42

Friday 19/12

£49

Saturday 20/12

£55

Sunday 21/12

£59

Monday 22/12

£57

Tuesday 23/12

£74

Wednesday 24/12

£59

Thursday 25/12

£57

Friday 26/12

£59

Saturday 27/12

£59

Sunday 28/12

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.

With a price starting from £36, Wednesday is the cheapest day for a coach from Prague to Brussels. Sunday instead is the most expensive day with prices starting from £44.

Night is the cheapest day time for bus tickets from Prague to Brussels, with £36. Morning is the most expensive time of the day with prices starting from £37.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Prague to Brussels are also emptier.

All bus stations and stops in Prague and Brussels

The map below shows you where to find all the bus stations in Prague and Brussels.

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Coach Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Hradčanská

Milady Horákové 115/107

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

Central Station

City Tours

Rue du Marché Aux Herbes 82

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Brussels? Compare all modes of transports from Prague to Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the coaches from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague - Brussels coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Prague - Brussels bus trip is available from £36 and takes 18h 15m. Compare offers and save money!

How much could I save by comparing buses from Prague to Brussels?

The connection Prague to Brussels is offered by 2 companies with ticket prices ranging from £36 to £233. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Prague - Brussels route on average every day?

Each day, the bus route from Prague to Brussels is offered by roughly 32 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Brussels from Prague take?

The quickest coach from Prague to Brussels is provided by FlixBus and takes 13h 55m. Coach tickets for this connection cost £53. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus to Brussels departs from Prague at 01:45. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Prague to Brussels?

The latest bus to Brussels departs from Prague at 22:15. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Prague - Brussels route?

Passengers looking to travel from Prague to Brussels can travel with FlixBus and European Sleeper. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and European Sleeper.

What can I take with me on the bus to Brussels from Prague?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Prague Brussels bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Prague to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!