What is the best way to travel from Chicago to San Diego?
Looking for a trip? Check and compare all the available Buses and Flights to San Diego from Chicago. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Chicago?
You can reach San Diego with just £149 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US69h 10m022:00ChicagoUnion Station17:10San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/12/2025 22:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 08/12/2025 17:10:00. 50 Economy ticket for £221 per person are available. Travel duration is 69h 10m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/12/2025 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 18:20:00. 50 Economy ticket for £224 per person are available. Travel duration is 58h 20m
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Greyhound US52h 39m012:01ChicagoDowntown Coach Station14:40San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 05/12/2025 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 14:40:00. 50 Economy ticket for £232 per person are available. Travel duration is 52h 39m
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FlixBus51h 50m016:30ChicagoDowntown Coach Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/12/2025 16:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 18:20:00. 50 Economy ticket for £235 per person are available. Travel duration is 51h 50m
Cheapest Buses Friday
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 06/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £156 per person are available. Travel duration is 57h 45m
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 06/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £157 per person are available. Travel duration is 62h 15m
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Greyhound US51h 39m012:01ChicagoDowntown Coach Station13:40San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 12:01:00 to La Jolla Village, San Diego (USA) arriving at 08/12/2025 13:40:00. 50 Economy ticket for £159 per person are available. Travel duration is 51h 39m
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FlixBus55h 45m016:30ChicagoDowntown Coach Station22:15San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £192 per person are available. Travel duration is 55h 45m
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FlixBus51h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 08/12/2025 17:35:00. 50 Economy ticket for £193 per person are available. Travel duration is 51h 5m
Cheapest Buses Saturday
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 10/12/2025 22:15:00. 50 Economy ticket for £215 per person are available. Travel duration is 62h 15m
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Greyhound US63h 50m010:00ChicagoUnion Station23:50San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 23:50:00. 50 Economy ticket for £215 per person are available. Travel duration is 63h 50m
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Greyhound US58h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 18:10:00. 50 Economy ticket for £220 per person are available. Travel duration is 58h 10m
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FlixBus55h 45m016:30ChicagoDowntown Coach Station22:15San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 10/12/2025 22:15:00. 50 Economy ticket for £221 per person are available. Travel duration is 55h 45m
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FlixBus51h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 18:10:00. 50 Economy ticket for £222 per person are available. Travel duration is 51h 40m
Cheapest Buses Monday
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Greyhound US51h 39m012:01ChicagoDowntown Coach Station13:40San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 12:01:00 to La Jolla Village, San Diego (USA) arriving at 12/12/2025 13:40:00. 50 Economy ticket for £149 per person are available. Travel duration is 51h 39m
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Greyhound US52h 9m012:01ChicagoDowntown Coach Station14:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 12:01:00 to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 14:10:00. 50 Economy ticket for £149 per person are available. Travel duration is 52h 9m
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Greyhound US74h 15m022:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 13/12/2025 22:15:00. 50 Economy ticket for £152 per person are available. Travel duration is 74h 15m
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 12/12/2025 22:15:00. 50 Economy ticket for £157 per person are available. Travel duration is 62h 15m
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 17:45:00. 50 Economy ticket for £157 per person are available. Travel duration is 57h 45m
Cheapest Buses Wednesday
What are the fastest trips from Chicago to San Diego?
