What is the best way to travel from Chicago to Louisville, KY?
Looking for a trip? Check and compare all the available Buses and Flights to Louisville, KY from Chicago. Look at different modes of transportation, search for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Louisville, KY from Chicago?
You can reach Louisville, KY with just £31 by taking a Bus from FlixBus, but there are many more cheap offers: we have selected the best ones for you for the next few days here.
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FlixBus11h 0m005:45Chicago95th Red Line Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 05:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 17:45:00. 50 Economy ticket for £31 per person are available. Travel duration is 11h 0m
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Greyhound US6h 50m014:10Chicago95th Red Line Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 14:10:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 22:00:00. 50 Economy ticket for £32 per person are available. Travel duration is 6h 50m
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FlixBus7h 0m005:25Chicago95th Red Line Station13:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 05:25:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 13:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 0m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
Cheapest Buses Saturday
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £33 per person are available. Travel duration is 7h 5m
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 22:00:00. 50 Economy ticket for £33 per person are available. Travel duration is 6h 15m
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Greyhound US6h 45m010:00ChicagoUnion Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £33 per person are available. Travel duration is 6h 45m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 09/12/2025 01:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 25m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 21:50:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 50m
Cheapest Buses Monday
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Greyhound US6h 15m006:10ChicagoDowntown Coach Station13:25Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 06:10:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 13:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 22:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 01:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 25m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 21:50:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 50m
Cheapest Buses Wednesday
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 22:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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Greyhound US6h 45m010:00ChicagoUnion Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/12/2025 10:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 45m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 12/12/2025 01:25:00. 50 Economy ticket for £35 per person are available. Travel duration is 6h 25m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 21:50:00. 50 Economy ticket for £37 per person are available. Travel duration is 7h 50m
Cheapest Buses Thursday
What are the fastest trips from Chicago to Louisville, KY?
You can get to Louisville, KY from Chicago in just 6h 15m with a Bus from Greyhound US. But this is just one option, click on any of the offers below to compare it with the other available modes of transportations.
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Greyhound US6h 50m014:10Chicago95th Red Line Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 14:10:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 22:00:00. 50 Economy ticket for £32 per person are available. Travel duration is 6h 50m
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FlixBus7h 0m005:25Chicago95th Red Line Station13:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 05:25:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 13:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 0m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 06/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
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FlixBus11h 0m005:45Chicago95th Red Line Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 06/12/2025 05:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 06/12/2025 17:45:00. 50 Economy ticket for £31 per person are available. Travel duration is 11h 0m
Fastest Buses Saturday
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 22:00:00. 50 Economy ticket for £33 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 09/12/2025 01:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 25m
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Greyhound US6h 45m010:00ChicagoUnion Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 08/12/2025 10:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £33 per person are available. Travel duration is 6h 45m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 17:45:00. 50 Economy ticket for £33 per person are available. Travel duration is 7h 5m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 08/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 08/12/2025 21:50:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 50m
Fastest Buses Monday
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Greyhound US6h 15m006:10ChicagoDowntown Coach Station13:25Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 06:10:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 13:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 22:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 01:25:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 25m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 10/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/12/2025 21:50:00. 50 Economy ticket for £35 per person are available. Travel duration is 7h 50m
Fastest Buses Wednesday
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Greyhound US6h 15m014:45ChicagoDowntown Coach Station22:00Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 14:45:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 22:00:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m018:00ChicagoDowntown Coach Station01:25Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 18:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 12/12/2025 01:25:00. 50 Economy ticket for £35 per person are available. Travel duration is 6h 25m
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Greyhound US6h 45m010:00ChicagoUnion Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/12/2025 10:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 6h 45m
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Greyhound US7h 5m009:40ChicagoDowntown Coach Station17:45Louisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 09:40:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 17:45:00. 50 Economy ticket for £34 per person are available. Travel duration is 7h 5m
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FlixBus7h 50m013:00ChicagoDowntown Coach Station21:50Louisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Coach Station, Chicago (USA) at 11/12/2025 13:00:00 to Greyhound Bus Station, Louisville, KY (USA) arriving at 11/12/2025 21:50:00. 50 Economy ticket for £37 per person are available. Travel duration is 7h 50m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Chicago to Louisville, KY
What are the most popular stations in Chicago and Louisville, KY?
In Chicago, you will usually depart from California & 35th Street Coach Stop, Downtown Coach Station or 95th Red Line Station, while in Louisville, KY you will be arriving at Greyhound Bus Station, International Airport or Convention Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Louisville, KY from Chicago? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and Louisville, KY, you can pay as low as £31 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from Greyhound US: you will get to Louisville, KY in just 6h 15m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and Louisville, KY are Greyhound US and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and Louisville, KY is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to New Albany, IN, and look at flights from Chicago Midway Airport, and landing at . Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to Louisville, KY?
The most popular companies between Chicago and Louisville, KY, are Greyhound US and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
All you need to know when you travel from Chicago to Louisville, KY
Check all information on comfort and services on all modes of transports from Chicago to Louisville, KY. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to Louisville, KY
How can I reach Louisville, KY from Chicago?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to Louisville, KY from Chicago.
How far is Louisville, KY from Chicago?
The distance between Chicago and Louisville, KY is 433.2 km.
What is the most ecofriendly mode of transport between Chicago and Louisville, KY?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 12 kgs of CO2, a train 15 kgs, a car 74 kgs, and a flight 107 kgs.
What is the cheapest mode of transport from Chicago to Louisville, KY?
You can get to Louisville, KY with just £31 by taking a Bus from FlixBus.
What is the fastest way to get from Chicago to Louisville, KY?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Louisville, KY in just 6h 15m with a Bus from Greyhound US.
More routes to Chicago and to Louisville, KY
Looking for more options? Here you can see the most popular routes to Chicago and to Louisville, KY. Simply click on a connection, and you’ll find all the details about the route!
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