What is the best way to travel from Chicago to San Diego?
Looking for a trip? Check and compare all the available Buses and Flights to San Diego from Chicago. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Chicago?
You can reach San Diego with just £76 by taking a Flight from American Airlines, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus59h 50m000:15ChicagoDowntown Coach Station10:05San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 00:15:00 to Seaport Village, San Diego (USA) arriving at 24/03/2026 10:05:00. 50 Economy ticket for £110 per person are available. Travel duration is 59h 50m
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Greyhound US55h 49m012:01ChicagoDowntown Coach Station17:50San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 24/03/2026 17:50:00. 50 Economy ticket for £115 per person are available. Travel duration is 55h 49m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 22/03/2026 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 24/03/2026 18:20:00. 50 Economy ticket for £117 per person are available. Travel duration is 58h 20m
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 22/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 24/03/2026 17:45:00. 50 Economy ticket for £117 per person are available. Travel duration is 57h 45m
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FlixBus51h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 24/03/2026 17:45:00. 50 Economy ticket for £119 per person are available. Travel duration is 51h 15m
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Viva Aerobus34h 23m001:15Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:38Tijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 01:15:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 09:38:00. 50 Economy ticket for £169 per person are available. Travel duration is 34h 23m
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Volaris22h 39m012:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:38Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 12:59:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 09:38:00. 50 Economy ticket for £175 per person are available. Travel duration is 22h 39m
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Frontier Airlines22h 37m005:11Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center01:48Tijuana AirportTijuana Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 05:11:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 01:48:00. 50 Economy ticket for £207 per person are available. Travel duration is 22h 37m
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Aeroméxico16h 51m015:38Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center06:29Tijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 15:38:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 06:29:00. 50 Economy ticket for £227 per person are available. Travel duration is 16h 51m
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Hawaiian Airlines13h 20m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:40Tijuana AirportTijuana Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 08:20:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 22/03/2026 19:40:00. 50 Economy ticket for £336 per person are available. Travel duration is 13h 20m
Cheapest Buses Sunday
Cheapest Flights Sunday
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American Airlines4h 34m020:06Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:40San Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 20:06:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:40:00. 50 Economy ticket for £76 per person are available. Travel duration is 4h 34m
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Hawaiian Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:41:00. 50 Economy ticket for £79 per person are available. Travel duration is 4h 42m
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Alaska Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:41:00. 50 Economy ticket for £80 per person are available. Travel duration is 4h 42m
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Frontier Airlines7h 48m018:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center00:08San Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 18:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 24/03/2026 00:08:00. 50 Economy ticket for £105 per person are available. Travel duration is 7h 48m
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Viva Aerobus27h 35m001:15Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center02:50Tijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 01:15:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 24/03/2026 02:50:00. 50 Economy ticket for £116 per person are available. Travel duration is 27h 35m
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United Airlines4h 40m016:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:00San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 16:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 19:00:00. 50 Economy ticket for £116 per person are available. Travel duration is 4h 40m
Cheapest Flights Monday
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Frontier Airlines21h 31m012:34Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center08:05San Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 12:34:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 08:05:00. 50 Economy ticket for £107 per person are available. Travel duration is 21h 31m
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United Airlines4h 40m016:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:00San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 16:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 19:00:00. 50 Economy ticket for £156 per person are available. Travel duration is 4h 40m
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Alaska Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 22:41:00. 50 Economy ticket for £158 per person are available. Travel duration is 4h 42m
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Hawaiian Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 22:41:00. 50 Economy ticket for £161 per person are available. Travel duration is 4h 42m
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Spirit Airlines29h 18m020:58Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center00:16San Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 20:58:00 to San Diego Airport, San Diego Airport (USA) arriving at 28/03/2026 00:16:00. 50 Economy ticket for £174 per person are available. Travel duration is 29h 18m
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Viva Aerobus15h 25m002:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:45Tijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 02:20:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 26/03/2026 15:45:00. 50 Economy ticket for £210 per person are available. Travel duration is 15h 25m
Cheapest Flights Thursday
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Frontier Airlines17h 29m022:36Chicago Midway AirportChicago Midway Airport14:05San Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 27/03/2026 22:36:00 to San Diego Airport, San Diego Airport (USA) arriving at 28/03/2026 14:05:00. 50 Economy ticket for £100 per person are available. Travel duration is 17h 29m
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United Airlines4h 42m007:05Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:47San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 07:05:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 09:47:00. 50 Economy ticket for £216 per person are available. Travel duration is 4h 42m
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Alaska Airlines4h 42m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:02San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 08:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 11:02:00. 50 Economy ticket for £230 per person are available. Travel duration is 4h 42m
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Aeroméxico27h 41m017:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:40Tijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 17:59:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 28/03/2026 19:40:00. 50 Economy ticket for £231 per person are available. Travel duration is 27h 41m
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Volaris12h 35m019:54Chicago Midway AirportChicago Midway Airport06:29Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 27/03/2026 19:54:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 28/03/2026 06:29:00. 50 Economy ticket for £236 per person are available. Travel duration is 12h 35m
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Hawaiian Airlines4h 42m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:02San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 08:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 11:02:00. 50 Economy ticket for £241 per person are available. Travel duration is 4h 42m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 27/03/2026 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 18:20:00. 50 Economy ticket for £125 per person are available. Travel duration is 58h 20m
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FlixBus51h 50m016:30ChicagoDowntown Coach Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 16:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 18:20:00. 50 Economy ticket for £125 per person are available. Travel duration is 51h 50m
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Greyhound US52h 39m012:01ChicagoDowntown Coach Station14:40San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 14:40:00. 50 Economy ticket for £126 per person are available. Travel duration is 52h 39m
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Greyhound US55h 49m012:01ChicagoDowntown Coach Station17:50San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 17:50:00. 50 Economy ticket for £127 per person are available. Travel duration is 55h 49m
Cheapest Flights Friday
Cheapest Buses Friday
What are the fastest trips from Chicago to San Diego?
