What is the best way to travel from Chicago to San Diego?
Looking for a trip? Check and compare all the available Buses and Flights to San Diego from Chicago. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Chicago?
You can reach San Diego with just £82 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 01/07/2025 21:30:00. 50 Economy ticket for £116 per person are available. Travel duration is 53h 0m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 01/07/2025 18:10:00. 50 Economy ticket for £117 per person are available. Travel duration is 49h 40m
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FlixBus49h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 01/07/2025 17:35:00. 50 Economy ticket for £117 per person are available. Travel duration is 49h 5m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 29/06/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 01/07/2025 21:30:00. 50 Economy ticket for £130 per person are available. Travel duration is 59h 30m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 29/06/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 01/07/2025 18:10:00. 50 Economy ticket for £130 per person are available. Travel duration is 56h 10m
Cheapest Buses Sunday
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 02/07/2025 18:10:00. 50 Economy ticket for £162 per person are available. Travel duration is 49h 40m
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FlixBus49h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 02/07/2025 17:35:00. 50 Economy ticket for £162 per person are available. Travel duration is 49h 5m
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FlixBus54h 15m009:45ChicagoDowntown Coach Station16:00San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 09:45:00 to La Jolla Village, San Diego (USA) arriving at 02/07/2025 16:00:00. 50 Economy ticket for £165 per person are available. Travel duration is 54h 15m
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Greyhound US59h 30m022:00ChicagoUnion Station09:30San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 30/06/2025 22:00:00 to Old Town Transit Center, San Diego (USA) arriving at 03/07/2025 09:30:00. 50 Economy ticket for £182 per person are available. Travel duration is 59h 30m
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Greyhound US71h 30m022:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 30/06/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 03/07/2025 21:30:00. 50 Economy ticket for £183 per person are available. Travel duration is 71h 30m
Cheapest Buses Monday
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 17:45:00. 50 Economy ticket for £82 per person are available. Travel duration is 49h 15m
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 04/07/2025 21:30:00. 50 Economy ticket for £82 per person are available. Travel duration is 53h 0m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 18:10:00. 50 Economy ticket for £86 per person are available. Travel duration is 49h 40m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 02/07/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 04/07/2025 21:30:00. 50 Economy ticket for £92 per person are available. Travel duration is 59h 30m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 02/07/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 18:10:00. 50 Economy ticket for £96 per person are available. Travel duration is 56h 10m
Cheapest Buses Wednesday
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 05/07/2025 21:30:00. 50 Economy ticket for £97 per person are available. Travel duration is 53h 0m
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 05/07/2025 17:45:00. 50 Economy ticket for £98 per person are available. Travel duration is 49h 15m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 05/07/2025 18:10:00. 50 Economy ticket for £99 per person are available. Travel duration is 49h 40m
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Greyhound US65h 40m022:00ChicagoUnion Station15:40San DiegoSDSU Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 03/07/2025 22:00:00 to SDSU Transit Center, San Diego (USA) arriving at 06/07/2025 15:40:00. 50 Economy ticket for £112 per person are available. Travel duration is 65h 40m
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Greyhound US60h 40m022:00ChicagoUnion Station10:40San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 03/07/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 06/07/2025 10:40:00. 50 Economy ticket for £123 per person are available. Travel duration is 60h 40m
Cheapest Buses Thursday
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FlixBus58h 25m000:15ChicagoDowntown Coach Station10:40San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/07/2025 00:15:00 to Seaport Village, San Diego (USA) arriving at 07/07/2025 10:40:00. 50 Economy ticket for £230 per person are available. Travel duration is 58h 25m
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 07/07/2025 17:45:00. 50 Economy ticket for £231 per person are available. Travel duration is 49h 15m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 07/07/2025 18:10:00. 50 Economy ticket for £232 per person are available. Travel duration is 56h 10m
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Greyhound US55h 35m010:00ChicagoUnion Station17:35San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to La Jolla Village, San Diego (USA) arriving at 07/07/2025 17:35:00. 50 Economy ticket for £232 per person are available. Travel duration is 55h 35m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 07/07/2025 21:30:00. 50 Economy ticket for £233 per person are available. Travel duration is 59h 30m
Cheapest Buses Saturday
What are the fastest trips from Chicago to San Diego?
