Bus and Coach from Santa Ana, CA to San Diego: Compare all prices

Compare all timetables for the bus from Santa Ana, CA to San Diego

Here is a selection of the cheapest bus trips from the schedule from Santa Ana, CA to San Diego from various bus operators like FlixBus, Limousine Express or Greyhound US for the next days.

today

£11

tomorrow

£10

Wednesday

£10

Thursday

£10

Friday

Saturday

£17

Sunday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	1h 45m	20:30	Santa Ana, CA	Bus Stop	22:15	San Diego	Seaport Village	Economy	£11	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 09/03/2026 20:30:00 to Seaport Village, San Diego (USA) arriving at 09/03/2026 22:15:00. 50 Economy ticket for £11 per person are available. Travel duration is 1h 45m
FlixBus	1h 50m	14:35	Santa Ana, CA	Bus Stop	16:25	San Diego	Old Town Transit Center	Economy	£13	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 09/03/2026 14:35:00 to Old Town Transit Center, San Diego (USA) arriving at 09/03/2026 16:25:00. 50 Economy ticket for £13 per person are available. Travel duration is 1h 50m
Greyhound US	1h 45m	22:05	Santa Ana, CA	Bus Stop	23:50	San Diego	Old Town Transit Center	Economy	£19	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 09/03/2026 22:05:00 to Old Town Transit Center, San Diego (USA) arriving at 09/03/2026 23:50:00. 50 Economy ticket for £19 per person are available. Travel duration is 1h 45m
FlixBus	2h 15m	20:30	Santa Ana, CA	Bus Stop	22:45	San Diego	San Ysidro Transit Center	Economy	£19	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 09/03/2026 20:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 09/03/2026 22:45:00. 50 Economy ticket for £19 per person are available. Travel duration is 2h 15m
Greyhound US	1h 45m	10:00	Santa Ana, CA	Bus Stop	11:45	San Diego	Old Town Transit Center	Economy	£23	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 09/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 09/03/2026 11:45:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	1h 50m	14:35	Santa Ana, CA	Bus Stop	16:25	San Diego	Old Town Transit Center	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 10/03/2026 14:35:00 to Old Town Transit Center, San Diego (USA) arriving at 10/03/2026 16:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 50m
FlixBus	1h 45m	20:30	Santa Ana, CA	Bus Stop	22:15	San Diego	Seaport Village	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 10/03/2026 20:30:00 to Seaport Village, San Diego (USA) arriving at 10/03/2026 22:15:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 45m
FlixBus	1h 20m	14:35	Santa Ana, CA	Bus Stop	15:55	San Diego	La Jolla Village	Economy	£13	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 10/03/2026 14:35:00 to La Jolla Village, San Diego (USA) arriving at 10/03/2026 15:55:00. 50 Economy ticket for £13 per person are available. Travel duration is 1h 20m
Greyhound US	1h 45m	22:05	Santa Ana, CA	Bus Stop	23:50	San Diego	Old Town Transit Center	Economy	£18	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 10/03/2026 22:05:00 to Old Town Transit Center, San Diego (USA) arriving at 10/03/2026 23:50:00. 50 Economy ticket for £18 per person are available. Travel duration is 1h 45m
Greyhound US	1h 45m	10:00	Santa Ana, CA	Bus Stop	11:45	San Diego	Old Town Transit Center	Economy	£19	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 10/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 10/03/2026 11:45:00. 50 Economy ticket for £19 per person are available. Travel duration is 1h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	1h 50m	14:35	Santa Ana, CA	Bus Stop	16:25	San Diego	Old Town Transit Center	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 11/03/2026 14:35:00 to Old Town Transit Center, San Diego (USA) arriving at 11/03/2026 16:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 50m
FlixBus	1h 45m	20:30	Santa Ana, CA	Bus Stop	22:15	San Diego	Seaport Village	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 11/03/2026 20:30:00 to Seaport Village, San Diego (USA) arriving at 11/03/2026 22:15:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 45m
