What is the best way to travel from Orlando, FL to Knoxville, TN?
Looking for a trip? Check and compare all the available Buses and Flights to Knoxville, TN from Orlando, FL. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Orlando, FL?
You can reach Knoxville, TN with just £53 by taking a Flight from Frontier Airlines, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 06:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/12/2025 21:50:00. 50 Economy ticket for £101 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 22:55:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/12/2025 22:40:00. 50 Economy ticket for £101 per person are available. Travel duration is 23h 45m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 22/12/2025 21:50:00. 50 Economy ticket for £104 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 23/12/2025 22:40:00. 50 Economy ticket for £104 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 15:40:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/12/2025 21:50:00. 50 Economy ticket for £110 per person are available. Travel duration is 30h 10m
Cheapest Buses Monday
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Frontier Airlines21h 28m018:47Orlando AirportOrlando Airport16:15Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 18:47:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/12/2025 16:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 21h 28m
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Spirit Airlines18h 45m021:30Orlando AirportOrlando Airport16:15Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 21:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/12/2025 16:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
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Spirit Airlines13h 52m006:45Orlando AirportOrlando Airport20:37Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 06:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 20:37:00. 50 Economy ticket for £130 per person are available. Travel duration is 13h 52m
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Frontier Airlines9h 51m006:00Orlando AirportOrlando Airport15:51Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 06:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 15:51:00. 50 Economy ticket for £267 per person are available. Travel duration is 9h 51m
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United Airlines7h 46m012:05Orlando AirportOrlando Airport19:51Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 12:05:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 19:51:00. 50 Economy ticket for £321 per person are available. Travel duration is 7h 46m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/12/2025 22:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 15:40:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/12/2025 21:50:00. 50 Economy ticket for £126 per person are available. Travel duration is 30h 10m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 23/12/2025 21:50:00. 50 Economy ticket for £132 per person are available. Travel duration is 15h 50m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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Allegiant Air1h 45m008:30Orlando AirportOrlando Airport10:15Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 08:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/12/2025 10:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 1h 45m
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Frontier Airlines23h 40m018:57Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:57:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £121 per person are available. Travel duration is 23h 40m
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Spirit Airlines21h 7m021:30Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 21:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £171 per person are available. Travel duration is 21h 7m
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Spirit Airlines25h 53m018:34Orlando AirportOrlando Airport20:27Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 20:27:00. 50 Economy ticket for £196 per person are available. Travel duration is 25h 53m
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Frontier Airlines23h 53m018:44Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:44:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £214 per person are available. Travel duration is 23h 53m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 27/12/2025 22:40:00. 50 Economy ticket for £112 per person are available. Travel duration is 23h 45m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 26/12/2025 21:50:00. 50 Economy ticket for £127 per person are available. Travel duration is 15h 50m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 15:40:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 27/12/2025 21:50:00. 50 Economy ticket for £150 per person are available. Travel duration is 30h 10m
Cheapest Flights Friday
Cheapest Buses Friday
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 06:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 28/12/2025 21:50:00. 50 Economy ticket for £92 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 22:55:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 29/12/2025 22:40:00. 50 Economy ticket for £92 per person are available. Travel duration is 23h 45m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 28/12/2025 21:50:00. 50 Economy ticket for £95 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 29/12/2025 22:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 15:40:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 29/12/2025 21:50:00. 50 Economy ticket for £106 per person are available. Travel duration is 30h 10m
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Breeze Airways10h 47m007:00Orlando AirportOrlando Airport17:47Knoxville AirportKnoxville Airport0EconomyA Flight from Breeze Airways goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 07:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 17:47:00. 50 Economy ticket for £132 per person are available. Travel duration is 10h 47m
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Spirit Airlines4h 21m018:34Orlando AirportOrlando Airport22:55Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 22:55:00. 50 Economy ticket for £156 per person are available. Travel duration is 4h 21m
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Spirit Airlines25h 56m018:34Orlando AirportOrlando Airport20:30Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 29/12/2025 20:30:00. 50 Economy ticket for £163 per person are available. Travel duration is 25h 56m
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Frontier Airlines9h 31m006:00Orlando AirportOrlando Airport15:31Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 06:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 15:31:00. 50 Economy ticket for £325 per person are available. Travel duration is 9h 31m
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Frontier Airlines19h 9m020:42Orlando AirportOrlando Airport15:51Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 20:42:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 29/12/2025 15:51:00. 50 Economy ticket for £325 per person are available. Travel duration is 19h 9m
Cheapest Buses Sunday
Cheapest Flights Sunday
What are the fastest trips from Orlando, FL to Knoxville, TN?
