What is the best way to travel from Prague to Brussels?
Looking for a trip? Check and compare all the available Buses and Flights to Brussels from Prague. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 4 available companies to find your perfect trip!
What is the cheapest way to reach Brussels from Prague?
You can reach Brussels with just £57 by taking a Flight from EasyJet Airline, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus14h 50m023:05PragueÚAN Florenc13:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 19/12/2025 23:05:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £76 per person are available. Travel duration is 14h 50m
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FlixBus18h 50m014:30PragueČerný Most09:20BrusselsNorth Station0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 19/12/2025 14:30:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:20:00. 50 Economy ticket for £77 per person are available. Travel duration is 18h 50m
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FlixBus19h 5m018:50Prague AirportPrague Airport - T1/213:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 19/12/2025 18:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 5m
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FlixBus15h 25m018:00PragueÚAN Florenc09:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 19/12/2025 18:00:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 25m
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FlixBus15h 40m017:45PragueWilsonova Coach Station09:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 19/12/2025 17:45:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 40m
Cheapest Buses Friday
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FlixBus13h 20m010:35PragueÚAN Florenc23:55BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 20/12/2025 10:35:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 23:55:00. 50 Economy ticket for £69 per person are available. Travel duration is 13h 20m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 20/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 13h 55m
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FlixBus14h 40m009:15Prague AirportPrague Airport - T1/223:55BrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 09:15:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 23:55:00. 50 Economy ticket for £73 per person are available. Travel duration is 14h 40m
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FlixBus19h 40m016:45PragueWilsonova Coach Station12:25BrusselsHeysel0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 16:45:00 to Heysel, Brussels (Belgium) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 40m
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Ryanair21h 20m015:45Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 15:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £159 per person are available. Travel duration is 21h 20m
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Buzz31h 5m006:00Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 06:00:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £171 per person are available. Travel duration is 31h 5m
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Skyscanner27h 45m009:20Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 09:20:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £175 per person are available. Travel duration is 27h 45m
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Volotea15h 25m021:40Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £186 per person are available. Travel duration is 15h 25m
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EasyJet Airline26h 10m010:55Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 10:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £192 per person are available. Travel duration is 26h 10m
Cheapest Buses Saturday
Cheapest Flights Saturday
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EasyJet Airline12h 15m008:30Prague AirportPrague Airport - T1/220:45Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 08:30:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 20:45:00. 50 Economy ticket for £57 per person are available. Travel duration is 12h 15m
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Skyscanner12h 45m008:00Prague AirportPrague Airport - T1/220:45Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 08:00:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 20:45:00. 50 Economy ticket for £62 per person are available. Travel duration is 12h 45m
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EasyJet Airline12h 5m008:30Prague AirportPrague Airport - T1/220:35Brussels AirportBrussels Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 08:30:00 to Brussels Airport, Brussels Airport (Belgium) arriving at 21/12/2025 20:35:00. 50 Economy ticket for £64 per person are available. Travel duration is 12h 5m
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Skyscanner5h 30m008:00Prague AirportPrague Airport - T1/213:30Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 08:00:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £67 per person are available. Travel duration is 5h 30m
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Buzz4h 5m007:40Prague AirportPrague Airport - T1/211:45Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 07:40:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 11:45:00. 50 Economy ticket for £86 per person are available. Travel duration is 4h 5m
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Buzz4h 10m018:20Prague AirportPrague Airport - T1/222:30Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 18:20:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 22:30:00. 50 Economy ticket for £86 per person are available. Travel duration is 4h 10m
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FlixBus13h 20m011:05PragueÚAN Florenc00:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 11:05:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 00:25:00. 50 Economy ticket for £73 per person are available. Travel duration is 13h 20m
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FlixBus19h 40m022:25PragueZličín18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 21/12/2025 22:25:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 19h 40m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 21/12/2025 18:05:00. 50 Economy ticket for £76 per person are available. Travel duration is 14h 15m
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European Sleeper15h 27m018:00PragueTrain station Wilsonova09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Train station Wilsonova, Prague (Czech Republic) at 21/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 09:27:00. 50 Economy ticket for £228 per person are available. Travel duration is 15h 27m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 09:27:00. 50 Economy ticket for £832 per person are available. Travel duration is 15h 27m
Cheapest Flights Sunday
Cheapest Buses Sunday