Greyhound US	1h 45m	22:05	Santa Ana, CA	Bus Stop	23:50	San Diego	Old Town Transit Center	Economy	£18	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 11/03/2026 22:05:00 to Old Town Transit Center, San Diego (USA) arriving at 11/03/2026 23:50:00. 50 Economy ticket for £18 per person are available. Travel duration is 1h 45m
Greyhound US	1h 45m	10:00	Santa Ana, CA	Bus Stop	11:45	San Diego	Old Town Transit Center	Economy	£19	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 11/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 11/03/2026 11:45:00. 50 Economy ticket for £19 per person are available. Travel duration is 1h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	1h 50m	14:35	Santa Ana, CA	Bus Stop	16:25	San Diego	Old Town Transit Center	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/03/2026 14:35:00 to Old Town Transit Center, San Diego (USA) arriving at 12/03/2026 16:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 50m
FlixBus	1h 45m	20:30	Santa Ana, CA	Bus Stop	22:15	San Diego	Seaport Village	Economy	£10	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/03/2026 20:30:00 to Seaport Village, San Diego (USA) arriving at 12/03/2026 22:15:00. 50 Economy ticket for £10 per person are available. Travel duration is 1h 45m
Greyhound US	1h 45m	22:05	Santa Ana, CA	Bus Stop	23:50	San Diego	Old Town Transit Center	Economy	£17	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/03/2026 22:05:00 to Old Town Transit Center, San Diego (USA) arriving at 12/03/2026 23:50:00. 50 Economy ticket for £17 per person are available. Travel duration is 1h 45m
Greyhound US	1h 45m	10:00	Santa Ana, CA	Bus Stop	11:45	San Diego	Old Town Transit Center	Economy	£18	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 12/03/2026 11:45:00. 50 Economy ticket for £18 per person are available. Travel duration is 1h 45m
Limousine Express	3h 5m	05:55	Santa Ana, CA	Bus Stop	09:00	San Diego	San Ysidro Transit Center	Basic	£29	A Bus from Limousine Express goes from Bus Stop, Santa Ana, CA (USA) at 12/03/2026 05:55:00 to San Ysidro Transit Center, San Diego (USA) arriving at 12/03/2026 09:00:00. 50 Basic ticket for £29 per person are available. Travel duration is 3h 5m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 15m	20:30	Santa Ana, CA	Bus Stop	22:45	San Diego	San Ysidro Transit Center	Economy	£17	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 14/03/2026 20:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 14/03/2026 22:45:00. 50 Economy ticket for £17 per person are available. Travel duration is 2h 15m
FlixBus	2h 35m	14:35	Santa Ana, CA	Bus Stop	17:10	San Diego	San Ysidro Transit Center	Economy	£18	A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 14/03/2026 14:35:00 to San Ysidro Transit Center, San Diego (USA) arriving at 14/03/2026 17:10:00. 50 Economy ticket for £18 per person are available. Travel duration is 2h 35m
Greyhound US	2h 20m	22:05	Santa Ana, CA	Bus Stop	00:25	San Diego	San Ysidro Transit Center	Economy	£24	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 14/03/2026 22:05:00 to San Ysidro Transit Center, San Diego (USA) arriving at 15/03/2026 00:25:00. 50 Economy ticket for £24 per person are available. Travel duration is 2h 20m
Greyhound US	2h 20m	10:00	Santa Ana, CA	Bus Stop	12:20	San Diego	San Ysidro Transit Center	Economy	£26	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 14/03/2026 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 14/03/2026 12:20:00. 50 Economy ticket for £26 per person are available. Travel duration is 2h 20m
Limousine Express	5h 5m	00:05	Santa Ana, CA	Bus Stop	05:10	San Diego	San Ysidro Transit Center	Basic	£31	A Bus from Limousine Express goes from Bus Stop, Santa Ana, CA (USA) at 14/03/2026 00:05:00 to San Ysidro Transit Center, San Diego (USA) arriving at 14/03/2026 05:10:00. 50 Basic ticket for £31 per person are available. Travel duration is 5h 5m