You can get to Knoxville, TN from Orlando, FL in just 1h 45m with a Flight from Allegiant Air. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 06:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 22/12/2025 21:50:00. 50 Economy ticket for £101 per person are available. Travel duration is 15h 50m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 22/12/2025 21:50:00. 50 Economy ticket for £104 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 22:55:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/12/2025 22:40:00. 50 Economy ticket for £101 per person are available. Travel duration is 23h 45m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 23/12/2025 22:40:00. 50 Economy ticket for £104 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 22/12/2025 15:40:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 23/12/2025 21:50:00. 50 Economy ticket for £110 per person are available. Travel duration is 30h 10m
Fastest Buses Monday
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United Airlines7h 46m012:05Orlando AirportOrlando Airport19:51Knoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 12:05:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 19:51:00. 50 Economy ticket for £321 per person are available. Travel duration is 7h 46m
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Frontier Airlines9h 51m006:00Orlando AirportOrlando Airport15:51Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 06:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 15:51:00. 50 Economy ticket for £267 per person are available. Travel duration is 9h 51m
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Spirit Airlines13h 52m006:45Orlando AirportOrlando Airport20:37Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 06:45:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 23/12/2025 20:37:00. 50 Economy ticket for £130 per person are available. Travel duration is 13h 52m
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Spirit Airlines18h 45m021:30Orlando AirportOrlando Airport16:15Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 21:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/12/2025 16:15:00. 50 Economy ticket for £76 per person are available. Travel duration is 18h 45m
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Frontier Airlines21h 28m018:47Orlando AirportOrlando Airport16:15Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 23/12/2025 18:47:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 24/12/2025 16:15:00. 50 Economy ticket for £53 per person are available. Travel duration is 21h 28m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 23/12/2025 21:50:00. 50 Economy ticket for £132 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/12/2025 22:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 23/12/2025 15:40:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 24/12/2025 21:50:00. 50 Economy ticket for £126 per person are available. Travel duration is 30h 10m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Allegiant Air1h 45m008:30Orlando AirportOrlando Airport10:15Knoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 08:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 26/12/2025 10:15:00. 50 Economy ticket for £83 per person are available. Travel duration is 1h 45m
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Spirit Airlines21h 7m021:30Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 21:30:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £171 per person are available. Travel duration is 21h 7m
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Frontier Airlines23h 40m018:57Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:57:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £121 per person are available. Travel duration is 23h 40m
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Frontier Airlines23h 53m018:44Orlando AirportOrlando Airport18:37Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:44:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 18:37:00. 50 Economy ticket for £214 per person are available. Travel duration is 23h 53m
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Spirit Airlines25h 53m018:34Orlando AirportOrlando Airport20:27Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 26/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 27/12/2025 20:27:00. 50 Economy ticket for £196 per person are available. Travel duration is 25h 53m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 26/12/2025 21:50:00. 50 Economy ticket for £127 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 27/12/2025 22:40:00. 50 Economy ticket for £112 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 26/12/2025 15:40:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 27/12/2025 21:50:00. 50 Economy ticket for £150 per person are available. Travel duration is 30h 10m
Fastest Flights Friday
Fastest Buses Friday
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Spirit Airlines4h 21m018:34Orlando AirportOrlando Airport22:55Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 22:55:00. 50 Economy ticket for £156 per person are available. Travel duration is 4h 21m
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Frontier Airlines9h 31m006:00Orlando AirportOrlando Airport15:31Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 06:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 15:31:00. 50 Economy ticket for £325 per person are available. Travel duration is 9h 31m
