What is the best way to travel from Rome to Prague?
Looking for a trip? Check and compare all the available Buses and Flights to Prague from Rome. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Rome?
You can reach Prague with just £23 by taking a Flight from Skyscanner, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus33h 0m004:40Rome Ciampino AirportRome Ciampino Airport13:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 16/12/2025 04:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 17/12/2025 13:40:00. 50 Economy ticket for £81 per person are available. Travel duration is 33h 0m
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FlixBus33h 10m004:40Rome Ciampino AirportRome Ciampino Airport13:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 16/12/2025 04:40:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 17/12/2025 13:50:00. 50 Economy ticket for £81 per person are available. Travel duration is 33h 10m
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 17/12/2025 17:30:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 17/12/2025 17:45:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 45m
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FlixBus28h 30m013:05RomeAnagnina Bus Station17:35PragueHradčanská0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 16/12/2025 13:05:00 to Hradčanská, Prague (Czech Republic) arriving at 17/12/2025 17:35:00. 50 Economy ticket for £81 per person are available. Travel duration is 28h 30m
Cheapest Buses Tuesday
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FlixBus24h 50m010:40RomeTiburtina Bus Station11:30PragueZličín0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 10:40:00 to Zličín, Prague (Czech Republic) arriving at 18/12/2025 11:30:00. 50 Economy ticket for £71 per person are available. Travel duration is 24h 50m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 18/12/2025 17:45:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m022:55RomeTiburtina Bus Station19:30PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 22:55:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 18/12/2025 19:30:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 35m
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 18/12/2025 17:30:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 30m
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FlixBus20h 25m022:55RomeTiburtina Bus Station19:20PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 22:55:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 18/12/2025 19:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 25m
Cheapest Buses Wednesday
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Skyscanner1h 50m006:15Rome Ciampino AirportRome Ciampino Airport08:05Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 06:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 08:05:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m006:40Rome Fiumicino AirportRome Fiumicino Airport08:40Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 08:40:00. 50 Economy ticket for £50 per person are available. Travel duration is 2h 0m
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Smartwings2h 0m014:00Rome Fiumicino AirportRome Fiumicino Airport16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 14:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 16:00:00. 50 Economy ticket for £50 per person are available. Travel duration is 2h 0m
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Wizz Air10h 45m022:15Rome Fiumicino AirportRome Fiumicino Airport09:00Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 22:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 09:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 10h 45m
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Buzz8h 20m008:25Rome Ciampino AirportRome Ciampino Airport16:45Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 08:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 16:45:00. 50 Economy ticket for £65 per person are available. Travel duration is 8h 20m
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 19/12/2025 09:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 22h 40m
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FlixBus25h 10m012:20RomeTiburtina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 12:20:00 to Roztyly, Prague (Czech Republic) arriving at 19/12/2025 13:30:00. 50 Economy ticket for £79 per person are available. Travel duration is 25h 10m
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FlixBus20h 45m009:30RomeTiburtina Bus Station06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 19/12/2025 06:15:00. 50 Economy ticket for £79 per person are available. Travel duration is 20h 45m
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FlixBus20h 30m009:30RomeTiburtina Bus Station06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/12/2025 06:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 20h 30m
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FlixBus23h 5m013:05RomeAnagnina Bus Station12:10PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 18/12/2025 13:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/12/2025 12:10:00. 50 Economy ticket for £79 per person are available. Travel duration is 23h 5m
Cheapest Flights Thursday
Cheapest Buses Thursday
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 17:30:00. 50 Economy ticket for £84 per person are available. Travel duration is 20h 30m
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FlixBus23h 20m021:00RomeTiburtina Bus Station20:20PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 20/12/2025 20:20:00. 50 Economy ticket for £84 per person are available. Travel duration is 23h 20m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 17:45:00. 50 Economy ticket for £84 per person are available. Travel duration is 20h 45m
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FlixBus24h 25m013:05RomeAnagnina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 19/12/2025 13:05:00 to Roztyly, Prague (Czech Republic) arriving at 20/12/2025 13:30:00. 50 Economy ticket for £85 per person are available. Travel duration is 24h 25m
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FlixBus24h 5m017:25RomeAnagnina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 19/12/2025 17:25:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 17:30:00. 50 Economy ticket for £85 per person are available. Travel duration is 24h 5m
Cheapest Buses Friday
