Bus tickets Santiago, RM to Santa Cruz, LI from £4

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Compare all timetables for the bus from Santiago, RM to Santa Cruz, LI

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to Santa Cruz, LI from various bus operators like FlixBus or Nueva Andimar Vip for the next days.

today
£6
tomorrow
Tuesday
£6
Wednesday
£6
Thursday
Friday
£4
Saturday
£6

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 18:59 Santiago, RM Sur Bus Station 21:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 19:29 Santiago, RM Sur Bus Station 22:09 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 19:59 Santiago, RM Sur Bus Station 22:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 20:59 Santiago, RM Sur Bus Station 23:39 Santa Cruz, LI Central Bus Station  Economy £6
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than £1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59
      Santiago, RM
      Sur Bus Station
      13:44
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      £3
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      13:45
      San Fernando, LI
      Central Bus Station
      14:35
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      £2
    Travel Time is 0h 4m shorter, and you will save £1

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 3h 5m 05:30 Santiago, RM Terminal San Borja 08:35 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 3h 5m 11:30 Santiago, RM Terminal San Borja 14:35 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 3h 5m 18:30 Santiago, RM Terminal San Borja 21:35 Santa Cruz, LI Central Bus Station  Economy £6
Nueva Andimar Vip 2h 40m 06:15 Santiago, RM Sur Bus Station 08:55 Santa Cruz, LI Central Bus Station  Economy £6
Nueva Andimar Vip 2h 40m 08:59 Santiago, RM Sur Bus Station 11:39 Santa Cruz, LI Central Bus Station  Economy £6
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than £1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59
      Santiago, RM
      Sur Bus Station
      13:44
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      £3
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      13:45
      San Fernando, LI
      Central Bus Station
      14:35
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      £2
    Travel Time is 0h 4m shorter, and you will save £1

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 06:15 Santiago, RM Sur Bus Station 08:55 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 08:59 Santiago, RM Sur Bus Station 11:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 09:59 Santiago, RM Sur Bus Station 12:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 10:59 Santiago, RM Sur Bus Station 13:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 11:29 Santiago, RM Sur Bus Station 14:09 Santa Cruz, LI Central Bus Station  Economy £6
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than £1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59
      Santiago, RM
      Sur Bus Station
      13:44
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      £3
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      13:45
      San Fernando, LI
      Central Bus Station
      14:35
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      £2
    Travel Time is 0h 4m shorter, and you will save £1

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 06:15 Santiago, RM Sur Bus Station 08:55 Santa Cruz, LI Central Bus Station  Economy £4
FlixBus 2h 40m 08:59 Santiago, RM Sur Bus Station 11:39 Santa Cruz, LI Central Bus Station  Economy £4
FlixBus 2h 40m 09:59 Santiago, RM Sur Bus Station 12:39 Santa Cruz, LI Central Bus Station  Economy £4
FlixBus 2h 40m 10:59 Santiago, RM Sur Bus Station 13:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 11:29 Santiago, RM Sur Bus Station 14:09 Santa Cruz, LI Central Bus Station  Economy £6

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 06:15 Santiago, RM Sur Bus Station 08:55 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 08:59 Santiago, RM Sur Bus Station 11:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 09:59 Santiago, RM Sur Bus Station 12:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 10:59 Santiago, RM Sur Bus Station 13:39 Santa Cruz, LI Central Bus Station  Economy £6
FlixBus 2h 40m 11:29 Santiago, RM Sur Bus Station 14:09 Santa Cruz, LI Central Bus Station  Economy £6
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than £1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59
      Santiago, RM
      Sur Bus Station
      13:44
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      £3
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      13:45
      San Fernando, LI
      Central Bus Station
      14:35
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      £2
    Travel Time is 0h 4m shorter, and you will save £1

Best Price Offer: The price for the cheapest coach from Santiago, RM to Santa Cruz, LI is £4 on 27/03/2026. Flexible travellers save on ticket prices.


