What is the best way to travel from Greenville, SC to Fort Myers, FL?
Looking for a trip? Check and compare all the available Buses and Flights to Fort Myers, FL from Greenville, SC. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Fort Myers, FL from Greenville, SC?
You can reach Fort Myers, FL with just £73 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 10:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 21h 0m
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FlixBus19h 20m019:45Greenville, SCWoodruff Rd15:05Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 19:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 15:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 19h 20m
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Greyhound US22h 0m014:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 14:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 12:45:00. 50 Economy ticket for £73 per person are available. Travel duration is 22h 0m
Cheapest Buses Friday
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 10:20:00. 50 Economy ticket for £85 per person are available. Travel duration is 21h 0m
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Greyhound US19h 0m017:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 17:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 12:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 19h 0m
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FlixBus36h 20m022:00Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 22:00:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 10/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 36h 20m
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FlixBus20h 35m019:45Greenville, SCWoodruff Rd16:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 19:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 16:20:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 35m
Cheapest Buses Monday
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 12/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 21h 0m
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FlixBus36h 20m022:00Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 22:00:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 13/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 36h 20m
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Greyhound US22h 0m014:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 14:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 12/12/2025 12:45:00. 50 Economy ticket for £86 per person are available. Travel duration is 22h 0m
Cheapest Buses Thursday
What are the fastest trips from Greenville, SC to Fort Myers, FL?
You can get to Fort Myers, FL from Greenville, SC in just 19h 0m with a Bus from Greyhound US. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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FlixBus19h 20m019:45Greenville, SCWoodruff Rd15:05Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 19:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 15:05:00. 50 Economy ticket for £73 per person are available. Travel duration is 19h 20m
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 10:20:00. 50 Economy ticket for £73 per person are available. Travel duration is 21h 0m
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Greyhound US22h 0m014:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 05/12/2025 14:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 06/12/2025 12:45:00. 50 Economy ticket for £73 per person are available. Travel duration is 22h 0m
Fastest Buses Friday
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Greyhound US19h 0m017:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 17:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 12:45:00. 50 Economy ticket for £85 per person are available. Travel duration is 19h 0m
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FlixBus20h 35m019:45Greenville, SCWoodruff Rd16:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 19:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 16:20:00. 50 Economy ticket for £103 per person are available. Travel duration is 20h 35m
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 09/12/2025 10:20:00. 50 Economy ticket for £85 per person are available. Travel duration is 21h 0m
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FlixBus36h 20m022:00Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 08/12/2025 22:00:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 10/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 36h 20m
Fastest Buses Monday
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FlixBus21h 0m013:20Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 13:20:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 12/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 21h 0m
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Greyhound US22h 0m014:45Greenville, SCWoodruff Rd12:45Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 14:45:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 12/12/2025 12:45:00. 50 Economy ticket for £86 per person are available. Travel duration is 22h 0m
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FlixBus36h 20m022:00Greenville, SCWoodruff Rd10:20Fort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 11/12/2025 22:00:00 to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 13/12/2025 10:20:00. 50 Economy ticket for £86 per person are available. Travel duration is 36h 20m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Greenville, SC to Fort Myers, FL
What are the most popular stations in Greenville, SC and Fort Myers, FL?
In Greenville, SC, you will usually depart from Woodruff Rd, McDonald's or Greyhound Bus Station, while in Fort Myers, FL you will be arriving at Cleveland Ave, Rosa Parks Transit Center or Daniels Pkwy, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Fort Myers, FL from Greenville, SC? With 4 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Greenville, SC and Fort Myers, FL, you can pay as low as £73 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from Greyhound US: you will get to Fort Myers, FL in just 19h 0m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Greenville, SC and Fort Myers, FL are FlixBus and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Greenville, SC and Fort Myers, FL is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Welcome, SC or to Palmona Park, FL, and look at flights from , and landing at Southwest Florida - Fort Myers Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Greenville, SC to Fort Myers, FL?
The most popular companies between Greenville, SC and Fort Myers, FL, are FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
All you need to know when you travel from Greenville, SC to Fort Myers, FL
Check all information on comfort and services on all modes of transports from Greenville, SC to Fort Myers, FL. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Greenville, SC to Fort Myers, FL
How can I reach Fort Myers, FL from Greenville, SC?
Every day, there are on average 4 connections between Bus and Flight, with which you can get to Fort Myers, FL from Greenville, SC.
How far is Fort Myers, FL from Greenville, SC?
The distance between Greenville, SC and Fort Myers, FL is 914.5 km.
What is the most ecofriendly mode of transport between Greenville, SC and Fort Myers, FL?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 155 kgs, and a flight 225 kgs.
What is the cheapest mode of transport from Greenville, SC to Fort Myers, FL?
You can get to Fort Myers, FL with just £73 by taking a Bus from FlixBus.
What is the fastest way to get from Greenville, SC to Fort Myers, FL?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Fort Myers, FL in just 19h 0m with a Bus from Greyhound US.
More routes to Greenville, SC and to Fort Myers, FL
Looking for more options? Here you can see the most popular routes to Greenville, SC and to Fort Myers, FL. Simply click on a connection, and you’ll find all the details about the route!