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LC Perú2h 0m019:20Rome Fiumicino AirportRome Fiumicino Airport21:20Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 19:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 21:20:00. 50 Economy ticket for £53 per person are available. Travel duration is 2h 0m
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Skyscanner1h 50m006:00Rome Ciampino AirportRome Ciampino Airport07:50Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 06:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 07:50:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 50m
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Buzz6h 30m008:35Rome Ciampino AirportRome Ciampino Airport15:05Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 08:35:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 15:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 6h 30m
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Wizz Air9h 50m021:25Rome Fiumicino AirportRome Fiumicino Airport07:15Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 21:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 07:15:00. 50 Economy ticket for £68 per person are available. Travel duration is 9h 50m
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Ryanair6h 45m017:30Rome Fiumicino AirportRome Fiumicino Airport00:15Prague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 17:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 00:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 6h 45m
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:25:00. 50 Economy ticket for £89 per person are available. Travel duration is 22h 40m
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FlixBus26h 45m010:45Rome Ciampino AirportRome Ciampino Airport13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 10:45:00 to Roztyly, Prague (Czech Republic) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £96 per person are available. Travel duration is 26h 45m
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FlixBus22h 15m023:05RomeTiburtina Bus Station21:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 20/12/2025 23:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 21:20:00. 50 Economy ticket for £98 per person are available. Travel duration is 22h 15m
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FlixBus24h 25m013:05RomeAnagnina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 20/12/2025 13:05:00 to Roztyly, Prague (Czech Republic) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £98 per person are available. Travel duration is 24h 25m
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FlixBus20h 20m013:05RomeAnagnina Bus Station09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 20/12/2025 13:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:25:00. 50 Economy ticket for £98 per person are available. Travel duration is 20h 20m
Cheapest Flights Saturday
Cheapest Buses Saturday
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 21/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 09:25:00. 50 Economy ticket for £97 per person are available. Travel duration is 22h 40m
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FlixBus20h 35m017:05RomeTiburtina Bus Station13:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 13:40:00. 50 Economy ticket for £97 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m017:05RomeTiburtina Bus Station13:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 17:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 13:50:00. 50 Economy ticket for £97 per person are available. Travel duration is 20h 45m
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FlixBus26h 45m010:45Rome Ciampino AirportRome Ciampino Airport13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 21/12/2025 10:45:00 to Roztyly, Prague (Czech Republic) arriving at 22/12/2025 13:30:00. 50 Economy ticket for £108 per person are available. Travel duration is 26h 45m
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FlixBus28h 5m022:55RomeTiburtina Bus Station03:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 22:55:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 03:00:00. 50 Economy ticket for £112 per person are available. Travel duration is 28h 5m
Cheapest Buses Sunday
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Buzz1h 50m020:05Rome Ciampino AirportRome Ciampino Airport21:55Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 20:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 21:55:00. 50 Economy ticket for £38 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m006:40Rome Fiumicino AirportRome Fiumicino Airport08:40Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 22/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 08:40:00. 50 Economy ticket for £40 per person are available. Travel duration is 2h 0m
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Skyscanner1h 50m006:00Rome Ciampino AirportRome Ciampino Airport07:50Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 06:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 07:50:00. 50 Economy ticket for £46 per person are available. Travel duration is 1h 50m
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Smartwings2h 0m014:00Rome Fiumicino AirportRome Fiumicino Airport16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 22/12/2025 14:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 16:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 2h 0m
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Ryanair6h 45m011:30Rome Ciampino AirportRome Ciampino Airport18:15Prague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 11:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 18:15:00. 50 Economy ticket for £73 per person are available. Travel duration is 6h 45m
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FlixBus23h 20m021:00RomeTiburtina Bus Station20:20PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 23/12/2025 20:20:00. 50 Economy ticket for £102 per person are available. Travel duration is 23h 20m
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FlixBus20h 30m009:30RomeTiburtina Bus Station06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 06:00:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 30m
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 17:30:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30RomeTiburtina Bus Station06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 06:15:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 45m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 17:45:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 45m
Cheapest Flights Monday
Cheapest Buses Monday
What are the fastest trips from Rome to Prague?
