What is the best way to travel from Palermo to Siena?
Looking for a trip? Check and compare all the available Buses and Trains to Siena from Palermo. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Siena from Palermo?
You can reach Siena with just £31 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 11:10:00 to Train Station, Siena (Italy) arriving at 28/06/2025 06:05:00. 50 Economy ticket for £40 per person are available. Travel duration is 18h 55m
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 15:25:00 to Train Station, Siena (Italy) arriving at 28/06/2025 07:45:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 20m
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FlixBus18h 5m017:10PalermoVia Tommaso Fazello Bus Stop11:15SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 17:10:00 to Train Station, Siena (Italy) arriving at 28/06/2025 11:15:00. 50 Economy ticket for £44 per person are available. Travel duration is 18h 5m
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FlixBus23h 10m018:15PalermoVia Tommaso Fazello Bus Stop17:25SienaPiazza Antonio Gramsci0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 18:15:00 to Piazza Antonio Gramsci, Siena (Italy) arriving at 28/06/2025 17:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 23h 10m
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FlixBus17h 55m018:15PalermoVia Tommaso Fazello Bus Stop12:10SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 18:15:00 to Train Station, Siena (Italy) arriving at 28/06/2025 12:10:00. 50 Economy ticket for £65 per person are available. Travel duration is 17h 55m
Cheapest Buses Friday
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 15:25:00 to Train Station, Siena (Italy) arriving at 01/07/2025 07:45:00. 50 Economy ticket for £32 per person are available. Travel duration is 16h 20m
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 11:10:00 to Train Station, Siena (Italy) arriving at 01/07/2025 06:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 18h 55m
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Sais Trasporti22h 40m018:00PalermoVia Tommaso Fazello Bus Stop16:40SienaCentral Bus Station0EconomyA Bus from Sais Trasporti goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 18:00:00 to Central Bus Station, Siena (Italy) arriving at 01/07/2025 16:40:00. 50 Economy ticket for £71 per person are available. Travel duration is 22h 40m
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FlixBus17h 55m018:15PalermoVia Tommaso Fazello Bus Stop12:10SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 18:15:00 to Train Station, Siena (Italy) arriving at 01/07/2025 12:10:00. 50 Economy ticket for £84 per person are available. Travel duration is 17h 55m
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Trenitalia14h 34m007:05PalermoCentral Station21:39SienaTrain Station0EconomyA Train from Trenitalia goes from Central Station, Palermo (Italy) at 30/06/2025 07:05:00 to Train Station, Siena (Italy) arriving at 30/06/2025 21:39:00. 50 Economy ticket for £75 per person are available. Travel duration is 14h 34m
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Trenitalia19h 37m012:58PalermoCentral Station08:35SienaTrain Station0EconomyA Train from Trenitalia goes from Central Station, Palermo (Italy) at 30/06/2025 12:58:00 to Train Station, Siena (Italy) arriving at 01/07/2025 08:35:00. 50 Economy ticket for £77 per person are available. Travel duration is 19h 37m
Cheapest Buses Monday
Cheapest Trains Monday
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 15:25:00 to Train Station, Siena (Italy) arriving at 04/07/2025 07:45:00. 50 Economy ticket for £31 per person are available. Travel duration is 16h 20m
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FlixBus18h 5m017:10PalermoVia Tommaso Fazello Bus Stop11:15SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 17:10:00 to Train Station, Siena (Italy) arriving at 04/07/2025 11:15:00. 50 Economy ticket for £58 per person are available. Travel duration is 18h 5m
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 11:10:00 to Train Station, Siena (Italy) arriving at 04/07/2025 06:05:00. 50 Economy ticket for £66 per person are available. Travel duration is 18h 55m
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FlixBus20h 5m018:15PalermoVia Tommaso Fazello Bus Stop14:20SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 18:15:00 to Train Station, Siena (Italy) arriving at 04/07/2025 14:20:00. 50 Economy ticket for £69 per person are available. Travel duration is 20h 5m
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FlixBus23h 10m018:15PalermoVia Tommaso Fazello Bus Stop17:25SienaPiazza Antonio Gramsci0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 18:15:00 to Piazza Antonio Gramsci, Siena (Italy) arriving at 04/07/2025 17:25:00. 50 Economy ticket for £75 per person are available. Travel duration is 23h 10m
Cheapest Buses Thursday
What are the fastest trips from Palermo to Siena?
