Which bus from Messina to Milan is the best?
Check the bus schedule for Messina to Milan. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus, Itabus or Autoservizi Salemi. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Itabus | 19h 20m | 10:20 | Messina | Central Station | 05:40 | Milan | Lampugnano Bus Station | Premium Economy | £48 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 18/09/2026 10:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/09/2026 05:40:00. 50 Premium Economy ticket for £48 per person are available. Travel duration is 19h 20m
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| Itabus | 19h 5m | 21:35 | Messina | Central Station | 16:40 | Milan | Lampugnano Bus Station | Premium Economy | £52 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 18/09/2026 21:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/09/2026 16:40:00. 50 Premium Economy ticket for £52 per person are available. Travel duration is 19h 5m
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| Itabus | 21h 50m | 10:20 | Messina | Piazza della Repubblica | 08:10 | Milan | San Donato Bus Station | Economy | £70 |
A Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 18/09/2026 10:20:00 to San Donato Bus Station, Milan (Italy) arriving at 19/09/2026 08:10:00. 50 Economy ticket for £70 per person are available. Travel duration is 21h 50m
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| FlixBus | 17h 30m | 20:15 | Messina | Piazza della Repubblica | 13:45 | Milan | Lampugnano Bus Station | Economy | £75 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 18/09/2026 20:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 19/09/2026 13:45:00. 50 Economy ticket for £75 per person are available. Travel duration is 17h 30m
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| FlixBus | 18h 20m | 10:55 | Messina | Piazza della Repubblica | 05:15 | Milan | San Donato Bus Station | Economy | £82 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 18/09/2026 10:55:00 to San Donato Bus Station, Milan (Italy) arriving at 19/09/2026 05:15:00. 50 Economy ticket for £82 per person are available. Travel duration is 18h 20m
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FlixBus20h 0m010:55MessinaPiazza della Repubblica21:30RomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 19/09/2026 10:55:00 to Tiburtina Bus Station, Rome (Italy) arriving at 19/09/2026 21:30:00. 50 Economy ticket for £23 per person are available. Travel duration is 10h 35m
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Itabus8h 40m022:15RomeTiburtina Coach Station06:55MilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 19/09/2026 22:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/09/2026 06:55:00. 50 Economy ticket for £9 per person are available. Travel duration is 8h 40m
Waiting Time 0h 45m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Itabus | 19h 30m | 23:20 | Messina | Central Station | 18:50 | Milan | San Donato Bus Station | Premium Economy | £34 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 19/09/2026 23:20:00 to San Donato Bus Station, Milan (Italy) arriving at 20/09/2026 18:50:00. 50 Premium Economy ticket for £34 per person are available. Travel duration is 19h 30m
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| Itabus | 19h 20m | 10:20 | Messina | Central Station | 05:40 | Milan | Lampugnano Bus Station | Premium Economy | £43 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 19/09/2026 10:20:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/09/2026 05:40:00. 50 Premium Economy ticket for £43 per person are available. Travel duration is 19h 20m
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| FlixBus | 18h 20m | 10:55 | Messina | Piazza della Repubblica | 05:15 | Milan | San Donato Bus Station | Economy | £72 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 19/09/2026 10:55:00 to San Donato Bus Station, Milan (Italy) arriving at 20/09/2026 05:15:00. 50 Economy ticket for £72 per person are available. Travel duration is 18h 20m
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| Autoservizi Salemi | 16h 35m | 21:15 | Messina | Piazza della Repubblica | 13:50 | Milan | Lampugnano Bus Station | Economy | £76 |
A Bus from Autoservizi Salemi goes from Piazza della Repubblica, Messina (Italy) at 19/09/2026 21:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 20/09/2026 13:50:00. 50 Economy ticket for £76 per person are available. Travel duration is 16h 35m
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| Autoservizi Salemi | 15h 55m | 21:15 | Messina | Piazza della Repubblica | 13:10 | Milan | San Donato Bus Station | Economy | £80 |
A Bus from Autoservizi Salemi goes from Piazza della Repubblica, Messina (Italy) at 19/09/2026 21:15:00 to San Donato Bus Station, Milan (Italy) arriving at 20/09/2026 13:10:00. 50 Economy ticket for £80 per person are available. Travel duration is 15h 55m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 24h 35m | 16:10 | Messina | Piazza della Repubblica | 16:45 | Milan | San Donato Bus Station | Economy | £56 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 20/09/2026 16:10:00 to San Donato Bus Station, Milan (Italy) arriving at 21/09/2026 16:45:00. 50 Economy ticket for £56 per person are available. Travel duration is 24h 35m