You can get to Prague from Rome in just 1h 50m with a Flight from Skyscanner. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 17/12/2025 17:30:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 16/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 17/12/2025 17:45:00. 50 Economy ticket for £81 per person are available. Travel duration is 20h 45m
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FlixBus28h 30m013:05RomeAnagnina Bus Station17:35PragueHradčanská0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 16/12/2025 13:05:00 to Hradčanská, Prague (Czech Republic) arriving at 17/12/2025 17:35:00. 50 Economy ticket for £81 per person are available. Travel duration is 28h 30m
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FlixBus33h 0m004:40Rome Ciampino AirportRome Ciampino Airport13:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 16/12/2025 04:40:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 17/12/2025 13:40:00. 50 Economy ticket for £81 per person are available. Travel duration is 33h 0m
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FlixBus33h 10m004:40Rome Ciampino AirportRome Ciampino Airport13:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 16/12/2025 04:40:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 17/12/2025 13:50:00. 50 Economy ticket for £81 per person are available. Travel duration is 33h 10m
Fastest Buses Tuesday
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FlixBus20h 25m022:55RomeTiburtina Bus Station19:20PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 22:55:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 18/12/2025 19:20:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 25m
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 18/12/2025 17:30:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 30m
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FlixBus20h 35m022:55RomeTiburtina Bus Station19:30PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 22:55:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 18/12/2025 19:30:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 18/12/2025 17:45:00. 50 Economy ticket for £72 per person are available. Travel duration is 20h 45m
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FlixBus24h 50m010:40RomeTiburtina Bus Station11:30PragueZličín0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 17/12/2025 10:40:00 to Zličín, Prague (Czech Republic) arriving at 18/12/2025 11:30:00. 50 Economy ticket for £71 per person are available. Travel duration is 24h 50m
Fastest Buses Wednesday
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Skyscanner1h 50m006:15Rome Ciampino AirportRome Ciampino Airport08:05Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 06:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 08:05:00. 50 Economy ticket for £23 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m006:40Rome Fiumicino AirportRome Fiumicino Airport08:40Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 08:40:00. 50 Economy ticket for £50 per person are available. Travel duration is 2h 0m
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Smartwings2h 0m014:00Rome Fiumicino AirportRome Fiumicino Airport16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 14:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 16:00:00. 50 Economy ticket for £50 per person are available. Travel duration is 2h 0m
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Buzz8h 20m008:25Rome Ciampino AirportRome Ciampino Airport16:45Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 08:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 18/12/2025 16:45:00. 50 Economy ticket for £65 per person are available. Travel duration is 8h 20m
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Wizz Air10h 45m022:15Rome Fiumicino AirportRome Fiumicino Airport09:00Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 18/12/2025 22:15:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 19/12/2025 09:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 10h 45m
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FlixBus20h 30m009:30RomeTiburtina Bus Station06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/12/2025 06:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30RomeTiburtina Bus Station06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 19/12/2025 06:15:00. 50 Economy ticket for £79 per person are available. Travel duration is 20h 45m
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 18/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 19/12/2025 09:25:00. 50 Economy ticket for £79 per person are available. Travel duration is 22h 40m
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FlixBus23h 5m013:05RomeAnagnina Bus Station12:10PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 18/12/2025 13:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 19/12/2025 12:10:00. 50 Economy ticket for £79 per person are available. Travel duration is 23h 5m
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FlixBus25h 10m012:20RomeTiburtina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 18/12/2025 12:20:00 to Roztyly, Prague (Czech Republic) arriving at 19/12/2025 13:30:00. 50 Economy ticket for £79 per person are available. Travel duration is 25h 10m
Fastest Flights Thursday
Fastest Buses Thursday
