What is the best way to travel from Isernia to Rome?
Looking for a trip? Check and compare all the available Carpool and Buses to Rome from Isernia. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Rome from Isernia?
You can reach Rome with just £8 by taking a Bus from MarinoBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 04/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 04/11/2026 14:00:00. 50 Economy ticket for £10 per person are available. Travel duration is 2h 25m
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Trenitalia5h 0m015:20IserniaCentral Bus Station20:20RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 04/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 04/11/2026 20:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 0m
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 04/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 04/11/2026 10:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 25m
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Trenitalia4h 35m015:20IserniaCentral Bus Station19:55RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 04/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 04/11/2026 19:55:00. 50 Economy ticket for £51 per person are available. Travel duration is 4h 35m
Cheapest Buses Wednesday
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 05/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 05/11/2026 14:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 2h 25m
Cheapest Buses Thursday
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 06/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 06/11/2026 10:50:00. 50 Economy ticket for £8 per person are available. Travel duration is 2h 25m
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Trenitalia3h 1m004:50IserniaCentral Bus Station07:51RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 04:50:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 07:51:00. 50 Economy ticket for £12 per person are available. Travel duration is 3h 1m
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Trenitalia5h 0m015:20IserniaCentral Bus Station20:20RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 20:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 0m
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Trenitalia4h 21m018:20IserniaCentral Bus Station22:41RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 18:20:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 22:41:00. 50 Economy ticket for £12 per person are available. Travel duration is 4h 21m
Cheapest Buses Friday
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 07/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 07/11/2026 14:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 2h 25m
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BlaBlaCar2h 30m008:00Isernia10:30Rome0EconomyA Car from BlaBlaCar goes from , Isernia (Italy) at 07/11/2026 08:00:00 to , Rome (Italy) arriving at 07/11/2026 10:30:00. 50 Economy ticket for £15 per person are available. Travel duration is 2h 30m
Cheapest Buses Saturday
Cheapest Carpool Saturday
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 08/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 08/11/2026 10:50:00. 50 Economy ticket for £8 per person are available. Travel duration is 2h 25m
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 08/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 08/11/2026 14:00:00. 50 Economy ticket for £10 per person are available. Travel duration is 2h 25m
Cheapest Buses Sunday
What are the fastest trips from Isernia to Rome?
You can get to Rome from Isernia in just 2h 25m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 04/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 04/11/2026 14:00:00. 50 Economy ticket for £10 per person are available. Travel duration is 2h 25m
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 04/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 04/11/2026 10:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 25m
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Trenitalia4h 35m015:20IserniaCentral Bus Station19:55RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 04/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 04/11/2026 19:55:00. 50 Economy ticket for £51 per person are available. Travel duration is 4h 35m
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Trenitalia5h 0m015:20IserniaCentral Bus Station20:20RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 04/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 04/11/2026 20:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 0m
Fastest Buses Wednesday
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 05/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 05/11/2026 14:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 2h 25m
Fastest Buses Thursday
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 06/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 06/11/2026 10:50:00. 50 Economy ticket for £8 per person are available. Travel duration is 2h 25m
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Trenitalia3h 1m004:50IserniaCentral Bus Station07:51RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 04:50:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 07:51:00. 50 Economy ticket for £12 per person are available. Travel duration is 3h 1m
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Trenitalia4h 21m018:20IserniaCentral Bus Station22:41RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 18:20:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 22:41:00. 50 Economy ticket for £12 per person are available. Travel duration is 4h 21m
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Trenitalia5h 0m015:20IserniaCentral Bus Station20:20RomeTermini Central Station0EconomyA Bus from Trenitalia goes from Central Bus Station, Isernia (Italy) at 06/11/2026 15:20:00 to Termini Central Station, Rome (Italy) arriving at 06/11/2026 20:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 5h 0m
Fastest Buses Friday
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 07/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 07/11/2026 14:00:00. 50 Economy ticket for £9 per person are available. Travel duration is 2h 25m
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BlaBlaCar2h 30m008:00Isernia10:30Rome0EconomyA Car from BlaBlaCar goes from , Isernia (Italy) at 07/11/2026 08:00:00 to , Rome (Italy) arriving at 07/11/2026 10:30:00. 50 Economy ticket for £15 per person are available. Travel duration is 2h 30m
Fastest Buses Saturday
Fastest Carpool Saturday
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MarinoBus2h 25m008:25IserniaCentral Bus Station10:50RomeTiburtina Bus Station0EconomyA Bus from MarinoBus goes from Central Bus Station, Isernia (Italy) at 08/11/2026 08:25:00 to Tiburtina Bus Station, Rome (Italy) arriving at 08/11/2026 10:50:00. 50 Economy ticket for £8 per person are available. Travel duration is 2h 25m
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FlixBus2h 25m011:35IserniaCentral Bus Station14:00RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 08/11/2026 11:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 08/11/2026 14:00:00. 50 Economy ticket for £10 per person are available. Travel duration is 2h 25m
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Isernia to Rome
What are the most popular stations in Isernia and Rome?
In Isernia, you will usually depart from Central Bus Station or Train Station, while in Rome you will be arriving at Termini Bus Station, Tiburtina Train Station or Tiburtina Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Rome from Isernia? With 2 connections between 3 Carpool and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Isernia and Rome, you can pay as low as £8 with a Bus from MarinoBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Rome in just 2h 25m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Isernia and Rome are Trenitalia, FlixBus and MarinoBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Isernia and Rome is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Carpinone or to Settebagni, and look at flights from , and landing at Rome Ciampino Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Isernia to Rome?
The most popular companies between Isernia and Rome, are Trenitalia, FlixBus and MarinoBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Trenitalia, FlixBus and MarinoBus
All you need to know when you travel from Isernia to Rome
Check all information on comfort and services on all modes of transports from Isernia to Rome. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Isernia to Rome
How can I reach Rome from Isernia?
Every day, there are on average 2 connections between Carpool and Bus, with which you can get to Rome from Isernia.
How far is Rome from Isernia?
The distance between Isernia and Rome is 147.8 km.
What is the most ecofriendly mode of transport between Isernia and Rome?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 4 kgs of CO2, a train 5 kgs, a car 25 kgs, and a flight 36 kgs.
What is the cheapest mode of transport from Isernia to Rome?
You can get to Rome with just £8 by taking a Bus from MarinoBus.
What is the fastest way to get from Isernia to Rome?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Rome in just 2h 25m with a Bus from FlixBus.
More routes to Isernia and to Rome
Looking for more options? Here you can see the most popular routes to Isernia and to Rome. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Isernia
- Chieti to Isernia
- Naples to Isernia
- Rome to Isernia
- San Salvo Marina to Isernia
- Trips to Rome
- Alba Adriatica to Rome
- Avezzano to Rome
- Bari to Rome
- Benevento to Rome
- Chieti to Rome
- Civitavecchia to Rome
- Cosenza to Rome
- Fisciano to Rome
- Fiumicino to Rome
- Frascineto to Rome
- Lamezia Terme to Rome
- Lauria to Rome
- London to Rome
- Nuremberg to Rome
- Palermo to Rome
- Pescara to Rome
- Porto San Giorgio to Rome
- Rome Ciampino Airport to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Sicignano degli Alburni to Rome
- Siena to Rome
- Venice to Rome
- Villa San Giovanni to Rome
