What is the best way to travel from Houston to St. Louis, MO?
Looking for a trip? Check and compare all the available Buses and Flights to St. Louis, MO from Houston. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 5 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Houston?
You can reach St. Louis, MO with just £78 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound Lines Mexico37h 15m009:30HoustonSW Agencia Autobuses22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 05/03/2026 09:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 22:45:00. 50 Economy ticket for £109 per person are available. Travel duration is 37h 15m
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FlixBus20h 35m010:35HoustonDowntown Houston07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 05/03/2026 10:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £109 per person are available. Travel duration is 20h 35m
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Greyhound US20h 55m001:50HoustonHarrisburg Blvd Station22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 05/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 05/03/2026 22:45:00. 50 Economy ticket for £110 per person are available. Travel duration is 20h 55m
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Greyhound US22h 55m008:15HoustonHarrisburg Blvd Station07:10St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 05/03/2026 08:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 55m
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FlixBus22h 15m008:55HoustonUptown/Upper Kirby07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 05/03/2026 08:55:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 15m
Cheapest Buses Thursday
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Greyhound US21h 0m001:50HoustonHarrisburg Blvd Station22:50St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 09/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 09/03/2026 22:50:00. 50 Economy ticket for £78 per person are available. Travel duration is 21h 0m
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Greyhound US22h 55m008:15HoustonHarrisburg Blvd Station07:10St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 09/03/2026 08:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 07:10:00. 50 Economy ticket for £78 per person are available. Travel duration is 22h 55m
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Valley Transit30h 20m006:35HoustonSW Agencia Autobuses12:55St. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 09/03/2026 06:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £78 per person are available. Travel duration is 30h 20m
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FlixBus22h 15m008:55HoustonUptown/Upper Kirby07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 09/03/2026 08:55:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 07:10:00. 50 Economy ticket for £78 per person are available. Travel duration is 22h 15m
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FlixBus25h 30m011:25HoustonUptown/Upper Kirby12:55St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 09/03/2026 11:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £78 per person are available. Travel duration is 25h 30m
Cheapest Buses Monday
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Greyhound US23h 10m013:45HoustonHarrisburg Blvd Station12:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/03/2026 13:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £84 per person are available. Travel duration is 23h 10m
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Greyhound US20h 55m001:50HoustonHarrisburg Blvd Station22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 22:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 20h 55m
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Valley Transit30h 20m006:35HoustonSW Agencia Autobuses12:55St. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/03/2026 06:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 30h 20m
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FlixBus25h 30m011:25HoustonUptown/Upper Kirby12:55St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 10/03/2026 11:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 25h 30m
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FlixBus26h 55m019:50HoustonUptown/Upper Kirby22:45St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 10/03/2026 19:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 22:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 26h 55m
Cheapest Buses Tuesday
What are the fastest trips from Houston to St. Louis, MO?
You can get to St. Louis, MO from Houston in just 20h 35m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus20h 35m010:35HoustonDowntown Houston07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 05/03/2026 10:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £109 per person are available. Travel duration is 20h 35m
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Greyhound US20h 55m001:50HoustonHarrisburg Blvd Station22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 05/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 05/03/2026 22:45:00. 50 Economy ticket for £110 per person are available. Travel duration is 20h 55m
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FlixBus22h 15m008:55HoustonUptown/Upper Kirby07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 05/03/2026 08:55:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 15m
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Greyhound US22h 55m008:15HoustonHarrisburg Blvd Station07:10St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 05/03/2026 08:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 07:10:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 55m
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Greyhound Lines Mexico37h 15m009:30HoustonSW Agencia Autobuses22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 05/03/2026 09:30:00 to Gateway Station, St. Louis, MO (USA) arriving at 06/03/2026 22:45:00. 50 Economy ticket for £109 per person are available. Travel duration is 37h 15m
Fastest Buses Thursday
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Greyhound US21h 0m001:50HoustonHarrisburg Blvd Station22:50St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 09/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 09/03/2026 22:50:00. 50 Economy ticket for £78 per person are available. Travel duration is 21h 0m
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FlixBus22h 15m008:55HoustonUptown/Upper Kirby07:10St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 09/03/2026 08:55:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 07:10:00. 50 Economy ticket for £78 per person are available. Travel duration is 22h 15m
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Greyhound US22h 55m008:15HoustonHarrisburg Blvd Station07:10St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 09/03/2026 08:15:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 07:10:00. 50 Economy ticket for £78 per person are available. Travel duration is 22h 55m
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FlixBus25h 30m011:25HoustonUptown/Upper Kirby12:55St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 09/03/2026 11:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £78 per person are available. Travel duration is 25h 30m
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Valley Transit30h 20m006:35HoustonSW Agencia Autobuses12:55St. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 09/03/2026 06:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £78 per person are available. Travel duration is 30h 20m
Fastest Buses Monday
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Greyhound US20h 55m001:50HoustonHarrisburg Blvd Station22:45St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/03/2026 01:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 10/03/2026 22:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 20h 55m
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Greyhound US23h 10m013:45HoustonHarrisburg Blvd Station12:55St. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/03/2026 13:45:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £84 per person are available. Travel duration is 23h 10m
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FlixBus25h 30m011:25HoustonUptown/Upper Kirby12:55St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 10/03/2026 11:25:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 25h 30m
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FlixBus26h 55m019:50HoustonUptown/Upper Kirby22:45St. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 10/03/2026 19:50:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 22:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 26h 55m
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Valley Transit30h 20m006:35HoustonSW Agencia Autobuses12:55St. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/03/2026 06:35:00 to Gateway Station, St. Louis, MO (USA) arriving at 11/03/2026 12:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 30h 20m
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Houston to St. Louis, MO
What are the most popular stations in Houston and St. Louis, MO?
In Houston, you will usually depart from Main St & Airline Dr, Lockwood or Hillcroft METRO Park and Ride Coach Station, while in St. Louis, MO you will be arriving at Skinker Boulevard, Lindbergh @ Hackberry NB Bus Stop or Gateway Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Houston? With 5 connections between 5 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Houston and St. Louis, MO, you can pay as low as £78 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to St. Louis, MO in just 20h 35m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Houston and St. Louis, MO are FlixBus, Greyhound US and Valley Transit, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Houston and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from West University Place, TX or to Sauget, IL, and look at flights from William P. Hobby Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Houston to St. Louis, MO?
The most popular companies between Houston and St. Louis, MO, are FlixBus, Greyhound US and Valley Transit. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Greyhound US, Valley Transit and 1 more.
All you need to know when you travel from Houston to St. Louis, MO
Check all information on comfort and services on all modes of transports from Houston to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Houston to St. Louis, MO
How can I reach St. Louis, MO from Houston?
Every day, there are on average 5 connections between Flight and Bus, with which you can get to St. Louis, MO from Houston.
How far is St. Louis, MO from Houston?
The distance between Houston and St. Louis, MO is 1,094.8 km.
What is the most ecofriendly mode of transport between Houston and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 30 kgs of CO2, a train 38 kgs, a car 186 kgs, and a flight 269 kgs.
What is the cheapest mode of transport from Houston to St. Louis, MO?
You can get to St. Louis, MO with just £78 by taking a Bus from Greyhound US.
What is the fastest way to get from Houston to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 20h 35m with a Bus from FlixBus.
More routes to Houston and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Houston and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
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