Bus tickets Prague to Brussels from £49

Compare all the coach companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus for the next days.

today
from £66
tomorrow
from £56
Tuesday
from £50
Wednesday
from £49
Thursday
from £50
Friday
from £58
Saturday
from £56

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £66
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £66
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £75
  • FlixBus
    16h 5m
    0
    21:50
    Prague
    Na Knížecí Station
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £81
  • FlixBus
    16h 30m
    0
    21:50
    Prague
    Na Knížecí Station
    14:20
    Brussels
    North Station
    0
    FlixBus
    Economy
    £82

Cheapest bus trips tomorrow

Prices are for one way and one person
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £56
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    15h 15m
    0
    23:05
    Prague
    ÚAN Florenc
    14:20
    Brussels
    North Station
    0
    FlixBus
    Economy
    £60
  • FlixBus
    16h 30m
    0
    21:50
    Prague
    Na Knížecí Station
    14:20
    Brussels
    North Station
    0
    FlixBus
    Economy
    £60

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    15h 55m
    0
    17:30
    Prague
    Wilsonova Coach Station
    09:25
    Brussels
    North Station
    0
    FlixBus
    Economy
    £52
  • FlixBus
    18h 45m
    0
    18:45
    Prague
    Wilsonova Coach Station
    13:30
    Brussels
    North Station
    0
    FlixBus
    Economy
    £52
  • FlixBus
    14h 45m
    0
    19:30
    Prague
    ÚAN Florenc
    10:15
    Brussels
    North Station
    0
    FlixBus
    Economy
    £52

Cheapest bus trips Wednesday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £49
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £49
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    18h 45m
    0
    18:45
    Prague
    Wilsonova Coach Station
    13:30
    Brussels
    North Station
    0
    FlixBus
    Economy
    £51

Cheapest bus trips Thursday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £50
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £52
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £55
  • FlixBus
    18h 40m
    0
    03:50
    Prague
    Wilsonova Coach Station
    22:30
    Brussels
    North Station
    0
    FlixBus
    Economy
    £58

Cheapest bus trips Friday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £60
  • FlixBus
    16h 5m
    0
    22:15
    Prague
    Na Knížecí Station
    14:20
    Brussels
    North Station
    0
    FlixBus
    Economy
    £63
  • Did you know that if you travel from Prague to Brussels via Bonn, you can save more than £9? You can find the corresponding connections below.
    • FlixBus
      14h 50m
      0
      23:05
      Prague
      ÚAN Florenc
      08:35
      Bonn
      Central Bus Station
      0
      FlixBus
      Economy
      £31
      • Waiting Time 0h 5m
    • FlixBus
      5h 15m
      0
      08:40
      Bonn
      Central Bus Station
      13:55
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      £19
    Travel time is 0h 55m longer, but you will save £9

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    03:50
    Prague
    Wilsonova Coach Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £56
  • FlixBus
    13h 55m
    0
    04:10
    Prague
    Na Knížecí Station
    18:05
    Brussels
    North Station
    0
    FlixBus
    Economy
    £56
  • FlixBus
    14h 50m
    0
    23:05
    Prague
    ÚAN Florenc
    13:55
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £56
  • FlixBus
    15h 5m
    0
    16:15
    Prague
    ÚAN Florenc
    07:20
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    £58
  • FlixBus
    17h 0m
    0
    01:45
    Prague
    Wilsonova Coach Station
    18:45
    Brussels
    North Station
    0
    FlixBus
    Economy
    £59
  • Did you know that if you travel from Prague to Brussels via Bonn, you can save more than £7? You can find the corresponding connections below.
    • FlixBus
      14h 50m
      0
      23:05
      Prague
      ÚAN Florenc
      08:35
      Bonn
      Central Bus Station
      0
      FlixBus
      Economy
      £31
      • Waiting Time 0h 5m
    • FlixBus
      5h 15m
      0
      08:40
      Bonn
      Central Bus Station
      13:55
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      £19
    Travel time is 0h 55m longer, but you will save £7

Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.
Monday is the busiest day, with more than 41 daily coaches from Prague to Brussels. Friday has instead the fewest connections, with only 38 daily coaches between Prague and Brussels.
The busiest time of the day is the Afternoon, with 112 coaches from Prague to Brussels, while Morning sees the fewest connections between Prague and Brussels, with 29 offers.

Facts about coaches from Prague to Brussels

Compare all providers like FlixBus that travel 39 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from £49!

Cheapest Bus £49
Fastest Bus 13h 55m
Earliest Coach 01:45
Latest Coach 23:05
Daily Bus Connections 39 Ø
Distance 718.5 km
Coach Companies FlixBus

Cheapest coach connections from Prague to Brussels

Every day, 39 buses from 1 coach companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 13/07/2025 and for the following days.

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 07/07
Tuesday 08/07
Wednesday 09/07
Thursday 10/07
Friday 11/07
Saturday 12/07
Sunday 13/07
£66
Monday 14/07
£92
Tuesday 15/07
£50
Wednesday 16/07
£49
Thursday 17/07
£50
Friday 18/07
£92
Saturday 19/07
£56
Sunday 20/07
£90
Monday 21/07
£50
Tuesday 22/07
£47
Wednesday 23/07
£46
Thursday 24/07
£49
Friday 25/07
£55
Saturday 26/07
£55
Sunday 27/07
£54
Monday 28/07
£46
Tuesday 29/07
£44
Wednesday 30/07
£43
Thursday 31/07
£44
Friday 01/08
£83
Saturday 02/08
£66
Sunday 03/08

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.
With a price starting from £49, Wednesday is the cheapest day for a coach from Prague to Brussels. Sunday instead is the most expensive day with prices starting from £66.
Night is the cheapest day time for bus tickets from Prague to Brussels, with £49. Morning is the most expensive time of the day with prices starting from £53.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Prague to Brussels are also emptier.

All bus stations and stops in Prague and Brussels

The map below shows you where to find all the bus stations in Prague and Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the coaches from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague - Brussels coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Prague - Brussels bus trip is available from £49 and takes 14h 15m. Compare offers and save money!

How much could I save by comparing buses from Prague to Brussels?

The connection Prague to Brussels is offered by 1 companies with ticket prices ranging from £49 to £131. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Prague - Brussels route on average every day?

Each day, the bus route from Prague to Brussels is offered by roughly 39 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Brussels from Prague take?

The quickest coach from Prague to Brussels is provided by FlixBus and takes 13h 55m. Coach tickets for this connection cost £66. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus to Brussels departs from Prague at 01:45. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Prague to Brussels?

The latest bus to Brussels departs from Prague at 23:05. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Prague - Brussels route?

Passengers looking to travel from Prague to Brussels can travel with FlixBus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the bus to Brussels from Prague?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Prague Brussels bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Prague to Brussels

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from Znojmo to Prague Bus from Znojmo to Prague
Coach Bibione to Prague Coach Bibione to Prague
Coach to Prague from Linz Coach to Prague from Linz
Coach Břeclav to Prague Coach Břeclav to Prague
Coaches Porto to Brussels Coaches Porto to Brussels
Bus Amsterdam to Brussels Bus Amsterdam to Brussels
Bus Leeds to Brussels Bus Leeds to Brussels
Buses Liverpool to Brussels Buses Liverpool to Brussels
Popular Airport Transfers to Prague and to Brussels
CheckMyBus › Coaches in Czech Republic › Coach to Prague › Coach to Brussels

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

deals,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

for

ads

personalisation.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.