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 17:30:00. 50 Economy ticket for £84 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 20/12/2025 17:45:00. 50 Economy ticket for £84 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m021:00RomeTiburtina Bus Station20:20PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 19/12/2025 21:00:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 20/12/2025 20:20:00. 50 Economy ticket for £84 per person are available. Travel duration is 23h 20m
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FlixBus24h 5m017:25RomeAnagnina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 19/12/2025 17:25:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 20/12/2025 17:30:00. 50 Economy ticket for £85 per person are available. Travel duration is 24h 5m
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FlixBus24h 25m013:05RomeAnagnina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 19/12/2025 13:05:00 to Roztyly, Prague (Czech Republic) arriving at 20/12/2025 13:30:00. 50 Economy ticket for £85 per person are available. Travel duration is 24h 25m
Fastest Buses Friday
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Skyscanner1h 50m006:00Rome Ciampino AirportRome Ciampino Airport07:50Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 06:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 07:50:00. 50 Economy ticket for £54 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m019:20Rome Fiumicino AirportRome Fiumicino Airport21:20Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 19:20:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 21:20:00. 50 Economy ticket for £53 per person are available. Travel duration is 2h 0m
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Buzz6h 30m008:35Rome Ciampino AirportRome Ciampino Airport15:05Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 08:35:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 20/12/2025 15:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 6h 30m
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Ryanair6h 45m017:30Rome Fiumicino AirportRome Fiumicino Airport00:15Prague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 17:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 00:15:00. 50 Economy ticket for £80 per person are available. Travel duration is 6h 45m
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Wizz Air9h 50m021:25Rome Fiumicino AirportRome Fiumicino Airport07:15Prague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 20/12/2025 21:25:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 21/12/2025 07:15:00. 50 Economy ticket for £68 per person are available. Travel duration is 9h 50m
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FlixBus20h 20m013:05RomeAnagnina Bus Station09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 20/12/2025 13:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:25:00. 50 Economy ticket for £98 per person are available. Travel duration is 20h 20m
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FlixBus22h 15m023:05RomeTiburtina Bus Station21:20PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 20/12/2025 23:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 21:20:00. 50 Economy ticket for £98 per person are available. Travel duration is 22h 15m
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 21/12/2025 09:25:00. 50 Economy ticket for £89 per person are available. Travel duration is 22h 40m
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FlixBus24h 25m013:05RomeAnagnina Bus Station13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 20/12/2025 13:05:00 to Roztyly, Prague (Czech Republic) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £98 per person are available. Travel duration is 24h 25m
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FlixBus26h 45m010:45Rome Ciampino AirportRome Ciampino Airport13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 20/12/2025 10:45:00 to Roztyly, Prague (Czech Republic) arriving at 21/12/2025 13:30:00. 50 Economy ticket for £96 per person are available. Travel duration is 26h 45m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus20h 35m017:05RomeTiburtina Bus Station13:40PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 17:05:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 22/12/2025 13:40:00. 50 Economy ticket for £97 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m017:05RomeTiburtina Bus Station13:50PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 17:05:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 13:50:00. 50 Economy ticket for £97 per person are available. Travel duration is 20h 45m
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FlixBus22h 40m010:45Rome Ciampino AirportRome Ciampino Airport09:25PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 21/12/2025 10:45:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 22/12/2025 09:25:00. 50 Economy ticket for £97 per person are available. Travel duration is 22h 40m
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FlixBus26h 45m010:45Rome Ciampino AirportRome Ciampino Airport13:30PragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 21/12/2025 10:45:00 to Roztyly, Prague (Czech Republic) arriving at 22/12/2025 13:30:00. 50 Economy ticket for £108 per person are available. Travel duration is 26h 45m
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FlixBus28h 5m022:55RomeTiburtina Bus Station03:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 21/12/2025 22:55:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 03:00:00. 50 Economy ticket for £112 per person are available. Travel duration is 28h 5m
Fastest Buses Sunday
