Coach Mexico City to Santiago Tuxtla from £49

Which bus from Mexico City to Santiago Tuxtla is the best?

Check the bus schedule for Mexico City to Santiago Tuxtla. Here is a selection of the cheapest coach trips for the next days from bus operators like ADO. To see the full timetable for all coaches just use or search and compare.

today

£52

tomorrow

£49

Friday

£52

Saturday

£52

Sunday

£52

Monday

£53

Tuesday

£52

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 17/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 18/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 15m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 17/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 18/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 14m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 17/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 18/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 17/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 18/12/2025 07:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m
ADO	8h 25m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 17/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 18/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £14? You can find the corresponding connections below.
- ClickBus MX
  
  11h 45m
  
  0
  
  07:15
  
  Mexico City
  Norte Bus Station
  
  14:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 19/12/2025 07:15:00 to Bus Stop, Veracruz (Mexico) arriving at 19/12/2025 14:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  16:05
  
  Veracruz
  Central bus station
  
  19:00
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £14
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 19/12/2025 16:05:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 19:00:00. 50 Economy ticket for £14 per person are available. Travel duration is 2h 55m
Travel time is 3h 30m longer, but you will save £14

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£49	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 18/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 05:15:00. 50 Economy ticket for £49 per person are available. Travel duration is 9h 15m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£49	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 18/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 08:24:00. 50 Economy ticket for £49 per person are available. Travel duration is 9h 14m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£49	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 18/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 05:15:00. 50 Economy ticket for £49 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£49	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 18/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 07:15:00. 50 Economy ticket for £49 per person are available. Travel duration is 9h 0m
ADO	8h 25m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:24	Santiago Tuxtla	Central Bus Station	Economy	£49	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 18/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 19/12/2025 08:24:00. 50 Economy ticket for £49 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £11? You can find the corresponding connections below.
- ClickBus MX
  
  11h 40m
  
  0
  
  09:15
  
  Mexico City
  Norte Bus Station
  
  16:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 20/12/2025 09:15:00 to Bus Stop, Veracruz (Mexico) arriving at 20/12/2025 16:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  18:00
  
  Veracruz
  Central bus station
  
  20:55
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £14
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 20/12/2025 18:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 20:55:00. 50 Economy ticket for £14 per person are available. Travel duration is 2h 55m
Travel time is 3h 25m longer, but you will save £11

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 19/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 15m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 19/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 14m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 19/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 19/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 07:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m
ADO	9h 0m	23:30	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:30	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 19/12/2025 23:30:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 08:30:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £14? You can find the corresponding connections below.
- ClickBus MX
  
  11h 40m
  
  0
  
  09:15
  
  Mexico City
  Norte Bus Station
  
  16:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 20/12/2025 09:15:00 to Bus Stop, Veracruz (Mexico) arriving at 20/12/2025 16:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  18:00
  
  Veracruz
  Central bus station
  
  20:55
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £14
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 20/12/2025 18:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 20/12/2025 20:55:00. 50 Economy ticket for £14 per person are available. Travel duration is 2h 55m
Travel time is 3h 25m longer, but you will save £14

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 20/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 21/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 15m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 20/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 21/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 14m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 20/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 21/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 20/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 21/12/2025 07:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m
ADO	8h 25m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 20/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 21/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £15? You can find the corresponding connections below.
- ClickBus MX
  
  11h 45m
  
  0
  
  07:15
  
  Mexico City
  Norte Bus Station
  
  14:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 07:15:00 to Bus Stop, Veracruz (Mexico) arriving at 22/12/2025 14:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  16:05
  
  Veracruz
  Central bus station
  
  19:00
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £13
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 22/12/2025 16:05:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 19:00:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 55m
Travel time is 3h 30m longer, but you will save £15

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	8h 55m	20:00	Mexico City	Norte Bus Station	04:55	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 21/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 04:55:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 55m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 21/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 14m
ADO	7h 55m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	04:55	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 21/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 04:55:00. 50 Economy ticket for £52 per person are available. Travel duration is 7h 55m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 21/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 07:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m
ADO	8h 25m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:24	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 21/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 08:24:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £15? You can find the corresponding connections below.
- ClickBus MX
  