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| FlixBus | 17h 30m | 20:15 | Messina | Piazza della Repubblica | 13:45 | Milan | Lampugnano Bus Station | Economy | £60 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 20/09/2026 20:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/09/2026 13:45:00. 50 Economy ticket for £60 per person are available. Travel duration is 17h 30m
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| Itabus | 19h 5m | 21:35 | Messina | Central Station | 16:40 | Milan | Lampugnano Bus Station | Premium Economy | £60 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 20/09/2026 21:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 21/09/2026 16:40:00. 50 Premium Economy ticket for £60 per person are available. Travel duration is 19h 5m
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| FlixBus | 18h 20m | 20:15 | Messina | Piazza della Repubblica | 14:35 | Milan | San Donato Bus Station | Economy | £76 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 20/09/2026 20:15:00 to San Donato Bus Station, Milan (Italy) arriving at 21/09/2026 14:35:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 20m
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Itabus25h 15m023:50MessinaCentral Station14:20RomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Central Station, Messina (Italy) at 20/09/2026 23:50:00 to Tiburtina Bus Station, Rome (Italy) arriving at 21/09/2026 14:20:00. 50 Premium Economy ticket for £14 per person are available. Travel duration is 14h 30m
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FlixBus8h 30m016:35RomeTiburtina Bus Station01:05MilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/09/2026 16:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/09/2026 01:05:00. 50 Economy ticket for £10 per person are available. Travel duration is 8h 30m
Waiting Time 2h 15m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 19h 25m | 01:30 | Messina | Piazza della Repubblica | 20:55 | Milan | San Donato Bus Station | Economy | £52 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 21/09/2026 01:30:00 to San Donato Bus Station, Milan (Italy) arriving at 21/09/2026 20:55:00. 50 Economy ticket for £52 per person are available. Travel duration is 19h 25m
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| FlixBus | 17h 30m | 20:15 | Messina | Piazza della Repubblica | 13:45 | Milan | Lampugnano Bus Station | Economy | £52 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 21/09/2026 20:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/09/2026 13:45:00. 50 Economy ticket for £52 per person are available. Travel duration is 17h 30m
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| Itabus | 19h 5m | 21:35 | Messina | Piazza della Repubblica | 16:40 | Milan | Lampugnano Bus Station | Economy | £52 |
A Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 21/09/2026 21:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/09/2026 16:40:00. 50 Economy ticket for £52 per person are available. Travel duration is 19h 5m
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| Itabus | 21h 20m | 10:20 | Messina | Central Station | 07:40 | Milan | San Donato Bus Station | Premium Economy | £65 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 21/09/2026 10:20:00 to San Donato Bus Station, Milan (Italy) arriving at 22/09/2026 07:40:00. 50 Premium Economy ticket for £65 per person are available. Travel duration is 21h 20m
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| Autoservizi Salemi | 15h 55m | 21:15 | Messina | Piazza della Repubblica | 13:10 | Milan | San Donato Bus Station | Economy | £69 |
A Bus from Autoservizi Salemi goes from Piazza della Repubblica, Messina (Italy) at 21/09/2026 21:15:00 to San Donato Bus Station, Milan (Italy) arriving at 22/09/2026 13:10:00. 50 Economy ticket for £69 per person are available. Travel duration is 15h 55m
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Itabus19h 5m021:35MessinaPiazza della Repubblica07:45RomeTiburtina Coach Station0EconomyA Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 22/09/2026 21:35:00 to Tiburtina Coach Station, Rome (Italy) arriving at 23/09/2026 07:45:00. 50 Economy ticket for £15 per person are available. Travel duration is 10h 10m
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Itabus8h 40m008:00RomeTiburtina Bus Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 23/09/2026 08:00:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/09/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 8h 40m
Waiting Time 0h 15m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Itabus | 19h 5m | 21:35 | Messina | Central Station | 16:40 | Milan | Lampugnano Bus Station | Premium Economy | £43 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 22/09/2026 21:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/09/2026 16:40:00. 50 Premium Economy ticket for £43 per person are available. Travel duration is 19h 5m
