What is the best way to travel from Knoxville, TN to Indianapolis?
Looking for a trip? Check and compare all the available Flights and Buses to Indianapolis from Knoxville, TN. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Indianapolis from Knoxville, TN?
You can reach Indianapolis with just £50 by taking a Bus from Greyhound US, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 05/06/2026 04:45:00. 50 Economy ticket for £57 per person are available. Travel duration is 10h 35m
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Greyhound US16h 25m019:40Knoxville, TNGreyhound Bus Station12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 05/06/2026 12:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 25m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 05/06/2026 08:25:00. 50 Economy ticket for £58 per person are available. Travel duration is 14h 15m
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Allegiant Air6h 29m007:15Knoxville AirportKnoxville Airport13:44Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 07:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 13:44:00. 50 Economy ticket for £111 per person are available. Travel duration is 6h 29m
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Skyscanner5h 7m013:54Knoxville AirportKnoxville Airport19:01Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 19:01:00. 50 Economy ticket for £212 per person are available. Travel duration is 5h 7m
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 23:59:00. 50 Economy ticket for £212 per person are available. Travel duration is 4h 40m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 12:53:00. 50 Economy ticket for £212 per person are available. Travel duration is 6h 53m
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United Airlines6h 10m010:20Knoxville AirportKnoxville Airport16:30Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 10:20:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 16:30:00. 50 Economy ticket for £281 per person are available. Travel duration is 6h 10m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 06/06/2026 12:05:00. 50 Economy ticket for £50 per person are available. Travel duration is 16h 25m
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 06/06/2026 08:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 14h 15m
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 06/06/2026 04:45:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 35m
Cheapest Buses Friday
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Skyscanner4h 28m005:45Knoxville AirportKnoxville Airport10:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 05:45:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 10:13:00. 50 Economy ticket for £126 per person are available. Travel duration is 4h 28m
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Allegiant Air16h 59m006:00Knoxville AirportKnoxville Airport22:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 22:59:00. 50 Economy ticket for £131 per person are available. Travel duration is 16h 59m
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Allegiant Air5h 3m017:56Knoxville AirportKnoxville Airport22:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 17:56:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 22:59:00. 50 Economy ticket for £131 per person are available. Travel duration is 5h 3m
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Skyscanner5h 7m013:54Knoxville AirportKnoxville Airport19:01Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 19:01:00. 50 Economy ticket for £211 per person are available. Travel duration is 5h 7m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 12:53:00. 50 Economy ticket for £211 per person are available. Travel duration is 6h 53m
Cheapest Flights Saturday
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Greyhound US16h 25m019:40Knoxville, TNGreyhound Bus Station12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 08/06/2026 12:05:00. 50 Economy ticket for £56 per person are available. Travel duration is 16h 25m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 08/06/2026 04:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 08/06/2026 08:25:00. 50 Economy ticket for £60 per person are available. Travel duration is 14h 15m
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Allegiant Air12h 14m008:15Knoxville AirportKnoxville Airport20:29Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 08:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 20:29:00. 50 Economy ticket for £190 per person are available. Travel duration is 12h 14m
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Allegiant Air6h 29m007:15Knoxville AirportKnoxville Airport13:44Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 07:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 13:44:00. 50 Economy ticket for £296 per person are available. Travel duration is 6h 29m
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Skyscanner4h 28m005:45Knoxville AirportKnoxville Airport10:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 05:45:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 10:13:00. 50 Economy ticket for £337 per person are available. Travel duration is 4h 28m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 12:53:00. 50 Economy ticket for £337 per person are available. Travel duration is 6h 53m
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 23:59:00. 50 Economy ticket for £338 per person are available. Travel duration is 4h 40m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 09/06/2026 08:25:00. 50 Economy ticket for £66 per person are available. Travel duration is 14h 15m
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 04:45:00. 50 Economy ticket for £66 per person are available. Travel duration is 10h 35m
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 12:05:00. 50 Economy ticket for £67 per person are available. Travel duration is 16h 25m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 04:45:00. 50 Economy ticket for £68 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 09/06/2026 08:25:00. 50 Economy ticket for £68 per person are available. Travel duration is 14h 15m
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Allegiant Air21h 43m018:39Knoxville AirportKnoxville Airport16:22Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 18:39:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 09/06/2026 16:22:00. 50 Economy ticket for £105 per person are available. Travel duration is 21h 43m
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Allegiant Air7h 22m013:41Knoxville AirportKnoxville Airport21:03Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 13:41:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 21:03:00. 50 Economy ticket for £190 per person are available. Travel duration is 7h 22m
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Skyscanner6h 19m013:54Knoxville AirportKnoxville Airport20:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 20:13:00. 50 Economy ticket for £280 per person are available. Travel duration is 6h 19m
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 23:59:00. 50 Economy ticket for £280 per person are available. Travel duration is 4h 40m
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United Airlines6h 10m010:20Knoxville AirportKnoxville Airport16:30Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 10:20:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 16:30:00. 50 Economy ticket for £337 per person are available. Travel duration is 6h 10m
Cheapest Buses Monday
Cheapest Flights Monday
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 11/06/2026 08:25:00. 50 Economy ticket for £65 per person are available. Travel duration is 14h 15m
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 04:45:00. 50 Economy ticket for £66 per person are available. Travel duration is 10h 35m
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 12:05:00. 50 Economy ticket for £66 per person are available. Travel duration is 16h 25m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 11/06/2026 08:25:00. 50 Economy ticket for £68 per person are available. Travel duration is 14h 15m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 04:45:00. 50 Economy ticket for £69 per person are available. Travel duration is 10h 35m
Cheapest Buses Wednesday
What are the fastest trips from Knoxville, TN to Indianapolis?
