What is the best way to travel from Orlando, FL to Greenville, SC?
Looking for a trip? Check and compare all the available Flights and Buses to Greenville, SC from Orlando, FL. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Greenville, SC from Orlando, FL?
You can reach Greenville, SC with just £162 by taking a Flight from United Airlines, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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United Airlines6h 30m007:00Orlando AirportOrlando Airport13:30Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 07:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 13:30:00. 50 Economy ticket for £212 per person are available. Travel duration is 6h 30m
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United Airlines7h 4m009:52Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 09:52:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £212 per person are available. Travel duration is 7h 4m
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United Airlines6h 2m010:54Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 10:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £213 per person are available. Travel duration is 6h 2m
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United Airlines7h 34m009:22Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 09:22:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £215 per person are available. Travel duration is 7h 34m
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United Airlines8h 31m012:27Orlando AirportOrlando Airport20:58Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 12:27:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 20:58:00. 50 Economy ticket for £284 per person are available. Travel duration is 8h 31m
Cheapest Flights Friday
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JetBlue Airways22h 13m010:00Orlando AirportOrlando Airport08:13Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 10:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 08:13:00. 50 Economy ticket for £178 per person are available. Travel duration is 22h 13m
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JetBlue Airways13h 19m018:54Orlando AirportOrlando Airport08:13Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 18:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 08:13:00. 50 Economy ticket for £188 per person are available. Travel duration is 13h 19m
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JetBlue Airways24h 51m010:00Orlando AirportOrlando Airport10:51Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 10:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 10:51:00. 50 Economy ticket for £190 per person are available. Travel duration is 24h 51m
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United Airlines6h 30m007:00Orlando AirportOrlando Airport13:30Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 07:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 08/11/2026 13:30:00. 50 Economy ticket for £254 per person are available. Travel duration is 6h 30m
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United Airlines5h 16m009:00Orlando AirportOrlando Airport14:16Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 09:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 08/11/2026 14:16:00. 50 Economy ticket for £254 per person are available. Travel duration is 5h 16m
Cheapest Flights Sunday
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United Airlines8h 31m012:27Orlando AirportOrlando Airport20:58Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 12:27:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 11/11/2026 20:58:00. 50 Economy ticket for £162 per person are available. Travel duration is 8h 31m
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United Airlines6h 2m010:54Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 10:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 11/11/2026 16:56:00. 50 Economy ticket for £184 per person are available. Travel duration is 6h 2m
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Frontier Airlines28h 21m015:03Orlando AirportOrlando Airport19:24Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 15:03:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 12/11/2026 19:24:00. 50 Economy ticket for £188 per person are available. Travel duration is 28h 21m
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JetBlue Airways19h 32m019:50Orlando AirportOrlando Airport15:22Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 19:50:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 12/11/2026 15:22:00. 50 Economy ticket for £304 per person are available. Travel duration is 19h 32m
Cheapest Flights Wednesday
What are the fastest trips from Orlando, FL to Greenville, SC?
You can get to Greenville, SC from Orlando, FL in just 5h 16m with a Flight from United Airlines. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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United Airlines6h 2m010:54Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 10:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £213 per person are available. Travel duration is 6h 2m
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United Airlines6h 30m007:00Orlando AirportOrlando Airport13:30Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 07:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 13:30:00. 50 Economy ticket for £212 per person are available. Travel duration is 6h 30m
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United Airlines7h 4m009:52Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 09:52:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £212 per person are available. Travel duration is 7h 4m
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United Airlines7h 34m009:22Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 09:22:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 16:56:00. 50 Economy ticket for £215 per person are available. Travel duration is 7h 34m
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United Airlines8h 31m012:27Orlando AirportOrlando Airport20:58Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 06/11/2026 12:27:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 06/11/2026 20:58:00. 50 Economy ticket for £284 per person are available. Travel duration is 8h 31m
Fastest Flights Friday
