What is the best way to travel from Philadelphia, PA to Knoxville, TN?
Looking for a trip? Check and compare all the available Flights and Buses to Knoxville, TN from Philadelphia, PA. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Philadelphia, PA?
You can reach Knoxville, TN with just £54 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 19/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 20h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 19/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 19/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 10m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 19/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 19/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 0m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 19/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 19/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 21h 30m
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Frontier Airlines23h 46m022:38Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 22:38:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:24:00. 50 Economy ticket for £79 per person are available. Travel duration is 23h 46m
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Allegiant Air17h 10m019:15Trenton–Mercer AirportTrenton–Mercer Airport12:25Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Trenton–Mercer Airport, Trenton–Mercer Airport (USA) at 19/04/2026 19:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 12:25:00. 50 Economy ticket for £115 per person are available. Travel duration is 17h 10m
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Spirit Airlines14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 19/04/2026 20:42:00. 50 Economy ticket for £134 per person are available. Travel duration is 14h 57m
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Skyscanner12h 12m008:30Greater Wilmington AirportGreater Wilmington Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Greater Wilmington Airport, Greater Wilmington Airport (USA) at 19/04/2026 08:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 19/04/2026 20:42:00. 50 Economy ticket for £138 per person are available. Travel duration is 12h 12m
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United Airlines28h 4m006:04Philadelphia AirportPhiladelphia Airport10:08Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 06:04:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 10:08:00. 50 Economy ticket for £272 per person are available. Travel duration is 28h 4m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 20/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 20/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 20h 0m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 20/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 16h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 20/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 20/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 22h 0m
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Allegiant Air26h 14m012:44Trenton–Mercer AirportTrenton–Mercer Airport14:58Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Trenton–Mercer Airport, Trenton–Mercer Airport (USA) at 20/04/2026 12:44:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 14:58:00. 50 Economy ticket for £82 per person are available. Travel duration is 26h 14m
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Frontier Airlines14h 54m007:30Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:24:00. 50 Economy ticket for £84 per person are available. Travel duration is 14h 54m
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Spirit Airlines26h 10m007:30Philadelphia AirportPhiladelphia Airport09:40Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 09:40:00. 50 Economy ticket for £84 per person are available. Travel duration is 26h 10m
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United Airlines5h 34m017:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 17:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:34:00. 50 Economy ticket for £236 per person are available. Travel duration is 5h 34m
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 15:09:00. 50 Economy ticket for £354 per person are available. Travel duration is 4h 36m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 21/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 20h 0m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 21/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 22h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 21/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 10m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 21/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 21/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 21h 30m
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Frontier Airlines21h 6m013:30Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 13:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £73 per person are available. Travel duration is 21h 6m
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Spirit Airlines28h 51m005:45Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £81 per person are available. Travel duration is 28h 51m
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Spirit Airlines16h 24m018:12Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 24m
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United Airlines12h 34m010:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 22:34:00. 50 Economy ticket for £272 per person are available. Travel duration is 12h 34m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 10m
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FlixBus24h 15m017:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 17:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 24h 15m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 21:50:00. 50 Economy ticket for £61 per person are available. Travel duration is 27h 20m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 22/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 0m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 22/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 22h 0m
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Allegiant Air26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £70 per person are available. Travel duration is 26h 30m
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Spirit Airlines26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £73 per person are available. Travel duration is 26h 30m
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Frontier Airlines25h 15m013:30Philadelphia AirportPhiladelphia Airport14:45Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 13:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 14:45:00. 50 Economy ticket for £98 per person are available. Travel duration is 25h 15m
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United Airlines13h 8m010:00Philadelphia AirportPhiladelphia Airport23:08Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 23:08:00. 50 Economy ticket for £272 per person are available. Travel duration is 13h 8m