  11h 45m
  
  0
  
  07:15
  
  Mexico City
  Norte Bus Station
  
  14:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 07:15:00 to Bus Stop, Veracruz (Mexico) arriving at 22/12/2025 14:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  16:05
  
  Veracruz
  Central bus station
  
  19:00
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £13
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 22/12/2025 16:05:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 19:00:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 55m
Travel time is 3h 50m longer, but you will save £15

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£53	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 23/12/2025 05:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 9h 15m
ADO	9h 14m	23:10	Mexico City	Norte Bus Station	08:24	Santiago Tuxtla	Central Bus Station	Economy	£53	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 23/12/2025 08:24:00. 50 Economy ticket for £53 per person are available. Travel duration is 9h 14m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£53	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 22/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 23/12/2025 05:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£53	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 22/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 23/12/2025 07:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 9h 0m
ADO	8h 25m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:24	Santiago Tuxtla	Central Bus Station	Economy	£53	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 22/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 23/12/2025 08:24:00. 50 Economy ticket for £53 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £16? You can find the corresponding connections below.
- ClickBus MX
  
  11h 45m
  
  0
  
  07:15
  
  Mexico City
  Norte Bus Station
  
  14:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 07:15:00 to Bus Stop, Veracruz (Mexico) arriving at 22/12/2025 14:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  16:05
  
  Veracruz
  Central bus station
  
  19:00
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £13
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 22/12/2025 16:05:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 19:00:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 55m
Travel time is 3h 30m longer, but you will save £16

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	20:00	Mexico City	Norte Bus Station	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 23/12/2025 20:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 24/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 15m
ADO	9h 34m	23:10	Mexico City	Norte Bus Station	08:44	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 23/12/2025 23:10:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 24/12/2025 08:44:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 34m
ADO	8h 15m	21:00	Mexico City	Terminal de Autobuses de Oriente (TAPO)	05:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 23/12/2025 21:00:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 24/12/2025 05:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 15m
ADO	9h 0m	22:15	Mexico City	Terminal de Autobuses de Oriente (TAPO)	07:15	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 23/12/2025 22:15:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 24/12/2025 07:15:00. 50 Economy ticket for £52 per person are available. Travel duration is 9h 0m
ADO	8h 45m	23:59	Mexico City	Terminal de Autobuses de Oriente (TAPO)	08:44	Santiago Tuxtla	Central Bus Station	Economy	£52	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 23/12/2025 23:59:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 24/12/2025 08:44:00. 50 Economy ticket for £52 per person are available. Travel duration is 8h 45m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than £15? You can find the corresponding connections below.
- ClickBus MX
  
  11h 45m
  
  0
  
  07:15
  
  Mexico City
  Norte Bus Station
  
  14:57
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  £24
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 22/12/2025 07:15:00 to Bus Stop, Veracruz (Mexico) arriving at 22/12/2025 14:57:00. 50 Economy ticket for £24 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  2h 55m
  
  0
  
  16:05
  
  Veracruz
  Central bus station
  
  19:00
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  £13
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 22/12/2025 16:05:00 to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 22/12/2025 19:00:00. 50 Economy ticket for £13 per person are available. Travel duration is 2h 55m
Travel time is 3h 30m longer, but you will save £15

Best Price Offer: The price for the cheapest coach from Mexico City to Santiago Tuxtla is £49 on 18/12/2025. Flexible travellers save on ticket prices.

All facts for Mexico City to Santiago Tuxtla bus at a glance

Compare all coach operators like ADO that travel daily 8 times by bus from Mexico City to Santiago Tuxtla in one click. Book your Mexico City to Santiago Tuxtla bus ticket starting from £49!

Cheapest Bus	£49
Fastest Bus	7h 55m
Earliest Coach	20:00
Latest Coach	23:59
Daily Bus Connections	8 Ø
Distance	417.0 km
Coach Companies	ADO

What are the cheapest coach tickets from Mexico City to Santiago Tuxtla?

Every day, 8 buses from 1 coach companies leave Mexico City for Santiago Tuxtla. Check the table below to find the cheapest prices for coach tickets for this route, starting from 17/12/2025 and for the following days. Make sure get the cheapest bus ticket!