You can get to Indianapolis from Knoxville, TN in just 4h 28m with a Flight from Skyscanner. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 23:59:00. 50 Economy ticket for £212 per person are available. Travel duration is 4h 40m
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Skyscanner5h 7m013:54Knoxville AirportKnoxville Airport19:01Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 19:01:00. 50 Economy ticket for £212 per person are available. Travel duration is 5h 7m
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United Airlines6h 10m010:20Knoxville AirportKnoxville Airport16:30Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 10:20:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 16:30:00. 50 Economy ticket for £281 per person are available. Travel duration is 6h 10m
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Allegiant Air6h 29m007:15Knoxville AirportKnoxville Airport13:44Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 07:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 13:44:00. 50 Economy ticket for £111 per person are available. Travel duration is 6h 29m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 04/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 04/06/2026 12:53:00. 50 Economy ticket for £212 per person are available. Travel duration is 6h 53m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 05/06/2026 04:45:00. 50 Economy ticket for £57 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 05/06/2026 08:25:00. 50 Economy ticket for £58 per person are available. Travel duration is 14h 15m
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Greyhound US16h 25m019:40Knoxville, TNGreyhound Bus Station12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 04/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 05/06/2026 12:05:00. 50 Economy ticket for £57 per person are available. Travel duration is 16h 25m
Fastest Flights Thursday
Fastest Buses Thursday
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 06/06/2026 04:45:00. 50 Economy ticket for £55 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 06/06/2026 08:25:00. 50 Economy ticket for £55 per person are available. Travel duration is 14h 15m
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 05/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 06/06/2026 12:05:00. 50 Economy ticket for £50 per person are available. Travel duration is 16h 25m
Fastest Buses Friday
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Skyscanner4h 28m005:45Knoxville AirportKnoxville Airport10:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 05:45:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 10:13:00. 50 Economy ticket for £126 per person are available. Travel duration is 4h 28m
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Allegiant Air5h 3m017:56Knoxville AirportKnoxville Airport22:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 17:56:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 22:59:00. 50 Economy ticket for £131 per person are available. Travel duration is 5h 3m
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Skyscanner5h 7m013:54Knoxville AirportKnoxville Airport19:01Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 19:01:00. 50 Economy ticket for £211 per person are available. Travel duration is 5h 7m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 12:53:00. 50 Economy ticket for £211 per person are available. Travel duration is 6h 53m
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Allegiant Air16h 59m006:00Knoxville AirportKnoxville Airport22:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 06/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 06/06/2026 22:59:00. 50 Economy ticket for £131 per person are available. Travel duration is 16h 59m
Fastest Flights Saturday
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Skyscanner4h 28m005:45Knoxville AirportKnoxville Airport10:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 05:45:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 10:13:00. 50 Economy ticket for £337 per person are available. Travel duration is 4h 28m
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 23:59:00. 50 Economy ticket for £338 per person are available. Travel duration is 4h 40m
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Allegiant Air6h 29m007:15Knoxville AirportKnoxville Airport13:44Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 07:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 13:44:00. 50 Economy ticket for £296 per person are available. Travel duration is 6h 29m
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United Airlines6h 53m006:00Knoxville AirportKnoxville Airport12:53Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 06:00:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 12:53:00. 50 Economy ticket for £337 per person are available. Travel duration is 6h 53m
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Allegiant Air12h 14m008:15Knoxville AirportKnoxville Airport20:29Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 07/06/2026 08:15:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 07/06/2026 20:29:00. 50 Economy ticket for £190 per person are available. Travel duration is 12h 14m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 08/06/2026 04:45:00. 50 Economy ticket for £58 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 08/06/2026 08:25:00. 50 Economy ticket for £60 per person are available. Travel duration is 14h 15m
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Greyhound US16h 25m019:40Knoxville, TNGreyhound Bus Station12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 07/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 08/06/2026 12:05:00. 50 Economy ticket for £56 per person are available. Travel duration is 16h 25m
Fastest Flights Sunday
Fastest Buses Sunday
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Skyscanner4h 40m019:19Knoxville AirportKnoxville Airport23:59Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 19:19:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 23:59:00. 50 Economy ticket for £280 per person are available. Travel duration is 4h 40m
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United Airlines6h 10m010:20Knoxville AirportKnoxville Airport16:30Indianapolis AirportIndianapolis Airport0EconomyA Flight from United Airlines goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 10:20:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 16:30:00. 50 Economy ticket for £337 per person are available. Travel duration is 6h 10m