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 15:09:00. 50 Economy ticket for £346 per person are available. Travel duration is 4h 36m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 10m
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FlixBus24h 15m017:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 17:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 24h 15m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 21:50:00. 50 Economy ticket for £57 per person are available. Travel duration is 27h 20m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 23/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 23/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 21h 30m
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Allegiant Air14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 57m
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Spirit Airlines14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £85 per person are available. Travel duration is 14h 57m
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Frontier Airlines15h 42m006:15Philadelphia AirportPhiladelphia Airport21:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 06:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 21:57:00. 50 Economy ticket for £120 per person are available. Travel duration is 15h 42m
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United Airlines12h 34m010:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 22:34:00. 50 Economy ticket for £321 per person are available. Travel duration is 12h 34m
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 15:09:00. 50 Economy ticket for £446 per person are available. Travel duration is 4h 36m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 20h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 21h 30m
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 24/04/2026 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 16h 0m
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 24/04/2026 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 22h 0m
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Allegiant Air17h 54m018:12Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £95 per person are available. Travel duration is 17h 54m
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Frontier Airlines19h 58m016:08Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 16:08:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £96 per person are available. Travel duration is 19h 58m
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Spirit Airlines17h 54m018:12Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £108 per person are available. Travel duration is 17h 54m
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Frontier Airlines20h 44m016:25Philadelphia AirportPhiladelphia Airport13:09Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 16:25:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 13:09:00. 50 Economy ticket for £135 per person are available. Travel duration is 20h 44m
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Spirit Airlines14h 54m007:30Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/04/2026 22:24:00. 50 Economy ticket for £136 per person are available. Travel duration is 14h 54m
Cheapest Buses Friday
Cheapest Flights Friday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 25/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 16h 10m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 25/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 16h 0m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 25/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 25/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 21h 30m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 25/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 20h 0m
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Frontier Airlines29h 41m016:16Philadelphia AirportPhiladelphia Airport21:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 16:16:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 21:57:00. 50 Economy ticket for £66 per person are available. Travel duration is 29h 41m
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Frontier Airlines18h 52m020:41Philadelphia AirportPhiladelphia Airport15:33Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 20:41:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 15:33:00. 50 Economy ticket for £71 per person are available. Travel duration is 18h 52m
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Spirit Airlines26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 20:42:00. 50 Economy ticket for £95 per person are available. Travel duration is 26h 30m
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Spirit Airlines20h 33m018:12Philadelphia AirportPhiladelphia Airport14:45Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 14:45:00. 50 Economy ticket for £104 per person are available. Travel duration is 20h 33m
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United Airlines16h 17m006:17Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 06:17:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 22:34:00. 50 Economy ticket for £256 per person are available. Travel duration is 16h 17m
Cheapest Buses Saturday
Cheapest Flights Saturday
What are the fastest trips from Philadelphia, PA to Knoxville, TN?
You can get to Knoxville, TN from Philadelphia, PA in just 4h 36m with a Flight from Skyscanner. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Skyscanner12h 12m008:30Greater Wilmington AirportGreater Wilmington Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Greater Wilmington Airport, Greater Wilmington Airport (USA) at 19/04/2026 08:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 19/04/2026 20:42:00. 50 Economy ticket for £138 per person are available. Travel duration is 12h 12m
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Spirit Airlines14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 19/04/2026 20:42:00. 50 Economy ticket for £134 per person are available. Travel duration is 14h 57m
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Allegiant Air17h 10m019:15Trenton–Mercer AirportTrenton–Mercer Airport12:25Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Trenton–Mercer Airport, Trenton–Mercer Airport (USA) at 19/04/2026 19:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 12:25:00. 50 Economy ticket for £115 per person are available. Travel duration is 17h 10m
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Frontier Airlines23h 46m022:38Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 22:38:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:24:00. 50 Economy ticket for £79 per person are available. Travel duration is 23h 46m