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 15/12

Tuesday 16/12

Wednesday 17/12

£52

Thursday 18/12

£49

Friday 19/12

£52

Saturday 20/12

£52

Sunday 21/12

£52

Monday 22/12

£53

Tuesday 23/12

£52

Wednesday 24/12

Thursday 25/12

£52

Friday 26/12

£53

Saturday 27/12

Sunday 28/12

£52

Monday 29/12

£52

Tuesday 30/12

£53

Wednesday 31/12

Thursday 01/01

Friday 02/01

£53

Saturday 03/01

£52

Sunday 04/01

£52

Monday 05/01

Tuesday 06/01

Wednesday 07/01

Thursday 08/01

£52

Friday 09/01

Saturday 10/01

Sunday 11/01

How to save money travelling from Mexico City to Santiago Tuxtla

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying higher prices for your trip? Plan your bus trips smartly. Here are a few hacks to save money on your coach journey.

Book the ticket from Mexico City to Santiago Tuxtla in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from Mexico City to Santiago Tuxtla, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Mexico City to Santiago Tuxtla are also emptier.

Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.

All bus stations and stops in Mexico City and Santiago Tuxtla

Here is a map with all coach stations in Mexico City and Santiago Tuxtla. Compare which stop is closest to your destination to save time to find the fastest buses and connections.

Norte Bus Station

Eje Central Lázaro Cárdenas

Terminal de Autobuses de Oriente (TAPO)

Calz. Ignacio Zaragoza 200

Terminal del Sur

Av. Taxqueña 1320

Observatorio Central Coach Station

Av Río de Tacubaya 122 232

Terminal Antas Tla

Emiliano Zapata 97

Central Bus Station

Morelos 190

All you need to know when you travel by bus from Mexico City to Santiago Tuxtla

Check all information on comfort and services on the coaches from Mexico City to Santiago Tuxtla. Which seat classes are available or what are the amenities of operators on your coach trip? Below you´ll find answers to your questions.

FAQs for Mexico City to Santiago Tuxtla bus

How much does a Mexico City Santiago Tuxtla coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Mexico City Santiago Tuxtla bus trip is available from £49 and takes 9h 15m. Compare offers and save money!

How much could I save by comparing buses from Mexico City to Santiago Tuxtla?

This connection is offered by 1 companies with ticket prices ranging from £49 to £53. Therefore, we suggest booking your ticket as soon as possible to ensure you’ll get the cheapest bus trip to Santiago Tuxtla.

How many connections are available for the Mexico City Santiago Tuxtla route on average every day?

Each day, the bus route from Mexico City to Santiago Tuxtla is offered by roughly 8 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Santiago Tuxtla from Mexico City take?

The quickest coach from Mexico City to Santiago Tuxtla is provided by ADO and takes 7h 55m. Coach tickets for this connection cost £53. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Mexico City to Santiago Tuxtla?

The earliest bus to Santiago Tuxtla departs from Mexico City at 20:00. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Mexico City to Santiago Tuxtla?

The latest bus to Santiago Tuxtla departs from Mexico City at 23:59. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Mexico City Santiago Tuxtla route?

Passengers looking to travel from Mexico City to Santiago Tuxtla can travel with ADO. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Mexico City and Santiago Tuxtla?

You can check all the direct connections between Mexico City and Santiago Tuxtla by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ADO.

What can I take with me on the bus to Santiago Tuxtla from Mexico City?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Mexico City Santiago Tuxtla bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Mexico City Santiago Tuxtla bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mexico City to Santiago Tuxtla on your planned travel date.

How does CheckMyBus find the best coach deals from Mexico City to Santiago Tuxtla?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Mexico City and Santiago Tuxtla. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mexico City to Santiago Tuxtla?

Prices and availability for 8 trips between Mexico City and Santiago Tuxtla change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mexico City to Santiago Tuxtla

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mexico City and to Santiago Tuxtla

Here’s an overview of the most popular bus routes to Mexico City and to Santiago Tuxtla. Simply click on the connection of your choice, and you’ll find all the details about your bus route!