Frequency of bus connections between Santiago, RM and Santa Cruz, LI

See here how frequent the connections between Santiago, RM and Santa Cruz, LI are, during different times and days of the week.
Tuesday is the busiest day, with more than 17 daily coaches from Santiago, RM to Santa Cruz, LI. Sunday has instead the fewest connections, with only 4 daily coaches between Santiago, RM and Santa Cruz, LI.
The busiest time of the day is the Morning, with 25 coaches from Santiago, RM to Santa Cruz, LI, while Night sees the fewest connections between Santiago, RM and Santa Cruz, LI, with 1 offers.

Facts about coaches from Santiago, RM to Santa Cruz, LI

Compare all providers like FlixBus and Nueva Andimar Vip that travel 12 times every day by bus from Santiago, RM to Santa Cruz, LI in one click! Book your bus ticket from Santiago, RM to Santa Cruz, LI starting from £4!

Cheapest Bus £4
Fastest Bus 2h 40m
Earliest Coach 18:59
Latest Coach 20:59
Daily Bus Connections 12 Ø
Distance 146.4 km
Coach Companies FlixBus and Nueva Andimar Vip

Cheapest coach connections from Santiago, RM to Santa Cruz, LI

Every day, 12 buses from 2 coach companies leave Santiago, RM for Santa Cruz, LI: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 22/03/2026 and for the following days.

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 16/03
Tuesday 17/03
Wednesday 18/03
Thursday 19/03
Friday 20/03
Saturday 21/03
Sunday 22/03
£5
Monday 23/03
Tuesday 24/03
£6
Wednesday 25/03
£6
Thursday 26/03
Friday 27/03
£5
Saturday 28/03
£6
Sunday 29/03
Monday 30/03
£5
Tuesday 31/03
£6
Wednesday 01/04
Thursday 02/04
£7
Friday 03/04
£5
Saturday 04/04
£6
Sunday 05/04
£6
Monday 06/04
£4
Tuesday 07/04
£5
Wednesday 08/04
£6
Thursday 09/04
£5
Friday 10/04
£5
Saturday 11/04
£6
Sunday 12/04

The cheapest time to travel from Santiago, RM to Santa Cruz, LI

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to Santa Cruz, LI, for the next 30 days.
With a price starting from £4, Friday is the cheapest day for a coach from Santiago, RM to Santa Cruz, LI. Wednesday instead is the most expensive day with prices starting from £6.
Morning is the cheapest day time for bus tickets from Santiago, RM to Santa Cruz, LI, with £4. Afternoon is the most expensive time of the day with prices starting from £6.

How to save money travelling from Santiago, RM to Santa Cruz, LI

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to Santa Cruz, LI in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to Santa Cruz, LI, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Santiago, RM to Santa Cruz, LI are also emptier.

Beloved bus companies from Santiago, RM to Santa Cruz, LI

These are the most booked bus companies between Santiago, RM to Santa Cruz, LI from our users.

FlixBus from Santiago, RM to Santa Cruz, LI

FlixBus

Here you will find the key facts about the FlixBus bus route Santiago, RM to Santa Cruz, LI:

Cheapest Price £4
Fastest Coach 2h 40m
Earliest Coach 18:59
Last Coach 20:59
Daily Connections 9 Ø
Found on 25/02/2026

All bus stations and stops in Santiago, RM and Santa Cruz, LI

The map below shows you where to find all the bus stations in Santiago, RM and Santa Cruz, LI.

Service and Comfort on the bus from Santiago, RM to Santa Cruz, LI

Want to know which seat classes are available on the coaches from Santiago, RM to Santa Cruz, LI? Or which bus companies serve the route Santiago, RM to Santa Cruz, LI? Below you will find answers to your questions.

FAQs about the Santiago, RM to Santa Cruz, LI bus

How much does a Santiago, RM - Santa Cruz, LI coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Santiago, RM - Santa Cruz, LI bus trip is available from £4 and takes 2h 40m. Compare offers and save money!

How much could I save by comparing buses from Santiago, RM to Santa Cruz, LI?

The connection Santiago, RM to Santa Cruz, LI is offered by 2 companies with ticket prices ranging from £4 to £6. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Santiago, RM - Santa Cruz, LI route on average every day?

