What is the best way to travel from Siena to Palermo?
Looking for a trip? Check and compare all the available Trains and Buses to Palermo from Siena. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Palermo from Siena?
You can reach Palermo with just £38 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus18h 15m021:00SienaTrain Station15:15PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 21:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 15:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 18h 15m
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FlixBus20h 55m022:25SienaTrain Station19:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 22:25:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 19:20:00. 50 Economy ticket for £41 per person are available. Travel duration is 20h 55m
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FlixBus16h 0m019:00SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 19:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 11:00:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 0m
Cheapest Buses Monday
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FlixBus16h 0m019:00SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 01/04/2026 19:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 02/04/2026 11:00:00. 50 Economy ticket for £118 per person are available. Travel duration is 16h 0m
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FlixBus20h 55m022:25SienaTrain Station19:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 01/04/2026 22:25:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 02/04/2026 19:20:00. 50 Economy ticket for £127 per person are available. Travel duration is 20h 55m
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Trenitalia14h 40m008:18SienaTrain Station22:58PalermoCentral Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 01/04/2026 08:18:00 to Central Station, Palermo (Italy) arriving at 01/04/2026 22:58:00. 50 Economy ticket for £126 per person are available. Travel duration is 14h 40m
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Trenitalia17h 54m019:18SienaTrain Station13:12PalermoCentral Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 01/04/2026 19:18:00 to Central Station, Palermo (Italy) arriving at 02/04/2026 13:12:00. 50 Economy ticket for £132 per person are available. Travel duration is 17h 54m
Cheapest Buses Wednesday
Cheapest Trains Wednesday
What are the fastest trips from Siena to Palermo?
You can get to Palermo from Siena in just 14h 40m with a Train from Trenitalia. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus16h 0m019:00SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 19:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 11:00:00. 50 Economy ticket for £49 per person are available. Travel duration is 16h 0m
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FlixBus18h 15m021:00SienaTrain Station15:15PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 21:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 15:15:00. 50 Economy ticket for £38 per person are available. Travel duration is 18h 15m
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FlixBus20h 55m022:25SienaTrain Station19:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 30/03/2026 22:25:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 31/03/2026 19:20:00. 50 Economy ticket for £41 per person are available. Travel duration is 20h 55m
Fastest Buses Monday
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Trenitalia14h 40m008:18SienaTrain Station22:58PalermoCentral Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 01/04/2026 08:18:00 to Central Station, Palermo (Italy) arriving at 01/04/2026 22:58:00. 50 Economy ticket for £126 per person are available. Travel duration is 14h 40m
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Trenitalia17h 54m019:18SienaTrain Station13:12PalermoCentral Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 01/04/2026 19:18:00 to Central Station, Palermo (Italy) arriving at 02/04/2026 13:12:00. 50 Economy ticket for £132 per person are available. Travel duration is 17h 54m
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FlixBus16h 0m019:00SienaTrain Station11:00PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 01/04/2026 19:00:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 02/04/2026 11:00:00. 50 Economy ticket for £118 per person are available. Travel duration is 16h 0m
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FlixBus20h 55m022:25SienaTrain Station19:20PalermoVia Tommaso Fazello Bus Stop0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 01/04/2026 22:25:00 to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 02/04/2026 19:20:00. 50 Economy ticket for £127 per person are available. Travel duration is 20h 55m
Fastest Trains Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Siena to Palermo
What are the most popular stations in Siena and Palermo?
In Siena, you will usually depart from Train Station, Bus Stop or Central Bus Station, while in Palermo you will be arriving at Cinisi Via Nazionale Coach Stop, Via Belgio or Via Fazello, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Palermo from Siena? With 3 connections between 2 Train and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Palermo, you can pay as low as £38 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Train from Trenitalia: you will get to Palermo in just 14h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Palermo are FlixBus and Trenitalia, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Palermo is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Ciaculli, and look at flights from , and landing at Palermo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Palermo?
The most popular companies between Siena and Palermo, are FlixBus and Trenitalia. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Train companies: Trenitalia
All you need to know when you travel from Siena to Palermo
Check all information on comfort and services on all modes of transports from Siena to Palermo. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Palermo
How can I reach Palermo from Siena?
Every day, there are on average 3 connections between Train and Bus, with which you can get to Palermo from Siena.
How far is Palermo from Siena?
The distance between Siena and Palermo is 603.3 km.
What is the most ecofriendly mode of transport between Siena and Palermo?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 16 kgs of CO2, a train 21 kgs, a car 103 kgs, and a flight 148 kgs.
What is the cheapest mode of transport from Siena to Palermo?
You can get to Palermo with just £38 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Palermo?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Palermo in just 14h 40m with a Train from Trenitalia.
More routes to Siena and to Palermo
Looking for more options? Here you can see the most popular routes to Siena and to Palermo. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Avellino to Siena
- Barletta to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Catanzaro to Siena
- Chieti to Siena
- Florence Airport to Siena
- Florence to Siena
- Grosseto to Siena
- Lucca to Siena
- Matera to Siena
- Milan to Siena
- Naples to Siena
- Padua to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Prato to Siena
- Rome to Siena
- Salerno to Siena
- Sicignano degli Alburni to Siena
- Trips to Palermo
- Agrigento to Palermo
- Bari to Palermo
- Bologna to Palermo
- Caltanissetta to Palermo
- Castelvetrano to Palermo
- Catania to Palermo
- Cosenza to Palermo
- Enna to Palermo
- Florence to Palermo
- Foggia to Palermo
- Gela to Palermo
- Licata to Palermo
- Messina to Palermo
- Milan to Palermo
- Naples to Palermo
- Palermo Airport to Palermo
- Pescara to Palermo
- Ragusa to Palermo
- Rome to Palermo
- Salerno to Palermo
- Trapani Airport to Palermo
- Trapani to Palermo
- Vibo Valentia to Palermo
- Vittoria to Palermo
