Which bus from Milan to Palermo is the best?
Check the bus schedule for Milan to Palermo. Here is a selection of the cheapest coach trips for the next days from bus operators like FlixBus. To see the full timetable for all coaches just use or search and compare.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £72 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 05/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 06/12/2025 11:00:00. 50 Economy ticket for £72 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 22h 55m | 15:30 | Milan | Lampugnano Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £83 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 05/12/2025 15:30:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 06/12/2025 14:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 22h 55m
|
||
| FlixBus | 25h 20m | 09:40 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £91 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 05/12/2025 09:40:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 06/12/2025 11:00:00. 50 Economy ticket for £91 per person are available. Travel duration is 25h 20m
|
||
| FlixBus | 23h 40m | 14:45 | Milan | San Donato Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £98 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 05/12/2025 14:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 06/12/2025 14:25:00. 50 Economy ticket for £98 per person are available. Travel duration is 23h 40m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £75 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 11:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 22h 55m | 15:30 | Milan | Lampugnano Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £79 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 15:30:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 22h 55m
|
||
| FlixBus | 23h 40m | 14:45 | Milan | San Donato Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £89 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 06/12/2025 14:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £89 per person are available. Travel duration is 23h 40m
|
||
| FlixBus | 25h 20m | 09:40 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £113 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 06/12/2025 09:40:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 11:00:00. 50 Economy ticket for £113 per person are available. Travel duration is 25h 20m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £75 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 07/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 08/12/2025 11:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 25h 0m | 10:00 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £96 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 07/12/2025 10:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 08/12/2025 11:00:00. 50 Economy ticket for £96 per person are available. Travel duration is 25h 0m
|
||
| FlixBus | 22h 55m | 15:30 | Milan | Lampugnano Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £98 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 07/12/2025 15:30:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 08/12/2025 14:25:00. 50 Economy ticket for £98 per person are available. Travel duration is 22h 55m
|
||
| FlixBus | 23h 40m | 14:45 | Milan | San Donato Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £102 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 07/12/2025 14:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 08/12/2025 14:25:00. 50 Economy ticket for £102 per person are available. Travel duration is 23h 40m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £76 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 08/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 09/12/2025 11:00:00. 50 Economy ticket for £76 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 25h 20m | 09:40 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £83 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 08/12/2025 09:40:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 09/12/2025 11:00:00. 50 Economy ticket for £83 per person are available. Travel duration is 25h 20m
|
||
| FlixBus | 22h 55m | 15:30 | Milan | Lampugnano Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £92 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 08/12/2025 15:30:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 09/12/2025 14:25:00. 50 Economy ticket for £92 per person are available. Travel duration is 22h 55m
|
||
| FlixBus | 23h 40m | 14:45 | Milan | San Donato Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £101 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 08/12/2025 14:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 09/12/2025 14:25:00. 50 Economy ticket for £101 per person are available. Travel duration is 23h 40m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £75 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 09/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 10/12/2025 11:00:00. 50 Economy ticket for £75 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 22h 55m | 15:30 | Milan | Lampugnano Bus Station | 14:25 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £83 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 09/12/2025 15:30:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 10/12/2025 14:25:00. 50 Economy ticket for £83 per person are available. Travel duration is 22h 55m
|
||
| FlixBus | 26h 10m | 08:50 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £89 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 09/12/2025 08:50:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 10/12/2025 11:00:00. 50 Economy ticket for £89 per person are available. Travel duration is 26h 10m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 22h 5m | 12:55 | Milan | Lampugnano Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £66 |
A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 10/12/2025 12:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 11/12/2025 11:00:00. 50 Economy ticket for £66 per person are available. Travel duration is 22h 5m
|
||
| FlixBus | 26h 10m | 08:50 | Milan | San Donato Bus Station | 11:00 | Palermo | Via Tommaso Fazello Bus Stop | Economy | £70 |
A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 10/12/2025 08:50:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 11/12/2025 11:00:00. 50 Economy ticket for £70 per person are available. Travel duration is 26h 10m
|
-
-
Distribusion27h 10m011:15MilanLampugnano Bus Station18:45SienaTrain Station0Premium EconomyA Bus from Distribusion goes from Lampugnano Bus Station, Milan (Italy) at 06/12/2025 11:15:00 to Train Station, Siena (Italy) arriving at 06/12/2025 18:45:00. 50 Premium Economy ticket for £11 per person are available. Travel duration is 7h 30m
-
FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 06/12/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 07/12/2025 14:25:00. 50 Economy ticket for £47 per person are available. Travel duration is 19h 30m
Waiting Time 0h 10m -
Best Price Offer: The price for the cheapest coach from Milan to Palermo is £54 on 03/12/2025. Flexible travellers save on ticket prices.