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| FlixBus | 19h 30m | 21:30 | Messina | Piazza della Repubblica | 17:00 | Milan | Lampugnano Bus Station | Economy | £51 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 22/09/2026 21:30:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/09/2026 17:00:00. 50 Economy ticket for £51 per person are available. Travel duration is 19h 30m
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| FlixBus | 20h 10m | 01:30 | Messina | Piazza della Repubblica | 21:40 | Milan | Lampugnano Bus Station | Economy | £53 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 22/09/2026 01:30:00 to Lampugnano Bus Station, Milan (Italy) arriving at 22/09/2026 21:40:00. 50 Economy ticket for £53 per person are available. Travel duration is 20h 10m
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| FlixBus | 20h 50m | 01:30 | Messina | Piazza della Repubblica | 22:20 | Milan | San Donato Bus Station | Economy | £53 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 22/09/2026 01:30:00 to San Donato Bus Station, Milan (Italy) arriving at 22/09/2026 22:20:00. 50 Economy ticket for £53 per person are available. Travel duration is 20h 50m
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Itabus19h 5m021:35MessinaPiazza della Repubblica07:45RomeTiburtina Coach Station0EconomyA Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 22/09/2026 21:35:00 to Tiburtina Coach Station, Rome (Italy) arriving at 23/09/2026 07:45:00. 50 Economy ticket for £15 per person are available. Travel duration is 10h 10m
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Itabus8h 40m008:00RomeTiburtina Bus Station16:40MilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 23/09/2026 08:00:00 to Lampugnano Bus Station, Milan (Italy) arriving at 23/09/2026 16:40:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 8h 40m
Waiting Time 0h 15m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 20m | 20:15 | Messina | Piazza della Repubblica | 14:35 | Milan | San Donato Bus Station | Economy | £45 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 23/09/2026 20:15:00 to San Donato Bus Station, Milan (Italy) arriving at 24/09/2026 14:35:00. 50 Economy ticket for £45 per person are available. Travel duration is 18h 20m
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| FlixBus | 17h 30m | 20:15 | Messina | Piazza della Repubblica | 13:45 | Milan | Lampugnano Bus Station | Economy | £47 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 23/09/2026 20:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/09/2026 13:45:00. 50 Economy ticket for £47 per person are available. Travel duration is 17h 30m
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| Itabus | 19h 5m | 21:35 | Messina | Central Station | 16:40 | Milan | Lampugnano Bus Station | Premium Economy | £52 |
A Bus from Itabus goes from Central Station, Messina (Italy) at 23/09/2026 21:35:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/09/2026 16:40:00. 50 Premium Economy ticket for £52 per person are available. Travel duration is 19h 5m
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| Autoservizi Salemi | 15h 55m | 21:15 | Messina | Piazza della Repubblica | 13:10 | Milan | San Donato Bus Station | Economy | £69 |
A Bus from Autoservizi Salemi goes from Piazza della Repubblica, Messina (Italy) at 23/09/2026 21:15:00 to San Donato Bus Station, Milan (Italy) arriving at 24/09/2026 13:10:00. 50 Economy ticket for £69 per person are available. Travel duration is 15h 55m
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| Autoservizi Salemi | 16h 35m | 21:15 | Messina | Piazza della Repubblica | 13:50 | Milan | Lampugnano Bus Station | Economy | £73 |
A Bus from Autoservizi Salemi goes from Piazza della Repubblica, Messina (Italy) at 23/09/2026 21:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/09/2026 13:50:00. 50 Economy ticket for £73 per person are available. Travel duration is 16h 35m
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Itabus21h 15m021:35MessinaPiazza della Repubblica07:45RomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 21:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 25/09/2026 07:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 10h 10m
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Itabus7h 50m011:00RomeTiburtina Coach Station18:50MilanSan Donato Bus Station0EconomyA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 25/09/2026 11:00:00 to San Donato Bus Station, Milan (Italy) arriving at 25/09/2026 18:50:00. 50 Economy ticket for £7 per person are available. Travel duration is 7h 50m
Waiting Time 3h 15m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 30m | 20:15 | Messina | Piazza della Repubblica | 13:45 | Milan | Lampugnano Bus Station | Economy | £45 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 20:15:00 to Lampugnano Bus Station, Milan (Italy) arriving at 25/09/2026 13:45:00. 50 Economy ticket for £45 per person are available. Travel duration is 17h 30m