You can get to San Diego from Chicago in just 49h 5m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus49h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 01/07/2025 17:35:00. 50 Economy ticket for £117 per person are available. Travel duration is 49h 5m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 01/07/2025 18:10:00. 50 Economy ticket for £117 per person are available. Travel duration is 49h 40m
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 29/06/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 01/07/2025 21:30:00. 50 Economy ticket for £116 per person are available. Travel duration is 53h 0m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 29/06/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 01/07/2025 18:10:00. 50 Economy ticket for £130 per person are available. Travel duration is 56h 10m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 29/06/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 01/07/2025 21:30:00. 50 Economy ticket for £130 per person are available. Travel duration is 59h 30m
Fastest Buses Sunday
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FlixBus49h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 02/07/2025 17:35:00. 50 Economy ticket for £162 per person are available. Travel duration is 49h 5m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 02/07/2025 18:10:00. 50 Economy ticket for £162 per person are available. Travel duration is 49h 40m
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FlixBus54h 15m009:45ChicagoDowntown Coach Station16:00San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 30/06/2025 09:45:00 to La Jolla Village, San Diego (USA) arriving at 02/07/2025 16:00:00. 50 Economy ticket for £165 per person are available. Travel duration is 54h 15m
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Greyhound US59h 30m022:00ChicagoUnion Station09:30San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 30/06/2025 22:00:00 to Old Town Transit Center, San Diego (USA) arriving at 03/07/2025 09:30:00. 50 Economy ticket for £182 per person are available. Travel duration is 59h 30m
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Greyhound US71h 30m022:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 30/06/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 03/07/2025 21:30:00. 50 Economy ticket for £183 per person are available. Travel duration is 71h 30m
Fastest Buses Monday
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 17:45:00. 50 Economy ticket for £82 per person are available. Travel duration is 49h 15m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 18:10:00. 50 Economy ticket for £86 per person are available. Travel duration is 49h 40m
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 02/07/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 04/07/2025 21:30:00. 50 Economy ticket for £82 per person are available. Travel duration is 53h 0m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 02/07/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 04/07/2025 18:10:00. 50 Economy ticket for £96 per person are available. Travel duration is 56h 10m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 02/07/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 04/07/2025 21:30:00. 50 Economy ticket for £92 per person are available. Travel duration is 59h 30m
Fastest Buses Wednesday
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 05/07/2025 17:45:00. 50 Economy ticket for £98 per person are available. Travel duration is 49h 15m
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FlixBus49h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 05/07/2025 18:10:00. 50 Economy ticket for £99 per person are available. Travel duration is 49h 40m
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FlixBus53h 0m016:30ChicagoDowntown Coach Station21:30San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 03/07/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 05/07/2025 21:30:00. 50 Economy ticket for £97 per person are available. Travel duration is 53h 0m
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Greyhound US60h 40m022:00ChicagoUnion Station10:40San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 03/07/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 06/07/2025 10:40:00. 50 Economy ticket for £123 per person are available. Travel duration is 60h 40m
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Greyhound US65h 40m022:00ChicagoUnion Station15:40San DiegoSDSU Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 03/07/2025 22:00:00 to SDSU Transit Center, San Diego (USA) arriving at 06/07/2025 15:40:00. 50 Economy ticket for £112 per person are available. Travel duration is 65h 40m
Fastest Buses Thursday
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FlixBus49h 15m016:30ChicagoDowntown Coach Station17:45San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/07/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 07/07/2025 17:45:00. 50 Economy ticket for £231 per person are available. Travel duration is 49h 15m
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Greyhound US55h 35m010:00ChicagoUnion Station17:35San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to La Jolla Village, San Diego (USA) arriving at 07/07/2025 17:35:00. 50 Economy ticket for £232 per person are available. Travel duration is 55h 35m
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Greyhound US56h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 07/07/2025 18:10:00. 50 Economy ticket for £232 per person are available. Travel duration is 56h 10m
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FlixBus58h 25m000:15ChicagoDowntown Coach Station10:40San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/07/2025 00:15:00 to Seaport Village, San Diego (USA) arriving at 07/07/2025 10:40:00. 50 Economy ticket for £230 per person are available. Travel duration is 58h 25m
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Greyhound US59h 30m010:00ChicagoUnion Station21:30San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/07/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 07/07/2025 21:30:00. 50 Economy ticket for £233 per person are available. Travel duration is 59h 30m
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from Chicago to San Diego
What are the most popular stations in Chicago and San Diego?
In Chicago, you will usually depart from Union Station, 95th Red Line Station or California & 35th Street Coach Stop, while in San Diego you will be arriving at Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Chicago? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and San Diego, you can pay as low as £82 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to San Diego in just 49h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and San Diego are FlixBus and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to San Diego Airport, and look at flights from Chicago Midway Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to San Diego?
The most popular companies between Chicago and San Diego, are FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
All you need to know when you travel from Chicago to San Diego
Check all information on comfort and services on all modes of transports from Chicago to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to San Diego
How can I reach San Diego from Chicago?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to San Diego from Chicago.
How far is San Diego from Chicago?
The distance between Chicago and San Diego is 2,784.7 km.
What is the most ecofriendly mode of transport between Chicago and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 75 kgs of CO2, a train 97 kgs, a car 473 kgs, and a flight 685 kgs.
What is the cheapest mode of transport from Chicago to San Diego?
You can get to San Diego with just £82 by taking a Bus from FlixBus.
What is the fastest way to get from Chicago to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 49h 5m with a Bus from FlixBus.
More routes to Chicago and to San Diego
Looking for more options? Here you can see the most popular routes to Chicago and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
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