What is the best way to travel from Philadelphia, PA to Knoxville, TN?
Looking for a trip? Check and compare all the available Buses and Flights to Knoxville, TN from Philadelphia, PA. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Philadelphia, PA?
You can reach Knoxville, TN with just £52 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 05/12/2025 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £85 per person are available. Travel duration is 22h 0m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £86 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £86 per person are available. Travel duration is 21h 30m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/12/2025 18:00:00. 50 Economy ticket for £87 per person are available. Travel duration is 16h 10m
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 05/12/2025 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/12/2025 18:00:00. 50 Economy ticket for £87 per person are available. Travel duration is 16h 0m
Cheapest Buses Friday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 06/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 30m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £66 per person are available. Travel duration is 21h 30m
Cheapest Buses Saturday
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 07/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 07/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 30m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 21h 30m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 20h 0m
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Frontier Airlines19h 21m020:36Philadelphia AirportPhiladelphia Airport15:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 20:36:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 15:57:00. 50 Economy ticket for £84 per person are available. Travel duration is 19h 21m
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Spirit Airlines13h 40m018:53Philadelphia AirportPhiladelphia Airport08:33Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 18:53:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 08:33:00. 50 Economy ticket for £98 per person are available. Travel duration is 13h 40m
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Spirit Airlines7h 2m005:30Philadelphia AirportPhiladelphia Airport12:32Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 12:32:00. 50 Economy ticket for £112 per person are available. Travel duration is 7h 2m
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 13:17:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 17:11:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 56m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £78 per person are available. Travel duration is 20h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 21h 30m
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 08/12/2025 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 16h 0m
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 08/12/2025 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 22h 0m
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Spirit Airlines16h 19m005:30Philadelphia AirportPhiladelphia Airport21:49Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 21:49:00. 50 Economy ticket for £95 per person are available. Travel duration is 16h 19m
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Frontier Airlines10h 58m011:15Philadelphia AirportPhiladelphia Airport22:13Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 11:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 22:13:00. 50 Economy ticket for £107 per person are available. Travel duration is 10h 58m
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Frontier Airlines7h 43m014:06Philadelphia AirportPhiladelphia Airport21:49Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 14:06:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 21:49:00. 50 Economy ticket for £111 per person are available. Travel duration is 7h 43m
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 13:17:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 17:11:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 56m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus25h 30m016:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 16:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 30m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 10/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 10m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 21:50:00. 50 Economy ticket for £53 per person are available. Travel duration is 27h 20m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 10/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 10/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 21h 30m
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Spirit Airlines6h 48m005:15Philadelphia AirportPhiladelphia Airport12:03Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 05:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 12:03:00. 50 Economy ticket for £95 per person are available. Travel duration is 6h 48m
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Spirit Airlines11h 49m005:30Philadelphia AirportPhiladelphia Airport17:19Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 17:19:00. 50 Economy ticket for £112 per person are available. Travel duration is 11h 49m
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 13:17:00. 50 Economy ticket for £338 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 17:11:00. 50 Economy ticket for £338 per person are available. Travel duration is 6h 56m
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Skyscanner4h 10m010:33Philadelphia AirportPhiladelphia Airport14:43Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 14:43:00. 50 Economy ticket for £338 per person are available. Travel duration is 4h 10m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 16h 10m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 11/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 11/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 21h 30m
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FlixBus23h 15m018:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 18:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 23h 15m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 10m
Cheapest Buses Thursday
What are the fastest trips from Philadelphia, PA to Knoxville, TN?
You can get to Knoxville, TN from Philadelphia, PA in just 4h 10m with a Flight from Skyscanner. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 05/12/2025 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/12/2025 18:00:00. 50 Economy ticket for £87 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/12/2025 18:00:00. 50 Economy ticket for £87 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £86 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 05/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £86 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 05/12/2025 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £85 per person are available. Travel duration is 22h 0m
Fastest Buses Friday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £64 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 06/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 30m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 06/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/12/2025 18:00:00. 50 Economy ticket for £66 per person are available. Travel duration is 21h 30m
Fastest Buses Saturday
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 13:17:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 17:11:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 56m
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Spirit Airlines7h 2m005:30Philadelphia AirportPhiladelphia Airport12:32Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 07/12/2025 12:32:00. 50 Economy ticket for £112 per person are available. Travel duration is 7h 2m
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Spirit Airlines13h 40m018:53Philadelphia AirportPhiladelphia Airport08:33Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 18:53:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 08:33:00. 50 Economy ticket for £98 per person are available. Travel duration is 13h 40m