What is the best day and time to travel by bus between Milan and Palermo?
All facts for Milan to Palermo bus at a glance
Compare all coach operators like FlixBus that travel daily 3 times by bus from Milan to Palermo in one click. Book your Milan to Palermo bus ticket starting from £54!
| Cheapest Bus | £54 |
| Fastest Bus | 22h 5m |
| Earliest Coach | 09:40 |
| Latest Coach | 12:55 |
| Daily Bus Connections | 3 Ø |
| Distance | 887.2 km |
| Coach Companies | FlixBus |
What are the cheapest coach tickets from Milan to Palermo?
Every day, 3 buses from 1 coach companies leave Milan for Palermo. Check the table below to find the cheapest prices for coach tickets for this route, starting from 04/12/2025 and for the following days. Make sure get the cheapest bus ticket!
The cheapest time to travel from Milan to Palermo
How to save money travelling from Milan to Palermo
Book the ticket from Milan to Palermo in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Milan to Palermo, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Milan to Palermo are also emptier.Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.
All bus stations and stops in Milan and Palermo
Here is a map with all coach stations in Milan and Palermo. Compare which stop is closest to your destination to save time to find the fastest buses and connections.
Compare the bus with other modes of transport
All you need to know when you travel by bus from Milan to Palermo
FAQs for Milan to Palermo bus
How much does a Milan Palermo coach trip cost?
How much could I save by comparing buses from Milan to Palermo?
How many connections are available for the Milan Palermo route on average every day?
How long does a bus to Palermo from Milan take?
What time is the first bus from Milan to Palermo?
What time is the last coach from Milan to Palermo?
Which bus companies serve the Milan Palermo route?
Is there a direct bus between Milan and Palermo?
What can I take with me on the bus to Palermo from Milan?
What equipment is available for the Milan Palermo bus route?
Available seat classes which are offered on the bus route Milan to Palermo
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Milan and to Palermo
- Bus Routes to Milan
- Buses Antey-Saint-Andrè to Milan
- Bus to Milan from Bari
- Bus Bremen to Milan
- Breuil-Cervinia to Milan coach
- Coach to Milan from Champoluc
- Coaches Cosenza to Milan
- Coach Courmayeur to Milan
- Foggia to Milan coach
- Freiburg to Milan coach
- Coach to Milan from Gioia Tauro
- Bus from Hanover to Milan
- Innsbruck to Milan bus
- Lamezia Terme to Milan coach
- Coach from London to Milan
- Coaches Madrid to Milan
- Buses Messina to Milan
- Coaches Padua to Milan
- Coach from Passo del Tonale to Milan
- Coach from Sala Consilina to Milan
- Turin to Milan coach
- Bus Routes to Palermo
- Coach Barcellona Pozzo di Gotto to Palermo
- Coach from Bari to Palermo
- Coach Bologna to Palermo
- Coach from Caltagirone to Palermo
- Cosenza to Palermo bus
- Buses Enna to Palermo
- Buses Lecce to Palermo
- Coach Licata to Palermo
- Coach from London to Palermo
- Coach Mazara del Vallo to Palermo
- Milazzo to Palermo coach
- Coach Modica to Palermo
- Bus to Palermo from Naples
- Coach to Palermo from Parma
- Coach to Palermo from Pescara
- Ragusa to Palermo coach
- Coach from Siracusa to Palermo
- Bus Turin to Palermo
- Bus from Villa San Giovanni to Palermo
- Vittoria to Palermo bus