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Buzz1h 50m020:05Rome Ciampino AirportRome Ciampino Airport21:55Prague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 20:05:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 21:55:00. 50 Economy ticket for £38 per person are available. Travel duration is 1h 50m
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Skyscanner1h 50m006:00Rome Ciampino AirportRome Ciampino Airport07:50Prague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 06:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 07:50:00. 50 Economy ticket for £46 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m006:40Rome Fiumicino AirportRome Fiumicino Airport08:40Prague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 22/12/2025 06:40:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 08:40:00. 50 Economy ticket for £40 per person are available. Travel duration is 2h 0m
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Smartwings2h 0m014:00Rome Fiumicino AirportRome Fiumicino Airport16:00Prague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 22/12/2025 14:00:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 16:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 2h 0m
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Ryanair6h 45m011:30Rome Ciampino AirportRome Ciampino Airport18:15Prague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 22/12/2025 11:30:00 to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 22/12/2025 18:15:00. 50 Economy ticket for £73 per person are available. Travel duration is 6h 45m
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FlixBus20h 30m009:30RomeTiburtina Bus Station06:00PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 09:30:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 06:00:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 30m
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FlixBus20h 30m021:00RomeTiburtina Bus Station17:30PragueWilsonova Coach Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to Wilsonova Coach Station, Prague (Czech Republic) arriving at 23/12/2025 17:30:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m009:30RomeTiburtina Bus Station06:15PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 09:30:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 06:15:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 45m
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FlixBus20h 45m021:00RomeTiburtina Bus Station17:45PragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to ÚAN Florenc, Prague (Czech Republic) arriving at 23/12/2025 17:45:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m021:00RomeTiburtina Bus Station20:20PragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 21:00:00 to Na Knížecí Station, Prague (Czech Republic) arriving at 23/12/2025 20:20:00. 50 Economy ticket for £102 per person are available. Travel duration is 23h 20m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Rome to Prague
What are the most popular stations in Rome and Prague?
In Rome, you will usually depart from Termini Bus Station, Termini Central Station or Ostiense Train Station, while in Prague you will be arriving at Wilsonova Coach Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Rome? With 7 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Prague, you can pay as low as £23 with a Flight from Skyscanner.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Prague in just 1h 50m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Prague are FlixBus, Skyscanner and LC Perú, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Horoměřice, and look at flights from Rome Ciampino Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Prague?
The most popular companies between Rome and Prague, are FlixBus, Skyscanner and LC Perú. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: Skyscanner, LC Perú, Buzz and 3 more.
All you need to know when you travel from Rome to Prague
Check all information on comfort and services on all modes of transports from Rome to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Prague
How can I reach Prague from Rome?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Prague from Rome.
How far is Prague from Rome?
The distance between Rome and Prague is 921.0 km.
What is the most ecofriendly mode of transport between Rome and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 157 kgs, and a flight 227 kgs.
What is the cheapest mode of transport from Rome to Prague?
You can get to Prague with just £23 by taking a Flight from Skyscanner.
What is the fastest way to get from Rome to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 50m with a Flight from Skyscanner.
More routes to Rome and to Prague
Looking for more options? Here you can see the most popular routes to Rome and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Catanzaro to Rome
- Chieti to Rome
- Civitanova to Rome
- Foggia to Rome
- Genoa to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Lecce to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Palermo to Rome
- Perugia to Rome
- Pescara to Rome
- Porto D'Ascoli to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Venice to Rome
- Trips to Prague
- Amsterdam to Prague
- Augsburg to Prague
- Bern to Prague
- Bologna to Prague
- Bratislava to Prague
- Břeclav to Prague
- Brno to Prague
- Hamburg to Prague
- Heidelberg to Prague
- Jihlava to Prague
- Karlsruhe to Prague
- Katowice to Prague
- Kosice to Prague
- Nuremberg to Prague
- Ostrava to Prague
- Paris to Prague
- Pilsen to Prague
- Prague Airport to Prague
- Presov to Prague
- St. Gallen to Prague
- Teplice to Prague
- Třebíč to Prague
- Warsaw to Prague
- Wroclaw to Prague