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Frontier Airlines19h 21m020:36Philadelphia AirportPhiladelphia Airport15:57Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 07/12/2025 20:36:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 15:57:00. 50 Economy ticket for £84 per person are available. Travel duration is 19h 21m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 22:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £60 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 07/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 21h 30m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 07/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 07/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £58 per person are available. Travel duration is 22h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 13:17:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 17:11:00. 50 Economy ticket for £363 per person are available. Travel duration is 6h 56m
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Frontier Airlines7h 43m014:06Philadelphia AirportPhiladelphia Airport21:49Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 14:06:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 21:49:00. 50 Economy ticket for £111 per person are available. Travel duration is 7h 43m
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Frontier Airlines10h 58m011:15Philadelphia AirportPhiladelphia Airport22:13Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 11:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 22:13:00. 50 Economy ticket for £107 per person are available. Travel duration is 10h 58m
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Spirit Airlines16h 19m005:30Philadelphia AirportPhiladelphia Airport21:49Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 08/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 08/12/2025 21:49:00. 50 Economy ticket for £95 per person are available. Travel duration is 16h 19m
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Greyhound US16h 0m002:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 08/12/2025 02:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m022:00Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 22:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £78 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m020:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia, PA (USA) at 08/12/2025 20:30:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PAIRS Building18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia, PA (USA) at 08/12/2025 20:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 09/12/2025 18:00:00. 50 Economy ticket for £79 per person are available. Travel duration is 22h 0m
Fastest Flights Monday
Fastest Buses Monday
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Skyscanner4h 10m010:33Philadelphia AirportPhiladelphia Airport14:43Knoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 10:33:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 14:43:00. 50 Economy ticket for £338 per person are available. Travel duration is 4h 10m
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United Airlines6h 47m006:30Philadelphia AirportPhiladelphia Airport13:17Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 06:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 13:17:00. 50 Economy ticket for £338 per person are available. Travel duration is 6h 47m
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Spirit Airlines6h 48m005:15Philadelphia AirportPhiladelphia Airport12:03Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 05:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 12:03:00. 50 Economy ticket for £95 per person are available. Travel duration is 6h 48m
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United Airlines6h 56m010:15Philadelphia AirportPhiladelphia Airport17:11Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 10:15:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 17:11:00. 50 Economy ticket for £338 per person are available. Travel duration is 6h 56m
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Spirit Airlines11h 49m005:30Philadelphia AirportPhiladelphia Airport17:19Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 10/12/2025 05:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 10/12/2025 17:19:00. 50 Economy ticket for £112 per person are available. Travel duration is 11h 49m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 10/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 10/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 10/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £53 per person are available. Travel duration is 22h 0m
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FlixBus25h 30m016:30Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 16:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £52 per person are available. Travel duration is 25h 30m
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FlixBus27h 20m018:30Philadelphia, PASpring Garden St Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 10/12/2025 18:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 21:50:00. 50 Economy ticket for £53 per person are available. Travel duration is 27h 20m
Fastest Flights Wednesday
Fastest Buses Wednesday
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 01:50:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 16h 10m
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FlixBus16h 10m001:50Philadelphia, PASpring Garden St Station18:00Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 01:50:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 11/12/2025 18:00:00. 50 Economy ticket for £59 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m020:30Philadelphia, PAConvention Center18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia, PA (USA) at 11/12/2025 20:30:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m020:00Philadelphia, PASchuylkill Ave and Walnut Street18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia, PA (USA) at 11/12/2025 20:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £56 per person are available. Travel duration is 22h 0m
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FlixBus23h 15m018:45Philadelphia, PASpring Garden St Station18:00Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia, PA (USA) at 11/12/2025 18:45:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 12/12/2025 18:00:00. 50 Economy ticket for £57 per person are available. Travel duration is 23h 15m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Philadelphia, PA to Knoxville, TN
What are the most popular stations in Philadelphia, PA and Knoxville, TN?
In Philadelphia, PA, you will usually depart from Spring Garden St Station, 30th Street Station or The Gallery, while in Knoxville, TN you will be arriving at Knoxville Area Transit Coach Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Philadelphia, PA? With 7 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Philadelphia, PA and Knoxville, TN, you can pay as low as £52 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Knoxville, TN in just 4h 10m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Philadelphia, PA and Knoxville, TN are Greyhound US, FlixBus and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Philadelphia, PA and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Millbourne, PA or to Wildwood, TN, and look at flights from Philadelphia Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Philadelphia, PA to Knoxville, TN?
The most popular companies between Philadelphia, PA and Knoxville, TN, are Greyhound US, FlixBus and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: United Airlines, Spirit Airlines, Frontier Airlines and 1 more.
All you need to know when you travel from Philadelphia, PA to Knoxville, TN
Check all information on comfort and services on all modes of transports from Philadelphia, PA to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Philadelphia, PA to Knoxville, TN
How can I reach Knoxville, TN from Philadelphia, PA?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Knoxville, TN from Philadelphia, PA.
How far is Knoxville, TN from Philadelphia, PA?
The distance between Philadelphia, PA and Knoxville, TN is 884.3 km.
What is the most ecofriendly mode of transport between Philadelphia, PA and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 150 kgs, and a flight 218 kgs.
What is the cheapest mode of transport from Philadelphia, PA to Knoxville, TN?
You can get to Knoxville, TN with just £52 by taking a Bus from FlixBus.
What is the fastest way to get from Philadelphia, PA to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 4h 10m with a Flight from Skyscanner.
More routes to Philadelphia, PA and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Philadelphia, PA and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!

