What is the best way to travel from St. Louis, MO to San Antonio, TX?
Looking for a trip? Check and compare all the available Flights and Buses to San Antonio, TX from St. Louis, MO. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Antonio, TX from St. Louis, MO?
You can reach San Antonio, TX with just £86 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US28h 40m016:30St. Louis, MOGateway Station21:10San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 06/03/2026 21:10:00. 50 Economy ticket for £90 per person are available. Travel duration is 28h 40m
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 12:55:00. 50 Economy ticket for £158 per person are available. Travel duration is 20h 55m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 17:35:00. 50 Economy ticket for £161 per person are available. Travel duration is 25h 5m
Cheapest Buses Thursday
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 23:55:00. 50 Economy ticket for £180 per person are available. Travel duration is 22h 35m
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 01:15:00. 50 Economy ticket for £180 per person are available. Travel duration is 23h 45m
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 12:55:00. 50 Economy ticket for £181 per person are available. Travel duration is 20h 55m
Cheapest Buses Friday
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 01:15:00. 50 Economy ticket for £133 per person are available. Travel duration is 23h 45m
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Greyhound US25h 35m016:30St. Louis, MOGateway Station19:05San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 19:05:00. 50 Economy ticket for £134 per person are available. Travel duration is 25h 35m
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FlixBus20h 5m016:00St. Louis, MOGateway Station13:05San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 13:05:00. 50 Economy ticket for £135 per person are available. Travel duration is 20h 5m
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 23:55:00. 50 Economy ticket for £136 per person are available. Travel duration is 22h 35m
Cheapest Buses Saturday
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Greyhound US22h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 01:15:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 45m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 17:35:00. 50 Economy ticket for £112 per person are available. Travel duration is 25h 5m
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Greyhound US30h 55m016:30St. Louis, MOGateway Station23:25San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 09/03/2026 23:25:00. 50 Economy ticket for £112 per person are available. Travel duration is 30h 55m
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 12:55:00. 50 Economy ticket for £112 per person are available. Travel duration is 20h 55m
Cheapest Buses Sunday
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 23:55:00. 50 Economy ticket for £105 per person are available. Travel duration is 22h 35m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 17:35:00. 50 Economy ticket for £105 per person are available. Travel duration is 25h 5m
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Greyhound US30h 55m016:30St. Louis, MOGateway Station23:25San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 10/03/2026 23:25:00. 50 Economy ticket for £105 per person are available. Travel duration is 30h 55m
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £107 per person are available. Travel duration is 20h 55m
Cheapest Buses Monday
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 23:55:00. 50 Economy ticket for £86 per person are available. Travel duration is 22h 35m
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 11/03/2026 01:15:00. 50 Economy ticket for £86 per person are available. Travel duration is 23h 45m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 11/03/2026 17:35:00. 50 Economy ticket for £86 per person are available. Travel duration is 25h 5m
Cheapest Buses Tuesday
What are the fastest trips from St. Louis, MO to San Antonio, TX?
You can get to San Antonio, TX from St. Louis, MO in just 20h 5m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 12:55:00. 50 Economy ticket for £158 per person are available. Travel duration is 20h 55m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 17:35:00. 50 Economy ticket for £161 per person are available. Travel duration is 25h 5m
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Greyhound US28h 40m016:30St. Louis, MOGateway Station21:10San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 05/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 06/03/2026 21:10:00. 50 Economy ticket for £90 per person are available. Travel duration is 28h 40m
Fastest Buses Thursday
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 12:55:00. 50 Economy ticket for £181 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 06/03/2026 23:55:00. 50 Economy ticket for £180 per person are available. Travel duration is 22h 35m
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 06/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 01:15:00. 50 Economy ticket for £180 per person are available. Travel duration is 23h 45m
Fastest Buses Friday
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FlixBus20h 5m016:00St. Louis, MOGateway Station13:05San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 13:05:00. 50 Economy ticket for £135 per person are available. Travel duration is 20h 5m
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 07/03/2026 23:55:00. 50 Economy ticket for £136 per person are available. Travel duration is 22h 35m
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 01:15:00. 50 Economy ticket for £133 per person are available. Travel duration is 23h 45m
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Greyhound US25h 35m016:30St. Louis, MOGateway Station19:05San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 07/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 08/03/2026 19:05:00. 50 Economy ticket for £134 per person are available. Travel duration is 25h 35m