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United Airlines28h 4m006:04Philadelphia AirportPhiladelphia Airport10:08Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 19/04/2026 06:04:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 10:08:00. 50 Economy ticket for £272 per person are available. Travel duration is 28h 4m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 19/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 19/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 19/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 19/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 19/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 19/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 19/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 22h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 15:09:00. 50 Economy ticket for £354 per person are available. Travel duration is 4h 36m
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United Airlines5h 34m017:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 17:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:34:00. 50 Economy ticket for £236 per person are available. Travel duration is 5h 34m
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Frontier Airlines14h 54m007:30Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 20/04/2026 22:24:00. 50 Economy ticket for £84 per person are available. Travel duration is 14h 54m
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Spirit Airlines26h 10m007:30Philadelphia AirportPhiladelphia Airport09:40Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 20/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 09:40:00. 50 Economy ticket for £84 per person are available. Travel duration is 26h 10m
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Allegiant Air26h 14m012:44Trenton–Mercer AirportTrenton–Mercer Airport14:58Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Trenton–Mercer Airport, Trenton–Mercer Airport (USA) at 20/04/2026 12:44:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 14:58:00. 50 Economy ticket for £82 per person are available. Travel duration is 26h 14m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 20/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 20/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 20/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 20/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 20/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £54 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 20/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £55 per person are available. Travel duration is 22h 0m
Fastest Flights Monday
Fastest Buses Monday
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United Airlines12h 34m010:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 21/04/2026 22:34:00. 50 Economy ticket for £272 per person are available. Travel duration is 12h 34m
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Spirit Airlines16h 24m018:12Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £81 per person are available. Travel duration is 16h 24m
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Frontier Airlines21h 6m013:30Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 13:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £73 per person are available. Travel duration is 21h 6m
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Spirit Airlines28h 51m005:45Philadelphia AirportPhiladelphia Airport10:36Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 21/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 10:36:00. 50 Economy ticket for £81 per person are available. Travel duration is 28h 51m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 21/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 21/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 21/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 21/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 21/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 21/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 22h 0m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 15:09:00. 50 Economy ticket for £346 per person are available. Travel duration is 4h 36m
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United Airlines13h 8m010:00Philadelphia AirportPhiladelphia Airport23:08Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 22/04/2026 23:08:00. 50 Economy ticket for £272 per person are available. Travel duration is 13h 8m
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Frontier Airlines25h 15m013:30Philadelphia AirportPhiladelphia Airport14:45Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 13:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 14:45:00. 50 Economy ticket for £98 per person are available. Travel duration is 25h 15m
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Allegiant Air26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £70 per person are available. Travel duration is 26h 30m
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Spirit Airlines26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 22/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £73 per person are available. Travel duration is 26h 30m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 22/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 16h 10m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 22/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 22h 0m
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FlixBus24h 15m017:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 17:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £61 per person are available. Travel duration is 24h 15m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 22/04/2026 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 21:50:00. 50 Economy ticket for £61 per person are available. Travel duration is 27h 20m
Fastest Flights Wednesday
Fastest Buses Wednesday
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Skyscanner4h 36m010:33Philadelphia AirportPhiladelphia Airport15:09Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 15:09:00. 50 Economy ticket for £446 per person are available. Travel duration is 4h 36m
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United Airlines12h 34m010:00Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 10:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 22:34:00. 50 Economy ticket for £321 per person are available. Travel duration is 12h 34m
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Allegiant Air14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £72 per person are available. Travel duration is 14h 57m
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Spirit Airlines14h 57m005:45Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 05:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 20:42:00. 50 Economy ticket for £85 per person are available. Travel duration is 14h 57m
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Frontier Airlines15h 42m006:15Philadelphia AirportPhiladelphia Airport21:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 23/04/2026 06:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/04/2026 21:57:00. 50 Economy ticket for £120 per person are available. Travel duration is 15h 42m