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FlixBus13h 20m011:05PragueÚAN Florenc00:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 22/12/2025 11:05:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 00:25:00. 50 Economy ticket for £67 per person are available. Travel duration is 13h 20m
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FlixBus19h 40m016:45PragueWilsonova Coach Station12:25BrusselsHeysel0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 16:45:00 to Heysel, Brussels (Belgium) arriving at 23/12/2025 12:25:00. 50 Economy ticket for £67 per person are available. Travel duration is 19h 40m
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FlixBus15h 35m008:50Prague AirportPrague Airport - T1/200:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 08:50:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 00:25:00. 50 Economy ticket for £70 per person are available. Travel duration is 15h 35m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £71 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £71 per person are available. Travel duration is 13h 55m
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Volotea35h 30m008:35Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 08:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £190 per person are available. Travel duration is 35h 30m
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Buzz7h 50m005:55Prague AirportPrague Airport - T1/213:45Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 05:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 22/12/2025 13:45:00. 50 Economy ticket for £197 per person are available. Travel duration is 7h 50m
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EasyJet Airline30h 15m013:50Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 13:50:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £212 per person are available. Travel duration is 30h 15m
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Smartwings7h 45m006:00Prague AirportPrague Airport - T1/213:45Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 06:00:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 22/12/2025 13:45:00. 50 Economy ticket for £215 per person are available. Travel duration is 7h 45m
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Ryanair23h 20m020:45Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 20:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £215 per person are available. Travel duration is 23h 20m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £69 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £69 per person are available. Travel duration is 13h 55m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 07:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 15h 5m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 09:27:00. 50 Economy ticket for £476 per person are available. Travel duration is 15h 27m
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Buzz14h 10m005:55Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 05:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £221 per person are available. Travel duration is 14h 10m
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Jet2.com29h 35m012:45Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 12:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £235 per person are available. Travel duration is 29h 35m
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Ryanair30h 45m011:35Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 11:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £251 per person are available. Travel duration is 30h 45m
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EasyJet Airline20h 40m021:40Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 21:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £268 per person are available. Travel duration is 20h 40m
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Smartwings35h 40m006:40Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 06:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £329 per person are available. Travel duration is 35h 40m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus14h 50m023:05PragueÚAN Florenc13:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 23:05:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 13:55:00. 50 Economy ticket for £61 per person are available. Travel duration is 14h 50m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 07:20:00. 50 Economy ticket for £63 per person are available. Travel duration is 15h 5m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 18:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 18:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 13h 55m
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FlixBus20h 0m011:20Prague AirportPrague Airport - T1/207:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 24/12/2025 11:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 07:20:00. 50 Economy ticket for £67 per person are available. Travel duration is 20h 0m
Cheapest Buses Wednesday
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 18:05:00. 50 Economy ticket for £61 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 25/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 18:05:00. 50 Economy ticket for £61 per person are available. Travel duration is 13h 55m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 07:20:00. 50 Economy ticket for £63 per person are available. Travel duration is 15h 5m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 09:27:00. 50 Economy ticket for £464 per person are available. Travel duration is 15h 27m
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Vueling Airlines30h 30m015:50Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 15:50:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £198 per person are available. Travel duration is 30h 30m
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Air Bagan29h 15m017:05Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Air Bagan goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 17:05:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £203 per person are available. Travel duration is 29h 15m
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Smartwings34h 45m011:35Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 11:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £206 per person are available. Travel duration is 34h 45m
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Transavia France25h 40m020:40Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Transavia France goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £298 per person are available. Travel duration is 25h 40m
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Brussels Airlines27h 35m018:45Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 18:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £346 per person are available. Travel duration is 27h 35m
Cheapest Buses Thursday
Cheapest Flights Thursday
What are the fastest trips from Prague to Brussels?