You can get to Siena from Palermo in just 14h 34m with a Train from Trenitalia. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 15:25:00 to Train Station, Siena (Italy) arriving at 28/06/2025 07:45:00. 50 Economy ticket for £44 per person are available. Travel duration is 16h 20m
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FlixBus17h 55m018:15PalermoVia Tommaso Fazello Bus Stop12:10SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 18:15:00 to Train Station, Siena (Italy) arriving at 28/06/2025 12:10:00. 50 Economy ticket for £65 per person are available. Travel duration is 17h 55m
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FlixBus18h 5m017:10PalermoVia Tommaso Fazello Bus Stop11:15SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 17:10:00 to Train Station, Siena (Italy) arriving at 28/06/2025 11:15:00. 50 Economy ticket for £44 per person are available. Travel duration is 18h 5m
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 11:10:00 to Train Station, Siena (Italy) arriving at 28/06/2025 06:05:00. 50 Economy ticket for £40 per person are available. Travel duration is 18h 55m
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FlixBus23h 10m018:15PalermoVia Tommaso Fazello Bus Stop17:25SienaPiazza Antonio Gramsci0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 27/06/2025 18:15:00 to Piazza Antonio Gramsci, Siena (Italy) arriving at 28/06/2025 17:25:00. 50 Economy ticket for £49 per person are available. Travel duration is 23h 10m
Fastest Buses Friday
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Trenitalia14h 34m007:05PalermoCentral Station21:39SienaTrain Station0EconomyA Train from Trenitalia goes from Central Station, Palermo (Italy) at 30/06/2025 07:05:00 to Train Station, Siena (Italy) arriving at 30/06/2025 21:39:00. 50 Economy ticket for £75 per person are available. Travel duration is 14h 34m
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Trenitalia19h 37m012:58PalermoCentral Station08:35SienaTrain Station0EconomyA Train from Trenitalia goes from Central Station, Palermo (Italy) at 30/06/2025 12:58:00 to Train Station, Siena (Italy) arriving at 01/07/2025 08:35:00. 50 Economy ticket for £77 per person are available. Travel duration is 19h 37m
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 15:25:00 to Train Station, Siena (Italy) arriving at 01/07/2025 07:45:00. 50 Economy ticket for £32 per person are available. Travel duration is 16h 20m
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FlixBus17h 55m018:15PalermoVia Tommaso Fazello Bus Stop12:10SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 18:15:00 to Train Station, Siena (Italy) arriving at 01/07/2025 12:10:00. 50 Economy ticket for £84 per person are available. Travel duration is 17h 55m
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 11:10:00 to Train Station, Siena (Italy) arriving at 01/07/2025 06:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 18h 55m
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Sais Trasporti22h 40m018:00PalermoVia Tommaso Fazello Bus Stop16:40SienaCentral Bus Station0EconomyA Bus from Sais Trasporti goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 30/06/2025 18:00:00 to Central Bus Station, Siena (Italy) arriving at 01/07/2025 16:40:00. 50 Economy ticket for £71 per person are available. Travel duration is 22h 40m
Fastest Trains Monday
Fastest Buses Monday
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FlixBus16h 20m015:25PalermoVia Tommaso Fazello Bus Stop07:45SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 15:25:00 to Train Station, Siena (Italy) arriving at 04/07/2025 07:45:00. 50 Economy ticket for £31 per person are available. Travel duration is 16h 20m
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FlixBus18h 5m017:10PalermoVia Tommaso Fazello Bus Stop11:15SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 17:10:00 to Train Station, Siena (Italy) arriving at 04/07/2025 11:15:00. 50 Economy ticket for £58 per person are available. Travel duration is 18h 5m
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FlixBus18h 55m011:10PalermoVia Tommaso Fazello Bus Stop06:05SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 11:10:00 to Train Station, Siena (Italy) arriving at 04/07/2025 06:05:00. 50 Economy ticket for £66 per person are available. Travel duration is 18h 55m
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FlixBus20h 5m018:15PalermoVia Tommaso Fazello Bus Stop14:20SienaTrain Station0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 18:15:00 to Train Station, Siena (Italy) arriving at 04/07/2025 14:20:00. 50 Economy ticket for £69 per person are available. Travel duration is 20h 5m
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FlixBus23h 10m018:15PalermoVia Tommaso Fazello Bus Stop17:25SienaPiazza Antonio Gramsci0EconomyA Bus from FlixBus goes from Via Tommaso Fazello Bus Stop, Palermo (Italy) at 03/07/2025 18:15:00 to Piazza Antonio Gramsci, Siena (Italy) arriving at 04/07/2025 17:25:00. 50 Economy ticket for £75 per person are available. Travel duration is 23h 10m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Palermo to Siena
What are the most popular stations in Palermo and Siena?