Did you know that if you travel from Santa Ana, CA to San Diego via Irvine, CA, you can save more than £0? You will find the corresponding connections below.
- FlixBus
  
  Save more than 1%
  
  2h 30m
  
  Santa Ana, CA
  
  8 km
  
  12:10
  
  Irvine, CA
  UC Irvine
  
  14:40
  
  San Diego
  San Ysidro Transit Center
  
  0 km
  
  Economy
  
  £17
  
  A Bus from FlixBus goes from UC Irvine, Irvine, CA (USA) at 14/03/2026 12:10:00 to San Ysidro Transit Center, San Diego (USA) arriving at 14/03/2026 14:40:00. 50 Economy ticket for £17 per person are available. Travel duration is 2h 30m

Best Price Offer: The price for the cheapest coach from Santa Ana, CA to San Diego is £7 on 24/03/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between Santa Ana, CA and San Diego

See here how frequent the connections between Santa Ana, CA and San Diego are, during different times and days of the week.

Thursday is the busiest day, with more than 24 daily coaches from Santa Ana, CA to San Diego. Wednesday has instead the fewest connections, with only 4 daily coaches between Santa Ana, CA and San Diego.

The busiest time of the day is the Evening, with 29 coaches from Santa Ana, CA to San Diego, while Night sees the fewest connections between Santa Ana, CA and San Diego, with 2 offers.

Facts about coaches from Santa Ana, CA to San Diego

Compare all providers like FlixBus, Limousine Express and Greyhound US that travel 13 times every day by bus from Santa Ana, CA to San Diego in one click! Book your bus ticket from Santa Ana, CA to San Diego starting from £7!

Cheapest Bus	£7
Fastest Bus	1h 15m
Earliest Coach	10:00
Latest Coach	22:45
Daily Bus Connections	13 Ø
Distance	131.9 km
Coach Companies	FlixBus, Limousine Express and Greyhound US

Cheapest coach connections from Santa Ana, CA to San Diego

Every day, 13 buses from 3 coach companies leave Santa Ana, CA for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/03/2026 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 09/03

£19

Tuesday 10/03

£10

Wednesday 11/03

£10

Thursday 12/03

£10

Friday 13/03

Saturday 14/03

£17

Sunday 15/03

Monday 16/03

£11

Tuesday 17/03

Wednesday 18/03

£10

Thursday 19/03

Friday 20/03

Saturday 21/03

£17

Sunday 22/03

£29

Monday 23/03

£7

Tuesday 24/03

£7

Wednesday 25/03

£13

Thursday 26/03

£17

Friday 27/03

£31

Saturday 28/03

£11

Sunday 29/03

£17

Monday 30/03

Tuesday 31/03

£18

Wednesday 01/04

£17

Thursday 02/04

£11

Friday 03/04

£10

Saturday 04/04

£10

Sunday 05/04

The cheapest time to travel from Santa Ana, CA to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Santa Ana, CA to San Diego, for the next 30 days.

With a price starting from £7, Tuesday is the cheapest day for a coach from Santa Ana, CA to San Diego. Saturday instead is the most expensive day with prices starting from £10.

Night is the cheapest day time for bus tickets from Santa Ana, CA to San Diego, with £7. Morning is the most expensive time of the day with prices starting from £18.

How to save money travelling from Santa Ana, CA to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Ana, CA to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Ana, CA to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Santa Ana, CA to San Diego are also emptier.

All bus stations and stops in Santa Ana, CA and San Diego

The map below shows you where to find all the bus stations in Santa Ana, CA and San Diego.

Bus Stop

1000 E Santa Ana Blvd 105

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Service and Comfort on the bus from Santa Ana, CA to San Diego

Want to know which seat classes are available on the coaches from Santa Ana, CA to San Diego? Or which bus companies serve the route Santa Ana, CA to San Diego? Below you will find answers to your questions.

FAQs about the Santa Ana, CA to San Diego bus

How much does a Santa Ana, CA - San Diego coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Santa Ana, CA - San Diego bus trip is available from £7 and takes 1h 45m. Compare offers and save money!

How much could I save by comparing buses from Santa Ana, CA to San Diego?

The connection Santa Ana, CA to San Diego is offered by 3 companies with ticket prices ranging from £7 to £33. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Santa Ana, CA - San Diego route on average every day?

Each day, the bus route from Santa Ana, CA to San Diego is offered by roughly 13 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to San Diego from Santa Ana, CA take?

The quickest coach from Santa Ana, CA to San Diego is provided by FlixBus and takes 1h 15m. Coach tickets for this connection cost £13. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Santa Ana, CA to San Diego?

The earliest bus to San Diego departs from Santa Ana, CA at 10:00. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Santa Ana, CA to San Diego?

The latest bus to San Diego departs from Santa Ana, CA at 22:45. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Santa Ana, CA - San Diego route?

Passengers looking to travel from Santa Ana, CA to San Diego can travel with FlixBus, Limousine Express and Greyhound US. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Santa Ana, CA and San Diego?

You can check all the direct connections between Santa Ana, CA and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Limousine Express and Greyhound US.

What can I take with me on the bus to San Diego from Santa Ana, CA?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Santa Ana, CA San Diego bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Ana, CA San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Ana, CA to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Santa Ana, CA to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 13 daily trips between Santa Ana, CA and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santa Ana, CA to San Diego?

Prices and availability for 13 trips between Santa Ana, CA and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santa Ana, CA to San Diego

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santa Ana, CA and to San Diego

Here’s an overview of the most popular bus routes to Santa Ana, CA and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!