You can get to Brussels from Prague in just 1h 30m with a Flight from Smartwings. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus14h 50m023:05PragueÚAN Florenc13:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 19/12/2025 23:05:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £76 per person are available. Travel duration is 14h 50m
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FlixBus15h 25m018:00PragueÚAN Florenc09:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 19/12/2025 18:00:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 25m
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FlixBus15h 40m017:45PragueWilsonova Coach Station09:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 19/12/2025 17:45:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 15h 40m
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FlixBus18h 50m014:30PragueČerný Most09:20BrusselsNorth Station0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 19/12/2025 14:30:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 09:20:00. 50 Economy ticket for £77 per person are available. Travel duration is 18h 50m
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FlixBus19h 5m018:50Prague AirportPrague Airport - T1/213:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 19/12/2025 18:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 20/12/2025 13:55:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 5m
Fastest Buses Friday
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FlixBus13h 20m010:35PragueÚAN Florenc23:55BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 20/12/2025 10:35:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 23:55:00. 50 Economy ticket for £69 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 20/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 14h 15m
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FlixBus14h 40m009:15Prague AirportPrague Airport - T1/223:55BrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 09:15:00 to North Station, Brussels (Belgium) arriving at 20/12/2025 23:55:00. 50 Economy ticket for £73 per person are available. Travel duration is 14h 40m
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FlixBus19h 40m016:45PragueWilsonova Coach Station12:25BrusselsHeysel0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 20/12/2025 16:45:00 to Heysel, Brussels (Belgium) arriving at 21/12/2025 12:25:00. 50 Economy ticket for £80 per person are available. Travel duration is 19h 40m
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Volotea15h 25m021:40Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 21:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £186 per person are available. Travel duration is 15h 25m
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Ryanair21h 20m015:45Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 15:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £159 per person are available. Travel duration is 21h 20m
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EasyJet Airline26h 10m010:55Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 10:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £192 per person are available. Travel duration is 26h 10m
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Skyscanner27h 45m009:20Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 09:20:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £175 per person are available. Travel duration is 27h 45m
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Buzz31h 5m006:00Prague AirportPrague Airport - T1/213:05Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 20/12/2025 06:00:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 21/12/2025 13:05:00. 50 Economy ticket for £171 per person are available. Travel duration is 31h 5m
Fastest Buses Saturday
Fastest Flights Saturday
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Smartwings1h 30m017:15Prague AirportPrague Airport - T1/218:45Brussels AirportBrussels Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 17:15:00 to Brussels Airport, Brussels Airport (Belgium) arriving at 21/12/2025 18:45:00. 50 Economy ticket for £97 per person are available. Travel duration is 1h 30m
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Buzz4h 5m007:40Prague AirportPrague Airport - T1/211:45Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 07:40:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 11:45:00. 50 Economy ticket for £86 per person are available. Travel duration is 4h 5m
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Buzz4h 10m018:20Prague AirportPrague Airport - T1/222:30Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 18:20:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 22:30:00. 50 Economy ticket for £86 per person are available. Travel duration is 4h 10m
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Skyscanner5h 30m008:00Prague AirportPrague Airport - T1/213:30Brussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 08:00:00 to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £67 per person are available. Travel duration is 5h 30m
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LOT Polish Airlines / Polskie Linie Lotnicze9h 10m009:35Prague AirportPrague Airport - T1/218:45Brussels AirportBrussels Airport0EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 09:35:00 to Brussels Airport, Brussels Airport (Belgium) arriving at 21/12/2025 18:45:00. 50 Economy ticket for £90 per person are available. Travel duration is 9h 10m
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KLM Cityhopper11h 20m020:15Prague AirportPrague Airport - T1/207:35Brussels AirportBrussels Airport0EconomyA Flight from KLM Cityhopper goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 21/12/2025 20:15:00 to Brussels Airport, Brussels Airport (Belgium) arriving at 22/12/2025 07:35:00. 50 Economy ticket for £122 per person are available. Travel duration is 11h 20m
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FlixBus13h 20m011:05PragueÚAN Florenc00:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 21/12/2025 11:05:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 00:25:00. 50 Economy ticket for £73 per person are available. Travel duration is 13h 20m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 21/12/2025 18:05:00. 50 Economy ticket for £76 per person are available. Travel duration is 14h 15m
