What is the best way to travel from Siena to Palermo?
Looking for a trip? Check and compare all the available Buses to Palermo from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Palermo from Siena?
You can reach Palermo with just £38 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 11:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 5m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 16:55:00. 50 Economy ticket for £68 per person are available. Travel duration is 19h 35m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 30/06/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 11:00:00. 50 Economy ticket for £90 per person are available. Travel duration is 20h 9m
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FlixBus22h 45m011:35SienaPiazza Antonio Gramsci10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Piazza Antonio Gramsci, Siena (Italy) at 30/06/2025 11:35:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 10:20:00. 50 Economy ticket for £96 per person are available. Travel duration is 22h 45m
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FlixBus18h 35m015:45SienaTrain Station10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 15:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 10:20:00. 50 Economy ticket for £96 per person are available. Travel duration is 18h 35m
Cheapest Buses Monday
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 11:00:00. 50 Economy ticket for £38 per person are available. Travel duration is 16h 5m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 16:55:00. 50 Economy ticket for £64 per person are available. Travel duration is 19h 35m
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FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 14:25:00. 50 Economy ticket for £69 per person are available. Travel duration is 19h 30m
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FlixBus22h 25m011:55SienaBus Stop10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 02/07/2025 11:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 10:20:00. 50 Economy ticket for £90 per person are available. Travel duration is 22h 25m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 02/07/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 11:00:00. 50 Economy ticket for £90 per person are available. Travel duration is 20h 9m
Cheapest Buses Wednesday
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 11:00:00. 50 Economy ticket for £66 per person are available. Travel duration is 16h 5m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 16:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 19h 35m
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FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 14:25:00. 50 Economy ticket for £97 per person are available. Travel duration is 19h 30m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 03/07/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 11:00:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 9m
Cheapest Buses Thursday
What are the fastest trips from Siena to Palermo?
You can get to Palermo from Siena in just 16h 5m with a Bus from FlixBus. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 11:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 5m
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FlixBus18h 35m015:45SienaTrain Station10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 15:45:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 10:20:00. 50 Economy ticket for £96 per person are available. Travel duration is 18h 35m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/06/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 16:55:00. 50 Economy ticket for £68 per person are available. Travel duration is 19h 35m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 30/06/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 11:00:00. 50 Economy ticket for £90 per person are available. Travel duration is 20h 9m
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FlixBus22h 45m011:35SienaPiazza Antonio Gramsci10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Piazza Antonio Gramsci, Siena (Italy) at 30/06/2025 11:35:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 01/07/2025 10:20:00. 50 Economy ticket for £96 per person are available. Travel duration is 22h 45m
Fastest Buses Monday
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 11:00:00. 50 Economy ticket for £38 per person are available. Travel duration is 16h 5m
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FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 14:25:00. 50 Economy ticket for £69 per person are available. Travel duration is 19h 30m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 02/07/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 16:55:00. 50 Economy ticket for £64 per person are available. Travel duration is 19h 35m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 02/07/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 11:00:00. 50 Economy ticket for £90 per person are available. Travel duration is 20h 9m
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FlixBus22h 25m011:55SienaBus Stop10:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 02/07/2025 11:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 03/07/2025 10:20:00. 50 Economy ticket for £90 per person are available. Travel duration is 22h 25m
Fastest Buses Wednesday
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FlixBus16h 5m018:55SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 11:00:00. 50 Economy ticket for £66 per person are available. Travel duration is 16h 5m
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FlixBus19h 30m018:55SienaTrain Station14:25PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 18:55:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 14:25:00. 50 Economy ticket for £97 per person are available. Travel duration is 19h 30m
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FlixBus19h 35m021:20SienaTrain Station16:55PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 03/07/2025 21:20:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 16:55:00. 50 Economy ticket for £85 per person are available. Travel duration is 19h 35m
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FlixBus20h 9m014:51SienaBus Stop11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Bus Stop, Siena (Italy) at 03/07/2025 14:51:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 04/07/2025 11:00:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 9m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Siena to Palermo
What are the most popular stations in Siena and Palermo?
In Siena, you will usually depart from Train Station, Bus Stop or Central Bus Station, while in Palermo you will be arriving at Central Station, Cinisi or Via Tommaso Fazello Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Palermo from Siena? With 4 connections between 1 Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Palermo, you can pay as low as £38 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Palermo in just 16h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Palermo are FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Palermo is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Ciaculli, and look at flights from , and landing at Palermo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Palermo?
The most popular companies between Siena and Palermo, are FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
All you need to know when you travel from Siena to Palermo
Check all information on comfort and services on all modes of transports from Siena to Palermo. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Palermo
How can I reach Palermo from Siena?
Every day, there are on average 4 connections between Bus, with which you can get to Palermo from Siena.
How far is Palermo from Siena?
The distance between Siena and Palermo is 603.3 km.
What is the most ecofriendly mode of transport between Siena and Palermo?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 16 kgs of CO2, a train 21 kgs, a car 103 kgs, and a flight 148 kgs.
What is the cheapest mode of transport from Siena to Palermo?
You can get to Palermo with just £38 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Palermo?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Palermo in just 16h 5m with a Bus from FlixBus.
More routes to Siena and to Palermo
Looking for more options? Here you can see the most popular routes to Siena and to Palermo. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Avellino to Siena
- Benevento to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Cerignola to Siena
- Florence to Siena
- Grosseto to Siena
- Grottaminarda to Siena
- La Spezia to Siena
- Lamezia Terme to Siena
- Lucca to Siena
- Milan to Siena
- Mosciano Sant'Angelo to Siena
- Naples to Siena
- Orvieto to Siena
- Perugia to Siena
- Pisa to Siena
- Prato to Siena
- Rome to Siena
- Verona to Siena
- Trips to Palermo
- Agira to Palermo
- Agrigento to Palermo
- Bari to Palermo
- Bologna to Palermo
- Brindisi to Palermo
- Catania to Palermo
- Catania-Fontanarossa Airport to Palermo
- Cosenza to Palermo
- Florence to Palermo
- Lamezia Terme to Palermo
- Marsala to Palermo
- Mazara del Vallo to Palermo
- Messina to Palermo
- Milan to Palermo
- Naples to Palermo
- Palermo Airport to Palermo
- Piazza Armerina to Palermo
- Ragusa to Palermo
- Rome to Palermo
- Siracusa to Palermo
- Taormina to Palermo
- Trapani Airport to Palermo
- Trapani to Palermo
- Vibo Valentia to Palermo