You can get to San Diego from Chicago in just 51h 5m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus51h 50m016:30ChicagoDowntown Coach Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 05/12/2025 16:30:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 18:20:00. 50 Economy ticket for £235 per person are available. Travel duration is 51h 50m
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Greyhound US52h 39m012:01ChicagoDowntown Coach Station14:40San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 05/12/2025 12:01:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 14:40:00. 50 Economy ticket for £232 per person are available. Travel duration is 52h 39m
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Greyhound US58h 20m010:00ChicagoUnion Station18:20San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/12/2025 10:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 07/12/2025 18:20:00. 50 Economy ticket for £224 per person are available. Travel duration is 58h 20m
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Greyhound US69h 10m022:00ChicagoUnion Station17:10San DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 05/12/2025 22:00:00 to San Ysidro Transit Center, San Diego (USA) arriving at 08/12/2025 17:10:00. 50 Economy ticket for £221 per person are available. Travel duration is 69h 10m
Fastest Buses Friday
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FlixBus51h 5m016:30ChicagoDowntown Coach Station17:35San DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 16:30:00 to La Jolla Village, San Diego (USA) arriving at 08/12/2025 17:35:00. 50 Economy ticket for £193 per person are available. Travel duration is 51h 5m
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Greyhound US51h 39m012:01ChicagoDowntown Coach Station13:40San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 12:01:00 to La Jolla Village, San Diego (USA) arriving at 08/12/2025 13:40:00. 50 Economy ticket for £159 per person are available. Travel duration is 51h 39m
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FlixBus55h 45m016:30ChicagoDowntown Coach Station22:15San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £192 per person are available. Travel duration is 55h 45m
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 06/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £156 per person are available. Travel duration is 57h 45m
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 06/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 08/12/2025 22:15:00. 50 Economy ticket for £157 per person are available. Travel duration is 62h 15m
Fastest Buses Saturday
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FlixBus51h 40m016:30ChicagoDowntown Coach Station18:10San DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 16:30:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 18:10:00. 50 Economy ticket for £222 per person are available. Travel duration is 51h 40m
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FlixBus55h 45m016:30ChicagoDowntown Coach Station22:15San DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 16:30:00 to Seaport Village, San Diego (USA) arriving at 10/12/2025 22:15:00. 50 Economy ticket for £221 per person are available. Travel duration is 55h 45m
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Greyhound US58h 10m010:00ChicagoUnion Station18:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 18:10:00. 50 Economy ticket for £220 per person are available. Travel duration is 58h 10m
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 10/12/2025 22:15:00. 50 Economy ticket for £215 per person are available. Travel duration is 62h 15m
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Greyhound US63h 50m010:00ChicagoUnion Station23:50San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 10/12/2025 23:50:00. 50 Economy ticket for £215 per person are available. Travel duration is 63h 50m
Fastest Buses Monday
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Greyhound US51h 39m012:01ChicagoDowntown Coach Station13:40San DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 12:01:00 to La Jolla Village, San Diego (USA) arriving at 12/12/2025 13:40:00. 50 Economy ticket for £149 per person are available. Travel duration is 51h 39m
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Greyhound US52h 9m012:01ChicagoDowntown Coach Station14:10San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 12:01:00 to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 14:10:00. 50 Economy ticket for £149 per person are available. Travel duration is 52h 9m
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Greyhound US57h 45m010:00ChicagoUnion Station17:45San DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 10:00:00 to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 17:45:00. 50 Economy ticket for £157 per person are available. Travel duration is 57h 45m
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Greyhound US62h 15m010:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 10:00:00 to Seaport Village, San Diego (USA) arriving at 12/12/2025 22:15:00. 50 Economy ticket for £157 per person are available. Travel duration is 62h 15m
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Greyhound US74h 15m022:00ChicagoUnion Station22:15San DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/12/2025 22:00:00 to Seaport Village, San Diego (USA) arriving at 13/12/2025 22:15:00. 50 Economy ticket for £152 per person are available. Travel duration is 74h 15m
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Chicago to San Diego
What are the most popular stations in Chicago and San Diego?
In Chicago, you will usually depart from California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, while in San Diego you will be arriving at San Ysidro Transit Center, University Av & Bancroft St Coach Stop or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Chicago? With 4 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and San Diego, you can pay as low as £149 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to San Diego in just 51h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and San Diego are Greyhound US and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to San Diego Airport, and look at flights from Chicago Midway Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to San Diego?
The most popular companies between Chicago and San Diego, are Greyhound US and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
All you need to know when you travel from Chicago to San Diego
Check all information on comfort and services on all modes of transports from Chicago to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to San Diego
How can I reach San Diego from Chicago?
Every day, there are on average 4 connections between Bus and Flight, with which you can get to San Diego from Chicago.
How far is San Diego from Chicago?
The distance between Chicago and San Diego is 2,784.7 km.
What is the most ecofriendly mode of transport between Chicago and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 75 kgs of CO2, a train 97 kgs, a car 473 kgs, and a flight 685 kgs.
What is the cheapest mode of transport from Chicago to San Diego?
You can get to San Diego with just £149 by taking a Bus from Greyhound US.
What is the fastest way to get from Chicago to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 51h 5m with a Bus from FlixBus.
More routes to Chicago and to San Diego
Looking for more options? Here you can see the most popular routes to Chicago and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
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