Fastest Buses Saturday
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 12:55:00. 50 Economy ticket for £112 per person are available. Travel duration is 20h 55m
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Greyhound US22h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 01:15:00. 50 Economy ticket for £110 per person are available. Travel duration is 22h 45m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 17:35:00. 50 Economy ticket for £112 per person are available. Travel duration is 25h 5m
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Greyhound US30h 55m016:30St. Louis, MOGateway Station23:25San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 08/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 09/03/2026 23:25:00. 50 Economy ticket for £112 per person are available. Travel duration is 30h 55m
Fastest Buses Sunday
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FlixBus20h 55m016:00St. Louis, MOGateway Station12:55San Antonio, TXCoach Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:00:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 12:55:00. 50 Economy ticket for £107 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 09/03/2026 23:55:00. 50 Economy ticket for £105 per person are available. Travel duration is 22h 35m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 17:35:00. 50 Economy ticket for £105 per person are available. Travel duration is 25h 5m
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Greyhound US30h 55m016:30St. Louis, MOGateway Station23:25San Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 09/03/2026 16:30:00 to Pearl District, San Antonio, TX (USA) arriving at 10/03/2026 23:25:00. 50 Economy ticket for £105 per person are available. Travel duration is 30h 55m
Fastest Buses Monday
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Greyhound US22h 35m001:20St. Louis, MOGateway Station23:55San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 01:20:00 to Coach Station, San Antonio, TX (USA) arriving at 10/03/2026 23:55:00. 50 Economy ticket for £86 per person are available. Travel duration is 22h 35m
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Greyhound US23h 45m001:30St. Louis, MOGateway Station01:15San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 01:30:00 to Coach Station, San Antonio, TX (USA) arriving at 11/03/2026 01:15:00. 50 Economy ticket for £86 per person are available. Travel duration is 23h 45m
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Greyhound US25h 5m016:30St. Louis, MOGateway Station17:35San Antonio, TXCoach Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/03/2026 16:30:00 to Coach Station, San Antonio, TX (USA) arriving at 11/03/2026 17:35:00. 50 Economy ticket for £86 per person are available. Travel duration is 25h 5m
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to San Antonio, TX
What are the most popular stations in St. Louis, MO and San Antonio, TX?
In St. Louis, MO, you will usually depart from Gateway Station, Skinker Boulevard or Lindbergh @ Hackberry NB Bus Stop, while in San Antonio, TX you will be arriving at Tornado Bus Company, Coach Station or W. Southcross & Buffalo Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Antonio, TX from St. Louis, MO? With 5 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and San Antonio, TX, you can pay as low as £86 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to San Antonio, TX in just 20h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and San Antonio, TX are Greyhound US and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and San Antonio, TX is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Olmos Park, TX, and look at flights from St. Louis Lambert Airport, and landing at San Antonio Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to San Antonio, TX?
The most popular companies between St. Louis, MO and San Antonio, TX, are Greyhound US and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
All you need to know when you travel from St. Louis, MO to San Antonio, TX
Check all information on comfort and services on all modes of transports from St. Louis, MO to San Antonio, TX. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to San Antonio, TX
How can I reach San Antonio, TX from St. Louis, MO?
Every day, there are on average 5 connections between Flight and Bus, with which you can get to San Antonio, TX from St. Louis, MO.
How far is San Antonio, TX from St. Louis, MO?
The distance between St. Louis, MO and San Antonio, TX is 1,274.6 km.
What is the most ecofriendly mode of transport between St. Louis, MO and San Antonio, TX?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 34 kgs of CO2, a train 45 kgs, a car 217 kgs, and a flight 314 kgs.
What is the cheapest mode of transport from St. Louis, MO to San Antonio, TX?
You can get to San Antonio, TX with just £86 by taking a Bus from Greyhound US.
What is the fastest way to get from St. Louis, MO to San Antonio, TX?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Antonio, TX in just 20h 5m with a Bus from FlixBus.
More routes to St. Louis, MO and to San Antonio, TX
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to San Antonio, TX. Simply click on a connection, and you’ll find all the details about the route!
- Trips to St. Louis, MO
- Atlanta, GA to St. Louis, MO
- Dallas to St. Louis, MO
- Houston to St. Louis, MO
- Monterrey, NL to St. Louis, MO
- Trips to San Antonio, TX
- Aguascalientes to San Antonio, TX
- Ciudad Juárez to San Antonio, TX
- Dallas to San Antonio, TX
- Durango, DG to San Antonio, TX
- El Paso, TX to San Antonio, TX
- Houston to San Antonio, TX
- Los Angeles to San Antonio, TX
- McAllen, TX to San Antonio, TX
- Memphis to San Antonio, TX
- Mexico City to San Antonio, TX
- Monterrey, NL to San Antonio, TX
- New Orleans, LA to San Antonio, TX
- Phoenix, AZ to San Antonio, TX
- Saltillo to San Antonio, TX
- San Diego to San Antonio, TX
- San Luis Potosí to San Antonio, TX
- Santiago de Queretaro to San Antonio, TX
- Torreón, CO to San Antonio, TX
