What is the best way to travel from Indianapolis to Knoxville, TN?
Looking for a trip? Check and compare all the available Flights and Buses to Knoxville, TN from Indianapolis. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Indianapolis?
You can reach Knoxville, TN with just £47 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 04/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 04/11/2026 19:50:00. 50 Economy ticket for £48 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 04/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 04/11/2026 22:30:00. 50 Economy ticket for £48 per person are available. Travel duration is 11h 15m
Cheapest Buses Wednesday
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 05/11/2026 22:30:00. 50 Economy ticket for £54 per person are available. Travel duration is 11h 15m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 05/11/2026 19:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/11/2026 22:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 11h 15m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/11/2026 19:50:00. 50 Economy ticket for £58 per person are available. Travel duration is 10h 40m
Cheapest Buses Thursday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 06/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/11/2026 19:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 06/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/11/2026 22:30:00. 50 Economy ticket for £55 per person are available. Travel duration is 11h 15m
Cheapest Buses Friday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/11/2026 19:50:00. 50 Economy ticket for £49 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/11/2026 22:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 11h 15m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/11/2026 19:50:00. 50 Economy ticket for £51 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/11/2026 22:30:00. 50 Economy ticket for £51 per person are available. Travel duration is 11h 15m
Cheapest Buses Saturday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/11/2026 19:50:00. 50 Economy ticket for £47 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/11/2026 22:30:00. 50 Economy ticket for £47 per person are available. Travel duration is 11h 15m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/11/2026 19:50:00. 50 Economy ticket for £50 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/11/2026 22:30:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 15m
Cheapest Buses Sunday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 09/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 09/11/2026 19:50:00. 50 Economy ticket for £48 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 09/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 09/11/2026 22:30:00. 50 Economy ticket for £48 per person are available. Travel duration is 11h 15m
Cheapest Buses Monday
What are the fastest trips from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN from Indianapolis in just 10h 40m with a Bus from Greyhound US. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 04/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 04/11/2026 19:50:00. 50 Economy ticket for £48 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 04/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 04/11/2026 22:30:00. 50 Economy ticket for £48 per person are available. Travel duration is 11h 15m
Fastest Buses Wednesday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 05/11/2026 19:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 40m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/11/2026 19:50:00. 50 Economy ticket for £58 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 05/11/2026 22:30:00. 50 Economy ticket for £54 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 05/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 05/11/2026 22:30:00. 50 Economy ticket for £57 per person are available. Travel duration is 11h 15m
Fastest Buses Thursday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 06/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/11/2026 19:50:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 06/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 06/11/2026 22:30:00. 50 Economy ticket for £55 per person are available. Travel duration is 11h 15m
Fastest Buses Friday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/11/2026 19:50:00. 50 Economy ticket for £49 per person are available. Travel duration is 10h 40m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/11/2026 19:50:00. 50 Economy ticket for £51 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 07/11/2026 22:30:00. 50 Economy ticket for £49 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 07/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 07/11/2026 22:30:00. 50 Economy ticket for £51 per person are available. Travel duration is 11h 15m
Fastest Buses Saturday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/11/2026 19:50:00. 50 Economy ticket for £47 per person are available. Travel duration is 10h 40m
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 09:10:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/11/2026 19:50:00. 50 Economy ticket for £50 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 08/11/2026 22:30:00. 50 Economy ticket for £47 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 08/11/2026 11:15:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 08/11/2026 22:30:00. 50 Economy ticket for £50 per person are available. Travel duration is 11h 15m
Fastest Buses Sunday
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Greyhound US10h 40m009:10IndianapolisCentral Coach Station19:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 09/11/2026 09:10:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 09/11/2026 19:50:00. 50 Economy ticket for £48 per person are available. Travel duration is 10h 40m
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Greyhound US11h 15m011:15IndianapolisCentral Coach Station22:30Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from Greyhound US goes from Central Coach Station, Indianapolis (USA) at 09/11/2026 11:15:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 09/11/2026 22:30:00. 50 Economy ticket for £48 per person are available. Travel duration is 11h 15m
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Indianapolis to Knoxville, TN
What are the most popular stations in Indianapolis and Knoxville, TN?
In Indianapolis, you will usually depart from Greyhound Bus Station, Central Coach Station or Downtown Transit Center, while in Knoxville, TN you will be arriving at Knoxville Area Transit Coach Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Indianapolis? With 3 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Indianapolis and Knoxville, TN, you can pay as low as £47 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from Greyhound US: you will get to Knoxville, TN in just 10h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Indianapolis and Knoxville, TN are Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Indianapolis and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Beech Grove, IN or to Wildwood, TN, and look at flights from Indianapolis Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Indianapolis to Knoxville, TN?
The most popular companies between Indianapolis and Knoxville, TN, are Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
All you need to know when you travel from Indianapolis to Knoxville, TN
Check all information on comfort and services on all modes of transports from Indianapolis to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Indianapolis to Knoxville, TN
How can I reach Knoxville, TN from Indianapolis?
Every day, there are on average 3 connections between Flight and Bus, with which you can get to Knoxville, TN from Indianapolis.
How far is Knoxville, TN from Indianapolis?
The distance between Indianapolis and Knoxville, TN is 466.2 km.
What is the most ecofriendly mode of transport between Indianapolis and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 13 kgs of CO2, a train 16 kgs, a car 79 kgs, and a flight 115 kgs.
What is the cheapest mode of transport from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN with just £47 by taking a Bus from Greyhound US.
What is the fastest way to get from Indianapolis to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 10h 40m with a Bus from Greyhound US.
More routes to Indianapolis and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Indianapolis and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!