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European Sleeper15h 27m018:00PragueTrain station Wilsonova09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Train station Wilsonova, Prague (Czech Republic) at 21/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 09:27:00. 50 Economy ticket for £228 per person are available. Travel duration is 15h 27m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 21/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 22/12/2025 09:27:00. 50 Economy ticket for £832 per person are available. Travel duration is 15h 27m
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FlixBus19h 40m022:25PragueZličín18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 21/12/2025 22:25:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 19h 40m
Fastest Flights Sunday
Fastest Buses Sunday
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Smartwings7h 45m006:00Prague AirportPrague Airport - T1/213:45Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 06:00:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 22/12/2025 13:45:00. 50 Economy ticket for £215 per person are available. Travel duration is 7h 45m
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Buzz7h 50m005:55Prague AirportPrague Airport - T1/213:45Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 05:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 22/12/2025 13:45:00. 50 Economy ticket for £197 per person are available. Travel duration is 7h 50m
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Ryanair23h 20m020:45Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 20:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £215 per person are available. Travel duration is 23h 20m
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EasyJet Airline30h 15m013:50Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 13:50:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £212 per person are available. Travel duration is 30h 15m
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Volotea35h 30m008:35Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Volotea goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 08:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £190 per person are available. Travel duration is 35h 30m
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FlixBus13h 20m011:05PragueÚAN Florenc00:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 22/12/2025 11:05:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 00:25:00. 50 Economy ticket for £67 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 22/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £71 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 22/12/2025 18:05:00. 50 Economy ticket for £71 per person are available. Travel duration is 14h 15m
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FlixBus15h 35m008:50Prague AirportPrague Airport - T1/200:25BrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 22/12/2025 08:50:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 00:25:00. 50 Economy ticket for £70 per person are available. Travel duration is 15h 35m
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FlixBus19h 40m016:45PragueWilsonova Coach Station12:25BrusselsHeysel0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 22/12/2025 16:45:00 to Heysel, Brussels (Belgium) arriving at 23/12/2025 12:25:00. 50 Economy ticket for £67 per person are available. Travel duration is 19h 40m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 23/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £69 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 18:05:00. 50 Economy ticket for £69 per person are available. Travel duration is 14h 15m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 23/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 07:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 15h 5m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 23/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 09:27:00. 50 Economy ticket for £476 per person are available. Travel duration is 15h 27m
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Buzz14h 10m005:55Prague AirportPrague Airport - T1/220:05Antwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 05:55:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 23/12/2025 20:05:00. 50 Economy ticket for £221 per person are available. Travel duration is 14h 10m
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EasyJet Airline20h 40m021:40Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 21:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £268 per person are available. Travel duration is 20h 40m
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Jet2.com29h 35m012:45Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 12:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £235 per person are available. Travel duration is 29h 35m
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Ryanair30h 45m011:35Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 11:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £251 per person are available. Travel duration is 30h 45m
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Smartwings35h 40m006:40Prague AirportPrague Airport - T1/218:20Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 23/12/2025 06:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 24/12/2025 18:20:00. 50 Economy ticket for £329 per person are available. Travel duration is 35h 40m
Fastest Buses Tuesday
Fastest Flights Tuesday
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 24/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 18:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 24/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 18:05:00. 50 Economy ticket for £65 per person are available. Travel duration is 14h 15m
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FlixBus14h 50m023:05PragueÚAN Florenc13:55BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 23:05:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 13:55:00. 50 Economy ticket for £61 per person are available. Travel duration is 14h 50m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 24/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 07:20:00. 50 Economy ticket for £63 per person are available. Travel duration is 15h 5m