Each day, the bus route from Santiago, RM to Santa Cruz, LI is offered by roughly 12 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Santa Cruz, LI from Santiago, RM take?

The quickest coach from Santiago, RM to Santa Cruz, LI is provided by FlixBus and takes 2h 40m. Coach tickets for this connection cost £6. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Santiago, RM to Santa Cruz, LI?

The earliest bus to Santa Cruz, LI departs from Santiago, RM at 18:59. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Santiago, RM to Santa Cruz, LI?

The latest bus to Santa Cruz, LI departs from Santiago, RM at 20:59. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Santiago, RM - Santa Cruz, LI route?

Passengers looking to travel from Santiago, RM to Santa Cruz, LI can travel with FlixBus and Nueva Andimar Vip. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Santiago, RM and Santa Cruz, LI?

You can check all the direct connections between Santiago, RM and Santa Cruz, LI by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Nueva Andimar Vip.

What can I take with me on the bus to Santa Cruz, LI from Santiago, RM?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Santiago, RM Santa Cruz, LI bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM Santa Cruz, LI bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to Santa Cruz, LI on your planned travel date.

How does CheckMyBus find the best bus deals from Santiago, RM to Santa Cruz, LI?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 12 daily trips between Santiago, RM and Santa Cruz, LI. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santiago, RM to Santa Cruz, LI?

Prices and availability for 12 trips between Santiago, RM and Santa Cruz, LI change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santiago, RM to Santa Cruz, LI

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santiago, RM and to Santa Cruz, LI

Here’s an overview of the most popular bus routes to Santiago, RM and to Santa Cruz, LI. Simply click on the connection of your choice, and you will find all the details about your bus route!
Coach from Pichilemu to Santa Cruz, LI Coach from Pichilemu to Santa Cruz, LI
Coach Buenos Aires to Santa Cruz, LI Coach Buenos Aires to Santa Cruz, LI
Bus to Santiago, RM from San Fernando, LI Bus to Santiago, RM from San Fernando, LI
Coach Parral to Santiago, RM Coach Parral to Santiago, RM
Coach to Santiago, RM from Pozo Almonte Coach to Santiago, RM from Pozo Almonte
Coach from Freire to Santiago, RM Coach from Freire to Santiago, RM
Buses Lanco to Santiago, RM Buses Lanco to Santiago, RM
Coaches São Paulo to Santiago, RM Coaches São Paulo to Santiago, RM
Loncura to Santiago, RM bus Loncura to Santiago, RM bus
Bus Molina to Santiago, RM Bus Molina to Santiago, RM
Coach Talcahuano to Santiago, RM Coach Talcahuano to Santiago, RM
Bus to Santiago, RM from Concón Bus to Santiago, RM from Concón
Coach Longaví to Santiago, RM Coach Longaví to Santiago, RM
Coach Vallenar to Santiago, RM Coach Vallenar to Santiago, RM
Coach Pichidangui to Santiago, RM Coach Pichidangui to Santiago, RM
Bus to Santiago, RM from Lautaro Bus to Santiago, RM from Lautaro
Pitrufquén to Santiago, RM bus Pitrufquén to Santiago, RM bus
Coach Cauquenes to Santiago, RM Coach Cauquenes to Santiago, RM
Bus Quintero to Santiago, RM Bus Quintero to Santiago, RM
Coach to Santiago, RM from Talca, ML Coach to Santiago, RM from Talca, ML
Bus to Santiago, RM from Villarrica (CL) Bus to Santiago, RM from Villarrica (CL)
Bus to Santiago, RM from Calama Bus to Santiago, RM from Calama
Coach from Viña del Mar to Santiago, RM Coach from Viña del Mar to Santiago, RM
Coaches La Serena to Santiago, RM Coaches La Serena to Santiago, RM
Popular Airport Transfers to Santiago, RM and to Santa Cruz, LI
CheckMyBus › Coaches in Chile › Coach to Santiago, RM › Coach to Santa Cruz, LI

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