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Skyscanner6h 19m013:54Knoxville AirportKnoxville Airport20:13Indianapolis AirportIndianapolis Airport0EconomyA Flight from Skyscanner goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 13:54:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 20:13:00. 50 Economy ticket for £280 per person are available. Travel duration is 6h 19m
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Allegiant Air7h 22m013:41Knoxville AirportKnoxville Airport21:03Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 13:41:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 08/06/2026 21:03:00. 50 Economy ticket for £190 per person are available. Travel duration is 7h 22m
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Allegiant Air21h 43m018:39Knoxville AirportKnoxville Airport16:22Indianapolis AirportIndianapolis Airport0EconomyA Flight from Allegiant Air goes from Knoxville Airport, Knoxville Airport (USA) at 08/06/2026 18:39:00 to Indianapolis Airport, Indianapolis Airport (USA) arriving at 09/06/2026 16:22:00. 50 Economy ticket for £105 per person are available. Travel duration is 21h 43m
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 04:45:00. 50 Economy ticket for £66 per person are available. Travel duration is 10h 35m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 04:45:00. 50 Economy ticket for £68 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 09/06/2026 08:25:00. 50 Economy ticket for £66 per person are available. Travel duration is 14h 15m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 08/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 09/06/2026 08:25:00. 50 Economy ticket for £68 per person are available. Travel duration is 14h 15m
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 08/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 09/06/2026 12:05:00. 50 Economy ticket for £67 per person are available. Travel duration is 16h 25m
Fastest Flights Monday
Fastest Buses Monday
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Greyhound US10h 35m018:10Knoxville, TNKnoxville Area Transit Coach Stop04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 04:45:00. 50 Economy ticket for £66 per person are available. Travel duration is 10h 35m
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Greyhound US10h 35m018:10Knoxville, TNGreyhound Bus Station04:45IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 04:45:00. 50 Economy ticket for £69 per person are available. Travel duration is 10h 35m
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Greyhound US14h 15m018:10Knoxville, TNKnoxville Area Transit Coach Stop08:25IndianapolisDowntown Transit Center0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Downtown Transit Center, Indianapolis (USA) arriving at 11/06/2026 08:25:00. 50 Economy ticket for £65 per person are available. Travel duration is 14h 15m
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Greyhound US14h 15m018:10Knoxville, TNGreyhound Bus Station08:25IndianapolisWashington / Delaware0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/06/2026 18:10:00 to Washington / Delaware, Indianapolis (USA) arriving at 11/06/2026 08:25:00. 50 Economy ticket for £68 per person are available. Travel duration is 14h 15m
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Greyhound US16h 25m019:40Knoxville, TNKnoxville Area Transit Coach Stop12:05IndianapolisCentral Coach Station0EconomyA Bus from Greyhound US goes from Knoxville Area Transit Coach Stop, Knoxville, TN (USA) at 10/06/2026 19:40:00 to Central Coach Station, Indianapolis (USA) arriving at 11/06/2026 12:05:00. 50 Economy ticket for £66 per person are available. Travel duration is 16h 25m
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Knoxville, TN to Indianapolis
What are the most popular stations in Knoxville, TN and Indianapolis?
In Knoxville, TN, you will usually depart from Knoxville Area Transit Coach Stop, Greyhound Bus Station or Transit Center, while in Indianapolis you will be arriving at Central Coach Station, Greyhound Bus Station or Downtown Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Indianapolis from Knoxville, TN? With 6 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Knoxville, TN and Indianapolis, you can pay as low as £50 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Indianapolis in just 4h 28m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Knoxville, TN and Indianapolis are Greyhound US, Skyscanner and Allegiant Air, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Knoxville, TN and Indianapolis is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Wildwood, TN or to Beech Grove, IN, and look at flights from Knoxville Airport, and landing at Indianapolis Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Knoxville, TN to Indianapolis?
The most popular companies between Knoxville, TN and Indianapolis, are Greyhound US, Skyscanner and Allegiant Air. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Skyscanner, Allegiant Air and United Airlines
All you need to know when you travel from Knoxville, TN to Indianapolis
Check all information on comfort and services on all modes of transports from Knoxville, TN to Indianapolis. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Knoxville, TN to Indianapolis
How can I reach Indianapolis from Knoxville, TN?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Indianapolis from Knoxville, TN.
How far is Indianapolis from Knoxville, TN?
The distance between Knoxville, TN and Indianapolis is 466.2 km.
What is the most ecofriendly mode of transport between Knoxville, TN and Indianapolis?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 13 kgs of CO2, a train 16 kgs, a car 79 kgs, and a flight 115 kgs.
What is the cheapest mode of transport from Knoxville, TN to Indianapolis?
You can get to Indianapolis with just £50 by taking a Bus from Greyhound US.
What is the fastest way to get from Knoxville, TN to Indianapolis?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Indianapolis in just 4h 28m with a Flight from Skyscanner.
More routes to Knoxville, TN and to Indianapolis
Looking for more options? Here you can see the most popular routes to Knoxville, TN and to Indianapolis. Simply click on a connection, and you’ll find all the details about the route!