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FlixBus20h 0m011:20Prague AirportPrague Airport - T1/207:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 24/12/2025 11:20:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 07:20:00. 50 Economy ticket for £67 per person are available. Travel duration is 20h 0m
Fastest Buses Wednesday
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FlixBus13h 55m004:10PragueNa Knížecí Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 25/12/2025 04:10:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 18:05:00. 50 Economy ticket for £61 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m003:50PragueWilsonova Coach Station18:05BrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 03:50:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 18:05:00. 50 Economy ticket for £61 per person are available. Travel duration is 14h 15m
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FlixBus15h 5m016:15PragueÚAN Florenc07:20BrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 25/12/2025 16:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 07:20:00. 50 Economy ticket for £63 per person are available. Travel duration is 15h 5m
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European Sleeper15h 27m018:00PragueWilsonova Coach Station09:27BrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Coach Station, Prague (Czech Republic) at 25/12/2025 18:00:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 09:27:00. 50 Economy ticket for £464 per person are available. Travel duration is 15h 27m
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Transavia France25h 40m020:40Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Transavia France goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 20:40:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £298 per person are available. Travel duration is 25h 40m
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Brussels Airlines27h 35m018:45Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 18:45:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £346 per person are available. Travel duration is 27h 35m
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Air Bagan29h 15m017:05Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Air Bagan goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 17:05:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £203 per person are available. Travel duration is 29h 15m
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Vueling Airlines30h 30m015:50Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 15:50:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £198 per person are available. Travel duration is 30h 30m
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Smartwings34h 45m011:35Prague AirportPrague Airport - T1/222:20Antwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 25/12/2025 11:35:00 to Antwerp Airport, Antwerp Airport (Belgium) arriving at 26/12/2025 22:20:00. 50 Economy ticket for £206 per person are available. Travel duration is 34h 45m
Fastest Buses Thursday
Fastest Flights Thursday
Here you will find all operators and timetables for a
Bus from Prague to Brussels
What are the most popular stations in Prague and Brussels?
In Prague, you will usually depart from Wilsonova Coach Station, ÚAN Florenc or Černý Most, while in Brussels you will be arriving at Midi Bus Station, North Station or Gare Centrale, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Brussels from Prague? With 9 connections between 4 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Brussels, you can pay as low as £57 with a Flight from EasyJet Airline.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Smartwings: you will get to Brussels in just 1h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Brussels are FlixBus, EasyJet Airline and Buzz, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Brussels is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Saint-Gilles, and look at flights from Prague Airport, and landing at Brussels South Charleroi Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Brussels?
The most popular companies between Prague and Brussels, are FlixBus, EasyJet Airline and Buzz. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: EasyJet Airline, Buzz, Smartwings and 11 more.
All you need to know when you travel from Prague to Brussels
Check all information on comfort and services on all modes of transports from Prague to Brussels. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Brussels
How can I reach Brussels from Prague?
Every day, there are on average 9 connections between Bus and Flight, with which you can get to Brussels from Prague.
How far is Brussels from Prague?
The distance between Prague and Brussels is 718.5 km.
What is the most ecofriendly mode of transport between Prague and Brussels?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Prague to Brussels?
You can get to Brussels with just £57 by taking a Flight from EasyJet Airline.
What is the fastest way to get from Prague to Brussels?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Brussels in just 1h 30m with a Flight from Smartwings.
More routes to Prague and to Brussels
Looking for more options? Here you can see the most popular routes to Prague and to Brussels. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Brno to Prague
- Budapest to Prague
- Česká Lípa to Prague
- Dresden to Prague
- Florence to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Linz to Prague
- London to Prague
- Lyon to Prague
- Milan to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Paris to Prague
- Pelhřimov to Prague
- Rome to Prague
- Třebíč to Prague
- Vienna to Prague
- Vilnius to Prague
- Zurich to Prague
- Trips to Brussels
- Basel to Brussels
- Berlin to Brussels
- Bremen to Brussels
- Bruges (BE) to Brussels
- Carcassonne to Brussels
- Dortmund to Brussels
- Dusseldorf to Brussels
- Frankfurt am Main to Brussels
- Hamburg to Brussels
- Innsbruck to Brussels
- Le Mans to Brussels
- Leeds to Brussels
- Leipzig to Brussels
- Lille to Brussels
- Madrid to Brussels
- Milan to Brussels
- Münster to Brussels
- Nottingham to Brussels
- Porto to Brussels
- Rotterdam to Brussels
- Saarbruecken to Brussels
- Salzburg to Brussels
- Sofia to Brussels
- Valencia to Brussels