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 23/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 23/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 21h 30m
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FlixBus24h 15m017:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 17:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 24h 15m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 23/04/2026 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 24/04/2026 21:50:00. 50 Economy ticket for £57 per person are available. Travel duration is 27h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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Spirit Airlines14h 54m007:30Philadelphia AirportPhiladelphia Airport22:24Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 07:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/04/2026 22:24:00. 50 Economy ticket for £136 per person are available. Travel duration is 14h 54m
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Allegiant Air17h 54m018:12Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £95 per person are available. Travel duration is 17h 54m
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Spirit Airlines17h 54m018:12Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £108 per person are available. Travel duration is 17h 54m
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Frontier Airlines19h 58m016:08Philadelphia AirportPhiladelphia Airport12:06Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 16:08:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 12:06:00. 50 Economy ticket for £96 per person are available. Travel duration is 19h 58m
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Frontier Airlines20h 44m016:25Philadelphia AirportPhiladelphia Airport13:09Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 24/04/2026 16:25:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 13:09:00. 50 Economy ticket for £135 per person are available. Travel duration is 20h 44m
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 24/04/2026 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 24/04/2026 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 24/04/2026 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 22h 0m
Fastest Flights Friday
Fastest Buses Friday
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Greyhound US16h 0m002:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 25/04/2026 02:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 25/04/2026 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 25/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 25/04/2026 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 25/04/2026 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 25/04/2026 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 26/04/2026 18:00:00. 50 Economy ticket for £63 per person are available. Travel duration is 22h 0m
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United Airlines16h 17m006:17Philadelphia AirportPhiladelphia Airport22:34Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 06:17:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 25/04/2026 22:34:00. 50 Economy ticket for £256 per person are available. Travel duration is 16h 17m
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Frontier Airlines18h 52m020:41Philadelphia AirportPhiladelphia Airport15:33Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 20:41:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 15:33:00. 50 Economy ticket for £71 per person are available. Travel duration is 18h 52m
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Spirit Airlines20h 33m018:12Philadelphia AirportPhiladelphia Airport14:45Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 14:45:00. 50 Economy ticket for £104 per person are available. Travel duration is 20h 33m
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Spirit Airlines26h 30m018:12Philadelphia AirportPhiladelphia Airport20:42Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 18:12:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 20:42:00. 50 Economy ticket for £95 per person are available. Travel duration is 26h 30m
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Frontier Airlines29h 41m016:16Philadelphia AirportPhiladelphia Airport21:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 25/04/2026 16:16:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/04/2026 21:57:00. 50 Economy ticket for £66 per person are available. Travel duration is 29h 41m
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Here you will find all operators and timetables for a
Bus from Philadelphia, PA to Knoxville, TN
What are the most popular stations in Philadelphia, PA and Knoxville, TN?
In Philadelphia, PA, you will usually depart from Spring Garden St Station, The Gallery or 30th Street Station, while in Knoxville, TN you will be arriving at Transit Center, Greyhound Bus Station or Knoxville Area Transit Coach Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Philadelphia, PA? With 10 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Philadelphia, PA and Knoxville, TN, you can pay as low as £54 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Knoxville, TN in just 4h 36m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Philadelphia, PA and Knoxville, TN are Greyhound US, FlixBus and Frontier Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Philadelphia, PA and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Millbourne, PA or to Wildwood, TN, and look at flights from Greater Wilmington Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Philadelphia, PA to Knoxville, TN?
The most popular companies between Philadelphia, PA and Knoxville, TN, are Greyhound US, FlixBus and Frontier Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Frontier Airlines, Spirit Airlines, United Airlines and 2 more.
All you need to know when you travel from Philadelphia, PA to Knoxville, TN
Check all information on comfort and services on all modes of transports from Philadelphia, PA to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Philadelphia, PA to Knoxville, TN
How can I reach Knoxville, TN from Philadelphia, PA?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to Knoxville, TN from Philadelphia, PA.
How far is Knoxville, TN from Philadelphia, PA?
The distance between Philadelphia, PA and Knoxville, TN is 884.3 km.
What is the most ecofriendly mode of transport between Philadelphia, PA and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 150 kgs, and a flight 218 kgs.
What is the cheapest mode of transport from Philadelphia, PA to Knoxville, TN?
You can get to Knoxville, TN with just £54 by taking a Bus from FlixBus.
What is the fastest way to get from Philadelphia, PA to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 4h 36m with a Flight from Skyscanner.
More routes to Philadelphia, PA and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Philadelphia, PA and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Philadelphia, PA
- Durham, NC to Philadelphia, PA
- New Orleans, LA to Philadelphia, PA
- Trips to Knoxville, TN
- Indianapolis to Knoxville, TN