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| FlixBus | 18h 20m | 20:15 | Messina | Piazza della Repubblica | 14:35 | Milan | San Donato Bus Station | Economy | £49 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 20:15:00 to San Donato Bus Station, Milan (Italy) arriving at 25/09/2026 14:35:00. 50 Economy ticket for £49 per person are available. Travel duration is 18h 20m
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| FlixBus | 20h 10m | 01:30 | Messina | Piazza della Repubblica | 21:40 | Milan | Lampugnano Bus Station | Economy | £53 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 01:30:00 to Lampugnano Bus Station, Milan (Italy) arriving at 24/09/2026 21:40:00. 50 Economy ticket for £53 per person are available. Travel duration is 20h 10m
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| FlixBus | 19h 25m | 01:30 | Messina | Piazza della Repubblica | 20:55 | Milan | San Donato Bus Station | Economy | £55 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 01:30:00 to San Donato Bus Station, Milan (Italy) arriving at 24/09/2026 20:55:00. 50 Economy ticket for £55 per person are available. Travel duration is 19h 25m
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| FlixBus | 18h 20m | 10:55 | Messina | Piazza della Repubblica | 05:15 | Milan | San Donato Bus Station | Economy | £60 |
A Bus from FlixBus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 10:55:00 to San Donato Bus Station, Milan (Italy) arriving at 25/09/2026 05:15:00. 50 Economy ticket for £60 per person are available. Travel duration is 18h 20m
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Itabus21h 15m021:35MessinaPiazza della Repubblica07:45RomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza della Repubblica, Messina (Italy) at 24/09/2026 21:35:00 to Tiburtina Bus Station, Rome (Italy) arriving at 25/09/2026 07:45:00. 50 Economy ticket for £12 per person are available. Travel duration is 10h 10m
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Itabus7h 50m011:00RomeTiburtina Coach Station18:50MilanSan Donato Bus Station0EconomyA Bus from Itabus goes from Tiburtina Coach Station, Rome (Italy) at 25/09/2026 11:00:00 to San Donato Bus Station, Milan (Italy) arriving at 25/09/2026 18:50:00. 50 Economy ticket for £7 per person are available. Travel duration is 7h 50m
Waiting Time 3h 15m -
Best Price Offer: The price for the cheapest coach from Messina to Milan is £34 on 19/09/2026. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between Messina and Milan?
All facts for Messina to Milan bus at a glance
Compare all coach operators like FlixBus, Itabus and Autoservizi Salemi that travel daily 17 times by bus from Messina to Milan in one click. Book your Messina to Milan bus ticket starting from £34!
| Cheapest Bus | £34 |
| Fastest Bus | 15h 55m |
| Earliest Coach | 10:20 |
| Latest Coach | 21:30 |
| Daily Bus Connections | 17 Ø |
| Distance | 964.8 km |
| Coach Companies | FlixBus, Itabus and Autoservizi Salemi |
What are the cheapest coach tickets from Messina to Milan?
Every day, 17 buses from 3 coach companies leave Messina for Milan. Check the table below to find the cheapest prices for coach tickets for this route, starting from 18/09/2026 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from Messina to Milan
How to save money travelling from Messina to Milan
Book the ticket from Messina to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Messina to Milan, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Messina to Milan are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
All bus stations and stops in Messina and Milan
Here is a map with all coach stations in Messina and Milan. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from Messina to Milan
FAQs for Messina to Milan bus
How much does a Messina Milan coach trip cost?
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How many connections are available for the Messina Milan route on average every day?
How long does a bus to Milan from Messina take?
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Which bus companies serve the Messina Milan route?
Is there a direct bus between Messina and Milan?
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What equipment is available for the Messina Milan bus route?
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Available seat classes which are offered on the bus route Messina to Milan
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
More bus routes to Messina and to Milan
- Bus Routes to Messina
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- Coach to Messina from Cefalù
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- Rome to Messina coach
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- Coach to Messina from Turin
- Bus Routes to Milan
- Bus from Bibione to Milan
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- Coach to Milan from Grenoble
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- Bus from Salerno to Milan
- Bus to Milan from Spotorno
- Coach to Milan from Taranto
- Coach to Milan from Turin
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