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United Airlines5h 16m009:00Orlando AirportOrlando Airport14:16Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 09:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 08/11/2026 14:16:00. 50 Economy ticket for £254 per person are available. Travel duration is 5h 16m
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United Airlines6h 30m007:00Orlando AirportOrlando Airport13:30Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 07:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 08/11/2026 13:30:00. 50 Economy ticket for £254 per person are available. Travel duration is 6h 30m
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JetBlue Airways13h 19m018:54Orlando AirportOrlando Airport08:13Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 18:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 08:13:00. 50 Economy ticket for £188 per person are available. Travel duration is 13h 19m
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JetBlue Airways22h 13m010:00Orlando AirportOrlando Airport08:13Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 10:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 08:13:00. 50 Economy ticket for £178 per person are available. Travel duration is 22h 13m
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JetBlue Airways24h 51m010:00Orlando AirportOrlando Airport10:51Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 08/11/2026 10:00:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 09/11/2026 10:51:00. 50 Economy ticket for £190 per person are available. Travel duration is 24h 51m
Fastest Flights Sunday
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United Airlines6h 2m010:54Orlando AirportOrlando Airport16:56Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 10:54:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 11/11/2026 16:56:00. 50 Economy ticket for £184 per person are available. Travel duration is 6h 2m
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United Airlines8h 31m012:27Orlando AirportOrlando Airport20:58Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from United Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 12:27:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 11/11/2026 20:58:00. 50 Economy ticket for £162 per person are available. Travel duration is 8h 31m
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JetBlue Airways19h 32m019:50Orlando AirportOrlando Airport15:22Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from JetBlue Airways goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 19:50:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 12/11/2026 15:22:00. 50 Economy ticket for £304 per person are available. Travel duration is 19h 32m
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Frontier Airlines28h 21m015:03Orlando AirportOrlando Airport19:24Greenville–Spartanburg AirportGreenville–Spartanburg Airport0EconomyA Flight from Frontier Airlines goes from Orlando Airport, Orlando Airport (USA) at 11/11/2026 15:03:00 to Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) arriving at 12/11/2026 19:24:00. 50 Economy ticket for £188 per person are available. Travel duration is 28h 21m
Fastest Flights Wednesday
Here you will find all operators and timetables for a
Bus from Orlando, FL to Greenville, SC
What are the most popular stations in Orlando, FL and Greenville, SC?
In Orlando, FL, you will usually depart from Coach Station, Dahlia Dr and S Semoran Blvd Coach Stop or Central Station, while in Greenville, SC you will be arriving at Woodruff Rd, McDonald's or Greyhound Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Greenville, SC from Orlando, FL? With 4 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Orlando, FL and Greenville, SC, you can pay as low as £162 with a Flight from United Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Greenville, SC in just 5h 16m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Orlando, FL and Greenville, SC are United Airlines, JetBlue Airways and Frontier Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Orlando, FL and Greenville, SC is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Fairview Shores, FL or to Welcome, SC, and look at flights from Orlando Airport, and landing at Greenville–Spartanburg Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Orlando, FL to Greenville, SC?
The most popular companies between Orlando, FL and Greenville, SC, are United Airlines, JetBlue Airways and Frontier Airlines. Be sure to check their seat class offers and the amenities that they provide.
Airlines: United Airlines, JetBlue Airways and Frontier Airlines
All you need to know when you travel from Orlando, FL to Greenville, SC
Check all information on comfort and services on all modes of transports from Orlando, FL to Greenville, SC. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Orlando, FL to Greenville, SC
How can I reach Greenville, SC from Orlando, FL?
Every day, there are on average 4 connections between Bus and Flight, with which you can get to Greenville, SC from Orlando, FL.
How far is Greenville, SC from Orlando, FL?
The distance between Orlando, FL and Greenville, SC is 708.3 km.
What is the most ecofriendly mode of transport between Orlando, FL and Greenville, SC?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 120 kgs, and a flight 174 kgs.
What is the cheapest mode of transport from Orlando, FL to Greenville, SC?
You can get to Greenville, SC with just £162 by taking a Flight from United Airlines.
What is the fastest way to get from Orlando, FL to Greenville, SC?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Greenville, SC in just 5h 16m with a Flight from United Airlines.
More routes to Orlando, FL and to Greenville, SC
Looking for more options? Here you can see the most popular routes to Orlando, FL and to Greenville, SC. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Orlando, FL
- Atlanta, GA to Orlando, FL
- Augusta, GA to Orlando, FL
- Baltimore, MD to Orlando, FL
- Boston, MA to Orlando, FL
- Brownsville, TX to Orlando, FL
- Charlotte, NC to Orlando, FL
- Columbus, OH to Orlando, FL
- Dallas to Orlando, FL
- El Paso, TX to Orlando, FL
- Fort Lauderdale, FL to Orlando, FL
- Indianapolis to Orlando, FL
- Miami Airport to Orlando, FL
- Miami to Orlando, FL
- Monterrey, NL to Orlando, FL
- Myrtle Beach, SC to Orlando, FL
- New Orleans, LA to Orlando, FL
- New York to Orlando, FL
- Philadelphia, PA to Orlando, FL
- San Antonio, TX to Orlando, FL
- Syracuse, NY to Orlando, FL
- Washington, DC to Orlando, FL
- Trips to Greenville, SC
- Nashville to Greenville, SC