You can get to San Diego from Chicago in just 4h 34m with a Flight from American Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Hawaiian Airlines13h 20m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:40Tijuana AirportTijuana Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 08:20:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 22/03/2026 19:40:00. 50 Economy ticket for £336 per person are available. Travel duration is 13h 20m
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Aeroméxico16h 51m015:38Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center06:29Tijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 15:38:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 06:29:00. 50 Economy ticket for £227 per person are available. Travel duration is 16h 51m
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Frontier Airlines22h 37m005:11Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center01:48Tijuana AirportTijuana Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 05:11:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 01:48:00. 50 Economy ticket for £207 per person are available. Travel duration is 22h 37m
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Volaris22h 39m012:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:38Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 12:59:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 09:38:00. 50 Economy ticket for £175 per person are available. Travel duration is 22h 39m
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Viva Aerobus34h 23m001:15Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:38Tijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 22/03/2026 01:15:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 23/03/2026 09:38:00. 50 Economy ticket for £169 per person are available. Travel duration is 34h 23m
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FlixBus51h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 24/03/2026 17:45:00. 50 Economy ticket for £119 per person are available. Travel duration is 51h 15m
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Greyhound US55h 49m012:01ChicagoDowntown Coach Station17:50San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 24/03/2026 17:50:00. 50 Economy ticket for £115 per person are available. Travel duration is 55h 49m
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 22/03/2026 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 24/03/2026 17:45:00. 50 Economy ticket for £117 per person are available. Travel duration is 57h 45m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 22/03/2026 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 24/03/2026 18:20:00. 50 Economy ticket for £117 per person are available. Travel duration is 58h 20m
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FlixBus59h 50m000:15ChicagoDowntown Coach Station10:05San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 22/03/2026 00:15:00 to Seaport Village, San Diego (USA) arriving at 24/03/2026 10:05:00. 50 Economy ticket for £110 per person are available. Travel duration is 59h 50m
Fastest Flights Sunday
Fastest Buses Sunday
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American Airlines4h 34m020:06Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:40San Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 20:06:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:40:00. 50 Economy ticket for £76 per person are available. Travel duration is 4h 34m
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United Airlines4h 40m016:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:00San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 16:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 19:00:00. 50 Economy ticket for £116 per person are available. Travel duration is 4h 40m
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Hawaiian Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:41:00. 50 Economy ticket for £79 per person are available. Travel duration is 4h 42m
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Alaska Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 23/03/2026 22:41:00. 50 Economy ticket for £80 per person are available. Travel duration is 4h 42m
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Frontier Airlines7h 48m018:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center00:08San Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 23/03/2026 18:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 24/03/2026 00:08:00. 50 Economy ticket for £105 per person are available. Travel duration is 7h 48m
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Volaris12h 35m019:54Chicago Midway AirportChicago Midway Airport06:29Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 23/03/2026 19:54:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 24/03/2026 06:29:00. 50 Economy ticket for £134 per person are available. Travel duration is 12h 35m
Fastest Flights Monday
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United Airlines4h 40m016:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:00San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 16:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 19:00:00. 50 Economy ticket for £156 per person are available. Travel duration is 4h 40m
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Alaska Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 22:41:00. 50 Economy ticket for £158 per person are available. Travel duration is 4h 42m
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Hawaiian Airlines4h 42m019:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center22:41San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 19:59:00 to San Diego Airport, San Diego Airport (USA) arriving at 26/03/2026 22:41:00. 50 Economy ticket for £161 per person are available. Travel duration is 4h 42m
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Volaris14h 49m012:59Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center01:48Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 12:59:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 27/03/2026 01:48:00. 50 Economy ticket for £229 per person are available. Travel duration is 14h 49m
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Spirit Airlines15h 5m006:05Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center19:10Tijuana AirportTijuana Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 06:05:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 26/03/2026 19:10:00. 50 Economy ticket for £270 per person are available. Travel duration is 15h 5m