In Palermo, you will usually depart from Central Station, Cinisi or Via Tommaso Fazello Bus Stop, while in Siena you will be arriving at Train Station, Bus Stop or Central Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Siena from Palermo? With 5 connections between 3 Bus and Train operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Palermo and Siena, you can pay as low as £31 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Train from Trenitalia: you will get to Siena in just 14h 34m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Palermo and Siena are FlixBus, Trenitalia and Sais Trasporti, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Palermo and Siena is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Ciaculli or to Castagno, and look at flights from Palermo Airport, and landing at . Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Palermo to Siena?
The most popular companies between Palermo and Siena, are FlixBus, Trenitalia and Sais Trasporti. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Sais Trasporti
Train companies: Trenitalia
All you need to know when you travel from Palermo to Siena
Check all information on comfort and services on all modes of transports from Palermo to Siena. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Palermo to Siena
How can I reach Siena from Palermo?
Every day, there are on average 5 connections between Bus and Train, with which you can get to Siena from Palermo.
How far is Siena from Palermo?
The distance between Palermo and Siena is 603.3 km.
What is the most ecofriendly mode of transport between Palermo and Siena?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 16 kgs of CO2, a train 21 kgs, a car 103 kgs, and a flight 148 kgs.
What is the cheapest mode of transport from Palermo to Siena?
You can get to Siena with just £31 by taking a Bus from FlixBus.
What is the fastest way to get from Palermo to Siena?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Siena in just 14h 34m with a Train from Trenitalia.
More routes to Palermo and to Siena
Looking for more options? Here you can see the most popular routes to Palermo and to Siena. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Palermo
- Agira to Palermo
- Agrigento to Palermo
- Bari to Palermo
- Bologna to Palermo
- Brindisi to Palermo
- Catania to Palermo
- Catania-Fontanarossa Airport to Palermo
- Cosenza to Palermo
- Florence to Palermo
- Lamezia Terme to Palermo
- Marsala to Palermo
- Mazara del Vallo to Palermo
- Messina to Palermo
- Milan to Palermo
- Naples to Palermo
- Palermo Airport to Palermo
- Piazza Armerina to Palermo
- Ragusa to Palermo
- Rome to Palermo
- Siracusa to Palermo
- Taormina to Palermo
- Trapani Airport to Palermo
- Trapani to Palermo
- Vibo Valentia to Palermo
- Trips to Siena
- Avellino to Siena
- Barletta to Siena
- Benevento to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Crotone to Siena
- Ferrara to Siena
- Florence to Siena
- Frosinone to Siena
- Lamezia Terme to Siena
- Milan to Siena
- Mosciano Sant'Angelo to Siena
- Naples to Siena
- Orvieto to Siena
- Perugia to Siena
- Pisa to Siena
- Prato to Siena
- Rome Ciampino Airport to Siena
- Rome to Siena