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Breeze Airways10h 47m007:00Orlando AirportOrlando Airport17:47Knoxville AirportKnoxville Airport0EconomyA Flight from Breeze Airways goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 07:00:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 28/12/2025 17:47:00. 50 Economy ticket for £132 per person are available. Travel duration is 10h 47m
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Frontier Airlines19h 9m020:42Orlando AirportOrlando Airport15:51Knoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 20:42:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 29/12/2025 15:51:00. 50 Economy ticket for £325 per person are available. Travel duration is 19h 9m
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Spirit Airlines25h 56m018:34Orlando AirportOrlando Airport20:30Knoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Orlando Airport, Orlando Airport (USA) at 28/12/2025 18:34:00 to Knoxville Airport, Knoxville Airport (USA) arriving at 29/12/2025 20:30:00. 50 Economy ticket for £163 per person are available. Travel duration is 25h 56m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 06:00:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 28/12/2025 21:50:00. 50 Economy ticket for £92 per person are available. Travel duration is 15h 50m
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FlixBus15h 50m006:00Orlando, FLCoach Station21:50Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 06:00:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 28/12/2025 21:50:00. 50 Economy ticket for £95 per person are available. Travel duration is 15h 50m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 22:55:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 29/12/2025 22:40:00. 50 Economy ticket for £92 per person are available. Travel duration is 23h 45m
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FlixBus23h 45m022:55Orlando, FLCoach Station22:40Knoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 22:55:00 to Greyhound Bus Station, Knoxville, TN (USA) arriving at 29/12/2025 22:40:00. 50 Economy ticket for £95 per person are available. Travel duration is 23h 45m
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FlixBus30h 10m015:40Orlando, FLCoach Station21:50Knoxville, TNKnoxville Area Transit Coach Stop0EconomyA Bus from FlixBus goes from Coach Station, Orlando, FL (USA) at 28/12/2025 15:40:00 to Knoxville Area Transit Coach Stop, Knoxville, TN (USA) arriving at 29/12/2025 21:50:00. 50 Economy ticket for £106 per person are available. Travel duration is 30h 10m
Fastest Flights Sunday
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Orlando, FL to Knoxville, TN
What are the most popular stations in Orlando, FL and Knoxville, TN?
In Orlando, FL, you will usually depart from Coach Station, Dahlia Dr and S Semoran Blvd Coach Stop or Central Station, while in Knoxville, TN you will be arriving at Knoxville Area Transit Coach Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Orlando, FL? With 7 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Orlando, FL and Knoxville, TN, you can pay as low as £53 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Allegiant Air: you will get to Knoxville, TN in just 1h 45m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Orlando, FL and Knoxville, TN are FlixBus, Frontier Airlines and Spirit Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Orlando, FL and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Fairview Shores, FL or to Wildwood, TN, and look at flights from Orlando Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Orlando, FL to Knoxville, TN?
The most popular companies between Orlando, FL and Knoxville, TN, are FlixBus, Frontier Airlines and Spirit Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: Frontier Airlines, Spirit Airlines, United Airlines and 2 more.
All you need to know when you travel from Orlando, FL to Knoxville, TN
Check all information on comfort and services on all modes of transports from Orlando, FL to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Orlando, FL to Knoxville, TN
How can I reach Knoxville, TN from Orlando, FL?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Knoxville, TN from Orlando, FL.
How far is Knoxville, TN from Orlando, FL?
The distance between Orlando, FL and Knoxville, TN is 859.1 km.
What is the most ecofriendly mode of transport between Orlando, FL and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 211 kgs.
What is the cheapest mode of transport from Orlando, FL to Knoxville, TN?
You can get to Knoxville, TN with just £53 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Orlando, FL to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 1h 45m with a Flight from Allegiant Air.
More routes to Orlando, FL and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Orlando, FL and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Orlando, FL
- Atlanta, GA to Orlando, FL
- Baltimore, MD to Orlando, FL
- Boston, MA to Orlando, FL
- Charlotte, NC to Orlando, FL
- Chicago to Orlando, FL
- Cincinnati to Orlando, FL
- Columbus, OH to Orlando, FL
- Dallas to Orlando, FL
- El Paso, TX to Orlando, FL
- Fort Lauderdale Airport to Orlando, FL
- Houston to Orlando, FL
- Miami Airport to Orlando, FL
- Miami Beach, FL to Orlando, FL
- Miami to Orlando, FL
- Monterrey, NL to Orlando, FL
- New York to Orlando, FL
- Newark to Orlando, FL
- Providence, RI to Orlando, FL
- Richmond, VA to Orlando, FL
- Syracuse, NY to Orlando, FL