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Viva Aerobus15h 25m002:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center15:45Tijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 26/03/2026 02:20:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 26/03/2026 15:45:00. 50 Economy ticket for £210 per person are available. Travel duration is 15h 25m
Fastest Flights Thursday
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United Airlines4h 42m007:05Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center09:47San Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 07:05:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 09:47:00. 50 Economy ticket for £216 per person are available. Travel duration is 4h 42m
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Alaska Airlines4h 42m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:02San Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 08:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 11:02:00. 50 Economy ticket for £230 per person are available. Travel duration is 4h 42m
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Hawaiian Airlines4h 42m008:20Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:02San Diego AirportSan Diego Airport0EconomyA Flight from Hawaiian Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 08:20:00 to San Diego Airport, San Diego Airport (USA) arriving at 27/03/2026 11:02:00. 50 Economy ticket for £241 per person are available. Travel duration is 4h 42m
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Volaris12h 35m019:54Chicago Midway AirportChicago Midway Airport06:29Tijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 27/03/2026 19:54:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 28/03/2026 06:29:00. 50 Economy ticket for £236 per person are available. Travel duration is 12h 35m
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Frontier Airlines17h 29m022:36Chicago Midway AirportChicago Midway Airport14:05San Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 27/03/2026 22:36:00 to San Diego Airport, San Diego Airport (USA) arriving at 28/03/2026 14:05:00. 50 Economy ticket for £100 per person are available. Travel duration is 17h 29m
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Spirit Airlines18h 54m015:21Chicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center08:15Tijuana AirportTijuana Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 27/03/2026 15:21:00 to Tijuana Airport, Tijuana Airport (Mexico) arriving at 28/03/2026 08:15:00. 50 Economy ticket for £386 per person are available. Travel duration is 18h 54m
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FlixBus51h 50m016:30ChicagoDowntown Coach Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 16:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 18:20:00. 50 Economy ticket for £125 per person are available. Travel duration is 51h 50m
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Greyhound US52h 39m012:01ChicagoDowntown Coach Station14:40San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 14:40:00. 50 Economy ticket for £126 per person are available. Travel duration is 52h 39m
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Greyhound US55h 49m012:01ChicagoDowntown Coach Station17:50San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 27/03/2026 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 17:50:00. 50 Economy ticket for £127 per person are available. Travel duration is 55h 49m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 27/03/2026 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 29/03/2026 18:20:00. 50 Economy ticket for £125 per person are available. Travel duration is 58h 20m
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Here you will find all operators and timetables for a
Bus from Chicago to San Diego
What are the most popular stations in Chicago and San Diego?
In Chicago, you will usually depart from California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, while in San Diego you will be arriving at San Ysidro Transit Center, Old Town Transit Center or University Av & Bancroft St Coach Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Chicago? With 11 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and San Diego, you can pay as low as £76 with a Flight from American Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from American Airlines: you will get to San Diego in just 4h 34m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and San Diego are Frontier Airlines, Greyhound US and Spirit Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to San Diego Airport, and look at flights from Chicago Midway Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to San Diego?
The most popular companies between Chicago and San Diego, are Frontier Airlines, Greyhound US and Spirit Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Frontier Airlines, Spirit Airlines, Viva Aerobus and 6 more.
All you need to know when you travel from Chicago to San Diego
Check all information on comfort and services on all modes of transports from Chicago to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to San Diego
How can I reach San Diego from Chicago?
Every day, there are on average 11 connections between Flight and Bus, with which you can get to San Diego from Chicago.
How far is San Diego from Chicago?
The distance between Chicago and San Diego is 2,784.7 km.
What is the most ecofriendly mode of transport between Chicago and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 75 kgs of CO2, a train 97 kgs, a car 473 kgs, and a flight 685 kgs.
What is the cheapest mode of transport from Chicago to San Diego?
You can get to San Diego with just £76 by taking a Flight from American Airlines.
What is the fastest way to get from Chicago to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 4h 34m with a Flight from American Airlines.
More routes to Chicago and to San Diego
Looking for more options? Here you can see the most popular routes to Chicago and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Cincinnati to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Houston to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Pearson Toronto Airport to Chicago
- Phoenix, AZ to Chicago
- Pittsburgh to Chicago
- San Antonio, TX to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
- Tulsa to Chicago
- Trips to San Diego
- Bakersfield, CA to San Diego
- El Paso, TX to San Diego
- Houston to San Diego
- Las Vegas to San Diego
- Mexico City to San Diego
- New York to San Diego
- Pasco, WA to San Diego
- Phoenix, AZ to San Diego
- Salt Lake City, UT to San Diego
- San Francisco to San Diego
- San Jose, CA to San Diego
- Yakima, WA to San Diego
